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Deferiprone protects the isolated atria from cardiotoxicity induced by doxorubicin

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Acta Pharmacologica Sinica 2006年第10期27卷 1333-1339页

作者： Ling-jie XU~(1,4) Liang JIN~1 Hong PAN~1 Ao-zhen ZHANG~2.Gang WEI~1 Ping-ping LI~3 Wei-yue LU~(1,5) ~1Fudan-PharmCo Drug Targeting Research Center,department of Pharmaceutics,~2.0} of Pharmacology,~3School of Pharmacy,Fudan {2.,Shanghai 2.0032.china ~4department of Pharmaceutics,School of Pharmacy,Guiyang Medical {2.,Guiyang 550004,china department of Pharmaceutics Fudan-PharmCo Drug Targeting Research Center Fudan University Shanghai China department of Pharmaceutics School of Pharmacy Guiyang Medical University Guiyang China department of Pharmacology Fudan University Shanghai China School of Pharmacy Fudan University Shanghai China

Aim:To investigate the effects of deferiprone on doxorubicin-inducedcardiotoxicity and determine its protection on cardiac contractility in vivo at tis-sue ***:Spontaneously-beating isolated atria from rats were pre-treated with deferiprone for 10 min at 1.2.mmol/L or 0.3 mmol/L,respectively beforeco-incubation with doxorubicin(DOX)at 0.03 mmol/L for 60 ***(dF/dt)was assessed every 10 min during the *** that,the tissuesaround the sinuatrial nodes were fixed for ultrastructural study;succinate dehy-drogenase(SDH)and Cu,Zn superoxide dismutase(Cu,Zn-SOD)activity,as wellas malondialdehyde(MDA)level of the atria were ***:Treatmentwith DOX alone resulted in a 49.34% reduction of the contractility,mitochondriaswelling,disruption of mitochondrial crista and decreased electron density of ***,with the presence of deferiprone,the negative inotropiceffect and lesions in the cardiac mitochondria structure induced by DOX ***,Zn-SOD activity increased by 12.97%-12.11%,the MDA leveldecreased by 2..12.-39.82. and succinate dehydrogenase(SDH)activity wasameliorated by 2..15%-34.76%.Conclusion:Deferiprone can efficiently pre-serve cardiac ***,the results of this study indicate thatdeferiprone is able to protect mitochondrial function and structure form damageinduced by *** cardiac protective potential of deferiprone could be due toits defense capability against oxidative damage.

关键词： deferiprone doxorubicin cardiotoxicity cardiac protection isolated atria

Isospin and symmetry energy study in nuclear EOS

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Science china(Physics,Mechanics & Astronomy) 2011年第S1期54卷 141-148页

作者： TIAN WenDong1, MA YuGang1, CAI XiangZhou1, FANG DeQing1, WANG HongWei1 & WU HongLi1,2.1 Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 2.1800, china 2.Graduate School of university of Science and Technology of china, Hefei 2.002., china Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai China Graduate School of university of Science and Technology of china Hefei China

This paper summarizes the isoscaling and isospin related studies in asymmetry nuclear reactions by different dynamic and sta tistical models. Isospin dependent quantum molecular dynamics model (IQMD) and lattice gas model (LGM) are used to study the isoscaling properties and isoscaling parameters dependence on incident energies, impact parameters, temperature and other parameters. In the LGM model, the signal of phase transition has been found in free neutron (proton) chemical potential dif ference Δμn or Δμp as a function of temperature, or in free neutron and proton chemical potential difference Δμn-Δμp. Density dependence of symmetry energy coefficient Csym(ρ/ρ0) is also studied in the frame of LGM, with the potential parameters which can reproduce the nuclear ground state property, soft density dependence of symmetry energy is deduced from the sim ulation results. Giant dipole resonance (GDR) induced by isospin asymmetry in entrance channel is also studied via IQMD model, and the dynamic dipole resonance shows isospin sensitivity on the isospin asymmetry of entrance channel and sym metry energy of the nuclear equation of state (EOS). GDR can also be regarded as a possible isospin sensitive signature.

关键词： nuclear EOS isospin isoscaling density giant dipole resonance

Stabilization of Chaotic Time Series by Proportional Pulse in the System Variable Based on Genetic Algorithm

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International Journal of Minerals,Metallurgy and Materials 1999年第3期13卷 228-229页

作者： Qing Li Deling Zheng Jianlong Zhou(Information Engineering School, university of Science and Technology Beijing, Beijing 100083. {2.)(Handan iron and Steel Co., Handan 056015, {2.) Information Engineering School University of Science and Technology Beijing Beijing 100083 China Handan Iron and Steel Co. Handan 056 015 China

The PPSV (Proportional Pulse in the System Variable) algorithm is a convenient method for the stabilization of the chaotic time series. It does not require any previous knowledge of the system. The PPSV method also has a shortcoming, that is, the determination off. is a procedure by trial and error, since it lacks of optimization. In order to overcome the blindness, GA (Genetic Algorithm), a search algorithm based on the mechanics of natural selection and natural genetics, is used to optimize the λi The new method is named as GAPPSV algorithm. The simulation results show that GAPPSV algorithm is very efficient because the control process is short and the steady-state error is small.

关键词： stabilization chaotic time series genetic algorithm

Non-Rigid Object Tracking by Anisotropic Kernel Mean Shift

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Transactions of Tianjin university 2007年第5期13卷 370-374页

作者：齐苏敏黄贤武 School of Electronics and Information Engineering Soochow University department of Computer Science Qufu Normal UniversityQufu 273165China

Mean shift,an iterative procedure that shifts each data point to the average of data points in its neighborhood,has been applied to object ***,the traditional mean shift tracker by isotropic kernel often loses the object with the changing object structure in video sequences,especially when the object structure varies *** paper proposes a non-rigid object tracker by anisotropic kernel mean shift in which the shape,scale,and orientation of the kernels adapt to the changing object *** experimental results show that the new tracker is self-adaptive and approximately twice faster than the traditional tracker,which ensures the robustness and real time of tracking.

关键词： object tracking mean shift anisotropic kernel modal matching

Performance evaluation of oil displacing agents for primary-minor layers of the Daqing Oilfield

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Petroleum Science 2011年第1期8卷 79-86页

作者： Zhang Jian Wang Shuxia Lu Xiangguo He Xianhua School of Petroleum Engineering China University of PetroleumBeijing 102249China School of Petroleum Engineering Northeast Petroleum UniversityDaqingHeilongjiang 163318China Information Section E＆D Research Institute of Daqing OilfieldDaqingHeilongjiang 163712China

A series of experiments were conducted to investigate the molecular coil dimension（D_h） and molecular configuration of partially hydrolyzed polyacrylamides（HPAM）,surfactant/HPAM system, and a living *** between the polymer coils and the porous media was evaluated by instrumental analysis and laboratory simulation ***,the performance of chemical flooding was *** indicated that the D_h decreased with an increase in water salinity and increased with an increase in polymer *** aqueous solution,the polymer presented three-dimensional reticular configuration and exhibited a fractal structure characterized by self-similarity. The polymer in the surfactant/HPAM system was mainly in the form of＂surfactant-polymer＂complex compound and the living polymer had an irregular＂flaky-reticular＂configuration which resulted in relatively poor compatibility between the molecular coils and the porous *** type of oil displacing agent and its slug size influenced the incremental oil *** the same oil displacing agent,a larger slug size would lead to a better chemical flooding *** the final recovery efficiency and economic benefits,high-concentration polymer flooding was selected as the optimimal enhanced oil recovery（EOR） technique and the incremental recovery efficiency was forecast to be 2.%.

关键词： Primary-minor layers molecular coil dimension molecular configuration compatibility

A NEW CLASS OF UNIFORMLY SECOND ORDERACCURATE DIFFRENCE SCHEMES FOR 2. SCALAR CONSERVATION LAWS

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Journal of Computational Mathematics 1997年第4期15卷 311-318页

作者： Juan Cheng(department of Aerodynamics, Nanjing university of Aeronautics & Astronautics,Nanjing, {2.)Jia-zun Dai (department of Mathematics, Physics and Mechanics, Nanjing university of Aeronautics & Astronautics, Nanjing, {2.) 南京航空航天大学空气动力学系江苏南京南京航空航天大学数学系江苏南京

In this paper, concerned with the Cauchy problem for 2. nonlinear hyperbolic conservation laws,we construct a class of uniformly second order accurate finite difference schemes, which are based on the E-schemes. By applying the conver gence theorem of Coquel-Le Floch [1], the family of approximate solutions defined by the scheme is proven to converge to the unique entropy weak L∞-solution. Furthermore, some numerical experiments on the Cauchy problem for the advection equation and the Riemann problem for the 2. Burgers equation are given and the relatively satisfied result is obtained.

关键词： Math A NEW CLASS OF UNIFORMLY SECOND ORDERACCURATE DIFFRENCE SCHEMES FOR 2. SCALAR CONSERVATION LAWS high Ph

THE TRANSIENT SOLUTION FOR M/G/1 QUEUEWITH SERVER VACATIONS

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Acta Mathematica Scientia 1997年第3期17卷 276-282页

作者：唐应辉 department of Applied Mathematics University of Electronic Science and Technology of China Chengdu 610054 China

In this paper, the transient solutions for M/G/1 queues with single server vacation and multiple server vacations are firstly studied, and the recursion expressions of their Laplace transform are given. Further the distribution and stochastic decomposition result of the queue length at a random point in equilibrium are directly obtained from the transient solution. As will be seen this paper provides a intuitive and elegant method for studying transient solutions for M/G/1 queues with single server.

关键词： server-vacation queue length transient solution stochastic decomposition

Numerical study of current fields near the Changjiang Estuary and impact of Quick-EnKF assimilation

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Acta Oceanologica Sinica 2011年第5期30卷 33-44页

作者： CHEN Xueen ZHAN Peng CHEN Jinrui QIAN Hongbao College of Physical and Environmental Oceanography Ocean University of China Qingdao 266100 China Administrative Center for china＇s Agenda 2. Beijing 100038 China

A 30-d current numerical simulation is running for the Yangshan Port,the Changjiang Estuary,the Hangzhou Bay and their adjacent seas using a finite volume coastal ocean model （FVCOM）,with Changjiang River runoff and wind effect being *** the open boundary,this model is driven by the water level obtained from prediction including eight main partial *** the harmonic analysis,the cotidal chart and the iso-amplitude line as well as the current ellipse distribution map are displayed to illustrate the propagation property of a tidal *** velocity of both the U and V components coincides with the actual measurement,which shows that the model result is credible to describe the hydrodynamic pattern in this sea *** this basis,real-time current data from high-frequency radar is assimilated with the implementation of quick ensemble Kalman filter,which takes the variation tendency of the state vector to compute the analysis field,instead of integrating the field for N （the number of ensemble） times as it used to in the standard EnKF,aiming at raising the efficiency of computation,reducing the error of prediction and at the same time,improving the forecast effect.

关键词： Yangshan Port finite volume coastal ocean model current quick ensemble Kalman filter assimilation

The flhDC gene affects motility and biofilm formation in Yersinia pseudotuberculosis

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Science china(Life Sciences) 2007年第6期50卷 814-821页

作者： WANG Yao1, DING LiSha1,2. HU YangBo1,2. ZHANG Yong1,2. YANG BaoYu1 & CHEN ShiYun1 1 Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, china 2.Graduate university of Chinese Academy of Sciences, Beijing 100049, china Wuhan Institute of Virology Chinese Academy of Sciences Wuhan China Graduate university of Chinese Academy of Sciences Beijing China

The flagella master regulatory gene flhDC of Yersinia pseudotuberculosis serotype III (YPIII) was mutated by deleting the middle region; replaced by a tetracycline resistant gene,; the subsequent mutant strain named YPIIIΔflhDC was obtained. Swimming assay showed that the swimming motility of the mutant strain was completely abolished. The promoter region of the flagella second-class regulatory gene fliA was fused with the lux box,; was conjugated with the mutant; the parent strains respectively for the first cross. LUCY assay result demonstrated that flhDC regulated the expression of fliA in YPIII as reported in E. coli. Biofilm formation of the mutant strain on abiotic; biotic surfaces was observed; quantified. The results showed that mutation of flhDC decreased biofilm formation on both abiotic; biotic surfaces,; abated the infection on Caenorhabdtis elegans. Our results suggest that mutation of the flagella master regulatory gene flhDC not only abolished the swimming motility, but also affected biofilm formation of YPIII on different surfaces. The new function of flhDC identified in this study provides a novel viewpoint for the control of bacterial biofilm formation.

关键词： Yersinia pseudotuberculosis, flhDC, motility, biofilm