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The role of proteomics in hepatic metastasis in colorectal cancer

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china Medical Abstracts 2006年第2期15卷 176-180页

作者：陈淑珍张国锋 Department of Gernerl Surgery Tongji HospitalTongji University(Shanghai 200065China)

Most colorectal cancer patients develop metastasis to the liver during the course of the disease. The success of metastatic hepatic cancer treatment is strongly dependent on early diagnosis and understanding of the molecular mechanisms and biological behaviors of colorectal cancer, especially its infiltration and *** proteomics, we can develop new biomarkers for diagnosis and early detection of hepatic metastasis in CRC and accelerate drug exposure.

关键词： proteomics colorectal cancer hepatic metastasis

Cell dycle inhibition attenuates microglial proliferation and production of IL-1beta,MlP-1alpha,and NO after focal cerebral ischemia in the rat

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Cell dycle inhibition attenuates microglial proliferation an...

Different model of whole brain response to emotional pictures between generalized anxiety disorder and panic disorder

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Qiang ZHANG~1,Chen CHEN~(1,2.,Jia-Gao LU~3,Min-Jie XIE~1,Deng-Ji PAN~1,Xiang LUO~1,Zhi-Yuan YU~1,Qiang DONG~(4*),Wei WANG~(1,*) 1 Department of Neurology,tongji hospital,tongji Medical College,Huazhong university of Science and Technology, Wuhan 430030,china 2.Department of Gerontology,First Afliated hospital of Zhengzhou university,Zhengzhou 450052.china 3 Department of Cardiology,tongji hospital,tongji Medical College,Huazhong university of Science and Technology, Wuhan 430030,china 4 Department of Neurology,Huashan hospital,Medical College of Fudan university,shanghai 2.0040,china

We recently showed that suppressing cell cycle progression inhibited reactive astrogliosis and promoted neuronal survival in an acute focal cerebral ischemia rat ***,it remains unclear whether and to what extent the beneficial effects of cell cycle inhibition might also be attributed to the inhibition of microglial proliferation and cytokine/ chemokine *** this study,we showed that application of the cell cycle inhibitor roscovitine before middle carotid artery occlusion(MCAO) in the rat inhibited microglial proliferation and cytokine/chemokine production,and reduced the number of cell-cycle-related proteins including cyclin A,cyclin B,and cyclin *** of these microglia-related changes may contribute to roscovitine’s effect on reducing neuronal apoptosis and in-farct volume,thus improving neurological *** the BV-2.microglia cell line,we showed that roscovitine not only inhibited oxygen-glucose deprivation(OGD) induced cell cycle activation by arresting the cells at G/S and G/M in a dose-dependent manner,but it also inhibited interleukin-1β,macrophage inammatory protein-1 alpha,and nitric oxide *** results suggest that cell cycle modulation results in neuroprotection in ischemia,mediated at least in part through inhibition of microglia proliferation and production of inflammatory cytokines such as IL-1β,MIP-1 alpha,and NO.

关键词： microglia cell cycle proliferation apoptosis

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Different model of whole brain response to emotional picture...

Two novel ways for Distinguishing sarcoidosis from sputum negative tuberculosis

中华医学会精神病学分会第九次全国学术会议

作者： LI Qing-wei,~1 WU Wen-yuan,~1 LI Chun-bo,~2.SHEN Yuan,~1 DA Gong-hual,~1 WANG Pei-jun~1 and WENG Xu-chu~3 1 tongji hospital of tongji university 2.shanghai Mental Health Center of shanghai Jiao Tong university 3 Hangzhou university

Objective To explore the different behavioral and related whole brain response to emotional pictures in individuals with generalized anxiety disorder or panic disorder(PD).

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Two novel ways for Distinguishing sarcoidosis from sputum ne...

Celiomesenteric trunk demonstrated by 3-dimensional contrast-enhanced magnetic resonance angiography

中华医学会呼吸病学年会——2.11（第十二次全国呼吸病学学术会议）

作者： Huiping Li,Qiuhong Li,Ying Zhou shanghai Pulmonary hospital,{2. university School of Medicine

Background To differentiate sarcoidosis(SA) from sputum negative tuberculosis(TB) is a challenge for clinical doctors,especially in a high TB prevalence country like *** established two novel ways for sarcoidosis and sputum negative tuberculosis differentiation. Methods *** samples were retrospectively collected from 104 patients with sarcoidosis,31 patients

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Hepatobiliary & Pancreatic Diseases International 2005年第3期4卷 472-474页

作者： Jiang Lin Author Affiliations:Department of Radiology, Zhongshan hospital, Fudan university, {2. 2.0032. china (Lin J) Department of Radiology Zhongshan Hospital Fudan University Shanghai 200032 China. linjiang@***

Celiomesenteric trunk is a rare vascular anomaly, which has significant clinical implications. 3-di-mensional contrast-enhanced magnetic resonance angiography (3D CE MRA) is a new imaging modality, non-invasive , fast and easy to perform. We describe a patient with a common celiomesenteric trunk demonstrated by 3D CE MRA. METHODS: A 45-year-old man was subjected to 3D CE MRA before transarterial chemoembolization (TACE) for hepatocellular carcinoma. The examination was performed on a 1.5T MR imager with a body coil. The contrast medium was gadopentetate dimeglumine. Source images from the hepatic arterial phase acquisition were reconstructed into MRA images. Intra-arterial digital subtraction angiography (DSA) during TACE was carried out 3 days after 3D CE MRA. RESULTS:On 3D CE MRA, a common trunk of the celiac and superior mesenteric artery was clearly depicted. The origin and course of the hepatic, splenic and superior mesenteric arteries were also visualized. These findings were confirmed by intra-arterial DSA. CONCLUSIONS: Celiomesenteric trunk can be well delineated by 3D CE MRA. The image is correlated precisely with that from DSA.

关键词： celiomesenteric trunk magnetic resonance angiography

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阿卡波糖对2.糖尿病病人胰岛素抵抗的影响

中国新药与临床杂志 2003年第9期22卷 535-538页

作者：吴国亭韩玉麒于永春滕小洪张巾超曲福军同济大学附属铁路医院内分泌科上海200072 哈尔滨医科大学附属第二医院内分泌科哈尔滨150086

目的 :探讨阿卡波糖对 2.糖尿病病人胰岛素抵抗的影响。方法 :16 0例 2.糖尿病病人随机分为 2. ,治疗组 80例口服阿卡波糖治疗 ,前 2.k ,5 0mg ,po ,tid ,2.k后 ,10 0mg ,po ,tid ;安慰剂组 80例口服安慰剂 ,方法同治疗组 ,疗程为 2.... 详细信息

目的 :探讨阿卡波糖对 2.糖尿病病人胰岛素抵抗的影响。方法 :16 0例 2.糖尿病病人随机分为 2. ,治疗组 80例口服阿卡波糖治疗 ,前 2.k ,5 0mg ,po ,tid ,2.k后 ,10 0mg ,po ,tid ;安慰剂组 80例口服安慰剂 ,方法同治疗组 ,疗程为 2.4wk。同时观察空腹及餐后 2.血糖、血清胰岛素水平、体重指数、糖化血红蛋白、空腹时的红细胞胰岛素受体和红细胞膜流动性治疗前后变化。结果 :(1)wk 4时 ,阿卡波糖明显降低病人的空腹血糖、餐后 2.血糖、糖化血红蛋白 ,下降值分别为 :(2..9±s 0 .8)mmol·L- 1,(4.0± 1.8)mmol·L- 1,(1.2. 2..1) % ,P2.) 2.4wk后 ,阿卡波糖降低病人的体重、空腹血清胰岛素、餐后 2.血清胰岛素 ,下降值分别为 :(6± 4 )kg·m- 2.,(10± 6 )MIU·L- 1,(14± 10 )MIU·L- 1,增加红细胞胰岛素受体 ,升高值为 :(80± 71)sites·RBC- 1,降低膜流动性 ,下降值为 :(1.5± 1.3) ,P <0 .0 1。结论 :阿卡波糖能改善

关键词：阿卡波糖 2.糖尿病胰岛素抵抗餐后血糖

Clinical progress on the examinations of lymphangiogenesis and lymph node metastasis in colorectal cancer

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外科研究与新技术 2005年第4期 316-321页

作者：黄漾张国锋范跃祖 Department of General Surgery Tongji HospitalTongji UniversityShanghai 200065China

Colorectal cancer (CRC) is one of human common malignant tumors that can metastasize to regional lymph nodes (RLNs) via lymphatics. The lymphangiogenesis and lymph node metastasis in CRC involves alterations of expressions of multiple biomarkers. So examinations on these biomarkers may provide significant valves for diagnosis, treatment and prognosis in CRC. This review focuses on the clinical examinations for lymphangiogenesis and lymph node metastasis with CRC in rencent years.

关键词： colorectal cancer lymphangoigenesis lymph node metastasis marker

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持续非卧床腹膜透析患者营养状况评价

同济大学学报（医学版） 2010年第1期31卷 49-52页

作者：陈胜芳崔春黎同济大学附属同济医院营养科上海200065 同济大学附属同济医院肾内科上海200065

目的探讨持续非卧床腹膜透析(continuous ambulatory peritoneal dialysis,CAPD)患者的营养状况。方法随机选择病情稳定,符合观察条件的透析患者52.(男/女,32.2.)。进行膳食营养评价、半定量SGA评分、人体测量以及生化指标检测。结果C... 详细信息

目的探讨持续非卧床腹膜透析(continuous ambulatory peritoneal dialysis,CAPD)患者的营养状况。方法随机选择病情稳定,符合观察条件的透析患者52.(男/女,32.2.)。进行膳食营养评价、半定量SGA评分、人体测量以及生化指标检测。结果CAPD患者营养不良发生率高:以SGA评分作为评价指标,78.8%的患者有不同程度的营养不良;以ALB作为评价指标,67.3%的患者营养不良;基于AMC判断,则有55.8%的患者营养不良。营养摄入量与营养评价指标关系密切:DEI与BMI呈正相关(P<0.05),与ALB、PA呈正相关(P<0.05,P<0.01),而与SGA、CRP呈负相关(P<0.01,P<0.05);DPI与PA呈正相关(P<0.01)。蛋白质摄入充分组PA明显高于摄入不足组(P<0.01);热量摄入充分组ALB高于摄入不足组(P<0.05)。结论CAPD患者营养不良发生率高,膳食营养与CAPD患者营养状况密切相关,就维持血浆蛋白而言,摄入充足的热量可能比蛋白质更重要。

关键词：腹膜透析患者营养评价营养不良

高血压病患者左心房重构与房性心律失常的关系

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同济大学学报（医学版） 2003年第3期24卷 222-223,226页

作者：魏娟邓兵同济大学医学院护理系上海200070 同济大学附属同济医院心内科上海200065

目的　研究高血压病患者左心房重构对房性心律失常的影响。方法　采用 12.联心电图、2.4h动态心电图和超声心动图检测 5 6例符合WHO高血压病诊断标准的病人。在 12.联心电图上测量计算最大P波间期(Pmax)、最小P波间期 (Pmin)和P波离散... 详细信息

目的　研究高血压病患者左心房重构对房性心律失常的影响。方法　采用 12.联心电图、2.4h动态心电图和超声心动图检测 5 6例符合WHO高血压病诊断标准的病人。在 12.联心电图上测量计算最大P波间期(Pmax)、最小P波间期 (Pmin)和P波离散度 (Pd)。根据 2.4h动态心电图检测结果 ,对所检出的房性心律失常按Kleigar分级标准进行分组 ,0～ 2.为轻度房性心律失常组 ,3～ 6级为复杂房性心律失常组。用超声心动图检测左心房内径。结果　高血压病患者左心房内径增大发生率 60 .7% ;左心房内径增大者发生严重复杂房性心律失常的比例为 76.74% ,左心房内径正常者为 2.2..72.% ,差异有显著性 ;左心房增大出现Pmax和Pd增大 ,Pd增大具有统计学意义 ;Pmax增大者发生严重复杂房性心律失常的比例为 82..76% ,Pmax正常者为 2.5 .93 % ,差异有显著性。结论　左心房增大与Pd增大有关。

关键词：高血压病房性心律失常 P波离散度左心房内径