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Microcosmic analysis of ductile shearing zones of coal seams of brittle deformation domain in superficial lithosphere

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Science china Earth sciences 2004年第5期47卷 393-404页

作者： JU Yiwen1,2. WANG Guiliang2. JIANG Bo2.& HOU Quanlin1 1. graduate school,{2., Beijing 100039, china 2. College of Mineral Resources and Geosciences, china University of Mining & Technology, Xuzhou 2.1008, china graduate school Chinese Academy of Sciences Beijing 100039 China College of Mineral Resources/Geosci. China University of Mining/Technol. Xuzhou 221008 China

The ductile shearing zones of coal seams in a brittle deformation domain in super-ficial lithosphere are put forward based on the study on bedding shearing and ductile rheology of coal seams. The macrocosmic and microcosmic characteristics include wrinkle fold, mymonitized zones and ductile planar structure of coal seams, etc., while the microcosmic characteristics may also include different optic-axis fabrics and the anisotropy of vitrinite reflectance as well as the change of chemical structure and organic geochemistry components. The forming mechanism is analyzed and the strain environment of ductile shearing zones of coal seams discussed. The result indicates that, in the superficial brittle deformation domain, the coal seams are easy to be deformed, resulting in not only brittle deformation but also ductile shearing deformation under the action of force. Because of simple shearing stress, the interlayer gliding or ductile rheology may take place between coal seams and wall rocks. Therefore, many ductile shearing zones come into being in superficial lithosphere (<5 km). The research on ductile shearing zone of brittle de-formation domain in superficial lithosphere is significant not only theoretically for the study of ductile shearing and ductile rheology of the lithosphere but also practically for the structural movement of coal seams, the formation and accumulation of coal-bed methane, and the preven-tion and harness of gas burst in coal mine.

关键词： brittle deformation domain, interlayer gliding, ductile rheology, ductile shearing zones of coal seams, coal mymonite, vitrinite reflectance anisotropy.

Development of a quantitative,cell-based,high-content screening assay for epidermal growth factor receptor modulators

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Acta Pharmacologica Sinica 2007年第10期28卷 1698-1704页

作者： Jue WANG~2.Xin XIE~(2.3)~2.The National Center for Drug Screening,Shanghai Institute of Materia Medica,chinese academy of {2. graduate school of chinese academyof {2. Shanghai 2.12.3,china The National Center for Drug Screening Shanghai Institute of Materia Medica Chinese Academy of Sciences graduate school of{2. Shanghai China

Aim:To develop a robust,cell-based,high-content screening （HCS） assay basedon receptor internalization for the identification of novel modulators of the epi-dermal growth factor receptor （EGFR）.Methods:Agonist-induced receptorinternalization is part of the signaling cascade of ***-taggedepidermal growth factor （EGF） was used to visualize the internalized receptor-ligand *** fluorescent intracellular spots were detected and mea-sured with an ArrayScan HCS *** that can competitively bind toEGFR or interfere with EGFR internalization process would result in a reducednumber and intensity of intracellular fluorescent *** assay was validated,optimized,and applied to a large-scale screening of a library containing 48 000synthetic ***:The competition between fluorescent EGF andunlabeled EGF reveals the IC50of unlabeled EGF is approximately 0.2.nmol/L,which is comparable with other published *** compounds with arelatively high degree of interference with EGFR internalization were *** of the compounds was proven to be agonist of the EGFR since it inducedphosphorylation of the receptor and extracellular signal-regulated protein ki-nase （ERK）.Conclusion:This automated,objective,and easy-to-use assay pro-vided abundant information,quantitative results,and demonstrated the potentialuse of HCS methods in searching membrane receptor modulators.

关键词： high-content screening epidermal growth factor receptor receptor internalization competitive binding

Statistical distribution of nonlinear random wave height

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Science china Earth sciences 2006年第4期49卷 443-448页

作者： HOU Yijun1, GUO Peifang1,2. SONG Guiting1,2. SONG Jinbao1, YIN Baoshu1 & ZHAO Xixi1,2.1. Institute of Oceanology, chinese academy of sciences, Qingdao 2.6071, china 2. {2. University of the chinese academy of sciences, Beijing 100039, china Institute of Oceanology Chinese Academy of Sciences Qingdao China graduate University of the chinese academy of sciences Beijing China

A statistical model of random wave is developed using Stokes wave theory of water wave dynamics. A new nonlinear probability distribution function of wave height is presented. The results indicate that wave steepness not only could be a parameter of the distribution function of wave height but also could reflect the degree of wave height distribution deviation from the Rayleigh distribution. The new wave height distribution overcomes the problem of Rayleigh distribution that the prediction of big wave is overestimated and the general wave is underestimated. The prediction of small probability wave height value of new distribution is also smaller than that of Rayleigh distribution. Wave height data taken from East china Normal University are used to verify the new distribution. The results in- dicate that the new distribution fits the measurements much better than the Rayleigh distribution.

关键词： Random ocean wave, nonlinearity, wave height distribution.

Genetic structure and phylogeography of a relict tree fern,Sphaeropteris brunoniana (Cyatheaceae) from china and Laos inferred from cpDNA sequence variations:Implications for conservation

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Journal of Systematics and Evolution 2011年第1期49卷 72-79页

作者： 1,2.Zi-Juan WANG 1 Kai-Yun GUAN 1 (Kunming Institute of Botany, chinese academy of sciences, Kunming 6502.4, china) 2.({2. University of chinese academy of sciences, Beijing 100049, china) (Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204 China) (graduate University of chinese academy of sciences Beijing 100049 China)

In this study, we analyzed the genetic structure and phylogeography of Sphaeropteris brunoniana from china and Laos. Combining cpDNA trnL-trnF and atpB-rbcL sequence variations, five haplotypes were identi- fied from the 10 investigated populations. Moderate haplotype diversity (h = 0.66580) and low nucleotide diver- sity (π = 0.2. × 10 ?3 ) were detected. The S. brunoniana in Yunnan region had much higher genetic diversity (h = 0.60195, π = 0.35 × 10 ?3 ) than that of Hainan–Laos (h = 0.00000, π = 0.00). A high level of genetic differentiation (94.74%) between the two regions was revealed by AMOVA. Nested clade analysis identified two major clusters of the five haplotypes, one clade in the Yunnan region and the other in Hainan–Laos. The analysis indicated that restricted gene flow with isolation by distance and allopatric fragmentation were likely the major processes that shaped the spatial distribution of the haplotypes. The isolated distribution of clades implied the emergence of independent refugia of this species in each region during Quaternary glaciations. The Yunnan populations frequently contained an ancestral haplotype, and most of them harbored other descendent haplotypes. Based on the distribution pattern of haplotypes and the nested clade analysis results, the Yunnan region potentially had several refugia of this species during glacial periods, whereas the Hainan populations were probable new colonizations.

关键词： atpB-rbcL Hainan–Laos phylogeography Sphaeropteris brunoniana trnL-trnF Yunnan.

Novel Tumor-associated Antigen of Hepatocellular Carcinoma Defined by Monoclonal Antibody E4-65

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Acta Biochimica et Biophysica Sinica 2007年第5期39卷 359-365页

作者： Ke ZOU~(1,2., Jihang JU~(1,2., and Hong XIE~~(1*)1 Institute of Biochemist13, and Cell Biology, Shanghai Institutes for Biological sciences, chinese academy of sciences, Shanghai 2.0031,{2.. 2.graduate school of the chinese academy of sciences Beijing 100049,{2. Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of SciencesShanghai 200031 China graduate school of the{2.Beijing 100049 China

A monoclonal antibody, E4-65, produced by immunizing mice with SMMC-772. cells, a human hepatocellular carcinoma (HCC) cell line, was used to identify and characterize an unreported HCC-associated antigen. Indirect immunofluorescence studies showed that E4-65 antibody reacted with five out of eight HCC cell lines, but not with 10 non-HCC tumor cell lines or a normal liver cell line. Using immunohistochemical examination, E4-65 antigen was detected on the cell membranes and in the cytoplasm of human liver tumor tissues, but was not found in most other tumors, or normal adult or fetal tissues, except for a weakly positive reaction in tissues of the digestive system. Western blot analysis showed that E4-65 antibody bound to a 45 kDa protein in the human HCC cell line and tissue lysates. Enzyme treatment and lectin blotting did not detect the carbohydrate chain in E4-65 antigen. This HCC-associated protein represents a potentially useful target for diagnoses and immunotherapy of human HCC.

关键词： hepatocellular carcinoma immunohistochemistry monoclonal antibody neoplasm antigen

Debris Flow Hazard Assessment Based on Support Vector Machine

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Wuhan University Journal of Natural sciences 2006年第4期11卷 897-900页

作者： YUAN Lifeng 1, 2., ZHANG Youshui 3 1. Institute of Mountain Hazards and Environment, chinese academy of sciences, Chengdu 610041, Sichuan, china 2. {2. University of chinese academy of sciences, Beijing 100049, china 3. Institute of Geographical sciences and Natural Resources Research, chinese academy of sciences, Beijing 100101, china Institute of Mountain Hazards and Environment Chinese Academy of Sciences Chengdu Sichuan China graduate University of chinese academy of sciences Beijing China Institute of Geographical sciences and Natural Resources Research Chinese Academy of Sciences Beijing China

Seven factors, including the maximum volume of once flow , occurrence frequency of debris flow , watershed area , main channel length , watershed relative height difference , valley incision density and the length ratio of sediment supplement are chosen as evaluation factors of debris flow hazard degree. Using support vector machine （SVM） theory, we selected 2.9 basic data of 37 debris flow channels in Yunnan Province as learning samples in this study. We create a debris flow hazard assessment model based on SVM. The model was validated though instance applications and showed encouraging results.

关键词： debris flow hazard assessment support vector machine (SVM)

Kinetics and reaction mechanism of phenol hydroxylation catalyzed by La-Cu_4FeAlCO_3

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Science china Chemistry 2005年第6期48卷 530-537页

作者： CHEN Chunxia1,2. XU Chenghua1, FENG Liangrong1, SUO Jishuan1 & QIU Fali1 1. Chengdu Institute of Organic Chemistry, chinese academy of sciences, Chengdu 610041, china {2. of the chinese academy of sciences, Beijing 100039, china Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu China graduate school of the{2. Beijing China

The present work synthesizes La-Cu4FeAlCO3 catalyst under microwave irradiation and characterizes its structure using XRD and IR techniques. The results show that the obtained La-Cu4FeAlCO3 has a hydrotalcite structure. In the phenol hydroxylation with H2.2.catalyzed by La-Cu4FeAlCO3, the effects of reaction time and phenol/H2.2.molar ratio on the phenol hy-droxylation, and relationships between the initial hydroxylation rate with concentration of the catalyst, phenol, H2.2.and reaction temperature are also investigated in details. It is shown the phenol conversion can reach 50.09% (mol percent) in the phenol hydroxylation catalyzed by La-Cu4FeAlCO3, under the reaction conditions of the molar ratio of phenol/H2.2.1/2. the amount ratio of phenol/catalyst 2., reaction temperature 343 K, reaction time 12. min, 10 mL distilled water as solvent. Moreover, a kinetic equation of v = k[La ? Cu 4 FeAlCO 3 ][C 6 H 5 OH][H 2.O 2.. and the activation energy of Ea=58.37 kJ/mol are obtained according to the kinetic studies. Due to the fact that the HO-Cu+-OH species are detected in La-Cu4FeAlCO3/H2.2.system by XPS, the new mechanism about the generation of hydroxyl free radicals in the phenol hydroxylation is pro-posed, which is supposed that HO-Cu+-OH species are transition state in this reaction.

关键词： rare earth, hydrotalcite, microwave irradiation, phenol hydroxylation, kinetics, reaction mechanism.

Synthesis of well-defined functional PE graft copoly-mers via ATRP process

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Science Bulletin 2005年第10期50卷 1048-1051页

作者： CAO Chengang1, 2. DONG Jinyong1 & HU Youliang1 1. CAS Key Laboratory of Engineering Plastics, Joint Laboratory of Polymer Science and Materials, Institute of Chemistry, chinese academy of {2., Beijing 100080, china 2. graduate school, chinese academy of sciences, Beijing 100039, china CAS Key Laboratory of Engineering Plastics Joint Laboratory of Polymer Science and Materials Institute of Chemistry Chinese Academy of Sciences Beijing China graduate school Chinese Academy of Sciences Beijing China

In summary, we have demonstrated a convenient yet highly efficient method for the preparation of PE-based graft copolymers via ATRP. By introducing a small amount of styrene groups into PE chains via the selective copolymerization of ethylene with 1,4-divinylbenzene catalyzed by Et(Ind)2.rCl2.MAO, the multifunctional ATRP initiator of 1-chloroethylbenzene-containing PE was readily achieved by a quantitative hydrochlorination reaction and was shown to be very effective for the initiation of graft polymerization of MMA and styrene to prepare structurally well-defined PE-based graft copolymers.

关键词： ATRP Synthesis of well-defined functional PE graft copoly-mers via ATRP process PE well

Geometry of Broad Line Regions of Active Galactic Nuclei

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chinese Journal of Astronomy and Astrophysics 2008年第1期8卷 50-62页

作者： Xiao-Rong Lü1 Key Laboratory for Particle Astrophysics, Institute of High Energy Physics, chinese academy of sciences, Beijing 100049 2.graduate {2. of chinese academy of sciences, Beijing 100049 Key Laboratory for Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 graduate school of{2. Beijing 100049

It has long remained an open question as to the geometry of the broad line region （BLR） in active galactic nuclei （AGNs）. The reverberation mapping technique which measures the response of the broad emission lines to the ionizing continuum, when combined with multiwavelength continuum fitted by sophisticated accretion disks, provides a way of probing the BLR geometry. We analyze a sample of 35 AGNs, which have been monitored by the reverberation mapping campaign. In view of energy budget, the reverberation-based BH masses are found to be in agreement with those obtained by accretion disk models in two thirds of the present sample while the reverberation mapping methods underestimate the BH masses in about one third of objects, as also suggested by CoUin et al. in a recent work. We point out that there are obviously two kinds of BLR geometry, which are strongly dependent on the Eddington ratio, and separated by the value LBol/LEdd - 0.1. These results prefer a scenario of the disk and wind configuration of the BLR and identify the Eddington ratio as the physical driver regulating the wind in the BLR.

关键词： accretion, accretion disks - galaxies active - galaxies Seyfert - quasars general