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肺结核患者营养管理护理实践专家共识

中国防痨杂志 2024年第5期46卷 495-501页

作者：中国防痨协会护理专业分会毛燕君方雪娥不详同济大学附属上海市肺科医院

肺结核住院患者营养风险若未及时纠正,易出现营养相关性疾病,如营养不良、药物性肝损伤、免疫功能低下、肺部感染等,从而增加抗结核治疗失败的风险。营养管理是治疗肺结核非常重要的辅助方法之一,但仍存在护理人员营养知识缺乏、营养评... 详细信息

肺结核住院患者营养风险若未及时纠正,易出现营养相关性疾病,如营养不良、药物性肝损伤、免疫功能低下、肺部感染等,从而增加抗结核治疗失败的风险。营养管理是治疗肺结核非常重要的辅助方法之一,但仍存在护理人员营养知识缺乏、营养评估标准不明确和管理流程不健全等相关问题,因此,规范结核病营养护理具有重要意义。基于此,中国防痨协会护理专业分会、同济大学附属上海市肺科医院联合组织专家,针对住院成人肺结核患者的营养管理护理问题,以临床实践为基础,运用文献分析法,结合结核病领域专家的工作经验,共同拟定《肺结核患者营养管理护理实践专家共识》,旨在为临床护理工作者实施营养管理提供指导依据,规范我国住院成人肺结核患者营养管理护理实践。

关键词：结核,肺营养评价营养支持护理总结性报告(主题)

Identification of glutamate transporters and receptors in mouse testis

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Acta Pharmacologica Sinica 2004年第03期25卷 112-117页

作者： Jia-hua HU,Na YANG2.Ying-hua MA,Jie JIANG,Jin-fu ZHANG3,Jian FEI4,Li-he GUO4 Laboratory of Molecular Cell Biology,Institute of Biochemistry and Cell Biology,shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,shanghai 2.0031 3Department of Urology,{2. hospital,{2. university,shanghai 2.0065,china Laboratory of Molecular Cell Biology Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological Sciences Chinese Academy of Sciences Department of Urology Tongji Hospital Tongji University

AIM: To investigate the presence of glutamate transporters and receptors in mouse testis. METHODS: Glutamate uptake analysis was performed to study the function of glutamate transporters in mouse testis. Comparative RT-PCR technique and sequencing analysis were used to study the expression of glutamate receptors and transport- ers in mouse testis. RESULTS: Mouse testis possessed glutamate uptake capacity with sodium-dependence. Vmax value of glutamate uptake was (1.60 ± 0.2.) pmol/min per mg protein and Km value of glutamate uptake was (11.0±1.6) μmol/L in mouse testis according to saturation analysis. Furthermore, the uptake activity could be inhibited by DHK (GLT1 selective inhibitor) and THA (glutamate uptake inhibitor). In addition, RT-PCR results revealed that glutamate transporters (GLT1 and EAAC1) and ionotropic glutamate receptors (NR1, NR2., GluR6 and KA2. were expressed in mouse testis. CONCLUSION: Glutamate transporters and receptors do exist in mouse testis.

关键词： glutamates receptors amino acid transport systems testis uptake

Influence of L-methionine-deprived total parenteral nutrition with 5-fluorouracil on gastric cancer and host metabolism

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World Journal of Gastroenterology 2001年第5期7卷 698-701页

作者： Hong-Bing Xiao~1 Wei-Xin Cao~2.Hao-Ran Yin~2.Yan-Zhen Lin~2.Shi-Hui Ye~1 1 Department of Surgery,Affiliated Railway hospital,tongji {2.,shanghai 2.0072.china2.Department of Surgery,Affiliated Ruijin hospital,shanghai Second Medical {2.,shanghai 2.002.,china Department of Surgery Affiliated Railway Hospital Tongji University Shanghai 200072 China. xhawbin@***

AIM: To investigate the influence of L-methionine-deprived total parenteral nutrition with 5-FU on gastric cancer and host metabolism. METHODS: N-methyl-N'-nitro-nitrosoguanidine (MNNG) induced gastric cancer rats were randomly divided into four groups: Met-containing TPN group (n=11), Met-deprived TPN group (n =12., Met-containing TPN+5-FU group (n=11) and Met-deprived TPN+5-FU group (n=12.. Five rats in each group were sacrificed after 7 days of treatment and the samples were taken for examination. The remaining rats in each group were then fed separately with normal diet after the treatment until death, the life span was noted. RESULTS: The tumors were enlarged in Met-containing group and shrank in Met-deprived group markedly after the treatment. The DNA index (DI) of tumor cells and the body weight (BW) of rats had no significant change in the two groups, however, the ratio of tumor cells'S phase was increased. The ratio of G2. phase went up in Met-containing group, but down in Met-deprived group. In the other two groups that 5-FU was added, the BW of rats, and the diameter of tumors, the DI of tumor cells, the S and G2. phase ratio of tumor cells were all decreased, particularly in Met-deprived plus 5-FU group. Pathological examination revealed that the necrotic foci of the tumor tissue increased after Met-deprived TPN treatment, and the nucleoli of tumor cells enlarged. In MetTPN+5-FU group, severe nuclear damage was also found by karyopyknosis and karyorrhexis, meanwhile there was slight degeneration in some liver and kidney cells. The serum free Met and Cysteine decreased markedly (P2..5 days in Met-containing TPN+5-FU group, and 43 days in Met-deprived TPN+5-FU group (P&

关键词： Parenteral Nutrition Animals Antimetabolites, Antineoplastic Body Weight DNA, Neoplasm Fluorouracil Male Methionine Rats Rats, Wistar Research Support, Non-U.S. Gov't S Phase Stomach Neoplasms

Gum mastic increases maspin expression in prostate cancer cells

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Acta Pharmacologica Sinica 2007年第4期28卷 567-572页

作者： Mei-lan HE~(2.3,6),Wei-wen CHEN~(2.6),Peng-ju ZHANG~2.An-li JIANG~2.Wei FAN~4,Hui-qing YUAN~2.Wen-wen LIU~2.Jian-yeZHANG~(2.5)~2.epartment of Biochemistry,Medical School,Shandong university,Ji-nan 2.0012.china ~3Institute of Cancer Research,Life Science andTechnology School,{2. university shanghai 2.0092.china ~4Gastric Intestine Department,Affiliated Qi-Lu hospital,Shandong university,Ji-nan 2.0012.china Department of Biochemistry Medical School Shandong University Ji-nan China Institute of Cancer Research Life Science and Technology School Tongji University Shanghai China Gastric Intestine Department Affiliated Qi-Lu Hospital Shandong University Ji-nan China

Aim:To study whether gum mastic,a natural resin,can regulate maspin expres-sion in prostate cancer cells,and further investigate the mechanisms involved inthis regulatory ***:RT-PCR and Western blotting were used todetect maspin expression at the transcriptional and translational *** assay was used to investigate the effect of gum mastic on the maspin *** binding activity of negative androgen-responsive element (ARE) and posi-tive Spl element in the maspin promoter were studied by electrophoretic mobilityshift ***:Gum mastic induced maspin mRNA and protein expression,and the maspin promoter activity was enhanced with gum mastic ***,gum mastic inhibited the ARE binding activity and increased the Sp 1 bindingactivity in the maspin ***:Gum mastic enhances maspin pro-moter activity by suppressing ARE binding activity and enhancing Spl bindingactivity,and the increased activity in the maspin promoter finally leads to the up-regulation of both its mRNA and protein levels.

关键词： gum mastic maspin expression ARE binding activity Spl binding activity

Mid-ventricular hypertrophic obstructive cardiomyopathy(MVHOCM) complicated with coronary artery disease:a case report

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Journal of Geriatric Cardiology 2008年第3期5卷 190-192页

作者： Haoming Song Cuimei Zhao Jinfa Jiang Yang Liu Yihan Chen Department of Cardiology,tongji hospital, tongji university, shanghai, 2.0065, P.R.china Dept. of Cardiology Tongji Hospital Tongji University 389 Xincun Rd. Shanghai 200065 China

Mid-ventricular hypertrophic obstructive cardiomyopathy (MVHOCM) is a rare type ofcardiomyopathy that can be accompanied by apical *** presented here a case report of MVHOCM with cornary artery *** sixty-four years old man was sent to hospital because ofventricular *** inversion T wave was showed on electrocardiography in the presence of abnormal coronary arteries and normal cardiac *** showed an hourglass appearance of the left ventricle with an aneurysm in the apex and a pressure gradient between the outflow tract of left ventricle and the middle of the left ventricle was revealed by left-heart catheterization.

关键词： hypertrophic obstructive cardiomyopathy coronary artery disease echocardiography

Histological Measurem ent of Hum an RetinalThickness

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Journal of Huazhong university of Science and Technology(Medical Sciences) 1999年第3期19卷 246-248页

作者： YANG Zhikuan, DU Shuhua Department of Ophthalmology, tongji hospital, tongji Medical university, Wuhan 430030 Department of Ophthalmology Tongji Hospital Tongji Medical University Wuhan 430030

The fresh eye balls from the accidental death adults were placed on low temperature slicer to cut into slices. The fresh sections was subjected to the direct measurement of retinal thickness by using CMIAS multi function real color pathologic imaging analysis system. The results showed that in the total of 6 eye balls measured, the mean retinal thickness was 310.92.34.14 μm. It was concluded that it was simple and had high confidence for the fresh eye ball low temperature frozen sections to directly measure the retinal thickness, which provided a histological method for the measurement of retinal thickness and the reference of retinal thickness of Chinese adults.

关键词： retinal thickness histology

Stimulus-responsive polymeric nanoparticles for biomedical applications

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Science china Chemistry 2010年第3期53卷 447-457页

作者： LI YongYong1,2.DONG HaiQing1,2.WANG Kang1,SHI DongLu 2.ZHANG XianZheng1 & ZHUO RenXi1 1Key Laboratory of Biomedical Polymers,Ministry of Education Department of Chemistry,Wuhan university,Wuhan 430072.china 2.nstitute for Advanced Materials and Nano Biomedicine(iNANO),{2. university,shanghai 2.0092.china 1. Key Laboratory of Biomedical Polymers Ministry of Education Department of Chemistry Wuhan University Wuhan 430072 China2. Institute for Advanced Materials and Nano Biomedicine (iNANO) Tongji University Shanghai 200092 China

Polymeric nanoparticles with unique properties are regarded as the most promising materials for biomedical applications including drug delivery and in vitro/in vivo *** them,stimulus-responsive polymeric nanoparticles,usually termed as "intelligent" nanoparticles,could undergo structure,shape,and property changes after being exposed to external signals including pH,temperature,magnetic field,and light,which could be used to modulate the macroscopical behavior of the *** paper reviews the recent progress in stimulus-responsive nanoparticles used for drug delivery and in vitro/in vivo imaging,with an emphasis on double/multiple stimulus-responsive systems and their biomedical applications.

关键词： polymer stimulus-responsive nanoparticles drug carrier cellular imaging

APPLICATIONS OF CFD TECHNIQUE IN THE DESIGN AND FLOW ANALYSIS OF IMPLANTABLE AXIAL FLOW BLOOD PUMP

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Journal of Hydrodynamics 2010年第4期22卷 518-525页

作者： FAN Hui-min HONG Fang-wen ZHANG Guo-ping YE Liang LIU Zhong-min shanghai East hospital Affiliated to {2. university Shanghai 200120 China china Ship Scientific Research Center Wuxi 214082 China

Based on established numerical methods and hydrodynamic performance testing facilities,CFD technique are applied to improve the design of the implantable axial flow blood pump and the flow analysis.（1） Applying brushless machine magnet steel,reducing its thickness while increasing the length,the flow channel＇s cross-section is increased,with no space connection between the large and the small rotators,and with a cone transition segment from the bearing to the principal axis,the flow is made *** rotating speed is lowered by 1000 rpm-12.0 rpm under the same flow rate and pressure head,and thus the hemolysis can be avoided.（2. Different outlet stator guiding vanes are selected for the same blood pump for analyses of hydrodynamic performances and flow *** excellent design not only can regulate the rotating flow field into an axial one,reduce the circulation loss and improve the pump efficiency,but also can avoid backflow,vortex and secondary flow at the pump outlet,and thus the thrombus can be prevented.（3） The calf live tests show that some residual clots exist at the inner wall of the outlet connection bends,which are analyzed and explained by CFD techniques and the corresponding improvements are *** results are verified by hydrodynamic performance tests and PIV flow field tests,and consistent conclusions are obtained.

关键词： axial flow blood pump CFD PIV

Biodistribution of fullerene derivative C_(60)(OH)_x(O)_y

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Chinese Science Bulletin 2001年第19期46卷 1615-1618页

作者： LI Qingnuan, XIU Yan, ZHANG Xiaodong, LIU Ruili, DU Qianqian, SUN Xiaoguang, CHEN Shaoliang & LI Wenxin1. shanghai Institute of Nuclear Research, Chinese Academy of Sciences, shanghai 2.1800,{2. 2. Department of Nuclear Medicine, Zhongshan hospital, Fudan university, shanghai 2.0032.{2. shanghai Institute of Nuclear Research Chinese Academy of Sciences Shanghai China Department of Nuclear Medicine Zhongshan Hospital Fudan University Shanghai China

The biological behavior of fullerene derivatives shows their considerable potential application in medicine field. To understand the biodistribution of C60 derivatives as drugs or drug carriers, a simple water-soluble derivative C60(OH)x(O)y was labeled with 99mTc. A r-counter and a single photo emission computed tomography (SPECT) were used to assess the biodistribution and metabolism of the labeled compound in mice and rabbits, respectively. The results showed that the compound could be absorbed rapidly by tissues, especially by coronal bone, breastbone, backbone, extremity honeycomb, liver and spleen. The clearance was slow from all tissues except for brain. The compound might be excreted through urine and enteron. The biodistribution shows some difference from that of Yamago et al. In this note, we discuss the possible reason leading to the difference. Further study is needed to find out to what extent the C60 itself determines the biodistribution of derivatives.

关键词： C60(OH)x(O)y 99mTc-labeling activity test SPECT imaging biodistribution.