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Reconstruction of the most recent common ancestor sequences of SARS-Cov S gene and detection of adaptive evolution in the spike protein

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Chinese Science Bulletin 2004年第12期49卷 1311-1313页

作者： ZHANG Yuan1, ZHENG Nan2.3. HAO Pei4,5 & ZHONG Yang6 1. Laboratory of Systematic and Evolutionary Botany, Institute of Bot- any, Chinese Academy of Sciences, Beijing 100093. china 2. College of Life Sciences, Beijing Normal {3., Beijing 100875, china 3. Institute of Viral Disease Control and Prevention, Chinese CDC, Beijing 100052. china 4. Bioinformation Center, shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, shanghai 2.003., china 5. shanghai Center for Bioinformation Technology, shanghai 2.02.5, china 6. School of Life Sciences, fudan university, shanghai 2.043., china 1. Laboratory of Systematic and Evolutionary Botany Institute of Botany Chinese Academy of Sciences 100093 Beijing China 2. College of Life Sciences Beijing Normal University 100875 Beijing China 3. Institute of Viral Disease Control and Prevention Chinese CDC 100052 Beijing China 4. Bioinformation Center Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 200031 Shanghai China 5. shanghai Center for Bioinformation Technology 200235 Shanghai China 6. School of Life Sciences Fudan University 200433 Shanghai China

The genome oiganization and expression strategy of severe acute respiratory syndrome coronavirus (SARS-CoV) have been described extensively. As a structural glycoprotein on the virion surface, the spike protein is responsible for binding to host cellular receptors and for the fusion between the viral envelope and the cellular membrane. It also induces neutralizing antibodies in the host and mediates cellular immunity. Previous studies suggested that amino acid replacements in the spike protein coulddramatically alter the pathogenesis and virulence of some coronaviruses. It is therefore reasonable to test the hypothesis that radical amino acid replacements in the spike protein, favored by environmental selective pressure during the process of SARS-CoV interspecific transmission, might make this pathogen adapt to a new host, In this study, we investigated a total of 108 complete sequences of the SARS-CoV S gene from Gen-Bank (until March 2., 2.04). After omission of those records containing frame-shift mutations or low quality sequences, e.g. ZJ01, and selection of one sequence for identical records, an alignment of 42.sequences was obtained using the program Clustal-X. Then, we reconstructed the most recent common ancestor (MRCA) sequences of theSARS-CoV S gene and detected the adaptive evolution in the spike protein.

关键词： SARS冠状病毒自适应进化基因表达糖蛋白分子免疫学波峰病毒

THE CODIMENSION FORMULA ON AF-COSUBMODULES

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Chinese Annals of Mathematics,Series B 2002年第3期23卷 419-424页

作者： GUO KUNYU Department of Mathematics, fudan university, shanghai 2.043.,{2. Department of Mathematics Fudan University Shanghai 200433 China

Let M1, M2.be submodules of analytic Hilbert module X on ?(? Cn) such that M1 ? M2.and dimM1/M2.= k < '. If M2.is an AF-cosubmodule, then the codimension dimM1/M2.of M2.in M1 equals the cardinality of zeros of M2.rel... 详细信息

Let M1, M2.be submodules of analytic Hilbert module X on ?(? Cn) such that M1 ? M2.and dimM1/M2.= k 2.is an AF-cosubmodule, then the codimension dimM1/M2.of M2.in M1 equals the cardinality of zeros of M2.related to MI by counting multiplicities. The codimension formula has some interesting applications. In particular, the author calculates out the dimension of Rudin quotient module, which is raised in [14].

关键词： AF-cosubmodule Characteristic space Analytic Hilbert module

GLOBAL CLASSICAL SOLUTIONS WITH SMALL INITIAL TOTAL VARIATION FOR QUASILINEAR HYPERBOLIC SYSTEMS

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Chinese Annals of Mathematics,Series B 2002年第3期23卷 335-348页

作者： YAN PING Institute of Mathematics, fudan university, shanghai 2.043.,{2. Institute of Mathematics Fudan University Shanghai 200433 China

By means of the continuous Glimm functional, a proof is given on the global existence of classical solutions to Cauchy problem for general first order quasilinear hyperbolic systems with small initial total variation.

关键词： Weak linear degeneracy Continuous Glimm functional Total variation Global classical solution Quasilinear hyperbolic system

Study of Product Quality Information and Construction of Its Decision-Making Support System and Measures to Improve People's Quality Concept

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厦门大学学报（自然科学版） 2002年第S1期41卷 234-235页

作者： RUAN Jin-yuan 1, SUN Shu-tao 2. YU Xin-qi 2. RUAN Xin 3.(1. Ordance Institute of General Equipment Department, Shijiazhuang 05 0000, china 2. Graduate School of Chinese Academic of Science, Beijing 100042. china 3. East china university of Science and Technology, shanghai 2.02.2. china 4. Meterology Bureau of Hebei Province, Shijiazhuang 05002., china)

The 2.th century is a "quality century". Facing the s evere challenge about quality, all the developed industry countries attach impor tance to the research and education about quality project. With the deepening of the reform of china and it’s joining to WTO, many industries and enterprises wi ll be confronted with severe challenge while being offered the opportunity to wa lk up to the world. The arrival of knowledge economy and web time has provided t he space for the innovation on enterprise management. It has also provided new m ethod and model for enterprise management, that is online management based on th e internet. The online management use an enterprise model including the goal of the enterprise and the scheme to carry out it to represent the whole operational of all the work. The online management is constructed on the integration of exp ert system, database, software and other technical models. How to scientifically manage the entire system of product, precisely master the condition of quantity and quality and analyze the rules of the change of produc t quality in order to carry out the overall control of quality, guarantee the go od condition of product as well as improve product quality and prolong it’s se rvice life was discussed in this thesis. Based on the above research the thesis also discussed how to develop the study on product quality information and const ruct it’s decision making support system. The concrete measures to improve peopl e’s concept of quality are also raised. Based on the type analysis, scientific management of product quality information should start from dynamic information of quality, instruction information as we ll as the information about the use, maintain, management and conservation of pr oduct, and induce them and further propose a design scheme of feedback system on product quality information, and then set up the blueprint of the information s ystem of product quality. This thesis included 7 chapters:*** type of qua

关键词： product guality information decision-making sup port system of management of guality information people’s guality concept

ON A CONSTRUCTION OF INERTIALMANIFOLDS FOR A CLASS OF SECOND ORDER IN TIME EVOLUTION EQUATIONS

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Chinese Annals of Mathematics,Series B 1999年第3期20卷 271-278页

作者： WANG ZONGXIN(Institute of Mathematics, fudan university, shanghai 2.043.,{2..) fudan Univ Inst Math Shanghai 200433 Peoples R China

Inertial manifolds for a class of second order in time dissipative equations are *** author also proves an asymptotic completeness property for the inertial manifolds and characterizes the inertial manifolds as the set of trajectories whose growth is at most of order O(e-μt ) for some p > 0. As applications, a nonlinear wave equation and a problem of nonlinear oscillations of a shallow shell are considered.

关键词： Dynamical systems Inertial manifolds Nonlinear evolution equations

Study on rare earth/alkaline earth oxide-doped CeO_2.solid electrolyte

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Rare Metals 2007年第4期26卷 311-316页

作者： YAN Kai ZHEN Qiang Song Xiwen School of Materials Science and Engineering Shanghai University Shanghai 200072 China Research Center of Nanoscience and Nanotechnology Shanghai Univeesity Shanghai 200444 China School of Materials Science and Engineering Inner Mongolia University of Science and Technology B aotou 014010 China

Five types of rare earth/alkaline earth oxide-doped CeO2.superfine-powders were synthesized by a low-temperature combustion technique. The relevant solid electrolyte materials were also sintered by pressureless sintering at different temperatures. The results of X-ray diffraction and transmission electron microscopy showed that the grain size of the powders was approximately 2.-3. nm, and rare earth/alkaline earth oxides were completely dissolved into ceria-based solid solution with fluorite structure. The electrical conductivities of the SmzO3.CeO2.system were measured by the ac impedance technique in air at temperatures ranging from 513.900℃. The results indicated that the ionic conductivities of Srno.2.Ce0.8Ol.875 solid electrolyte increase with increasing sintering temperature, and the relationship between the conductivities and measuring temperature obeys the An＇henius equation. Then the SmzO3.CeO2.material was further doped with other rare earth/alkaline earth oxide, and the conductivities improve with the effective index.

关键词： doped ceria rare earth/alkaline earth oxide solid electrolyte conductivity effective index

A NONLOCAL NONLINEAR BOUNDARYVALUE PROBLEM FOR THE HEAT EQUATIONS

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Chinese Annals of Mathematics,Series B 1996年第3期17卷 365-374页

作者： YAN JINHAI(Department of Mathematics, fudan university, shanghai 2.043.,{2.) fudan UNIV DEPT MATHSHANGHAI 200433PEOPLES R CHINA

The existence and limit behaviour of the solution for a kind of nonlocal nonlinear boundaryvalue condition on a part of the boundary is studied for the heat equation, which physicallymeans that the potential is the function of the total flux. When this part of boundary shrinksto a point in a certain wayt this condition either results in a Dirac measure or simply disappearsin the corresponding problem.

关键词： Heat equation Nonlinear boundary problem Potential Limit behavior

Convex quadratic programming relaxations for parallel machine scheduling with controllable processing times subject to release times

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Progress in Natural Science:Materials International 2004年第9期 14-20页

作者： ZHANG Feng 1,2.*, CHEN Feng 3.and TANG Guochun 1,2.(1. Department of Mathematics, shanghai Second Polytechnic {3., shanghai 2.12.9, china 2. Department of Mathematics, Tongji {3., shanghai 2.0092. china 3. Department of Mathematics, shanghai {3., shanghai 2.043., china) Department of Mathematics，shanghai Second Polytechnic university，shanghai {3.1{3.9，china Department of Mathematics Tongji University，Shanghai 200092，China Department of Mathematics，shanghai university，shanghai {3.，china

Scheduling unrelated parallel machines with controllable processing times subject to release times is investigated. Based on the convex quadratic programming relaxation and the randomized rounding strategy, a 2.approximation algorithm is obtained for a special case with the all or none property and then a 3.approximation algorithm is presented for general problem.

关键词： scheduling with controllable processing time release time quadratic programming approximation algorithm.

Mesozoic subduction-accretion zone in northeastern South china Sea inferred from geophysical interpretations

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Science china Earth Sciences 2006年第5期49卷 471-482页

作者： ZHOU Di1, WANG Wanyin2. WANG Jialin3. PANG Xiong4, CAI Dongsheng5 & SUN Zhen1 1. Key Laboratory of Marginal Sea Geology, South china Sea Institute of Oceanology, Chinese Academy of Sciences, Guang- zhou 5103.1, china 2. College of Geological and Topographical Engineering, Chang’an {2., Xi’an 710054, china 3. Key Laboratory of Marine Geology, Tongji {2., shanghai 2.0092. china 4. china National Offshore Oil Co. Limited – Shenzhen Branch, Shenzhen 518067, china 5. china National Offshore Oil Co. Limited – Research Center, Beijing 10002., china 1. Key Laboratory of Marginal Sea Geology South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou 510301 China 2. College of Geological and Topographical Engineering Chang’an University Xi’an 710054 China 3. Key Laboratory of Marine Geology Tongji University Shanghai 200092 China 4. china National Offshore Oil Co. Limited — Shenzhen Branch Shenzhen 518067 China 5. china National Offshore Oil Co. Limited — Research Center Beijing 100027 China

A segment of Mesozoic subduction-accretion zone was inferred across thenortheastern South china Sea at approximately NE450 orientation. Basic evidence includes thefollowing: A belt of peek gross horizontal Bouguer gravity gradient (PGHGBA) is comparable in sizeand intensity to that of the Manila subduction-accretion zone. A belt of high positive magneticanomalies appears to the north and sub-parallel to the PGHGBA, representing the volcanic arcassociated to the subduction zone. The PGHGBA crosses obliquely both Cenozoic structures and presentseafloor topography, indicating a pre-Cenozoic age. The segment is offset left-laterally byNW-running strike-slip faults, in concord with the Mesozoic stress field of South china. Inaddition, the existence of the subduction zone is supported by wide-angle seismic data obtained indifferent years by different institutions. At approximate localities, a north-dipping ramp of Mohosurface is indicated by records of ocean-bottom seismometers, and a strong reflector about 8 kmbeneath the Moho reflector is indicated by both OBS and long-cable seismic records. Theidentification of a segment of Mesozoic subduction zone in NE South china Sea fills nicely the gapof the Great Late Mesozoic Circum SE Asia Subduction-acrretion Zone, which extended from Sumatra,Java, SE Kalimantan to N Palawan, and from Taiwan, Ryukyu to SW Japan.

关键词： Mesozoic, subduction zone, SE Asia, NE South china Sea, geophysics.