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Kctd10 regulates heart morphogenesis by repressing the trans-activity of Tbx5

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Kctd10 regulates heart morphogenesis by repressing the trans...

JClic Crosswords in Chemistry Class

2.12.国发育生物学大会

作者： Xiangjun Tong 1*,Yao Zu 1*,Wenyuan Li 1,Jing Yang 1,Lingxiao Ying 1,Da Liu 1,Shuo Lin 2.Bo Zhang 1 1 Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education,Center of Developmental Biology and Genetics,College of Life Sciences,Peking university,Beijing 100871,P.R.China 2.department of Molecular,Cell & Developmental Biology,university of california los angeles,los angeles,CA,usa

T-box(Tbx) transcription factors play essential roles in cardiac development in *** particular,Tbx5 is the key regulator for the formation of cardiac ***5 is a dosage-dependent transcription factor,so it must be accurately ***,we revealed that Kctd10,a member of potassium channel tetramerization domain(KCTD) containing family,physically interacted with Tbx5 to regulate its *** isolated a mutant of heart malformation in zebrafish and identified that kctd10 was the affected *** myocardial precursors and chamber identity of the heart were not affected in the mutant as the relevant markers were *** contrast,the genes specifically expressed at atrioventricular canal were all *** expression of tbx2. and hyaluronan synthase 2.has2. occured before the emergence of heart *** down of has2.alleviated the phenotype of heart defect in kctd10 morphant and the misexpression of both bmp4 and notch lb was *** of morpholino against tbx5 in kctd10 morphant rescued the ectopic expression of *** work further revealed that kctd10 bound to Tbx5 and suppressed the trans-activation of tbx2. and atrial natriuretic factor(anf) in a dose-dependent manner. Conclusions:Taken together,our findings suggest that the interaction between kctd10 and Tbx5 is essential for the expression pattern of tbx2. and the formation of atrioventricular canal.

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Journal of Chemistry and Chemical Engineering 2015年第4期9卷 303-308页

作者： Maria de los angeles Montiel Montoya department of Chemistry National Preparatory School No. 4 National Autonomous University of Mexico Mexico 11870 Mexico

Eight crosswords made in JClic were applied to twenty nine students from group 654, in area 2. at ENP （national preparatory school） No. 4 （a national public high school） in order to review Unit 2.and introduce the following Unit of Chemistry IV. Two surveys were applied in scholars in order to evaluate： the application of crosswords and of ICT （information and communications technology）. The results show that students like ICT because it is a relaxing mechanism to learn, JClic games were also liked by the majority due to the team work, so it induces to considerable learning.

关键词： ICT JClic amusing teaching-learning activities crosswords organic chemistry.

Comparison of PBDE congener profiles and concentration levels in human specimens from China and the US and identification of human exposure sources

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Science China Chemistry 2010年第5期53卷 995-1002页

作者： SHE JianWen 1,SHE YiFan 2.&SONG WenLu 2.1 Biochemistry Section,Environmental Health Laboratory Branch,california department of Public Health,Richmond,CA 94804,{2.2.hemistry Section,Food and Drug Laboratory Branch,california department of Public Health,Richmond,CA 94804,usa Environmental Health Laboratory Branch California Department of Public Health Biochemistry Section Richmond USA Food and Drug Laboratory Branch California Department of Public Health Chemistry Section Richmond USA

In an effort to investigate the status of human exposure to PBDEs in China,available monitoring data in human specimens(including breast milk,serums,and blood) was collected from the general population as well as specific groups that are occupationally *** exposure profiles and concentration levels were compared with their counterparts in the United States of *** was found that PBDE burdens in general Chinese population are one order lower and have different congener profiles from that in the US,showing higher percentages of BDE-2. or BDE-153 in human specimens from *** and residents in electronic wastes recycling regions or areas of commercial PBDE manufacturing have the highest PBDE exposure levels reported worldwide,which are close or higher than the exposure levels of the general population in the US. Highly brominated congeners,such as BDE-2.7 and 2.9,are among the major PBDE congeners,and BDE-2.9 has the highest percentage(above 50%) for all occupational populations *** components analysis(PCA) demonstrates that the exposure of the general population in the US is closely related to penta-BDE while the human burden in China is *** PBDE in indoor air(gas phase) in the US is highly correlated with the PBDE burden in the general population in the US,indicating a major exposure *** the occupationally exposed populations in China,the congener profiles are closely related to the commercial deca-BDE *** of exposure profiles for general and occupational populations in China suggests that it is essential to include more highly brominated congeners,such as BDE-2.7 and 2.9,in future human exposure studies,in order to assess the real burdens and profiles of PBDEs exposure in *** pollution prevention and occupational protection procedures are in need in China to avoid the PBDE contamination problem that has occurred in the US.

关键词： human exposure PBDEs congener profiles concentration levels source source identification China and usa

Measurement of Thermal Expansion Coefficients with Holographic Technique

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Journal of Thermal Science 1995年第1期4卷 67-74页

作者： Zhifeng Zhang(department of Mechanical and Environmental Engineering, university of {2. at Santa Barbara, CA93106, usa. department of Mechanical and Environmental Engineering University of California at Santa Barbara USA

A simplified mathematical model was created for measurement of thermal expansion coefficients of thinsheet materials with holographic technique. Experimental set-ups corresponding to the mathematicalmodel were designed and built for both tests above room temperature and at low temperatures. Afringe control technique was introduced for low temperature measurements to compensate rigid bodymovement. Thin sheet specimens of silicon and aluminum alloy (7075) were tested with the developedtechnique. The tested results are in good agreement with reported data and thus verify the validityof the developed technique. The thermal expansion coefficients of the tested materials ranged from2.5×10-6C-1 to 2..6×0-60C-1.

关键词： thermal expansion holographic measurement low temperature tests deformation tests.

Matrix metalloproteinases and their expression in mammary gland

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Cell Research 1998年第3期8卷 187-194页

作者： URIA JOSE A ZENA WERB(department of Anatomy, university of {2. San Francisco, CA 94143-0452. usa. department of Anatomy University of California San Francisco CA USA

The matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that play a key role in both normal and pathological processes involving tissue remodeling events. The expression of these proteolytic enzymes is highly regulated by a balance between extracellular matrix (ECM) deposition and its degradation, and is controlled by growth factors, cytokines, hormones, as well as interactions with the ECM macromolecules. Furthermore, the activity of the MMPs is regulated by their natural endogenous inhibitors, which are members of the tissue inhibitor of metalloproteinases (TIMP) family. In the normal mammary gland, MMPs are expressed during ductal development, lobulo-alveolar development in pregnancy and involution after lactation. Under pathological conditions, such as tumorigenesis, the dysregulated expression of MMPs play a role in tumor initiation, progression and malignant conversion as well as facilitating invasion and motastasis of malignant cells through degradation of the ECM and basement membranes. Matrix metalloproteinases and their expression in mammary gland

关键词： Matrix metalloproteinases ECM cancer progression mammary gland

INITIATION OF SEDIMENT MOTION INLAMINAR OVERLAND FLOW

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International Journal of Sediment Research 1999年第2期14卷 325-332页

作者： Gary LI (department of Geography & Environmental Studies california State {2. Hayward, CA 94542.usa.

Due to its extremely shallow in depth, the overland flow hydraulics is affected by surface roughness. raindrop impact, and in the case of laminar flow, fluid viscosity. The initiation of sediment in overland flow is subsequently influenced by these factors and differs greatly from that in river flows. This study is to investigate, by means of flume experiments, the effects of stone roughness, raindrops and fluid viscosity on the initiation of sediment motion in laminar overland flow. It was found that the critical dimensionless shear stress in laminar overland flow is much smaller when surface roughness and rainfall are present than when they are not. Surface roughness and rainfall generate disturbances in the flow which entrain otherwise immobile sediment. As a result, the threshold of motion in laminar flow on a rough surface with rainfall is similar to that in turbulent flow. It was found that critical flow power in laminar flow on rough surfaces in positively correlated with fluid viscosity and negatively correlated with rainfall intensity and surface roughness.

关键词： Overland flow Surface roughness Raindrop impact Initiation of sediment. Critical dimensionless shear stress

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人类基因组突变热点区的简并度特异基因

生物化学与生物物理进展 2004年第12期31卷 1091-1098页

作者：刘强徐军陈润生中国科学院生物物理研究所北京100101 department of Physiological Science and Laboratory of Neuroendocrinology of The Brain Research Institute University of California

突变热点区域是基因突变相对集中的区域 ,在生物的遗传和变异中有特殊的地位 .针对特殊条件下发生突变形成的突变热点区域进行了相关研究 .而人类基因组序列的测定和人类基因框架图的绘制 ,为在全基因组范围内进行突变热点研究提供了条... 详细信息

突变热点区域是基因突变相对集中的区域 ,在生物的遗传和变异中有特殊的地位 .针对特殊条件下发生突变形成的突变热点区域进行了相关研究 .而人类基因组序列的测定和人类基因框架图的绘制 ,为在全基因组范围内进行突变热点研究提供了条件 .分析了人类基因组中 2.831个基因突变热点区域上简并度的性质 ,对突变热点区集中在高简并度区或者低简并度区的基因生物学功能进行了分析和分类 .研究的焦点集中在某类功能的基因简并度特性一致的情况上 .对搜集到的基因简并度特性利用聚类计算进行分析 ,找到了一些特殊的功能类 ,属于其中某类功能的基因能够通过聚类分析聚合到一起 ,从而说明简并度特性也是相近的。

关键词：突变热点,简并度,聚类分析,人类基因组,单核苷酸多态性(SNP)

MESHFREE HOMOGENIZATION OF MAGNETOSTRICTIVE PARTICLE-FILLED ELASTOMER BASED ON THE ASYMPTOTIC EXPANSION APPROACH

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MESHFREE HOMOGENIZATION OF MAGNETOSTRICTIVE PARTICLE-FILLED ...

A Genome-wide Functional Characterization of Arabidopsis Regulatory Calcium Sensors in Pollen Tubes

中国力学学会学术大会'2.05

作者： Wang D D Chen JS ( Depertment of Civil Engineering, Xiamen university, Xiamen 361005, China) (department of Civil and Environmental Engineering, university of california, los angeles, CA 90095, usa.

Starting from the asymptotic expansion of governing equations, a unit cell micromechanics model is set up to determine the effective constitutive equations of the Magnetostrictive Particle-Filled Elastomer(MPFE). An interface-enriched reproducing kernel approximation (I-RKA) with embedded derivative discontinuities on the material interface is presented to model the unit cell. This formulation does not need additional degrees of

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Journal of Integrative Plant Biology 2009年第8期51卷 751-761页

作者： Liming Zhou1,2. Ying Fu1,2.and Zhenbiao Yang2.3 (1State Key Laboratory of Plant Physiology and Biochemistry, department of Plant Sciences, College of Biological Sciences, China Agricultural university, Beijing 100193, China 2.hina Agricultural university (CAU)-university of california, Riverside (UCR) Joint Center for Biological Sciences and Biotechnology, College of Biological Sciences, China Agricultural university, Beijing 100193, China 3Center for Plant Cell Biology and department of Botany and Plant Sciences, university of california, Riverside, CA 92.2., usa. State Key Laboratory of Plant Physiology and Biochemistry Department of Plant Sciences College of Biological Sciences China Agricultural University Beijing 100193 China China Agricultural university (CAU)-university of {2. Riverside (UCR) Joint Center for Biological Sciences and Biotechnology College of Biological Sciences China Agricultural University Beijing 100193 China Center for Plant Cell Biology and department of Botany and Plant Sciences University of California Riverside CA 92521 USA)

Calcium, an ubiquitous second messenger, plays an essential and versatile role in cellular signaling. The diverse function of calcium signals is achieved by an excess of calcium sensors. Plants possess large numbers of calcium sensors, most of which have not been functionally characterized. To identify physiologically relevant calcium sensors in a specific cell type, we conducted a genome-wide functional survey in pollen tubes, for which spatiotemporal calcium signals are well-characterized and required for polarized tip growth. *** members of calrnodulin （CAM）, CaM-like （CML）, calcium-dependent protein kinase （CDPK） and calcineurin B-like protein （CBL） families were tagged with green fluorescence protein （GFP） and their localization patterns and overexpression phenotypes were characterized in tobacco pollen tubes. We found that several fusion proteins showed distinct overexpression phenotypes and subcellular localization patterns. CDPK2.-GFP was localized to the vegetative nucleus and the generative cell/sperms. CDPK32.GFP caused severe growth depolarization. CBL2.GFP and CBL3-GFP exhibited dynamic patterns of subcellular localization, including several endomembrane compartments, the apical plasma membrane （PM）, and cytoskeleton-like structures in pollen tubes. Their overexpression also inhibited pollen tube elongation and induced growth depolarization. These putative calcium sensors are excellent candidates for the calcium sensors responsible for the regulation of calcium homeostasis and calciumdependent tip growth and growth oscillation in pollen tubes.

关键词： Arabidopsis calcium sensor calcium signaling Rho-related GTPase from plants subcellular localization tip growth