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The role of Akt on Arsenic trioxide suppression of 3.3.L1 preadipocyte dif-ferentiation

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Cell Research 2005年第5期15卷 379-386页

作者： Zhi Xin WANG1, Chun Sun JIANG1, Lei LIU1, Xiao Hui WANG1, Hai Jing JIN1, Qiao WU2. Quan CHEN1,* 1State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, chinese academy of {2., {3. 100080, China 2.ollege of life Science, Xiamen university, Xiamen 3.1005, China StateKeyLaboratoryofBiomembraneandMembraneBiotechnology InstituteofZoologyChineseAcademyofSciencesBeijing

The present study investigates the molecular details of how arsenic trioxide inhibits preadipocyte differentiation and examines the role of Akt/PKB in regulation of differentiation and apoptosis. Continual exposure of arsenic trioxide, at the clinic achievable dosage that does not induce apoptosis, suppressed 3.3.L1 cell differentiation into fat cells by inhibiting the expression of PPARγ and C/EBPα and disrupting the interaction between PPARγ and RXRα, which determines the programming of the adipogenic genes. Interestingly, if we treated the cells for 12.or 2. h and then withdrew arsenic trioxide, the cells were able to differentiate to the comparable levels of untreated cells as assayed by the activity of GAPDH, the biochemical marker of preadipocyte differentiation. Long term treatment blocked the differentiation and the activity of GAPDH could not recover to the comparable levels of untreated cells. Continual exposure of arsenic trioxide caused accumulation in G2.M phase and the accumulation of p2.. We found that arsenic trioxide induced the expression and the phosphorylation of Akt/PKB and it inhibited the interaction between Akt/PKB and PPARγ . Akt/PKB inhibitor appears to block the arsenic trioxide suppression of differentiation. Our results suggested that Akt/PKB may play a role in suppression of apoptosis and negatively regulate preadipocyte differentiation.

关键词： preadipocyte cell differentiation apoptosis Akt/PKB Arsenic trioxide.

PROBABILITY DAMAGE TOLERANCEEVALUATION METHOD FORMULTI-CRACKED STRUCTURE

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chinese Journal of Aeronautics 1995年第3期8卷 191-197页

作者： TongMingho FeiBinjun LiuWenting(beijing university of Aeronautics and Astronautics, beijing, China, 100083.

ＰＲＯＢＡＢＩＬＩＴＹＤＡＭＡＧＥＴＯＬＥＲＡＮＣＥＥＶＡＬＵＡＴＩＯＮＭＥＴＨＯＤＦＯＲＭＵＬＴＩ－ＣＲＡＣＫＥＤＳＴＲＵＣＴＵＲＥＴｏｎｇＭｉｎｇｈｏ；ＦｅｉＢｉｎｊｕｎ；ＬｉｕＷｅｎｔｉｎｇ（ＢｅｉｊｉｎｇＵｎ... 详细信息

ＰＲＯＢＡＢＩＬＩＴＹＤＡＭＡＧＥＴＯＬＥＲＡＮＣＥＥＶＡＬＵＡＴＩＯＮＭＥＴＨＯＤＦＯＲＭＵＬＴＩ－ＣＲＡＣＫＥＤＳＴＲＵＣＴＵＲＥＴｏｎｇＭｉｎｇｈｏ；ＦｅｉＢｉｎｊｕｎ；ＬｉｕＷｅｎｔｉｎｇ（ＢｅｉｊｉｎｇＵｎｉｖｅｒｓｉｔｙｏｆＡｅｒｏｎａｕ...

关键词： probability theory fracture mechanics tolerances (mechanics) reliability

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机器学习与网络信息处理

计算机工程与应用 2004年第33期40卷 189-191页

作者：李嘉佑何清史忠植中国科技大学合肥230027 中国科学院计算技术研究所智能信息处理重点实验室北京100080

机器学习在网络信息处理中占有重要地位。GHunt是一个采用多项机器学习技术的网络信息智能获取与处理系统。首先,这一系统支持分布式的网络信息并行搜索与内容过滤;其次,采用机器学习技术,包括文本分类、聚类,文本概念抽取,从概念层次... 详细信息

机器学习在网络信息处理中占有重要地位。GHunt是一个采用多项机器学习技术的网络信息智能获取与处理系统。首先,这一系统支持分布式的网络信息并行搜索与内容过滤;其次,采用机器学习技术,包括文本分类、聚类,文本概念抽取,从概念层次理解文本信息;再次,基于概念语义空间有效地统一文本信息管理;最后提供高效的基于概念语义的文本信息检索,以及个性化的专题组织与信息推送服务。文中着重阐述了系统中所用到的机器学习技术。

关键词：网络信息机器学习概念语义空间分类聚类

LINEAR PREDICTION APPROACH IN AIRBORNE ADAPTIVE ARRAYS

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chinese Journal of Aeronautics 1996年第1期9卷 64-70页

作者： Su Jie Li Chunsheng Zhou Yinqing(Department of Electronic Engineering, beijing university of Aeronautics and Astronautics, beijing, China, 100083. Department of Electronic Engineering Beijing Univ. Aero. and Astronaut. Beijing 100083 China

To cope with the time-varying and Dopper-broadened clutter in airborne phase array radars, it is required that the signal processing should be adaptive and two-dimensional both in time and in space. However, the optimum two-dimensional adaptive processing is hard to realize real-timely because it requires a large amount of computation. From the idea of approximating the clutter process by using an auto regressive process, a linear prediction approach is proposed to realize the adaptive space-time processing of airborne adaptive array signals. The research shows that the clutter process can be well approximated by a low-order AR process, so a low-order linear prediction receiver can get a sub-optimum performance at a very low expense. Besides, the low-order linear prediction receiver has additional degrees of freedom to cope with other colored noises and interferences. In consideration of the many advantages of the linear prediction receiver in both algorithms and realizations, it has a good prospect in its application to air borne adaptive array signal processing.

关键词： signal processing phased arrays radar linear prediction adaptive filters

深层气泥岩盖层封闭能力的综合评价——以东濮凹陷杜桥白地区沙河街组三段泥岩盖层为例

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石油与天然气地质 2003年第2期24卷 191-195页

作者：谈玉明任来义张洪安张金报胥菊珍金振华中国科学院广州地球化学研究所中国石化中原油田分公司勘探开发科学研究院河南濮阳457001 石油大学地球资源与信息学院中国石化中原油田分公司勘探开发科学研究院中国地质大学北京100083

通过对东濮凹陷杜桥白地区沙河街组三段深层气盖层泥岩样品实验测试分析和研究 ,结果表明孔隙度的变化主要受深度和层位的控制 ;渗透率与深度关系密切 ,受层位的影响不大 ,与孔隙度等参数之间也没有明显的相关关系 ;突破压力随深度加大... 详细信息

通过对东濮凹陷杜桥白地区沙河街组三段深层气盖层泥岩样品实验测试分析和研究 ,结果表明孔隙度的变化主要受深度和层位的控制 ;渗透率与深度关系密切 ,受层位的影响不大 ,与孔隙度等参数之间也没有明显的相关关系 ;突破压力随深度加大而增大 ,但这一趋势并不是十分突出 ;突破压力与层位的对应关系较明显 ,Es4 3.亚段的突破压力最大 ,Es2. 亚段次之 ,而Es3.3.则相对较低。为了准确评价盖层封闭能力 ,选择了孔隙度、渗透率、排替压力、孔径 4个盖层评价的指标参数 ,并根据其重要性的大小分别给予 0 1,0 3.0 5和 0 1的权系数 ,以确定东濮凹陷深层气盖层的评价标准 :当综合评价的权值大于 0 8时 ,为封闭能力好的 1类盖层 ;当权值为 0 6～ 0 8时 ,为封闭能力中等的 2.盖层 ;而权值为 0 5～ 3.盖层 ;权值为 0 3. 3.则为非盖层。

关键词：泥岩封盖层物性封闭能力突破压力评价标准东濮凹陷

Cloning,expression and binding specificity analysis of odorant binding protein 3.of the lucerne plant bug,Adelphocoris lineolatus(Goeze)

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Science Bulletin 2010年第34期55卷 3913-3923页

作者： GU ShaoHua1,SUN Yang1,2.REN LiYan1,2.ZHANG XueYing1,ZHANG YongJun1,WU KongMing1 & GUO YuYuan1 1State Key Laboratory for Biology of Plant Diseases and Insect Pests,Institute of Plant Protection,chinese {3. of Agricultural {2.,{3. 100193.China 2.ollege of Agriculture and Biotechnology,China Agricultural university,{3. 100193.China

Credible evidence shows that odorant binding proteins(OBPs)are required for insect olfaction perception and play a key role in transporting hydrophobic odorants across the sensillum lymph to the olfactory receptors(ORs).In the present study,a novel OBP(AlinOBP3.gene from the lucerne plant bug,Adelphocoris lineolatus,was cloned and *** expression pattern of AlinOBP3.was evaluated by qPCR,which indicated that AlinOBP3.was dominantly expressed in *** binding properties of AlinOBP3.with 9 cotton volatiles and 5 sex pheromone analogs were measured by fluorescence competitive binding assays with the fluorescence probe *** results revealed that of 9 cotton volatiles,Myrcene,β-Ocimene and α-Phellandrene can bind with AlinOBP3.α-Phellandrene especially bound to AlinOBP3.with a high binding affinity,with a dissociation constant of 56.68 μmol/*** the 5 sex pheromone analogs,Hexyl butyrate had the strongest binding affinity with AlinOBP3.with a dissociation constant as 59.53.μmol/*** butyrate,trans-2.Hexenyl butyrate and Ethyl butyrate had medium binding affinities with AlinOBP3.with dissociation constants of 2.7.3.,108.77 and 143.47 μmol/L,*** results suggest that AlinOBP3.might be a pheromone binding protein(PBP)with a dual-function for the perception of sex pheromones and plant volatiles.

关键词： Adelphocoris lineolatus(Goeze) odorant binding protein gene expression Western blot expression pattern fluorescence competitive binding assays

Towards the purely semiconducting boron and nitrogen co-doped single-walled carbon nanotubes

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Towards the purely semiconducting boron and nitrogen co-dope...

2.11中国材料研讨会

作者： Wenlong Wang,Zhi Xu,Muhong Wu,Xuedong Bai,and Enge Wang,beijing National Laboratory for Condensed Matter Physics,Institute of Physics,chinese {2. of {3. School of Physics,Peking university

＜正＞Ever since their discovery,carbon nanotubes（CNTs）,and single-walled carbonnanotubes（C-SWNTs）in particular,have taken a leading position in nanoscienceresearch owing to their well-known

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来源： cnki会议评论

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基于数据仓库的EIS数据管理体系结构

计算机工程与应用 2003年第19期39卷 17-20页

作者：王锁柱孙玉芳中国科学院软件研究所山西师范大学数学与计算机学院临汾041004

该文采用数据仓库的思想构建了EIS的数据管理体系结构,以满足EIS的数据分布性、格式多样性和结构复杂性的要求,克服了现有EIS响应速度低、可用性差等方面的缺陷。在该体系结构中,分别设置了硬信息获取、软信息挖掘模块和硬软信息集成、... 详细信息

该文采用数据仓库的思想构建了EIS的数据管理体系结构,以满足EIS的数据分布性、格式多样性和结构复杂性的要求,克服了现有EIS响应速度低、可用性差等方面的缺陷。在该体系结构中,分别设置了硬信息获取、软信息挖掘模块和硬软信息集成、链接模块,并就实现的关键技术提出了解决方式。

关键词：高层管理信息系统数据管理数据仓库

A STUDY ON THE MARGINAL ANALYSIS METHOD FOR THE AIRLINE YIELD MANAGEMENT

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chinese Journal of Aeronautics 1992年第4期 270-276页

作者： Guan Jian-cheng(beijing university of Aeronautics and Astronautics,beijing,100083.China)

The current situation and the history of two-fare-class seat inventory control problemfor the airline yield management in the air transportation of the passengers are *** a new marginal analytical method determining the optimal allotment forthe two-class problem is presented with an emphasis on the theoretical aspects of the problemas compared with the traditional *** on the fact that the passengers’ demandnumber is a discrete random variable the formula deduction is demonstrated *** formula obtained in this paper which shows that the optimal seat allotment relatesto the distributions of both high-fare demand and low-fare demand has made someimprovements for the traditional formulae in this *** the formula deductedin this paper to the traditional formulae the results of the computational example of thenew formula show that the method is more accurate and also practical.

关键词： A STUDY ON THE MARGINAL ANALYSIS METHOD FOR THE AIRLINE YIELD MANAGEMENT high