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Cytotoxicity of Contact Lens Care Solution to Human Corneal Epithelium in Vitro

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眼科学报 1998年第1期14卷 45-47页

作者： Xiangming Gong, Xingwu ZhongDepartment of Optometry, Zhongshan Ophrhalmic center, Sun Yat-sen University of Medical sciences, {2. 510060, china Department of Optometry Zhongshan Ophrhalmic Center Sun Yat-sen University of Medical Sciences Guangzhou 510060 China

Purpose: To investigate the cytotoxicity of soft contact lens multi-purpose care solutions which are now in common use in ***: The cell culture method was used. Cytotoxicity was indicated by significant increases in the number of dead cells relative to ***: Cells were exposed to soft contact lens care solutions for 15 min. They were irregular in shape and variable in size. The intercellular space increased and variable in *** in-tercelluar space increased and the cells became scrunken. With the time of exposure elongated , damage of cells became more ***: Four kinds of soft contact lens multi-purpose care solutions may have harmful effects on the culture of human corneal epithelial cells. Soaked lenses should be rinsed with saline before being placed in the eyes in order to reduce the potential toxicity of contact lens care solutions. Eye science 1998; 14 :45 - 47.

关键词：细胞毒素隐形眼镜保护液角膜上皮细胞

A Clinical Analysis of Idiopathic Orbital Inflammatory Pseudotumor

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眼科学报 2000年第3期16卷 208-213页

作者： Jianhua Yan, Zhongyao Wu, Yongping LiZhongshan Ophthalmic center, Sun Yat-sen University of Medical sciences. {2. 510060 china Zhongshan Ophthalmic center Sun Yat-sen University of Medical Sciences Guangzhou 510060 China

Purpose: To observe the clinical findings and response to treatment in patients with a diagnosis of idiopathic orbital inflammatory ***: 2.9 idiopathic orbital inflammatory pseudotumor cases seen between Jan 1, 1978 and Dec 31, 1999 in our hospital were evaluated retrospectively. Results: Of the 2.9 cases, 118 were male and 91 were female; there were 90 in the right eye, 81 left eye and 38 both eyes. Patients age ranged from 4 to 80 years (mean 44.4). Proptosis (66%), palpable mass (65%), swollen eyelid (55%), increased orbital pressure (55%) and motility restriction (48%) were the five most common presenting signs. According to radiologic and surgical findings, focal mass within orbit was the most frequent subtype (43% ), followed by lacrimal inflammatory pseudotumor (32.), diffuse orbital inflammation (10%), myositis (8%) . Perineuritis (2.), periscleritis(2.), acute inflammation (2.) and eyelid pseudotumor (1%) were rare clinical findings. The response to treatment (with a mean

关键词：炎性假瘤眼眶肿瘤自发性临床分析

Identification and characterization of two novel box H/ACA snoRNAs from Schizosaccharomyces pombe

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Progress in Natural Science:Materials International 2005年第6期15卷 507-514页

作者： LI Siguang, ZHOU Hui, ZHANG Peng, LUO Yuping and QU Lianghu*(Key Laboratory of Gene Engineering of the Ministry of Education, Biotechnology research center, Zhongshan University, {2. 5102.5, china) Key Laboratory of Gene Engineering of the Ministry of Education Biotechnology Research Center Zhongshan University Guangzhou 510275 China

Through constructing a specialized cDNA library based on small RNAs isolated from partial purified nuclei of Schizosaccharomyces pombe, two novel noncoding RNAs, termed Sp15-70 and Sp18-61, have been identified. Bioinformatics analysis reveals that both the novel RNAs possess a typical secondary structure of box H/ACA snoRNA and antisense elements to rRNAs. According to the relationship between the structure and function of box H/ACA snoRNA, Sp15-70 was predicted to direct pseudouridylation in 2.S rRNA at U2.01 and U2.98; Sp18-61 was predicted to direct pseudouridylation in 18S rRNA at U2.8 and 2.S rRNA at U2.41. The four predicted pseudouridylation sites were all verified experimentally by the CMC-primer extension analysis. Both Sp15-70 and Sp18-61 were encoded by single copies which were located in the intergenic regions between the CDS of two protein-coding genes on chromosome Ⅰ and Ⅲ of S. pombe, respectively. Putative TATA-like elements can be found upstream from the 5′ end of these snoRNA genes, suggesting that they could be transcribed from their own promoters. Comparison of the two snoRNAs and their functional homologues in diverse organisms reveals that extensive recombinations among different snoRNAs have occurred during the evolution from their primitive progenitors.

关键词： box H/ACA snoRNA RNA pseudouridylation gene evolution Schizosaccharomyces pombe.

Percutaneous radiofrequency ablation approach through the spleen:initial case report for pancreatic tail gastrinoma

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chinese Journal of Cancer 2010年第9期29卷 836-841页

作者： Pei-Hong Wu1,2. Chang-Chuan Pan1,2. Zi-Lin Huang1,2. Wang Li1,2. Ming Zhao1,2. Zhi-Wei Zhou1,3 1 State Key Laboratory of Oncology in South china, guangzhou, Guangdong 510060, P.R.{2. 2.Department of Medical Imaging & Interventional Radiology, Sun Yat-sen University Cancer center, guangzhou, Guangdong 510060, P.R.{2. 3 Department of Abdominal Oncology, Sun Yat-sen University Cancer center, guangzhou, Guangdong 510060, P.R.{2. Department of Medical Imaging& Interventional Radiology Sun Yat-s en University Cancer Center State Key Laboratory of Oncology in South China Guangdong Guangzhou 510060 Department of Abdominal Oncology Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Guangdong Guangzhou 510060

gastrinoma has a low incidence, and the pancreas-originated gastrinoma is *** gastrinoma patients with liver metastases have poor prognosis and short *** treatment to reduce the tumor burden helps to improve symptoms and slows down tumor progression for patients with unresectable *** report a case of pancreatic tail gastrinoma with unresectable liver *** patient received a comprehensive minimally invasive interventional treatment, that is, chemoembolization and radiofrequency ablation for liver metastases, and percutaneous transplenic radiofrequency ablation combined with radioactive 12.I seed implantation for pancreatic tail *** patient was followed up for more than 2. months, and showed no clear evidence of tumor *** explored the safety and feasibility of percutaneous transplenic radiofrequency ablation for unresectable pancreatic tail *** transplenic approach allow more indications for minimally invasive therapy and provides a new treatment option not only for patients with unresectable pancreatic tail tumor but also for patients refusing surgery.

关键词：射频消融胃泌素病例报告尾部局部治疗手术切除肿瘤病介入治疗

RELATIONSHIP BETWEEN CORNEAL DELLEN AND TEARFILM BREAKUP TIME

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眼科学报 1991年第1期7卷 43-46页

作者： Guanghuan Mai Shaomei Yang Eye Hospital, Zhangshan Ophthalmic center Sun Yat-sen University of Medical sciences {2., china Eye Hospital Zhangshan Ophthalmic Center Sun Yat-sen University of Medical Sciences Guangzhou China.

The BUT of 51 strabismus patients were measured before and after operation. The average pre-op BUT was 2..75 seconds(10.96"-91.80"). The post-op BUT in all operated eyes were reduced significantly, no matter what procedures had been performed and whether dellen appeared or not(P2..2."(pre-op) to 8.61"(post-op). The incidence of dellen was 2..54% in this study. The incidence of dellen after rectus resection procedure(47.75%) was much higher tha...

关键词： dellen strabismic surgery BUT

Prolif erative Inhibition of Rabbit Lens Epithelial Cell——Preliminary Investigation for Prevention of After Cataract

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眼科学报 1995年第1期11卷 32-36页

作者： Xiaobo Su,Shaozhen Li,Jianliang ZhengZhongshan Ophthalmic center, Sun Yat-sen University of Medical sciences {2. 510060, china Zhongshan Ophthalmic center Sun Yat-sen University of Medical Sciences Guangzhou China.

Purpose:To study the ability of Homoharringtonine(Hh),5-Fluorouracil(5-Fu).and Adriamycin(ADM)on inhibiting the proliferation of rabbit lens epitthelium,*** rabbit lenses were removed from freshly enucleated eyes under sterile *** rabbit lens eptithlia(RLE)were isolated and culatured:(1)The passage RLE were placed in 2.-well tissue culture plates and incubated for *** exposed to different concentrations of Hh,5-Fu,and ADMfor 2.and 72.ours;(2.The passage RLEandHh(0.084μg/ml).5-Fu(0.058μg/ml）,ADM(0.45ng/ml)were placed and cultured for 2.hours;(3)The morphological changes of RLE exposed to different concentrations of Hh,5-Fu and ADM were studied under light ***:The ID50 of Hh,5-Fu and ADMexposed to RLEfor 2.hours were 0.84μg/ml, 0.58μg/ml and4.50ng/ml,respectively,and those for 72.ous were0.49μg/ml,0.33μg/ml and3.85ng/*** attachment rate of RLE after being cu-latured for 2.hours with Hh,5-Fu and ADM were respectinely83.6%,89.1%and 87.3%,The morphological changes of RLE demonstrated that obvious changes in the cell membran e and cytoplasm were found even in lower concentra-tion ,but changes in the nuclei could only be found in higher concentation of these ***:Hh can not only inhibit the proliferation of RLE but also reduce the number of attached *** is suggested that Hh may be more useful for the pre-vention of after cataract than 5-Fu and ADM.

关键词：晶状体上皮细胞增生性抑制后天性白内障预防动物实验

On Translating Similes and Metaphors in Traditional chinese Medicine Literature

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语言与文化研究 2007年第1期1卷 88-96页

作者： china Petroleum china {2. Training center Qiu Hualing {2. chinese Medical University He Yi china Petroleum china {2. Training center guangzhou chinese Medical University

This research is to explore the approaches to translating similes and metaphors in TCM works into English based on the translation principles and methods suggested by foreign *** the analysis,conclusions are drawn:①The principle of making sense should be emphasized,since TCM works mainly concentrate on conveying the objective information about human’s physical conditions during diagnosis and therapy.②Literal translation approach can be applied in translating similes to describe the symptoms and signs of the patients.③The translation of metaphors is more *** can be converted into the form of similes or with certain explanations to achieve the comprehensibility of the target *** some images can be left out from the metaphors or necessary explanations added to make them comprehensible to English readers.

关键词： Traditional chinese Medicine chinese-English Trans

Changes in Local Immune Functions in Mooren's Ulcer

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Eye Science 1996年第1期16卷 33-35页

作者： Zheng Wang, Jiaqi Chen, Huling ZhengZhongshan Ophthalmic center, Sun Yat-sen Unicersity of Medical sciences, {2. 510060,china Zhongshan Ophthalmic center Sun Yat-sen University of Medical Sciences Guangzhou China.

Purpose: To the investigate changes in local immune functions of the cornea and the adjacent conjunctiva, and their roles in the mechanism of the disease. Method: The cornea and adjacent bulbar conjunctiva taken from 14 patients with Mooren’s ulcer were stained immunohistochemically for CD3, CD4, CD8, HLA-DR, GD1 and ***: An aberrant expression of HLA-DR antigen by a large number of kerato-conjunctival epithelial cells and keratocytes in the corneal stroma was found. The CD4 + /CD8+ ratio is significantly higher than normal control. Conclusion: The aberrant expression of MHC- II antigen in the resident cells at the peripheral cornea and the adjacent conjunctiva, along with a raised local TH/ Ts ratio leading to an excessive autoimmune reactivity is possibly the direct cause of Mooren’s ulcer. Eye Science 1996; 12. 33-35.

关键词： Mooren’s ulcer cornea antibody

BL Lac Objects and Unified Model

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天文研究与技术 1999年第S1期 210-212页

作者： Fan J.H. (Yunnan Observatory, The chinese academy of sciences, Kunming 650011, china) (National Astronomical Observatories, The chinese academy of sciences) (center for Astrophysics, guangzhou Normal University, guangzhou 510400, china e mail: jhfan@g

In this paper: 1. The assumption of the dependence of Doppler factor on the emission frequency (δ v≈δ 0 18logvv o , Fan et al. 1993, ApJ., 415, 113) is used to explain the observational differences between the radio selected BL Lac objects (RBLs) and the X Ray Selected BL lac objects (XBLs): a) Hubble relation; b) different multiwavelength correlations; c) different regions in the effective spectral index (α RO - α OX ) diagram; d) different polarization. The results suggest that RBLs and XBLs are the same. 2. From the analysis of the relation between infrared magnitude and redshift, it is proposed that the parent population of BL Lac objects should be FRI radio galaxies and FRII(G) radio galaxies showing the optical spectra of a galaxy. 3. From the superluminal motion, the assumption (δ v≈δ 0 18+logvv 0 ) is confirmed. 4. Based on the relation between polarization and Doppler factor (Fan et al. 1997a), it is proposed that the f, ratio of the beamed luminosity to the unbeamed luminosity in the source frame of OVVs/HPQs is smaller than that of BL Lac objects: f RBLs ～ 6f FSRQs .

关键词： BL Lac Objects and Unified Model