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Aurora B facilitates cholangiocarcinoma progression by stabilizing c-Myc

Animal Models and Experimental Medicine 2024年第05期 626-640页

作者： Ke Liu Xuxuan Zhou Fei Huang Lihao Liu Zijian Xu chongqing Gao Keke Zhang Jian Hong Nan Yao Guohua Cheng College of Pharmacy Jinan University department of Pathophysiology School of Medicine Jinan University School of Medicine Jinan University

Background: Cholangiocarcinoma(CCA), a malignancy that arises from biliary epithelial cells, has a dismal prognosis, and few targeted therapies are available. Aurora B, a key mitotic regulator, has been reported to be involved in the progression of various tumors, yet its role in CCA is still ***: Human CCA tissues and murine spontaneous CCA models were used to assess Aurora B expression in CCA. A loss-of-function model was constructed in CCA cells to determine the role of Aurora B in CCA progression. Subcutaneous and liver orthotopic xenograft models were used to assess the therapeutic potential of Aurora B inhibitors in ***: In murine spontaneous CCA models, Aurora B was significantly upregulated. Elevated Aurora B expression was also observed in 62.3% of human specimens in our validation cohort(143 CCA specimens), and high Aurora B expression was positively correlated with pathological parameters of tumors and poor survival. Knockdown of Aurora B by siRNA and heteroduplex oligonucleotide(HDO)or an Aurora B kinase inhibitor(AZD1152. significantly suppressed CCA progression via G2.M arrest induction. An interaction between Aurora B and c-Myc was found in CCA cells. Targeting Aurora B significantly reduced this interaction and accelerated the proteasomal degradation of c-Myc, suggesting that Aurora B promoted the malignant properties of CCA by stabilizing c-Myc. Furthermore, sequential application of AZD1152.or Aurora B HDO drastically improved the efficacy of gemcitabine in ***: Aurora B plays an essential role in CCA progression by modulating c-Myc stability and represents a new target for treatment and chemosensitization in CCA.

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CARBIDE PRECIPITATION AND BAINITE TRANSFORMATION IN Fe-C-Si ALLOY

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Acta Metallurgica Sinica(English Letters) 1996年第5期9卷 373-378页

作者： R.L. Zuo L. Fang and P. D. Ding(department of Metallurgy and Materials Engineering, chongqing university,{2., china)

The upper bainite formed isothermally at 480℃ C in Fe-0. 38C-1. 73Si alloy was studied by using transmission electron microscopy (TEM). It was found by electron diffraction and crystallographic analysis that bainitic carbide precipitation originated from bainitic ferrite (BF), in which the initial supersaturation did not come up to the average carbon content of the alloy. It is suggested that bainite transformation in steel should be a coupled process of transformation dislocation movement controlled by carbon diffusion in austenite.

关键词： bainite carbide shear dislocation

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The Young's moduli prediction of random distributed short-fiber-reinforced polypropylene foams using finite element method

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Science china(Technological Sciences) 2009年第1期52卷 72-78页

作者： WANG Bo1, WANG RongXiu2.& WU Yong1 1 School of Mathematic Science, chongqing Institute of Technology, chongqing 400050,{2. 2.department of Computer Science and Information Engineering, chongqing Technology and Business university, chongqing 400067,{2. School of Mathematic Science Chongqing Institute of Technology Chongqing 400050 China department of Computer Science and Information Engineering Chongqing Technology and Business University Chongqing 400067 China

The elastic moduli of short-fiber-reinforced foams depend critically on the fiber content and fiber length, as well as on the fiber orientation distribution. Based on periodic tetrakaidecahedrons, the finite element models with short-fiber reinforcement were proposed in this paper to examine the effects of the fiber content and fiber length on Young's modulus. The fiber length distribution and fiber orientation distribution were also considered. The proposed models featured in a three-dimensional diorama with random short-fiber distribution within or on the surfaces of the walls and edges of the closed-cells of polypropylene (PP) foams. The fiber length/orientation distributions were modeled by Gaussian prob-ability density functions. Different fiber volume fractions, different lengths, and different distributions were investigated. The predicted Young's moduli of the PP foams with short-glass-fiber or short-carbon-fiber reinforcement were compared with other theoretic and experimental results, and the agreement was found to be satisfactory. The proposed finite element models were proved to be acceptable to predict the Young's moduli of the grafted closed-cell PP foams with short-fiber reinforcement.

关键词： short-fiber reinforcement Young’s modulus finite element Gaussian distribution

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A note on the crossed product R(A, α) associated with PSL_2.R)

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Science china Mathematics 2008年第11期51卷 2081-2088页

作者： WU WenMing 1 School of Mathematical and Computer Science, chongqing Normal university, chongqing 400047, china 2.department of Mathematical Science, Tsinghua university, Beijing 100084, china School of Mathematical and Computer Science Chongqing Normal University Chongqing China department of Mathematical Science Tsinghua University Beijing China

Given the hyperbolic measure dxdy/y2.on the upper half plane H, the rational actions of PSL2.R) on H induces a continuous unitary representation α of this group on the Hilbert space L2.H, dxdy/y2.. Supposing that A = {Mf : f ∈ L∞(H, dxdy/y2.}, we show that the crossed product R(A,α) is of type I. In fact, the crossed product R(A,α) is *-isomorphic to the von Neumann algebra B(L2.P,ν))■LK, where LK is the abelian group von Neumann algebra generated by the left regular representation of K.

关键词： crossed product rational actions PSL2.R) von Neumann algebras

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On Factorization of Meromorphic Functions

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Acta Mathematica Sinica,English Series 1997年第4期13卷 509-512页

作者： Qiao Jin Gu Yongxing department of Applied Mathematics, chongqing university,{2., china 重庆大学应用数学系重庆

This paper improves on the results of Noda, Y., Li Baoqing and Song Guodong, and proves the following theorem: Let f(z) be a transcendental meromorphic function. Then the set {a ∈C; (z-a)f(z) is not prime} is at mos... 详细信息

关键词： Meromorphic function Primality

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A Numerical Stress-strain Response Model of All Grades of Concretes under Uniaxial Compression

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Journal of Wuhan university of Technology(Materials Science) 2006年第3期21卷 149-152页

作者：王勇威 College of Water Resource & Hydropower Sichuan UniversityChengdu 610065China

An important problem facing stress-strain response modeling of concrete is the complexity of the compressive strength grades. 2. groups of speeimens with different cubic compressive strength （56.3- 164.9 MPa ） hate beets numerically analyzed. Using only the compressive strength, a stress-strain response model of different concrete grade was established. The numerical simulation model not only qualitatively reproduces the relationship of uniaxial compressive strength, peak value stress and cubic compressive strength, but realizes the consistence of the ascending branch of stress-strain cunts with different strength grades by introducing the correction coefficient k. The results indicate k increases gradually from 0 to approximate 1 with the increase of the compressive strength, corresponding to the transition from the paracurve to straight line branch in stress-strain curves. When k is 0, the madel is identical to the Hognestad equation. A good agreement with the experiment data was obtained.

关键词： high-strength concrete stress-strain response mechanical property

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KINETICS OF DESULFURIZATION OF LOW TITANIA SLAG IN BLAST FURNACE

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Acta Metallurgica Sinica(English Letters) 1992年第7期5卷 8-11页

作者： YAN Yuzhang LAN Hong, chongqing university, chongqing,{2. YAN Yuzhang, Associate Professor, department of Metallurgy and Materials Engineering, chongqing university, chongqing 630044,{2.

The desulphurizing reaction of the blast furnace low titania slag under the condition of no external agitation is confirmed to be of a first order. The controlling step is the diffusion of S in slag. The measures to a... 详细信息

关键词： low titania slag reaction rate activation energy diffusion

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Persistence of bounded solutions to degenerate Sobolev-Galpern equations

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Science china Mathematics 2010年第11期53卷 2831-2846页

作者： ZHU ChangRong1 & ZHANG WeiNian2. 1School of Mathematics, chongqing university, chongqing 400044,{2. 2.angtze Center of Mathematics and department of Mathematics, Sichuan university, Chengdu 610064,{2. 1. School of Mathematics Chongqing University Chongqing 400044 China2. Yangtze Center of Mathematics and Department of Mathematics Sichuan University Chengdu 610064 China

In this paper the persistence of bounded solutions to degenerate evolution equations of Sobolev-Galpern type is discussed. In order to define the evolution operator well, we study the existence and uniqueness of solutions to its linear form. On this basis we discuss exponential dichotomies of the evolution operator and give the Fredholm alternative result for bounded solutions of nonhomogeneous linear degenerate equations. This result enables us to give a condition for the persistence of bounded solutions of a general degenerate nonlinear autonomous equation under a nonautonomous perturbation.

关键词： degenerate evolution equation Sobolev-Galpern type boundedness Fredholm alternative exponential dichotomy

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THERMODYNAMICS OF V REDUCTION IN SMELTING REDUCTION SLAG FOR V-Ti-CONTAINING MAGNETITE

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Acta Metallurgica Sinica(English Letters) 1993年第12期6卷 4+400-404页

作者： ZHANG Binhuai LIU Qingcai LI Changwei ZOU Deyu SUN Jinbiao chongqing university,chongqing,{2. professor,department of Metallurgy and Materials Engineering,chongqing university,chongqing 630044,{2.

For slag system of CaO-SiO_2.Al_2._3-MgO-V_2._5,the time of V reduction to appro ch the dynamical equilibrium is about 6 h,the equilibrium time is not evidently influenced by the ratio CaO/SiO_2.and shortens with the increase of *** the ratio of the weight of slag to that of iron bath is 1/2.CaO/SiO_2.0.8 and tomperature 1773 *** maxium distribution coefficeent of V reduction is 32.4 and maxium recovery of V is 96.1%.

关键词： magnetite smelting reduction thermodynamics vanadium

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EFFECT　OF　COBALT　ION　IMPLANTATION　ON　THE　ELECTROchemistry　OF　NICKEL　ELECTRODE

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Chinese Chemical Letters 1994年第11期5卷 979-982页

作者： Sheng Tao ZHANG Zong Qing HUANG(department of Applied chemistry.{2. university. chongqing 630044)

The effect of cobalt implanled on the electrochemistry of nickel electrode in 1 mol/L NaOH was studied withspectroscopic cllipsomerty in-situ and electrochemical *** implantation with cobalt into nickelimproved the charging efficiency of nickel hydroxide/oxy-hydroxide electrode and made the transferring rate of nickel hydroxide to discharging activity material(NiOOH)obtain 10% *** implantation with cobaltalmost had not effect on the complex refractive index of nickel substrate.

关键词： IMPLANTATION THE ELECTROchemistry OF EFFECT COBALT

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