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Parameter estimation for whole-body kinetic model of FDG metabolism

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Progress in Natural Science:Materials International 2006年第11期16卷 1164-1170页

作者： CUI Yunfeng~1, BAI Jing~1**, CHEN Yingmao~2.and TIAN Jiahe~2.1. Department of biomedical engineering, Tsinghua {2., beijing 100084, china 2. Department of Nuclear Medicine, General Hospital of PLA, beijing 100853, china) [a]Department of biomedical engineering Tsinghua University Beijing China [b]Department of Nuclear Medicine General Hospital of PLA Beijing China

Based on the radioactive tracer [ ~ 18 F]2.fluoro-2.deoxy-D-glucose （FDG）, positron emission tomography （PET）, and compartment model, the tracer kinetic study has become an important method to investigate the glucose metabolic kinetics in human body. In this work, the kinetic parameters of three-compartment and four-parameter model for the FDG metabolism in the tissues of myocardium, lung, liver, stomach, spleen, pancreas, and marrow were estimated through some dynamic FDG-PET experiments. Together with published brain and skeletal muscle parameters, a relatively complete whole-body model was presented. In the liver model, the dual blood supply from the hepatic artery and the portal vein to the liver was considered for parameter estimation, and the more accurate results were obtained using the dual-input rather than the single arterial-input. The established whole-body model provides the functional information of FDG metabolism in human body. It can be used to further investigate the glucose metabolism, and also be used for the simulation and visualization of FDG metabolic process in human body.

关键词： compartment model FDG PET parameter estimation.

Electric-stimulus rate encoding algorithm of Mandarin tonal information in cochlear implant

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Progress in Natural Science:Materials International 2006年第12期16卷 1315-1321页

作者： GUAN Tian~1, GONG Qin~1 and YE Datian~2.*(1. Department of biomedical engineering, Tsinghua {2., beijing 100084, china 2. Research Center of biomedical engineering, Graduate School at Shenzhen, Tsinghua {2., Shenzhen 518055, china) [a]Department of biomedical engineering Tsinghua University Beijing China [b]Research Center of biomedical engineering Graduate School at Shenzhen Tsinghua University Shenzhen China

The modern multi-channel cochlear implants usually extract and encode the temporal envelope cues. This kind of algorithms can hardly satisfy the users who speak tonal languages, such as Mandarin. Many studies have tried to enhance the recognition ability of Mandarin through encoding tonal information and made suggestions to frequency-modulate the fixed pulse-rate carrier with the extracted tonal information based on the rate-pitch theory in electric hearing. However, how to encode and deliver the tonal information such as F_0by changing electric-stimulus rate has not got further study in clinical electric-stimulus mode. The present paper focuses on this matter by piecewise calculating the appreciable electric-stimulus rates. Then an electric-stimulus encoding algorithm of Mandarin tone is brought forward and testified through acoustic simulations. Such conclusion can be drawn that this algorithm of electric-stimulus rate could convey tonal information well and help to enhance the Mandarin speech recognition ability.

关键词： cochlear implant tone fundamental frequency electric-stimulus rate.

Explanation of the mechanism of carcinogenesis and syntheses of anticancer agents with high selectivity

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Science china Chemistry 2006年第1期49卷 44-62页

作者： DAI Qianhuan1,2.1. Center of Chemistry and Bioengineering of Cancer Research, beijing polytechnic university (Now known as {2. Univer-sity of Technology), beijing 10002., china 2. Center of Environmental Sciences, Peking university, {2. 100871, china 1. Center of Chemistry and Bioengineering of Cancer Research Beijing Polytechnic University Beijing 100022 China 2. Center of Environmental Sciences Peking University Beijing 100871 China

In 1979, the mechanism of chemical carcinogenesis, a challenging anddifficult scientific problem pending for a number of years, was explained by Dai Qianhuan. Themechanism named di-region theory predicted that a carcinogen always metabolizes to form a specialbi-functional alky-lating agent. This agent induces cross-linkages between the complementary basepairs in DMA and switches on initial mutageneses in genomes including point and frameshiftmutations. This, in turn, induces further deep mutageneses including the production of variouschimeric chromosomes, deletions and other aberrations found in genomes. In the end this initiatescarcinogenesis of the whole cell through the reverse transcription mechanism after a lengthyincubation period. Recently, this laboratory has verified that physical carcinogenesis, includingthe oncogenesis induced by radiation and asbestos as well as the carcinogenesis induced byendogenous factors such as estrogen or diethyl-stilbestrol switch on carcinogenesis by inducing theformation of cross-linkages between the complementary base pairs in DNA. Di-region theory has nowbeen supported by many experimental observations such as mutational spectra of various *** potential for carcinogenesis, teratogenesis, sterility and mutagenesis lumped together asgenetic toxicity appears to originate almost uniformly from the cross-linking between complementarybases, i.e. malignant cross-linking, which is in accordance with di-region theory. Other forms ofcross-linking between non-complementary bases, benign cross-linkings, show bi-functional alkylationanticancer activity but lack genetic toxicity. The predictable design and synthesis of a highselectivity anticancer agent with high efficacy and low genetic toxicity, a goal long pursued incancer chemotherapy, have been realized for the first time in this laboratory by inhibitingmalignant and heightening benign cross-linking using the principles of di-region theory. A series ofpatented new anticanc

关键词： mechanism of carcinogenesis, di-region theory, minoplatin, selectivity of anticancer agent, cross-linking between DNA bases, anticancer platinum complexes, predictive design of anticancer agent, second generation anticancer agent.

Suitability evaluation for land reclamation in mining area:A case study of Gaoqiao bauxite mine

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中国有色金属学会会刊：英文版 2011年第S3期21卷 506-515页

作者： WANG Shi-dong1, 2. LIU Chang-hua2. ZHANG He-bing2.1. College of Resources Science and Technology, beijing Normal university, beijing 100875, china 2. School of Surveying and Land Information engineering, Henan polytechnic university, Jiaozuo 454000, china [a] College of Resources Science and Technology Beijing Normal University Beijing 100875 China [b] School of Surveying and Land Information engineering Henan Polytechnic University Jiaozuo 454000 China

Suitability evaluation plays an important role in land reclamation because the choice of evaluation methods affects the accuracy and objectivity of the suitability evaluation results. Furthermore, it influences the decision-making related to land reclamation. An improved method, which is called limit comprehensive conditions method, was developed after different suitability evaluation methods were studied. Based on this method, the reclaimed land of the Gaoqiao bauxite mining area was evaluated. The Gaoqiao mining area was divided into seven evaluation units that were evaluated respectively by selecting evaluation factors and establishing grade standards. The results show that the proposed method is more applicable and easier to handle. Moreover, its evaluation results are more scientific compared with the traditional evaluation methods. The improved method can be beneficial to the rapid monitoring and the effective management of reclaimed land in the opencast mine area.

关键词： mining area land reclamation suitability evaluation Gaoqiao bauxite mine

Digital close-range photogrammetric application to small-scale physical simulation experiment

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中国有色金属学会会刊：英文版 2011年第S3期21卷 681-685页

作者： LI Chun-yi1, CUI Xi-min2. YU Yi-ju3 1. School of Surveying and Landing Information engineering, Henan polytechnic {2., Jiaozuo 454003, china 2. College of Geoscience and Surveying engineering, china {2. of Mining and Technology, beijing 100083, china 3. Surveying and Mapping Press, beijing 100045, china [a] School of Surveying and Landing Information engineering Henan Polytechnic University Jiaozuo 454003 China [b] College of Geoscience and Surveying engineering China University of Mining and Technology Beijing 100083 China [c] Surveying and Mapping Press Beijing 100045 China

In order to research the possibility of digital close-range photogrammetric surveying in small scale physical simulation experiment, physical model coinciding with engineering practice was constructed based on similar theory. The datum processing method and surveying precision of digital close-range photogrammetric were analyzed. And the function relationship between overburden subsidence factor qr and the ratio z/H of stratum horizon z and mining depth H was researched. The results show that surveying points position mean error along horizontal direction is ±0.131 mm and vertical direction is ±0.192.mm. Therefore, multi-taking station cross direction digital close-range photogrammetric can completely satisfy the precision need of physical simulation experiment. And the empirical formula can be utilized to represent evolution law of stratum subsidence factor.

关键词： close-range photogrammetric physical simulation light-rays adjustment surveying precision subsidence factor

Relationship between surface subsidence factor and mining depth of strip pillar mining

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中国有色金属学会会刊：英文版 2011年第S3期21卷 594-598页

作者： GUO Wen-bing1, 2. HOU Quan-lin 1, ZOU You-feng2.1. College of Earth Science, Graduate university of Chinese Academy of Sciences, beijing 100049,{2. 2. School of Energy Science and engineering, Henan polytechnic university, Jiaozuo 454000,{2. Chinese Acad Sci Coll Earth Sci Grad Univ Beijing 100049 Peoples R China Henan Polytech Univ Sch Energy Sci & Engn Jiaozuo 454000 Peoples R China

Strip pillar mining is one of the most important technical measures to control mining subsidence in china. Mining depth is one of the most important factors that can affect the mining subsidence in strip pillar mining. Six numerical simulation models were set up to simulate the surface subsidence of strip pillar mining in different mining depths. The mining depth in these six models ranges from 300 to 800 m. The simulated results were compared and analyzed. The formula was established based on the simulated results. It demonstrated that the subsidence of strip pillar mining method is related to mining depth. While the other conditions are the same, the subsidence of strip pillar mining increases with the increase of mining depth by logarithmic relationship.

关键词： subsidence factor strip pillar mining mining depth numerical simulation

Quick image-processing method of UAV without control points data in earthquake disaster area

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中国有色金属学会会刊：英文版 2011年第S3期21卷 523-528页

作者： LI Chang-chun1, ZHANG Guang-sheng1, LEI Tian-jie2. 3, GONG A-du2. 3 1. School of Surveying & Land Information engineering, Henan polytechnic {2., Jiaozuo 454000, china 2. Key Laboratory of Environmental Change and Natural Disaster, Ministry of Education, beijing Normal {2., beijing 100875, china 3. Ministry of Civil Affairs/Ministry of Education of china Academy of Disaster Reduction and Emergency Management, beijing Normal {2., beijing 100875, china [a] School of Surveying & Land Information engineering Henan Polytechnic University Jiaozuo 454000 China [b] Key Laboratory of Environmental Change and Natural Disaster Ministry of Education Beijing Normal University Beijing 100875 China [c] Ministry of Civil Affairs/Ministry of Education of china Academy of Disaster Reduction and Emergency Management Beijing Normal University Beijing 100875 China

The methods of unmanned aerial vehicles images splicing rapidly and rectifying without control points data, only using auxiliary data recorded by unmanned aerial vehicle (UAV) system, were researched. Two algorithms were proposed, including UAV images auto- splicing rapidly after image blocking and UAV images rectifying based on pseudo center points of auxiliary data. When SIFT algorithm for UAV images splicing is applied, the accuracy is very high, but the efficiency is very low. The splicing efficiency is improved greatly based on SIFT algorithm after image blocking. The results show that rectifying accuracy is very high and has no visual dislocation when pseudo center points of auxiliary data is applied.

关键词： unmanned aerial vehicles SIFT algorithm blocking quickly splicing rectification

Time-variation of the near 5-month period of sunspot numbers

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Chinese Science Bulletin 2002年第23期47卷 1969-1973页

作者： HAN Yanben1 & HAN Yonggang1,2.. National Astronomical Observatories, Chinese Academy of Sciences, beijing 100012. china 2. Department of Applied Mathematics,{2., beijing 10002., china National Astronomical Observatories Chinese Academy of Sciences Beijing China Department of Applied Mathematics Beijing Polytechnic University Beijing China

The variation of the near 5-month period of sunspot numbers is discussed on the basis of the wavelet transform of the daily sunspot number series in the 14th-2.nd solar cycles. The result shows that the period exists in every cycle and its energy density (amplitude) is comparatively large in the peak section of the cycle. In the distinct cycle, the length and intensity of the period is different, which means that the period varies with time. The near 2.-day period is also analyzed and it is found to be time-variable and even not very stable in the peak section of the cycle. The variations of the two periods show that the near 5-month period should not be simply regarded as the multiples of the near 2.-day period.

关键词： solar activity sunspot time-variation wavelet.

Improvement of the classification accuracy in discriminating diabetic retinopathy by multifocal electroretinogram analysis

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Progress in Natural Science:Materials International 2007年第8期17卷 913-918页

作者： Xu Jin~1 Hu Guangshu~(1**) Huang Houbin~2.(1.Department of biomedical engineering,Tsinghua {2.,beijing 100084,china 2.Department of Ophthalmology,General Hospital of Chinese PLA,beijing 100853,china) [a]Department of biomedical engineering Tsinghua University Beijing China [b]Department of Ophthalmology General Hospital of Chinese PLA Beijing China

The multifocal electroretinogram (mfERG) is a newly developed electrophysiological *** this paper,a classifi- cation method is proposed for early diagnosis of the diabetic retinopathy using mfERG *** records were obtained from eyes of healthy individuals and patients with diabetes at different *** each mfERG record,103 local responses were *** value of each point on all the mfERG local responses was looked as one potential feature to classify the experimental *** sub- sets were selected from the feature space by comparing the inter-intra *** on the selected feature subset,Fisher's linear classi- fiers were *** the final classification decision of the record was made by voting all the classifiers' *** the method to classify all experimental subjects,very low error rates were *** crucial properties of the diabetic retinopathy classification method are also discussed.

关键词： diabetic retinopathy multifocal electroretinogram feature selection linear classifier