检索结果-南通市图书馆

Advancement of Studies on Vitellogenin of Crustaceans

在线全文

学校读者我要写书评

暂无评论

Animal Husbandry and Feed Science 2012年第2期4卷 86-90,92页

作者： SHUI Yan 1 ,ZHOU Xin 1,2.1. Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization,Ministry of Agriculture,Freshwater Fisheries Research center, Chinese Academy of Fishery Sciences,Wuxi 2.4081,China 2. Wuxi Fishery College,Nanjing Agricultural university,Wuxi 2.4081,China

[Objective]The paper briefly summarizes the gene cloning and molecular research progress of vitellogenin in crustaceans belonging to Decapod. [Method]The molecular characteristics of identified Vg proteins in crustacean are reviewed from the aspects of protein synthesis,molec- ular structure,phylogenetic evolution,hormonal regulation of gene expression and biological functions. [Result]The similarity of structure and func- tion in homologous protein are pointed out; phylogenetic relationships among molecules are analyzed; the main characteristics of Vg interspecific protein in Decapod are summarized,and the special parts different from other species are raised. [Conclusion]The study can offer some help for the further study of Vg gene,and provides theoretical basis for ovary development mechanism of crabs.

关键词： Decapod Vitellogenin Gene

Various Growth Patterns and Morphology Transitions of Metal leaves

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Southeast university(English Edition) 1996年第1期12卷 48-52页

作者： Wang Junsheng （1. National Lab of molecular and Biomolecular Electronics, Southeast {2., Nanjing 2.0018 2. Department of Computer Science, Nanjing {2., Nanjing 2.0008) Lu Wanqin （center of Educational Technology, Nanjing {2., N

In electrodeless deposition, various patterns, such as dense branching morphology (DBM), dendritic morphology and double morphology growth, were observed in AgNO 3, CuSO 4, Pb(CH 3COO) 2.aqueous solutions with d... 详细信息

关键词： electrodeless deposition fractal potential Laplace equation

Intramuscular delivery of rAAV-mediated kallikrein gene reduces hypertension and prevents cardiovascular injuries in model rats

在线全文

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2007年第12期28卷 1898-1906页

作者： Yao WANG~(2.3),Ling-bo HOU~(2.3),Zhen-jun LIU~2.Yan WANG~2.Chun-lian CHEN~2.Xiao XIAO~(2.4),Dao-wen WANG~(2.5)~2.Institute of Hypertension and Department of Internal Medicine,Tongji Hospital,Tongji Medical College,Huazhong university of Science andTechnology,Wuhan 430030,China ~4 Departments of molecular Genetics and Biochentistry and Gene Therapy {2. university of Pittsburgh,Pittsburgh,PA 152.1,USA Institute of Hypertension and Department of Internal Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Departments of molecular Genetics and Biochemistry and Gene Therapy center Universit

Aim:The overexpression of the human tissue kallikrein （HK） gene can reduceblood pressure and ameliorate the secondary syndromes associated with hyper-tension in animal *** current study was designed to investigate hy-potensive effect of intramuscular delivery of HK ***:We generatedan recombinant adeno-associated virus （rAAV） vector expressing human tissuekallikrein under the control of a cytomegalovirus promoter and administered therAAV-HK vector to a spontaneously hypertensive rat model at a dose of 1×1010virons/rat through intramuscular ***:A persistent,high-level ex-pression of HK post-gene delivery was confirmed by *** systolic bloodpressure in the rats receiving rAAV-LacZ and saline increased from 171.3 mmHg to182.3 mmHg 2. weeks' post *** contrast,the delivery of the HK gene byAAV vectors attenuated the increase of the systolic blood pressure in the *** systolic blood pressure was only slightly lowered （from a level of 174mmHg to 170.5 mmHg） post-vector *** difference in blood pres-sure between the treated group and the control groups is statistically significantat 12.6 *** hypotensive effect of rAAV-HK persisted until the end of thetesting *** addition,a significant amelioration of cardiovascularhypertrophy,renal injury,and collagen depositions in the rAAV-HK-treated ani-mals were also ***:All the effects are comparable with thoseof intravenous ***,the intramuscular administration of rAAV-HKmay be used in gene therapy for hypertension.

关键词： recombinant adeno-associated virus vector human tissue kallikrein intramuscular administration hypertension gene therapy cardiovascular remodeling spontaneously hypertensive rat

Discussion of an Enrichment Mechanism of Precious Metals by Base Metals and Mattes in Pyro-metallurgical Processes

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

工程科学（英文版） 2007年第3期5卷 2-9页

作者： Chen Jing1,Huang Kun2.1.College of Chemistry and Chemical Engineering,Yunnan university,Kunming 650092.P.R.China 2. College of Chemistry and molecular Engineering,Peking university,Beijing 100871,P.R.China)

The enrichment mechanisms of precious metals by base metals or their mattes in pyro-metallurgical processes are discussed at the atomic level in this *** reasons brought forward for a trace amount of precious metals to be trapped into base metals or mattes are that the melted slag phases possess different chemical structures and properties from that of the melted base metal or matte *** for the melted slag phase,its formation is thought to depend on the covalent bonds and the ionic bonds between Si,O atoms and Ca2.,Mg2.,Fe2. ions to tie up each *** the bridging electrons in the slag phase are all thought as the localized electrons,the precious metal atoms are not stable among ***,as for the metal phase,its formation is thought depend on the metal bonds to bind up the metal *** the electrons in the metal phases can move freely among the atoms,the precious metal atoms that enter the metal phase can cause the system's free energy to *** the melted mattes phase,because it has high electrical conductivities(between 103～104 s·cm-1) at higher temperatures,and its temperature coefficients presents the negative values,its conductance mechanism belongs with the electronic *** property of the mattes is in fact similar to that of the metal at their melted state,so the precious metal atoms will enter the matte phase instead of the slag phase in a matte-smelting process.

关键词： enrichment mechanism precious metals base metals mattes

The intracellular mechanism of alpha-fetoprotein promoting the proliferation of NIH 3T3 cells

在线全文

学校读者我要写书评

暂无评论

Cell Research 2002年第2期12卷 151-156页

作者： MENG SEN LI, PING FENG LI, FBI YI YANG, SHI PENG HE, Guo GUANG DU, GANG LI1 Department of Biochemistry and molecular Biology, 2.Department of Biophysics, Health Science center, Peking {2., Beijing 100083, China 1Department of Biochemistry and molecular Biology Health Science Center Peking University Beijing 100083 China 1Department of Biochemistry and molecular Biology Health Science Center Peking University Beijing 100083 China 1Department of Biochemistry and molecular Biology Health Science Center Peking University Beijing 100083 China 2.epartment of Biophysics Health Science Center Peking University Beijing 100083 China 1Department of Biochemistry and molecular Biology Health Science Center Peking University Beijing 100083 China 1Department of Biochemistry and molecular Biology Health Science Center Peking University Beijing 100083 China

AIM The existence and properties of alpha-fetoprotein (AFP) receptor on the surface of NIH 3T3 cells and the effects of AFP on cellular signal transduction pathway were investigated. METHODS The effect of AFP on the proliferation of NIH 3T3 cells was measured by incorporation of 3H-TdR. Receptor-binding assay of 12.I-AFP was performed to detect the properties of AFP receptor in NIH 3T3 cells. The influences of AFP on the [cAMP]i and the activities of protein kinase A (PKA) were determined. Western blot was used to detect the change of K-ras P2. protein expression. RESULTS The proliferation of NIH 3T3 cells treated with 0-80 mg/L of AFP was significantly enhanced. The Scatchard analysis indicated that there were two classes of binding sites with KD of 2.72.×10-9M (Bmax=12.10 sites per cell) and 8.931× 10-8M (Bmax=119700 sites per cell) respectively. In the presence of AFP (2. mg/L), the content of cAMP and activities of PKA were significantly elevated . The level of K-ras P2. protein was upregulated by

关键词： Alpha-fetoprotein receptor signal transduction monoclonal antibody gene expression.

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

肿瘤能量代谢机制研究进展

生物化学与生物物理进展 2011年第7期38卷 585-592页

作者：罗湘建曹亚中南大学肿瘤研究所长沙410078 中南大学分子影像研究中心长沙410078

细胞的能量主要来自糖酵解和线粒体的有氧氧化.细胞活性和能量状态密切相关,恶性肿瘤由于其生长迅速,常常出现葡萄糖摄取量增高、糖酵解增加和乳酸堆积现象.通过介绍肿瘤能量代谢机制研究进展,结合代谢成像技术,将会有助于深入揭示肿瘤... 详细信息

细胞的能量主要来自糖酵解和线粒体的有氧氧化.细胞活性和能量状态密切相关,恶性肿瘤由于其生长迅速,常常出现葡萄糖摄取量增高、糖酵解增加和乳酸堆积现象.通过介绍肿瘤能量代谢机制研究进展,结合代谢成像技术,将会有助于深入揭示肿瘤能量代谢改变与肿瘤进展的因果关联,为靶向能量代谢的肿瘤治疗策略提供新的视野和契机.

关键词：能量代谢 Warburg效应低氧诱导因子 p53

Carcinogenesis switched on by DNA cross-link between complementary bases aroused by aflatoxin and N-nitroso compounds

在线全文

学校读者我要写书评

暂无评论

Progress in Natural Science:Materials International 2003年第8期 3-9页

作者： DAI Qianhuan , LU Ping, PENG Shaohua and ZHANG Qingrong (1. center of Environmental Science, Peking university, Beijing 100871, China 2. center for Chemistry and Bioengineering of Cancer, Beijing Polytechnic university, Beijing 10002., China)

The di-region theory put forward by Dai Qianhuan, a molecular mechanism of chemical carcinogenesis, concluded thatthe carcinogenesis induced by most of the environmental carcinogens is switched on by the cross-linking between DNA complementarybases aroused by the bifunctional alkylation of their metabolic intermediates. It was evidenced in this paper with DNA filter elution methodthat one carcinogenic mycotoxin, aflatoxin G1, four carcinogenic N-nitroso compounds, N-nitrosodiethyl-amine, N-nitrosodibutyl-amine,N-nitrosomorpholine and N-nitrosopyrrolidine, one carcinogenic diazo color, 4-dimethylaminodiazobenzene and one carcinogenic nitrogen-containing heterocyclic compound, quinoline, all induced DNA interstrands cross-linking with dosage correlation after metabolic ***, the non-carcinogens in corresponding series for control, aflatoxin B2. N-nitroso-diphenylamine, 4'-bromo-4-dimethylamino-diazobenzene and isoquinoline, cannot induce DNA interstrands cross-linking at all in the same co

关键词： cross-linking between DNA complementary bases di-region theory mycotoxin N-nitroso compounds mechanism of carcinogenesis mutational spectrum.

Stability of Titanium-aluminium Nitride (Ti_2.lN) at High Pressure and High Temperatures

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Wuhan university of Technology(Materials Science) 2011年第5期26卷 914-919页

作者：安佩寇自力 Institute of atomic and molecular Physics Sichuan University

The stability of Ti2.lN at high pressure of 5 GPa and different temperatures of 700-1 600 ℃ was investigated using X-ray diffraction （XRD）,scanning electron microscopy （SEM） equipped with an energy dispersive spectrometer （EDS）.Ti2.lN was found to be stable at temperatures as high as 1 400 ℃under 5 GPa for 2. min,and was proved that it held better structure stability than Ti2.lC under 5 GPa through comparative experiments of Ti2.lN and Ti2.lC （representative compounds of M2.X phases （2.1 phase））.The reaction process at high pressure had some difference from that at ambient pressure/vacuum,and Ti2.lN directly decomposed to TiN and TiAl at 5 GPa and 1 500 ℃ for 2. ***,the mechanism of phase segregation was *** addition,the behavior of Ti2.lN contacting with Zr at high pressure and high temperature （HPHT） was also studied.

关键词： Ti2.lN high pressure and high temperature stability X-rMechanism and Kinetic Model of

TEM STUDY OF C-B_4C-SiC COMPOSITES WITH SILICON ADDITIVE

在线全文

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 1995年第2期8卷 92-96页

作者： ZHAO Lihua WU Lijun HUANG Qizhong YANG Qiaoqin 1)(Material Research and Test center,Hunan university,Changsha,China)2.(Powder Metallurgy Research Institute,center-South university of Technology,Changsha,China)3)(Laboratory of atomic Imaging of Solids, Ins Hunan Univ Changsha China

C-B4C-SiC composites with silicon additive obtained by the hot press sintering method are studied by means of transmission electron microscopy(TEM).When the specimens are heated to 1800℃,their structure does not *** the specimens are heated to 2.00℃,carbon begins to graphitize. Moreover,two monoclinic phases are *** monoclinic phase named as the M phase belongs to C-center monoclinic lattice with a=0.90nm,b=0.59nm,c=0.54nm and β=119.3°.The other monoclinic phase named as the Ml phase also belongs to C-center monoclinic lattice but with a=0.85nm,b=0.49nm,c=0.53nm and β=12..6°.

关键词： C-B_4C-SiC composite electron microscopy