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Prediction of Tumor Outcome Based on Gene Expression Data

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wuhan University Journal of Natural Sciences 2004年第2期9卷 177-182页

作者： Liu Juan 1,2. Hitoshi Iba 3 1. School of Computer, wuhan University, wuhan 430072. hubei,{2. 2. State key Laboratory of software engineering, wuhan 430072. hubei,{2. 3. Department of Frontier Informatics, University of Tokyo, Tokyo 113-8656, Japan wuhan University School of Computer Wuhan Hubei China (GRID:grid.49470.3e) (ISNI:***) State key Laboratory of software {2. Wuhan Hubei China (GRID:grid.49470.3e) University of Tokyo Department of Frontier Informatics Tokyo Japan (GRID:grid.26999.3d) (ISNI:***)

Gene expression microarray data can be used to classify tumor types. We proposed a new procedure to classify human tumor samples based on microarray gene expressions by using a hybrid supervised learning method called MOEA+WV (Multi-Objective Evolutionary Algorithm+Weighted Voting). MOEA is used to search for a relatively few subsets of informative genes from the high-dimensional gene space, and WV is used as a classification tool. This new method has been applied to predicate the subtypes of lymphoma and outcomes of medulloblastoma. The results are relatively accurate and meaningful compared to those from other methods. key words bioinformatics - tumor classification - Pareto optimization - MOEA CLC number Q 786 - TP 181 Foundation item: Supported by the National Natural Science Foundation of china (60301009), the Foundation of Young Scholars of Ministry of Education of china (150118) and Chenguang Project of wuhan City ({4.11{4.009).Biography: Liu Juan (1970-), female, Associate Professor, Postdoctoral, research direction: bioinformatics, data mining, machine learning.

关键词： bioinformatics tumor classification Pareto optimization MOEA

A Hybrid Genetic Algorithm for Reduct of Attributes in Decision System Based on Rough Set Theory

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wuhan University Journal of Natural Sciences 2002年第3期7卷 285-289页

作者： Dai Jian\|hua 1,2., Li Yuan\|xiang 1,2.,Liu Qun 3 1. State key Laboratory of software {2., wuhan University, wuhan 430072. hubei,china 2. School of Computer, wuhan University, wuhan 430072. hubei, china 3. School of Computer Science, wuhan University State Key Laboratory of Software Engineering Wuhan Hubei China (GRID:grid.49470.3e) (ISNI:***) wuhan University School of Computer Wuhan Hubei China (GRID:grid.49470.3e) (ISNI:***) Chongqing University of Posts & Telecommunications School of Computer Science Chongqing China (GRID:grid.411587.e) (ISNI:***)

Knowledge reduction is an important issue when dealing with huge amounts of data. And it has been proved that computing the minimal reduct of decision system is NP-complete. By introducing heuristic information into genetic algorithm, we proposed a heuristic genetic algorithm. In the genetic algorithm, we constructed a new operator to maintaining the classification ability. The experiment shows that our algorithm is efficient and effective for minimal reduct, even for the special example that the simple heuristic algorithm can’t get the right result.

关键词： rough set reduction genetic algorithm heuristic algorithm

An efficient method for detecting concurrency errors in object-oriented programs

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Science china(Information Sciences) 2012年第12期55卷 2774-2784页

作者： HE YanXiang 1,2.WU Wei 2.& CHEN Yong 2.1 School of Computers,wuhan University,wuhan {2.china 2.State key Laboratory of software engineering,wuhan University,wuhan {2.china 1. School of Computers Wuhan University Wuhan 430072 China2. State Key Laboratory of Software Engineering Wuhan University Wuhan 430072 China

Multicore and multi-threaded processors have become the norm for modern ***,concurrent programs have become more and more prevalent despite being difficult to write and *** errors are highly likely to appear in concurrent code,conventional error detection methods such as model checking,theorem proving,and code analysis do not scale smoothly to concurrent *** is an indispensable technique for detecting concurrency errors,but it involves a great deal of manual work and is *** paper presents an automatic method for detecting concurrency errors in classes in object-oriented *** method uses a heuristic algorithm to automatically generate test cases that can effectively trigger ***,each test case is executed automatically and a fast method is adopted to identify the actual concurrency error from anomalous run *** have implemented a prototype of the method and applied it to some typical Java *** shows that our method is more effective and faster than previous work.

关键词： concurrency error dynamic test data race atomicity violations test case generation

A Feedback-Based Web Search Engine

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wuhan University Journal of Natural Sciences 2004年第5期9卷 561-568页

作者： ZHANG Wei-feng 1,2.3 , XU Bao-wen 2.3,4., ZHOU Xiao-yu 2.3,4.1. Department of Computer Science and engineering, Nanjing University of Posts and Telecommunications, Nanjing 2.0003, Jiangsu, china 2. Department of Computer Science and engineering, Southeast University, Nanjing 2.0096, Jiangsu, china 3. Jiangsu Institute of software Quality, Nanjing 2.0096 Jiangsu, china 4. The State key Laboratory of software engineering, wuhan University, wuhan 430072. hubei, china Department of Computer Science and engineering Nanjing University of Posts and Telecommunications . Nanjing 210003 Jiangsu China

Web search engines are very useful information service tools in the Internet. The current web search engines produce search results relating to the search terms and the actual information collected by them. Since the selections of the search results cannot affect the future ones, they may not cover most people’s interests. In this paper, feedback information produced by the user’s accessing lists will be represented by the rough set and can reconstruct the query string and influence the search results. And thus the search engines can provide self-adaptability. key words WWW - search engine - query reconstruction - feedback CLC number TP 311. 135.4.Foundation item: Supported by the National Natural Science Fundation of china (60373066). National Grand Fundamental Research 973 Program of china (2.02.B312.0). Opening Foundation of State key Laboratory of software engineering in wuhan University, Opening Foundation of Jiangsu key Laboratory of Computer Information Processing Technology in Soochow UniversityBiography: ZHANG Wei-feng (1975-), male, Ph.D. research direction: artificial intelligence, search engine, data mining, network language.

关键词： WWW search engine query reconstruction feedback

A hybrid matching method for geospatial services in a composition-oriented environment

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Science china(Technological Sciences) 2010年第S1期53卷 213-220页

作者： LUO An 1,2.WANG YanDong 1,2.& CHEN ShengHua 2.1 State key Laboratory of {4. {2.,wuhan University,wuhan 430072.china 2.State key Laboratory of Information {2. in Surveying,Mapping and Remote Sensing,wuhan University,wuhan 4.0079,china 1. State key Laboratory of software {2. Wuhan University Wuhan 430072 China 2. State key Laboratory of Information engineering in Surveying Mapping and Remote Sensing Wuhan University Wuhan 430079 China

With the development of Internet and GIS,large volumes of spatial data,powerful computing resources and many spatial data processing functions are published in the form of Web *** suitable geospatial services in the composition-oriented environment is a crucial *** semantic Web provides a kind of technology to find and compose various service resources automatically through the *** paper proposes a hybrid method for the semantic matching of geospatial *** method includes two *** 1 puts forward a multi-level semantic matching approach,which matches single geospatial service at four levels:classification,input/output,precondition/effect and the quality of service(QoS).This multi-level matching approach makes single service matching quicker and more *** 2.puts forward a matching algorithm for a geospatial service chain based on the *** algorithm adopts a trace algorithm,taking account of the effect of the *** restricts the input/output parameters of the current service by the input/output parameters of service chain,pre-service and *** matches the atomic service dynamically in a composition-oriented environment,and accurately converts the abstract model of geospatial services into an executable geospatial service chain.A case study of the flood analysis for the Poyang Lake illustrates the effectiveness of our context-based matching method for geospatial services.

关键词： geospatial services semantic context composition service match

Genetic Algorithm for Chinese Postman Problems

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wuhan University Journal of Natural Sciences 2003年第S1期8卷 316-318页

作者： Jiang Hua, Kang Li-shanState key Laboratory of software {2., wuhan University,wuhan 430072.hubei, china wuhan University State Key Laboratory of Software Engineering Wuhan Hubei China (GRID:grid.49470.3e) (ISNI:***)

Chinese Postman Problem is an unsettled graphic problem. It was approached seldom by evolutionary computation. Now we use genetic algorithm to solve Chinese Postman Problem in undirected graph and get good results. It could be extended to solve Chinese postman problem in directed graph. We make these efforts for exploring in optimizing the mixed Chinese postman problem.

关键词： Chinese postman problem Eularian graph genetic algorithm evolutionary computation

Extended multivariate public key cryptosystems with secure encryption function

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Science china(Information Sciences) 2011年第6期54卷 1161-1171页

作者： WANG HouZhen 1,2., ZHANG HuanGuo 1,2., WANG ZhangYi 1,2.& TANG Ming 1,2.1 The {4. Laboratory of Aerospace Information Security and Trusted Computing, Ministry of Education, School of Computer, wuhan University, wuhan 4.0079, china 2.State {4. Laboratory of software engineering, wuhan University, wuhan {14. china 1. The key Laboratory of Aerospace Information Security and Trusted Computing Ministry of Education School of Computer Wuhan University Wuhan 430079 China2. State Key Laboratory of Software Engineering Wuhan University Wuhan 430072 China

Advances in quantum computers pose great threats on the currently used public key cryptographic algorithms such as RSA and ECC. As a promising candidate secure against attackers equipped with quantum computational power, multivariate public key cryptosystems (MPKCs) have attracted increasing attention in recently years. Unfortunately, the existing MPKCs can only be used as a multivariate signature scheme, and it remains unknown how to construct an efficient MPKC enabling secure encryption. Furthermore, some multivariate signature schemes have been shown insecure in recent years, and it is also not trivial to build MPKC which can serve as a secure signature scheme. By employing the basic MQ-trapdoors, this paper proposes a novel MPKC and shows how it can be used as a multivariate signature scheme and a multivariate encryption scheme, respectively. The goal is achieved by incorporating our new hash authentication techniques and some modification methods such as the Shamir's minus method. Thorough analysis shows that our schemes are secure and efficient. Our MPKC gives a positive response to the challenges in multivariate public key cryptography.

关键词： cryptography post-quantum cryptography MQ problem hash function

Building Distributed Web GIS: A Mobile Agent Based Approach

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wuhan University Journal of Natural Sciences 2001年第Z1期6卷 474-481页

作者： jhguan@*** Guan Ji hong 1 , Zhou Shui geng 2., Bian Fu ling 3, Meng Ling kui 3 1. School of Computer, wuhan University, wuhan {2.{4. 2. State key Laboratory of software engineering, wuhan University, wuhan {2. Chin School of Computer Wuhan University Wuhan 430072 China

The diversity of GISs and the wide spread availability of WWW have led to an increasing amount of research on integrating a variety of heterogeneous and autonomous GISs in a cooperative environment to construct a new generation of GIS characterizing in open architecture, distributed computation, interoperability, and extensibility. Our on going research project MADGIS (Mobile Agent based Distributed Geographic Information System) is reported, in which we propose the architecture of MADGIS to meet the requirements of integrating distributed GIS applications under Internet environment. We first describe the architecture of MADGIS, and detailed discussions focusing on the structure of client site, server site and mobile agent in MADGIS. Then we explore key techniques for MADGIS implementation.

关键词： distributed GIS mobile agent architecture mobility interoperability

A Design Method of Business Application Framework Based on software Patterns

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wuhan University Journal of Natural Sciences 2001年第Z1期6卷 204-208页

作者： He Ke\|qing 1, Yang Chun wen 1, Ying Shi 2.1. School of Computer Science, wuhan University, wuhan {2.{4. 2. State key Laboratory of software engineering, wuhan University, wuhan {2.{4. School of Computer Science Wuhan University Wuhan 430072 China

This paper discusses design and implementation method of Business Application Framework based on software patterns, and then presents MVC pattern of architecture and the method of dynamical update promulgation for Business Application Framework. We discuss adaptation of Abstract Factory for the kernel functionality of Business Application Framework, such as data creation, manipulation, composition, etc. It also presents class model and its class structure of Abstract Factory pattern. Finally, we briefly discuss the update, modification, and reconstruction method of Business Application Framework.

关键词： object oriented MVC pattern Abstract Factory pattern software framework UML role model