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Hyaluronic acid fragments evoke Kupffer cells via TLR4 signaling pathway

science China(Life sciences) 2009年第2期52卷 147-154页

作者： ZHANG JinXiang1, WANG Hui2. XIAO Qing3, LIANG HuiFang4, LI ZhuoYa4, JIANG ChunFang1, WU HeShui5 & ZHENG QiChang5 1 department of Emergency Surgery, Union Hospital Affiliated to huazhong university of science and technology, {2. 43002., China 2.department of Medical Genetics, Tongji Medical College Affiliated to huazhong university of science and technology, {2. 430030, China 3 department of Ophthalmology, Union Hospital Affiliated to huazhong university of science and technology, {2. 43002., China 4 department of Medical Immunology, Tongji Medical College Affiliated to huazhong university of science and technology, {2. 430030, China 5 department of General Surgery, Union Hospital Affiliated to huazhong university of science and technology, {2. 43002., China 1. department of Emergency Surgery Union Hospital Affiliated to Huazhong University of Science and Technology Wuhan 430022 China 2. department of Medical Genetics Tongji Medical College Affiliated to Huazhong University of Science and Technology Wuhan 430030 China 3. department of Ophthalmology Union Hospital Affiliated to Huazhong University of Science and Technology Wuhan 430022 China 4. department of Medical Immunology Tongji Medical College Affiliated to Huazhong University of Science and Technology Wuhan 430030 China 5. department of General Surgery Union Hospital Affiliated to Huazhong University of Science and Technology Wuhan 430022 China

Kupffer cells, expressing toll-like receptor 4 (TLR4), play a central role in hepatic ischemia/reperfusion (I/R) injury. Hyaluronic acid (HA) fragments, degradative products of high-molecular-weight HA (HMW-HA), acquire the ability to activate immune cells under inflammatory conditions. Here we inves- tigated whether HA fragments could activate Kupffer cells and analyzed the underlying mechanism. Kupffer cells were isolated from wild-type mice (WT, C3H/HeN) and TLR4 mutant mice (C3H/HeJ) and HA fragments were produced by the methods of enzyme digestion and chromatography. Then Kupffer cells were stimulated by HA fragments or other control stimuli. The activation of Kupffer cells was estimated as the release of pro-inflammatory cytokines. The activation of p38 MAPK pathway of Kupffer cells was checked and blocking experiments were done as well. The results indicated that HA fragments acquired the ability to activate Kupffer cells in vitro, which was TLR4 dependent and not due to contamination of lipopolysaccharide. Experiments of p38 MAPK kinase inhibition by SB-2.3580 verified p38 MAPK was required in HA fragments induced Kupffer cells activation. This suggests that HA fragments, degradative products of one of the major glycosaminoglycans of the extracellular matrix, play critical roles in Kupffer cell activation mediated by TLR4 signaling pathway, which is, at least partially, de- pendent on p38 MAPK activation.

关键词： Kupffer cells hyaluronic acid fragments toll-like receptor 4 p38 MAPK lipoplysaccharide reperfusion injury liver

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PARALLEL LATTICE BGK SIMULATION OF NATURAL CONVECTION IN A CAVITY

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Journal of Hydrodynamics 2005年第5期17卷 564-570页

作者： SHI Bao-chang LIU Hong-juan Parallel Computing Institute Huazhong University of Science and Technology Wuhan 430074 China department of Mathematics Huazhong University of Science and Technology Wuhan 430074 China

A Coupled Lattice Bhatnagar Gross Krook （CLBGK） model was proposed with a robust boundary scheme to model the Bossinesq incompressible flows. The LBGK method is a powerful approach, but is also computationally demanding. Therefore, parallel computing was implemented, and the codes were run on the parallel computer “Lenovo DeepComp 1800” with 2. nodes written in C＋＋ using the Message Passing Interface （MPI） library. Numerical results for natural convection in a cavity with the Rayleigh number （ Ra ） ranging from 10^6 to 4× 10^10 were presented, and found to agree well with the previous work. And with the increase of the resolution rate, the accuracy has been greatly improved. In addition, new models were set up by applying different equilibriums to the CLBGK model to simulate the same problem, which all yield sound results.

关键词： Lattice Bhatnagar Gross-Krook ( LB( K )model, Lattice Boltzmann Method (LBM), natural convection, parallel computing, high resolution

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The optimization of DNA encodings based on GA/SA algorithms

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Progress in Natural science:Materials International 2007年第6期17卷 739-744页

作者： Wang Wei1, Zheng Xuedong2. Zhang Qiang1 and Xu Jin2.1. Liaoning Key Laboratory of Intelligent Information Processing, Dalian university, Dalian 11662., China 2. department of Control {2. and Engineering, huazhong university of science and technology, wuhan 43.074, China) [a]Liaoning Key Laboratory of Intelligent Information Processing Dalian University Dalian China [b]department of Control science and Engineering Huazhong Univerisity of Science and Technology Wuhn China

The design of DNA sequence plays an important role in improving the reliability of DNA computation. Proper constrained terms that DNA sequence should satisfy are selected, and then the evaluation formulas of each DNA individual corresponding to the selected constrained terms are proposed. The heuristic improved genetic algorithm (GA)/simulated annealing (SA) algorithm is presented to solve the multi-objective optimize problem, and the DNA sequence design system is developed. Furthermore, an example is illustrated to show the efficiency of our method given here.

关键词： DNA encoding multi-objective optimize GA/SA algorithms

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Electrical Measurement to Assess Hydration Process and the Porosity Formation

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Journal of wuhan university of {2.(Materials science) 2008年第5期23卷 761-766页

作者：魏小胜 department of Civil Engineering Huazhong University of Science and Technology

The change of electrical resistivity with time at early ages was used to investigate the hydration process and the porosity development. Porosity reduction process of cement-based materials hydration was developed by a proposed method. The porosity reduction is fast at the setting period. The results find that the pore discontinuity occurs faster at lower water/cement ratios than at higher water/cement ratios which is similar to the results of the Percolation method.

关键词： electrical resistivity hydration setting time percolation

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Interfacial Microstructure and Properties of Ti(C, N)/Ni Bonded by Transient Liquid-phase Diffusion

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Journal of wuhan university of {2.(Materials science) 2009年第3期24卷 432-439页

作者：周世权熊惟皓 School of Mechanical science and Engineering Huazhong University of Science and Technology department of Mechanical Engineering University of Waterloo School of Materials science and Engineering Huazhong University of Science and Technology

Effects of the main process parameters（temperature and time） on microstructure and properties of Ti（C, N）/Ni interface bonded by （Cu＋Nb） interlayer in a vacuum diffusion bonding device were investigated. The interfacial microstructures consisted initially of Ni3Nb metallic compound and eutectic of Ni3Nb ＋ CuNiss, and finally transformed to （Ti, Nb）（C, N）＋Ni3Nb near Ti （C, N） and NiCuss ＋ Ni3Nb near Ni when diffusion bonding temperature was 1 52.-1 573 K. It was clear that Cu was a constituent in the transient liquid phase （TLP） into which Ni was dissolved by forming Cu-Ni transition liquid. Nb was dissolved in Cu-Ni transition liquid rapidly. Ti （C, N） conld be wetted by resultant Ni-Nb-Cu transient liquid phase which was followed by a little （Ti, Nb）（C, N） solid solution formed at interface. This increased the interface combining capability. Ultimately the interface shear strength was able to reach 140 MPa. The theoretle analysis and experimental results show that the growth of interfacial reaction layer Ni3Nb accords with parabola law, and the activation energy of diffusion reaction is 115.0±0.5 kJ/mol, while the diffusion reaction speed constant is 12.53 mm/s^1/2.

关键词： vacuum diffusion bonding transient liquid phase (TLP) diffusion bonding interlayer activation energy

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Quantum Theory of Femtosecond Soliton Propagation in Single-Mode Optical Fibers

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Communications in Theoretical Physics 2004年第6期41卷 943-948页

作者： CHEN Shi-Hua ZHANG Shao-Wu SHI Du-Fang department of Physics,huazhong university of science and technology,{2.,China department of Physics Huazhong University of Science and Technology Wuhan 430074 China

In this paper we have derived the generalized QNLS equation with considering the third-order dispersion andKerr dispersion,which can be applicable to the femtosecond regime and is suitable for discussing the quantum propertiesof femtosecond solitons in single-mode optical fibers,as compared with its classical *** quantum operatorequation can be solved by many methods such as the linearized perturbations and phase-space ***,owingto the fact that this quantum equation is rather similar to its classical counterpart,all these methods can be facilitatedto a great extent by citing correctly the classical results obtained before.

关键词： generalized QNLS equation single-mode-optical fibers third-order dispersion

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Preparation and ferroelectric properties of Bi_(3.4)Ce_(0.6)Ti_3O_(12. thin films grown by sol-gel method

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science China(Technological sciences) 2008年第1期51卷 10-15页

作者： GUO DongYun1, LI MeiYa1, LIU Jun1, YU BenFang1, PEI Ling1, WANG YunBo2. YU Jun2.& YANG Bin2.1 department of Physics, wuhan {2., wuhan 430072. China 2.department of Electronic science and technology, huazhong university of science and technology, wuhan 43.074, China department of Physics Wuhan UniversityWuhan 430072China

We have investigated the preparation and properties of Bi3.4Ce0.6Ti3O12.thin films. The Bi3.4Ce0.6Ti3O12.thin films were fabricated on the Pt/Ti/SiO2.Si substrates using sol-gel method. The structure and morphology of the films were characterized us- ing X-ray diffraction and atomic force microscopy. The thin films showed a perovskite phase and dense microstructure. The dielectric constant and the dissi- pation factor of the Bi3.4Ce0.6Ti3O12.thin films were about 172.and 0.031 at 1 kHz, respectively. The 2.r and 2.c of the Bi3.4Ce0.6Ti3O12.thin films were 67.1 μC/cm2.and 2.9.7 kV/cm, respectively, under an applied field of 600 kV/cm. The Bi3.4Ce0.6Ti3O12.film did not show fatigue up to 4.46×109 switching cycles at a frequency of 1 MHz, and showed good insulating behavior according to the test of leakage current.

关键词： Bi3.4Ce0.6Ti3O12 thin film sol-gel method ferroelectric property dielectric fatigue leakage current

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Second-order consensus in networks of dynamic agents with communication time-delays

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Journal of Systems Engineering and Electronics 2010年第1期21卷 88-94页

作者： Bo Yang1,2. Huajing Fang3, and Hua Wang4 1. School of Navigation, wuhan university of {2., wuhan 430063, P. R. China 2. wuhan Second Ship Design and Research Institute, wuhan 430064, P. R. China 3. department of Control science and Engineering, huazhong university of science and technology, wuhan 43.074, P. R. China 4. department of Aerospace and Mechanical Engineering, Boston university, Boston MA02.15, USA School of Navigation Wuhan University of Technology Wuhan 430063 P. R. China wuhan Second Ship Design and Research Institute Wuhan 430064 E R. China department of Control science and Engineering Huazhong University of Science and Technology Wuhan 430074 P. R. China department of Aerospace and Mechanical Engineering Boston University Boston MA02215 USA

This paper proposes second-order consensus protocols with time-delays and gives the measure of the robustness of the protocols to the time-delay existing in the network of agents with second-order dynamics. By employing a frequency domain method, it is proven that the information states and their time derivatives of all the agents in the network achieve consensus asymptotically, respectively, for appropriate communication timedelay if the topology of weighted network is connected. Particularly, a tight upper bound on the communication time-delay that can be tolerated in the dynamic network is found. The consensus protocols are distributed in the sense that each agent only needs information from its neighboring agents, which reduces the complexity of connections between neighboring agents significantly. Numerical simulation results are provided to demonstrate the effectiveness and the sharpness of the theoretical results for second-order consensus in networks in the presence of communication time-delays.

关键词： second-order consensus protocols dynamic networks algebraic graph theory frequency domain analysis com-munication constraints.

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GREEN'S FUNCTIONS FOR 2. PROBLEMS OF ANISOTROPIC PIEZOELECTRIC MATERIAL WITH A STRIP REGION

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Acta Mechanica Solida Sinica 2000年第2期13卷 149-154页

作者： Hu Yiantai Huang Yuying Chen Chuanyao Zhong Weifang (Dept.of mechanics,huazhong university of science and technology,{2.,China) huazhong Univ Sci & Technol Dept Mech Wuhan 430074 Peoples R China

By using Stroh's formalism and the conformal mapping technique,we derive the simple ex- plicit elastic fields of a generalized line dislocation and a generalized line force in a general anisotropic piezo- electric strip with fixed surfaces,which are two fixed conductor *** solutions obtained are usually considered as Green's functions which play important roles in the boundary element *** Coulomb forces of the distributed charges along the region boundaries on the line charge q at z^0 are analysed in detail. The results are valid not only for plane and antiplane problems but also for the coupled problems between in- plane and outplane deformations.

关键词： Stroh's formalism conformal mapping technique piezoelectricity anisotropie elasticity Green's functions Coulomb forces

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THE NUMERICAL SIMULATION OF FLOW IN ALUMINUM REDUCTION CELLS

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Journal of Hydrodynamics 1991年第1期3卷 11-15页

作者： Zhuang Ye-gao Zhang Qi-de, department of mechanics, {2. university of Scieuce and technology, wuhan 43.074, P. R. China huazhong Univ of science and Technology Wuhan China

The electromagnetic force causes a circulation of both cryolite and the metal in the aluminum reduction cells. This motion has the effect of reducing the current efficiency of the cell, and increases the distance between the an- ode and the cathode. Using the time-averaged Navier-Stokes equations and the K-e model of turbulence this paper numerically calculated the distributions of velocities, pressure, turbulent kinetic energy in the cells and deforma- tion of the interface of cryolite and metal. These results may be used to control the process of production and to improve the design of the cells.

关键词： Pr Flow THE NUMERICAL SIMULATION OF FLOW IN ALUMINUM REDUCTION CELLS

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