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Beneficial effects of melatonin in experimental models of Alzheimer disease

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Acta Pharmacologica Sinica 2006年第2期27卷 129-139页

作者： Yong CHENG~2.Zheng FENG~3 Qing-zhu ZHANG~4 Jun-tian ZHANG~(2.5) ~2.epartment of Pharmacology,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,china:~3Department of Anesthesiology,University of California,San Diego,and Veterans Affairs Medical center,3350 La Jolla Village Drive,San Diego,CA 92.61,USA:~4Department of Pharmacology,College of Pharmacy,Shandong University,Jinan 2.0012.china InstituteofMateriaMedica ChineseAcademyofMedicalSciencesandPUMCBeijing100050China DepartmentofAnesthesiology UniversityofCaliforniaSanDiegoandVeteransAffairsMedicalCenterUSA CollegeofPharmacy ShandongUniversity

Alzheimer’s disease(AD),a progressive degenerative disorder,is characterizedby the presence of amyloid deposits,neurofibrillary tangles and neuron *** evidence indicates that antioxidants could be useful either for the pre-vention or treatment of *** has been shown that melatonin is a potent antioxi-dant and free radical ***,melatonin stimulates severalantioxidative enzymes and improves mitochondrial energy *** find-ings led us to study amyloid precursor protein transgenic mice,ovariectomizedrats,and pheochromocytoma and astroglioma cell lines,to observe whether mela-tonin had any effect on Alzheimer’s symptoms or pathological *** foundthat melatonin had many beneficial effects in experimental models of AD,includ-ing improvement of cognitive function,anti-oxidative injury,anti-apoptosis,inhi-bition of β-amyloid(Aβ)deposition and Aβ fiber *** groups haveshown that melatonin has an inhibitory effect on tau protein *** actions may potentially slow down or stop the progression of dementia.

关键词： melatonin Alzheimer disease beta-amyloid protein calcium overload APP transgenic mice ovariectomized rats tau protein hyperphosphorylation

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集水面积阈值确定方法的比较研究

水电能源科学 2009年第5期27卷 11-14,171页

作者：杨邦任立良河海大学水资源高效利用与工程安全国家工程研究中心江苏南京210098

针对坡面径流模拟算法引入集水面积阈值划分流域内的河网与坡地直接影响了生成的数字河网精度,探讨并比较了多种推求流域集水面积阈值的方法。结果表明,各种方法可互补;采用集水面积与河道平均坡降关系和采用集水面积与河网密度曲线具... 详细信息

针对坡面径流模拟算法引入集水面积阈值划分流域内的河网与坡地直接影响了生成的数字河网精度,探讨并比较了多种推求流域集水面积阈值的方法。结果表明,各种方法可互补;采用集水面积与河道平均坡降关系和采用集水面积与河网密度曲线具有较好的一致性;流域面积越大,采用宽度分布推求阈值准确,流域面积越小,采用水系分形推求阈值准确;集水面积阈值在流域内各处并非完全相同,应考虑采用多个阈值。

关键词：集水面积阈值数字高程模型数字水系分形河网宽度

Significance of stress on mobilization of ore-forming materials

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Chinese Science Bulletin 1999年第S2期44卷 139-141页

作者： MA Rui and JIANG Qigang Research center of Metamorphic Dynamics of Changchun University of Science and Technology, Changchun 130061, china Research center of Metamorphic Dynamics Changchun University of Science and Technology Changchun 130061 China

METALLOGENIC processes represent migration and concentration of useful elements, which are controlled by a number of factors. Among varied geological factors, stress is very improtant. Stress could not only causethe fracture and deformation, but also is closely related to the mobilization and migration of ore-formingmaterials, especially for hydrothermal deposits. Varied experiments have been carried out to showthe above phenomenon. The sample is carbonaceous slate collected from the Taiyangding Group of the Nuo ’ ergai area,Sichuan Province. The rock is fresh, creckless, containing 40×10-9 of gold and high content of organiccarbon. Under a microscope, it is black. A group of state cleavage is observed, fine quartz and uniformily distributed carbonaceous materials. The quartz is<0.01 mm in diametre. Using high temperature

关键词： stress mobilization ore-formmg material.

Intracytoplasmic sperm injection in cases with a history of in vitro fertilization failure

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Asian Journal of Andrology 2003年第1期5卷 69-72页

作者： Zhi-Ling LI, Hong LIN, Xin-Neng ZHANG, Wan-Fen XIAO Reproduction center, First Affiliated Hospital, Medical College, Shantou University, Shantou 515041, china Reproduction center First Affiliated Hospital Medical College Shantou University Shantou 515041 China. lizhilin@***

Aim: To evaluate the effect of intracytoplasmic sperm injection (ICSI) in the management of cases with a history of conventional in vitro fertilization (IVF) failure. Methods: Two groups of patients, 19 with normal semen parameters and a history of IVF failure (metaphase Ⅱ oocytes: 0~30 %) and 2. with severe male factor infertility received ICSI technology during the same period. Ovarian stimulation was achieved by conventional procedure. Transvaginal ultrasound-guided oocyte collection was done 35~37 h after human chorionic gonadotrophin (hCG) injection. Only metaphase Ⅱ oocytes were selected for microinjection. Results: Fertilization was achieved with ICSI in all the patients. The fertilization rate (75.6 %±2..1 % vs. 73.9 %±19.2.%), cleavage rate (85.1 %±19.3 % vs. 82.7 %±2..1 %), clinical pregnancy rate per embryo transfer cycle (31.6 % vs. 2..6 %) and implantation rate per embryo (15.3 % vs. 14.4 %) did not differ significantly between the two groups. Conclusion: ICSI is a valuable method for couples with a history of IVF failure. These patients may have a similar ICSI result as in severe male infertility.

关键词： intracytoplasmic sperm injection in vitro fertilization male factor infertility fertilization failure

南刘寄奴中的一个新1,10-裂环愈创木烷型倍半萜(英文)

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中国天然药物 2012年第5期10卷 358-362页

作者：昝珂陈筱清屠鹏飞北京大学药学院天然药物及仿生药物国家重点实验室北京100191 首都医科大学中医药学院北京100069

目的:研究南刘寄奴中化学成分。方法:采用硅胶和 ODS 等柱层析分离手段以及半制备高效液相, 运用 NMR、MS 以及理化性质鉴定化合物的结构。结果:从南刘寄奴中分离得到 8 个化合物, 其结构鉴定为 3β-ethoxytanapartholide (1), ((4S*,5S... 详细信息

目的:研究南刘寄奴中化学成分。方法:采用硅胶和 ODS 等柱层析分离手段以及半制备高效液相, 运用 NMR、MS 以及理化性质鉴定化合物的结构。结果:从南刘寄奴中分离得到 8 个化合物, 其结构鉴定为 3β-ethoxytanapartholide (1), ((4S*,5S*)-dihydro-5-[(1R*, 2.*)-2.hydroxy-2.methyl-5-oxo-3-cyclopenten-1-yl]-3-methylene-4-(3-oxobutyl)-2.3H)-furanone) (2., ligucy-peronol (3), cyperusol C (4), santamarin (5), 1α, 2., 3α, 4α, 10α-pentahydroxyguaia-11(13)-ene-12. 6α-olide (6), balanophonin (7),methyl 3-(2.-hydroxy-4’-methoxyphenyl) propanoate (8)。结论:化合物 1 是新人工产物, 化合物 4 和 8 为首次从蒿属中分离得到, 化合物 2.3, 5–7 为首次从该植物中分离得到。

关键词：南刘寄奴蒿属化学成分 1,10-裂环愈创木烷型倍半萜

A new trick to tune down TGFβ signal

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Cell Research 2004年第5期14卷 439-440页

作者： Jian ZHANG* center for Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, No. 3 Nan-Yi-Tiao, Zhong Guan Cun, Beijing 100080, china center for Developmental Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences No. 3 Nan-Yi-Tiao Zhong Guan Cun Beijing 100080 China

Signal transduction in early embryogenesis needs to be properly controlled. A new player involved in tuning down TGF β signaling has now been identified – new evidence that multi-layer control of signaling is essent... 详细信息

关键词： A new trick to tune down TGF signal

Orexins excite cerebellar interpositus nuclear neurons in rats via orexin 2.receptors in vitro

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Orexins excite cerebellar interpositus nuclear neurons in ra...

Duplication and expression analysis of multicopy miRNA gene family members in Arabidopsis and rice

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Lei YU,Xiao-Yang ZHANG,Jun ZHANG,Jing-Ning ZHU*,Jian-Jun WANG~* Department of Biological Science and Technology and State Key Laboratory of Pharmaceutical Biotechnology,School of Life Sciences,nanjing University,nanjing {2.china

Orexin A and orexin B(also called hypocretin-1 and -2.,both derived from the common precursor prepro-orexin, are synthesized exclusively within the central nervous *** the cell bodies of neurons producing orexins are narrowly concentrated in the lateral hypothalamus/perifornical region,the orexinergic fibers widely project to various regions in the brain including the cerebellum,an important subcortical center for motor ***,orexins were considered to be neurotransmitters that centrally stimulate food intake,but it soon became evident that orexins are involved in many basic physiological processes including energy homeostasis,sleep-awake cycle,nociception,food and drug addiction,as well as ***,little is known about roles of orexins in central motor ***,the present study was designed to investigate the effect of orexins on neuronal activity of the cerebellar interpositus nucleus (IN),one of the final outputs of the *** this study,western blot and immunofluorescence histochemical results both showed that orexin 1 receptors(OXR) and orexin 2.receptors(OXR) were present in the rat cerebellar IN. Using brain slice preparations and extracellular recordings,186 IN neurons with tonic discharges were recorded from 12. cerebellar *** slices with orexin A(100 nM-1μM) or orexin B(100 nM-1μM) both produced 96 recorded cerebellar IN neurons(96/186,51.6%) a concentration-dependent excitatory *** orexins-induced excitation was not blocked by the low-Ca/high-Mg medium(n = 8),supporting a direct postsynaptic action of the *** OXR antagonist SB-334867(10-30μM) did not block the excitatory response of cerebellar IN neurons to orexins(n = 2.), but[Ala,D-Leu]orexin B(300 nM-1μM),a highly selective OXR agonist,mimicked the excitatory effect of orexins on the cerebellar IN neurons(n = 18).These results demonstrate that orexins excite the cerebellar EN neurons through OXR, although both

关键词： cerebellar interpositus nucleus orexin A orexin B orexinl receptors orexin 2.receptors motor control

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Cell Research 2006年第5期16卷 507-518页

作者： Danhua Jiang~(1,2. Changsong Yin~1 Aiping Yu~(1,3) Xiaofan Zhou~1 Wanqi Liang~(1,4) Zheng Yuan~1 Yun Xu~1 Qingbo Yu~1 Tieqiao Wen~2.Dabing Zhang~(1,4) ~1SJTU-SIBS-PSU Joint center for Life Sciences,School of Life Science and Biotechnology,Shanghai Jiao Tong University 800 Dongchuan Road,Shanghai 2.02.0, china ~2.chool of Life Science,Shanghai University,99 Shangda Road,Shanghai 2.0444,china ~3College of Life and Environment Sciences,Shanghai Normal University,100 Guilin Road, Shanghai 2.02.4,china ~4Key Laboratory of Agricultural Genetics and Breeding,Agro-biotech Research center,Shanghai Academy of Agricultural Sciences,2.01 Beidi Road,Shanghai 2.1106,china SJTU-SIBS-PSUJointcenterforLifeSciences SchoolofLifeScienceandBiotechnologyShanghaiJiaoTongUniversity800DongchuanRoadShanghai200240China SchoolofLifeScience ShanghaiUniversity99ShangdaRoadShanghai200444

To understand the expansion of multicopy microRNA (miRNA) families in plants,we localized the reported miRNAgenes from Arabidopsis and rice to their chromosomes,respectively,and observed that 37% of 117 miRNA genes fromArabidopsis and 35% of 173 miRNA genes from rice were segmental duplications in the *** order to characterizewhether the expression diversification has occurred among plant multicopy miRNA family members,we designed PCRprimers targeting 48 predicted miRNA precursors from 10 families in Arabidopsis and *** from RT-PCR datasuggest that the transcribed precursors of members within the same miRNA family were present at different *** addition,although miR160 and miR162.sequences were conserved in Arabidopsis and rice,we found that theexpression patterns of these genes differed between the two *** data suggested that expression diversifica-tion has occurred in multicopy miRNA families,increasing our understanding of the expression regulation of miRNAsin plants.

关键词： gene duplication microRNA multicopy

偏向型技术进步对长江经济带全要素能源效率影响研究

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中国软科学 2018年第3期 110-119页

作者：吴传清杜宇武汉大学经济与管理学院湖北武汉430072 武汉大学区域经济研究中心湖北武汉430072

探究偏向型技术进步对全要素能源效率的影响关系对推动经济发展方式向质量效率型转变具有重要意义。基于1997-2.15年长江经济带沿线11省市面板数据,采用三要素超越对数生产函数,测算长江经济带上中下游地区技术进步偏向性指数和全要素... 详细信息

探究偏向型技术进步对全要素能源效率的影响关系对推动经济发展方式向质量效率型转变具有重要意义。基于1997-2.15年长江经济带沿线11省市面板数据,采用三要素超越对数生产函数,测算长江经济带上中下游地区技术进步偏向性指数和全要素能源效率。研究结果表明:长江经济带全要素能源效率地区差异显著,上中下游地区依次递增;偏向型技术进步对长江经济带全要素能源效率具有明显促进作用,下游地区技术进步偏向人力资本,中上游地区技术进步偏向物质资本。进一步提高长江经济带全要素能源效率,需完善创新软环境,加强区域技术合作,促进创新成果转化,优化要素配置结构,推动服务型政府建设。

关键词：长江经济带偏向型技术进步全要素能源效率