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研究生心理卫生状况及相关因素研究

同济大学学报（医学版） 2002年第2期23卷 141-143页

作者：孟馥樊文有李春波何康梅傅晓燕同济大学附属同济医院上海200065 同济大学研究生院上海200092

目的　了解研究生心理卫生状况、人格特征 ,探索其与社会学因素的关系。方法　采用艾森克人格问卷(EPQ)、90项症状自评量表 (SCL - 90 )等心理评估工具及社会学状况调查表连续三年对 2.42.在校研究生进行有关调查。结果　在研究生心理... 详细信息

目的　了解研究生心理卫生状况、人格特征 ,探索其与社会学因素的关系。方法　采用艾森克人格问卷(EPQ)、90项症状自评量表 (SCL - 90 )等心理评估工具及社会学状况调查表连续三年对 2.42.在校研究生进行有关调查。结果　在研究生心理卫生状况的界定中 ,有 2.4.8%研究生SCL - 90的总分高于常模 ,其中高于常模 1个标准差者为 8.6 % ,高于 1.5个标准差者为 3.4%。心理评估量表得分与年龄、与专业类型、幼时家庭氛围等因素呈显著性相关。结论　研究生群体的心理卫生状况值得广泛重视。

关键词：研究生心理卫生状况相关因素

SOME OF THE IMMUNOLOGICAL PARAMETERS OF GASTRIC CARCINOMA

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Medical Bulletin of shanghai Jiaotong university 1990年第1期13卷 14-21页

作者：陆汉明金礼春 Department of Internal Medicine Xinhua Hospital SSMU Shanghai tongji university {2. Shanghai

In patients with gastric carcinoma the determination of the activities of some cellular and humoral factors may reflect the immunological state of the patient, the stage and extent of the disease, and help estimate the effects of treatment and prognosis. Moreover, experimental studies and preliminary clinical trials of some of these cellular elements and humoral factors in the treatment of gastric carcinoma have opened a new field of adoptive immunotherapy.

关键词： gastric carcinoma T lymphocyte subpopulations K cell NK cell LAK cell interleukin-2 secretory IgA oncoantigens

雷公藤红素诱导CEM-6T细胞凋亡的机制研究

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上海免疫学杂志 2003年第3期23卷 187-189页

作者：鲍一笑张登海张玲珍孔宪涛上海第二医科大学附属新华医院上海儿童医学中心上海200092 同济大学附属上海东方医院上海200120 第二军医大学附属长征医院实验科上海200003

在已经证明雷公藤红素能诱导人T淋巴细胞株CEM 6T细胞凋亡的基础上 ,进一步探讨此凋亡过程的机制。本项目研究雷公藤红素诱导CEM 6T细胞凋亡过程中Fas/FasL、ICEmRNA的变化以及ICE抑制剂、磷酸酶抑制剂对凋亡的影响。结果发现 ( 1)CEM 6... 详细信息

在已经证明雷公藤红素能诱导人T淋巴细胞株CEM 6T细胞凋亡的基础上 ,进一步探讨此凋亡过程的机制。本项目研究雷公藤红素诱导CEM 6T细胞凋亡过程中Fas/FasL、ICEmRNA的变化以及ICE抑制剂、磷酸酶抑制剂对凋亡的影响。结果发现 ( 1)CEM 6T细胞表达Fas,不表达FasL ,雷公藤红素处理不能改变这一情况 ;( 2.)雷公藤红素不能改变ICEmRNA的表达水平 ,但ICE抑制剂Ac YVAD CHO能使雷公藤红素诱导CEM 6T的凋亡率下降 ;( 3) 1 5 μmol/L磷酸酶抑制剂okadaicacid能使凋亡率下降。提示雷公藤红素诱导CEM 6T细胞凋亡不依赖Fas/FasL ,而与细胞内原已存在的ICE有关。

关键词：雷公藤红素淋巴细胞凋亡

Rbpj serves as a specific suppressor in the neurogenesis of noradrenergic neurons in mouse locus coeruleus

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Rbpj serves as a specific suppressor in the neurogenesis of ...

Risk factors of Beijing genotyping mycobacterium tuberculosis and its relationship with resistance and clinical symptoms

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Ming SHI~(1,*),Ze-Lan HU~2.Min-Hua ZHENG~3,Ying HUANG~1,Gang ZHAO~1,Hua HAN~3,Yu-Qiang DING~(2.*) 1 Department of Neurology,Xijng hospital,Fourth Military Medical university,Xi''an 710032.{2. 2.tongji university School of Medicine,shanghai 2.0092.{2. 3 Department of Medical Genetics and Developmental Biology,Fourth Military Medical university,Xi''an 710032. china

＜正＞Objective The locus coeruleus（LC） is the main source of noradrenaline in the brain and implicated in a broad spectrum of physiological and behavioral ***,genetic pathways controlling the generation of noradrenergic neurons are largely unknown in the mammalian *** report here that Rbpj,the key nuclear effector in Notch signaling pathway,functions as a specific suppressor in the neurogenesis of this group of neurons in the *** Rbpj expression in the dorsal rhombomere 1（r1） where LC neurons are born were conditionally inactivated by crossing Wntl-Cre and EnlCre/+ with Rbpjflox/flox *** mount and sections in situ hybridization,immunohistochemistry, BrdU birthdating assay,dual-luciferase assay,mouse embryo electroporation and explant culture were performed to explore the mechanism under which Rbpj regulates the neurogenesis of LC neurons in the mouse ***（1） Ablation of Rbpj resulted in a dramatic increase of Mash 1-expressing LC progenitor cells,Phox2.- and Phox2.-expressing early-differentiated,and dopamine-hydroxylase（Dbh）- and tyrosine hydroxylase（TH）-expressing late-differentiated LC neurons.（2. Other types of neurons that are also derived from the dorsal r1,such as principal trigeminal sensory nucleus, parabrachial complex,superior vestibular nucleus,external granular cells,Purkinje cells and deep cerebellar nuclei,were either reduced or unchanged.（3） BrdU birthdating assay showed that both enhanced and prolonged neurogenesis occurred in Rbpj mutant mice.（4） Embryo explant culture data showed that mis-expression of dominant-negative form of Rbpj in the dorsal r1 led to an increase of TH-positive cells,whereas that of constitutive active form of Rbpj resulted in a decrease of TH-positive cells.（5） Dual-luciferase assay showed that Rbpj repressed Mash1 transcription in *** Taken together,our results indicate that Rbpj functions as a specific and negative factor in controlling the neurogenesis of noradrenerg

关键词： Rbpj locus coeruleus Notch neurogenesis rhombomere 1 Wntl-Cre

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Risk factors of Beijing genotyping mycobacterium tuberculosi...

第二届国际防痨和肺部疾病联合会亚太区学术大会暨2.09年中国防痨协会学术会议

作者： FAN lin QIN lian-hua WANG jie HU zhong-yi TANG sheng-jie XIAO he-ping tongji university affiliated {2. pulmonary hospital,the {2. key lab of tuberculosis, {2. 2.0433,china

Objective To analyse the risk factors of Beijing genotyping mycobacterium tuberculosis (MTB)and its relationship with resistane and clinical symptoms. Methods:Collect the sputum of patients from shanghai and Jiansu、Zhejiang province,172.cases with transmitted pulmonary TB which were stayed at hospital during July,2.07～

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针药结合治疗椎动脉型颈椎病的疗效观察

上海针灸杂志 2004年第9期23卷 16-18页

作者：石红庄海春上海闵行区梅陇镇社区卫生服务中心 200237 同济大学附属铁路医院 200072

目的　观察针药治疗椎动脉型颈椎病的疗效。方法　 10 0例患者随机分两组 ,治疗组采用针灸配合药物、牵引治疗 ,对照组采用药物与牵引治疗 ,治疗前后均做 TCD检测对比 L VA、RVA、BA的 Vm值变化 ,且进行证型治疗前后比较。结果　治疗组... 详细信息

目的　观察针药治疗椎动脉型颈椎病的疗效。方法　 10 0例患者随机分两组 ,治疗组采用针灸配合药物、牵引治疗 ,对照组采用药物与牵引治疗 ,治疗前后均做 TCD检测对比 L VA、RVA、BA的 Vm值变化 ,且进行证型治疗前后比较。结果　治疗组总有效率 96 % ,对照组总有效率 80 % ,经统计学处理 (P<0 .0 5 ) ;两组治疗前后 TCD检测均有显著性差异 (P<0 .0 5 ) ,但治疗组比对照组更能改善椎 -基底动脉供血状况 ,两组证型治疗前后比较有显著性差异 (P<0 .0 5 ) ,治疗组对痰湿中阻型、气虚血瘀型疗效最明显。结论　针灸配合药物治疗椎动脉型颈椎病能起到针药协同作用 ,能更好地改善椎 -基底动脉供血状况 ,从而改善临床症状。

关键词：椎动脉型颈椎病 TCD 针灸疗法药物疗法牵引术

Arterial phase of biphase enhancement spiral CT in diagnosis of small hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2002年第1期1卷 68-71页

作者： Kang-Rong Zhou Fu-Hua Yan Bei-Wu Tu From the Department of Radiology, Zhongshan hospital, Fudan university, {2., 2.0032. china Department of Radiology Zhongshan Hospital Fudan University Shanghai 200032 China. zhoukr@***

Objectives: To evaluate the value of the arterial phase(AP) of biphase enhanced spiral CT(SCT) in the di-agnosis of small HCC and to investigate the criteria,initial time, ending time and duration of ***: From May 1995 to March 1999, patients withsmall HCC proved surgically and pathologically in-cluding 49 patients (n=53) in group A, 148 (n=186) ingroup B and 52.(n=52. in group C were *** dynamic enhanced SCT scans were performedin all patients of the three groups and additional sin-gle-level dynamic scans only done in the group C. Thedetectability, diagnostic accuracy of lesions and en-hancement of the lesions in AP were analyzed statisti-cally. In addition, the initial time, ending time andduration of AP were ***: The results of the group A showed the de-tectability of small HCC was 88.68% in AP and90.57% in both phases, higher than those by ultra-sound. Markedly enhanced lesions in AP accounted for76% and 78% in the groups B and C respectively. Theinitial time, ending time and duration of AP measuredon single-level dynamic scans were 16.9s, 39.6s and2..7s on average ***: The biphase dynamic SCT especially itsarterial phase appears to be very valuable in diagnosingsmall HCCs. In light of short duration of AP, under-standing and strict control of AP is obviously impera-tive.

关键词： carcinoma hepatocellular diagnosis imaging scanning spiral CT

放疗用高能电子束光栏不固定限束方式下照射野大小对输出量的影响

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现代医学 2002年第3期30卷 154-156页

作者：陶建民胡杰王凡刘启平同济大学附属铁路医院放疗科上海200072 同济大学附属同济医院放疗科上海200070

目的　研究高能电子束光栏不固定限束方式下照射野大小对输出量的影响。方法　采用GESaturne 41型直线加速器 ,以 12.eV和 9MeV高能电子束为辐射源 ,用Farmer 2.5 70剂量仪测量各种不同照射野的输出剂量率 ,以 10cm× 10cm照射野为基准 ... 详细信息

目的　研究高能电子束光栏不固定限束方式下照射野大小对输出量的影响。方法　采用GESaturne 41型直线加速器 ,以 12.eV和 9MeV高能电子束为辐射源 ,用Farmer 2.5 70剂量仪测量各种不同照射野的输出剂量率 ,以 10cm× 10cm照射野为基准 ,进行归一 ,计算输出因子。结果　在该种限束方式下 ,当保持Y方向 (准直器上铅门 )为实际照射野的长边时 ,采用公式S =2.b/(a +b)计算等效方野 ,然后计算等效输出因子 ,它与实际测量值之间的误差小于 2.%。结论　对这种电子束限束方式 ,只要保持Y方向为实际照射野的长边 ,可以采用面积周长比公式S =2.b/(a +b)计算等效方野 ,然后计算等效输出因子。

关键词：光栏不固定限束方式照射野输出量放射治疗高能电子束输出因子

聚合酶链反应法测定幽门螺杆菌的VacA、CagA基因

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同济大学学报（医学版） 2003年第5期24卷 388-390,394页

作者：张志强张金芳许树长同济大学医学院预防医学教研室上海200070 同济大学附属同济医院上海200065

目的　用聚合酶链反应法 (polymerasechainreaction ,PCR)测定食管粘膜和胃窦粘膜中幽门螺杆菌 (Heli cobacterpylori,Hp)的两个特征性致病因子 :细胞毒素相关蛋白 (CagA)和细胞空泡毒素 (VacA) ,比较其临床意义。方法　对有典型反流症... 详细信息

目的　用聚合酶链反应法 (polymerasechainreaction ,PCR)测定食管粘膜和胃窦粘膜中幽门螺杆菌 (Heli cobacterpylori,Hp)的两个特征性致病因子 :细胞毒素相关蛋白 (CagA)和细胞空泡毒素 (VacA) ,比较其临床意义。方法　对有典型反流症状的患者并经胃镜检查诊断为反流性食管炎 (reflaxesophagitis ,RE) 53例作为病例组。无典型反流症状的患者并经胃镜检查诊断为慢性胃炎 2.5例作为对照组 ,分别取食管下端粘膜和胃窦粘膜各 3块 ,并分别行快速尿素酶试验、病理Hp检查和Hp培养 ,从食管及胃窦粘膜中分离Hp菌株 ,应用聚合酶链反应方法行CagA基因、VacA基因检测。结果　病例组、对照组中食管粘膜的Hp阳性率分别为 14 / 53 (2.6.4%)、8/ 2.5(3 2.%) ,两者差异无显著性 (P >0 .0 5) ;胃窦粘膜的Hp阳性率分别为 2.0 / 53 (3 7.8%)、16/ 2.5(64%) ,两者差异有显著性 (P2.0 ,3 0 %)明显低于对照组 (10 / 16,62..5%) (P 2.0 (3 0 %)、7/ 16(43 .8%) ,两者差异无显著性 (P >0 .0 5)。胃窦粘膜Hp阳性率差异有显著性(P <0 .0 1)。结论　CagA、VacA的测定对Hp的分型有指导意义。Hp与RE关系密切 ,尤其是CagA +的Hp感染可能在RE的发?

关键词：聚合酶链反应幽门螺杆菌细胞空泡毒素 VacA基因 CagA基因