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The manifest right accessory pathway led to reversible left ventricular dyssynchrony and dysfunction

上海医学 2007年第S1期30卷 224-225页

作者： SHAN Qijun, JIN Yu, CAO K ejiang From department of Cardiology, First Affiliated hospital of Nanjing Medical {2., Nanjing 2.002., china

We report observations in a 7 year old girl with manifest right accessory pathway (AP) and depressed cardiac function. Her Echocardiogram showed LV dilatation with asynchronous ventricular wall motion and LVEF reduction. The electrophysiological study demonstrated a para-his AP. She underwent successfully ablation and without any complications. The Echo validated that asynchronous ventricular wall motion disappeared after ablation. Her cardiac size and function was normal after follow up of three month. Our findings suggested that manifest AP leading to asynchronous ventricular motion was a possible cause of left ventricular dilation and dysfunction. Catheter ablation could reverse cardiac remodeling in such patient. Case report A seven year old girl was referred to our hospital for fainting episode in last six month. To exclude cephalic syncope, she underwent electroencephalogram, the result was negative. The electrocardiogram (ECG) showed right AP. An apparent delta wave looked like LBBB pattern with short PR interval (80ms) and long QRS duration (180ms) (figure 1 left panel). Echocardiogram (Echo) revealed left ventricle dilatation and left ventricular ejection fraction reduction (LVDd=52.m, LVEF=46%). Asynchronous ventriclular wall motion and moderate mitral valve regurgitation also observed on Tissue Doppler imaging (TDI). She underwent electrophysiology study (EPS) and ablation procedure on the 5th hospital day. The intracardiac electrogram showed a para-His AP with antegrade conduction. The orthodromic SVT (2.1 bpm) was induce right ventricular apex programmed stimulation. During SVT episode, her symptom was similar to spontaneous one. After successful ablation, delta wave on ECG disappeared and SVT can not be induced with or without isoproterenol. Normal atrial-ventricular conduction was kept without any complications. Prior to discharge, Echo showed the LVEF slightly improved and TDI indicated that asynchronous ventricular wall motion disappeared. She was d

关键词： manifest accessory dilatation ejection ablation remodeling medication reversible conduction asynchro

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去甲斑蝥素对人胆囊癌细胞系侵袭转移及其相关基因的抑制效应

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中国新药与临床杂志 2004年第8期23卷 522-525页

作者：范跃祖傅锦业赵泽明陈春球同济大学附属同济医院外科上海200065

目的 :探讨去甲斑蝥素 (NCTD)对人胆囊癌细胞侵袭转移及其相关基因的抑制效应。方法 :培养人胆囊癌GBC SD细胞 ,应用Matrigel实验、过河实验、SABC方法检测NCTD对GBC SD细胞侵袭、运动和基质溶解相关基因蛋白明胶酶A即金属蛋白酶 2.(MMP... 详细信息

目的 :探讨去甲斑蝥素 (NCTD)对人胆囊癌细胞侵袭转移及其相关基因的抑制效应。方法 :培养人胆囊癌GBC SD细胞 ,应用Matrigel实验、过河实验、SABC方法检测NCTD对GBC SD细胞侵袭、运动和基质溶解相关基因蛋白明胶酶A即金属蛋白酶 2.(MMP2.) ,金属蛋白酶 2.织抑制剂 (TIM P2.)表达的影响。结果 :NCTD在 5mg·L- 1时即可抑制GBC SD细胞的体外侵袭、运动能力 ,随药物浓度提高过膜细胞减少 ,过膜死亡细胞增多 ,过河时间延长(P 2.表达下降 ,TIMP2.达上升 ,MMP2./TIMP2.比值下降 (P 2.,TIMP2.表达有关。

关键词：胆囊肿瘤肿瘤侵润明胶酶A 金属蛋白酶2.织抑制剂去甲斑蝥素

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全凭静脉麻醉在乳房肿块切除术中的应用

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铁道医学 2002年第1期30卷 13-15页

作者：张磊韩松同济大学附属同济医院麻醉科上海200065

目的　观察咪唑安定加氯胺酮或异丙酚加芬太尼全凭静脉麻醉用于乳房肿块切除术中的麻醉效果及其对循环、呼吸的影响。方法　将 6 0例患者随机分为咪唑安定氯胺酮组 (Ⅰ组、3.例 )及异丙酚芬太尼组 (Ⅱ组、3.例 )。术中连续监测心率 ... 详细信息

目的　观察咪唑安定加氯胺酮或异丙酚加芬太尼全凭静脉麻醉用于乳房肿块切除术中的麻醉效果及其对循环、呼吸的影响。方法　将 6 0例患者随机分为咪唑安定氯胺酮组 (Ⅰ组、3.例 )及异丙酚芬太尼组 (Ⅱ组、3.例 )。术中连续监测心率 (HR)、平均动脉压 (MAP)和指脉氧 (SpO2.) ,观察麻醉效果及并发症。结果　两组麻醉效果均满意 ,Ⅱ组较Ⅰ组对循环、呼吸抑制均明显 (P <0 .0 5 ) ,但能自行恢复。结论　咪唑安定加氯胺酮或异丙酚加芬太尼全凭静脉麻醉用于乳房肿块切除术 ,安全舒适 ,方便可行 ,患者恢复迅速。

关键词：全凭静脉麻醉咪唑安定氯胺酮异丙酚芬太尼乳房肿块切除术应用

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面肌痉挛异常肌反应与F波之间的相关性研究

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上海医学 2003年第S1期26卷 27-29页

作者：海舰李世亭潘庆刚李善泉同济大学附属同济医院神经外科上海200065 上海第二医科大学附属仁济医院神经外科

目的　建立面肌痉挛 (HFS)动物模型 ,探讨异常肌反应 (AMR)与F波之间的相关性。方法　 10只新西兰大白兔采用出茎乳孔段面神经主干脱髓鞘和血管压迫的方法复制HFS动物模型。术后第 6周 ,刺激面神经下颌缘支 ,分别在同侧眼轮匝肌和颏肌... 详细信息

目的　建立面肌痉挛 (HFS)动物模型 ,探讨异常肌反应 (AMR)与F波之间的相关性。方法　 10只新西兰大白兔采用出茎乳孔段面神经主干脱髓鞘和血管压迫的方法复制HFS动物模型。术后第 6周 ,刺激面神经下颌缘支 ,分别在同侧眼轮匝肌和颏肌上检测AMR及F波 ,比较AMR/M、F/M波幅比率和AMR、F波持续时间之间的关系。结果　AMR/M和F/M波幅比率之间呈正相关 (r =0 .860 2.,P 2.,P <0 .0 1)。结论　F波与AMR有同源性 ,为HFS的术前诊断。

关键词：面肌痉挛异常肌反应 F波动物模型

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急性下壁心肌梗死伴房室传导阻滞与梗死相关动脉的相关性分析

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上海医学 2003年第S1期26卷 57-59页

作者：车琳蒋金法徐文俊邓兵左洪鹏同济大学附属同济医院心内科上海200065

目的　研究急性下壁心肌梗死伴房室传导阻滞 (AVB)与梗死相关动脉之间的关系。方法　将 5 7例急性下壁心肌梗死患者分为房室传导阻滞组 (AVB组 ,2.7例 )和无房室传导阻滞组 (NAVB组 ,3.0例 ) ,研究两组间的梗死相关动脉 ,并分析两组冠... 详细信息

目的　研究急性下壁心肌梗死伴房室传导阻滞 (AVB)与梗死相关动脉之间的关系。方法　将 5 7例急性下壁心肌梗死患者分为房室传导阻滞组 (AVB组 ,2.7例 )和无房室传导阻滞组 (NAVB组 ,3.0例 ) ,研究两组间的梗死相关动脉 ,并分析两组冠状动脉病变支数及优势型冠状动脉病变对AVB发生的影响。结果　急性下壁心肌梗死的梗死相关动脉主要是右冠状动脉 ,下壁心肌梗死合并AVB与多支血管病变无关 ,但与优势型冠状动脉狭窄有关 ,并且优势型冠状动脉狭窄是急性下壁心肌梗死合并AVB的独立危险因素。

关键词：心肌梗死房室传导阻滞梗死相关动脉

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Diagnosis of chronic anterior cruciate ligament Injury

Diagnosis of chronic anterior cruciate ligament Injury

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第2.届FIMS世界运动医学大会

作者： Gao Kai, Wang Lide department of Sports Science,shanghai {2. of Sport, shanghai, china department of Orthopaedics, 1st hospital, Dalian Medical {2., Dalian, china

Objective: To evaluate the value of clinical examination and magnetic resonance imaging in diagnosing chronic anterior cruciate ligament injury. Methods: 65 patients with the diagnosis of chronic anterior cruciate ligament injury were retrospectively analyzed the course of diagnosis and treatment. All the patients had suffered from

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Intestinal expressions of eNOSmRNA and iNOSmRNA in rats with acute liver failure

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World Journal of Gastroenterology 2001年第5期7卷 652-656页

作者： Jian-Min Qin~1 Yang-De Zhang~2.1 department of Hepatobiliary & Enteric Surgery.Xiangya hospital,Hunan Medical {2.,Changsha 410008,Hunan Province,china2.department of Hepatobiliary & Enteric Surgery,Xiangya hospital,Hunan Medical {2.,Changsha 410008,Hunan Province,china Biological Signal Transduction Center Eastern Hepatobiliary Surgery Hospital the Second Military Medical University Shanghai 200438 China. Jianminqin@***

AIM: To observe the gene expression change of eNOSmRNA and iNOSmRNA in the small and large intestines with acute liver failure (ALF), and to reveal the biological function of NO on the pathogenesis of ALF and multiple organs dysfunction at the molecular level. METHODS: Sixty male Wistar rats were selected, weighing from 2.0g to 3.0g, and divided into 5 groups randomly: SO, ALF (6h, 12.), L-Arg, L-NAME, L-Arg and L-NAME, each group with 10 rats. The dose of L-Arg was ***(-1), and L-NAME was ***(-1), the reagents diluted by normal saline were injected through tail vein 3. minutes pre and post operation. The rats in the ALF group were respectively sacrificed postoperatively at 6h, 12., and the rats in the other groups were sacrificed postoperatively at 6h. The tissues of small and large intestines were harvested in 4% paraforaldehyde containing the reagent of DEPC and fixed at 6h, embedded in paraffin, and 4 microm section was cut. The expression of eNOSmRNA and iNOSmRNA in these tissues was determined with in situ hybridization, and analyzed with the {3. analysis system of CMM-3.and SPSS statistical software. RESULTS: The expression of eNOSmRNA in the large intestine and iNOSmRNA in the small and large intestines increased significantly at 6h after ALF, but the expression of iNOSmRNA in the small and large intestines reduced notably at 12. after ALF (P<0.05); the expression of eNOSmRNA in the large intestine and iNOSmRNA in the small and large intestines decreased significantly with the reagents of L-Arg at 6h ALF, but the expression of eNOSmRNA and iNOSmRNA in the small and large intestines decreased totally with the reagents of L-NAME or association with L-Arg 6h ALF. CONCLUSION: The expression of eNOSmRNA in the large intestine increased notably at the early stage of ALF, NO induced by the enzyme of eNOS from the transplantation of eNOSmRNA can protect the function of the large intestine, the high expression of iNOSmRNA is involved in the damaged fu

关键词： Acute Disease Animals Gene Expression Regulation, Enzymologic Intestines Liver Failure Male Nitric Oxide Synthase Nitric Oxide Synthase Type II Nitric Oxide Synthase Type III RNA, Messenger Rats Rats, Wistar

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结扎前列腺动脉Madigan前列腺切除术2.8例报道

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上海医学 2004年第5期27卷 314-315页

作者：曹承华桂亚平袁涛卞崔冬张进王天如同济大学附属同济医院泌尿外科上海200065

目的　介绍改进的Madigan术式———结扎前列腺动脉Madigan前列腺切除术 ,展示一种更为完善的开放前列腺手术方法。方法　回顾性分析 2.5 8例行预先结扎前列腺动脉Madigan前列腺切除术患者的临床资料。结果　 2.5 8例行结扎前列腺动脉M... 详细信息

目的　介绍改进的Madigan术式———结扎前列腺动脉Madigan前列腺切除术 ,展示一种更为完善的开放前列腺手术方法。方法　回顾性分析 2.5 8例行预先结扎前列腺动脉Madigan前列腺切除术患者的临床资料。结果　 2.5 8例行结扎前列腺动脉Madigan切除术患者术后除 3.排尿困难外 ,余均恢复良好。无尿失禁、切口感染和术后出血。结论　结扎前列腺动脉Madigan前列腺切除术的疗效好、并发症少 ,但手术操作中尚存在一些值得注意的问题。

关键词：前列腺切除术 Madigan术良性前列腺增生外科手术治疗

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Human Leukocyte Antigen-DRB1 Alleles Influence Diffuse Panbronchiolitis in Chinese Han Subjects

Human Leukocyte Antigen-DRB1 Alleles Influence Diffuse Panbr...

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中华医学会呼吸病学年会——2.11（第十二次全国呼吸病学学术会议）

作者： Yuan Zhang~() 1 department of Respiratory Diseases,shanghai Pulmonary {2. {3. university School of Medicine, shanghai 2.043.,china 2.Laboratory of Molecular Cell Biology,Institute of Biochemistry and Cell Biology,shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,shanghai,2.003.,china 3.Division of Pulmonary,Allergy,and Critical Care Medicine,department of Medicine,Duke university School of Medicine,Durham,NC 2.710,USA.

Background and objective Human HLA genes,especially HLA-A,B,and DRB1,which are highly polymorphic,have been thought to be candidate loci for the etiology of diffuse panbronchiolitis (DPB).This study aimed to assess the association between the polymorphism of HLA-A,B and DRB1 alleles and DPB in Chinese Han subjects,and to determine the association of single

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Depressant effect and mechanism of atorvastatin on the chronic rejection of aortic allograft in rats

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china Medical Abstracts 2008年第2期17卷 160-162,165页

作者：左克强钱振宇黄道景龚凯汤敬东 department of Vascular Surgery Tongji HospitalTongji University

Objective To investigate the depressant effect and mechanism of atorvastatin on the chronic rejection of aortic allograft in rats. Methods： The models of abdominal aorta transplantation were made with micro-surgery in rats. The recipients were divided into three groups： allograft control group, atorvastatin-treated group and isograft control group. Vascular intimal thickness in all of the groups were observed by histological examination. The expression of PCNA and α-SMA were determined by immunohistochemistry. The content of nitric oxide was determined by nitrate reductase chromatometry. Results： The vascular intimal thickness in rats of atorvastatin-treated group （11.60% ± 2.40% ） were lower than those in allograft control group （3..60 % ± 6.40 % ; P 〈 0.05） and higher than those in isograft control group （1.15 % ± 0.65 %; P〈 0.05 ）. The expression level of PCNA was decreased in atorvastatin-treated group （4.80% ± 0.80% ） than allograft control group （18.40% ± 1.80% ; P〈0.05） and higher than isograft group （1.2.% ± 0.40% ; P〈0.05）. Conclusion： The expression of PCNA in the transplant aorta could be suppressed by atorvastatin, which resalted in relief of chronic rejection of aortic allograft.

关键词： Atorvastatin Transplant Chronic rejection Proliferation cell nuclear antigen α-smooth muscle actin Nitric oxide

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