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Science Bulletin 2023年第16期68卷 1800-1808,M0004页

作者：高峰戴林斌王琼刘畅邓克学程昭昭吕心怡吴燕张子伊陶青青袁晶李世平王越苏娅程忻倪俊吴志英张舒婷施炯申勇 china Aging and Neurodegenerative Initiative(CANDI)Consortium Department of Neurology Institute on Aging and Brain DisordersThe First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Neurodegenerative Disorder Research center Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China Department of Radiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Neurology West China HospitalSichuan UniversityChengdu 610041China Department of Neurology and Research center of Neurology Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310058China Department of Neurology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100006China Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Department of Neurology National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghai 200040China Anhui Province key laboratory of Biomedical Aging Research University of Science and Technology of ChinaHefei 230001China 不详

阿尔茨海默病(AD)的生物标志物在血液中含量可能因种族、老年性疾病与各种环境风险因素等不同而存在差异,尚缺乏系统性的研究来评估AD生物标志物在中国老年及AD患者人群中的变化以及是否具有准确预测脑内淀粉样蛋白沉积的能力.本工作为... 详细信息

阿尔茨海默病(AD)的生物标志物在血液中含量可能因种族、老年性疾病与各种环境风险因素等不同而存在差异,尚缺乏系统性的研究来评估AD生物标志物在中国老年及AD患者人群中的变化以及是否具有准确预测脑内淀粉样蛋白沉积的能力.本工作为一项多中心纵向队列研究,共纳入来自全国各地6个不同临床中心的817个血液样本.研究测量了多个国际上通用的AD生物标志物,包括β-淀粉样蛋白40与42、磷酸化Tau(pTau)蛋白、总Tau蛋白、神经纤维丝轻链(NFL)和胶质纤维酸性蛋白(GFAP),并使用淀粉样斑块PET示踪剂和核磁结构影像对受试者进行综合评估.研究发现,APOE基因型与血浆pTau或血清GFAP组合的预测模型对脑内淀粉样斑块的沉积状态具有较好的区分能力.此外,研究还发现GFAP基线水平越高的患者其神经退行性变的速度越快.本研究结果基于多中心数据,论证了AD血液生物标志物在中国汉族人群中的实用性和应用前景,提示了血液pTau和GFAP是检测AD早期症状的有效指标,为我国AD的早期诊断和治疗提供了参考.

关键词：临床中心 Tau蛋白神经退行性变生物标志物老年性疾病基线水平血液样本示踪剂

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Current management of chemotherapy-induced neutropenia in adults:key points and new challenges

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Cancer Biology & Medicine 2020年第4期17卷 896-909页

作者： Committee of Neoplastic Supportive-Care(CONS),china Anti-Cancer Association Committee of Clinical Chemotherapy,china Anti-Cancer Association Yi Ba Yuankai Shi Wenqi Jiang Jifeng Feng Ying Cheng Li Xiao Qingyuan Zhang Wensheng Qiu Binghe Xu Ruihua Xu Bo Shen Zhiguo Luo Xiaodong Xie Jianhua Chang Mengzhao Wang Yufu Li Yuerong Shuang Zuoxing Niu Bo Liu Jun Zhang Li Zhang Herui Yao Conghua Xie Huiqiang Huang Wangjun Liao Gongyan Chen Xiaotian Zhang Hanxiang An Yanhong Deng Ping Gong Jianping Xiong Qinghua Yao Xin An Cheng Chen Yanxia Shi Jialei Wang Xiaohua Wang Zhiqiang Wang Puyuan Xing Sheng Yang Chenfei Zhou 不详 Department of Gastrointestinal Medical Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China Department of Medical Oncology National Cancer CenterCancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060China Department of Medical Oncology Jiangsu Cancer HospitalNanjing 210009China Department of Oncology Jilin Province Cancer HospitalChangchun 130012China Department of Oncology Zhongshan Hospital Affiliated to Xiamen UniversityXiamen 361004China Department of Oncology Cancer Hospital Harbin Medical UniversityHarbin 150081China Department of Oncology Affiliated Hospital of Qingdao UniversityQingdao 266003China Department of Medical Oncology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology General Hospital of Shenyang Military RegionShenyang 110016China Department of Pulmonary and Critical Care Medicine Peking Union Medical College HospitalBeijing 100730China Department of Hematology Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhou 450008China Lymphoma and Myeloma Department Jiangxi Cancer HospitalNanchang 330029China Department of Medical Oncology Shandong Cancer HospitalShandong Academy of Medical SciencesJinan 250117China Department of Oncology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China MSun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou 510120China Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityWuhan 430070China Department of Oncology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Department of Gastrointestinal Oncology Peki ng University Cancer Hospital&InstituteBeijing 100142China Department of

Chemotherapy-induced neutropenia(CIN)is a potentially fatal and common complication in myelosuppressive *** timing and grade of CIN may play prognostic and predictive roles in cancer *** is associated with older age,poor functional and nutritional status,the presence of significant comorbidities,the type of cancer,previous chemotherapy cycles,the stage of the disease,specific chemotherapy regimens,and combined *** are many key points and new challenges in the management of CIN in adults including:(1)Genetic risk factors to evaluate the patient’s risk for CIN remain ***,these risk factors urgently need to be identified.(2)Febrile neutropenia(FN)remains one of the most common reasons for oncological *** consensus nomogram for FN risk assessment has been established.(3)Different assessment tools[e.g.,Multinational Association for Supportive Care in Cancer(MASCC),the Clinical Index of Stable Febrile Neutropenia(CISNE)score model,and other tools]have been suggested to help stratify the risk of complications in patients with ***,current tools have *** CISNE score model is useful to support decision-making,especially for patients with stable FN.(4)There are still some challenges,including the benefits of granulocyte colony stimulating factor treatment and the optimal antibiotic regimen in emergency management of *** view of the current reports,our group discusses the key points,new challenges,and management of CIN.

关键词： Chemotherapy-induced neutropenia(CIN) febrile neutropenia cancer risk stratification granulocyte-colony stimulating factor(G-CSF)

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Executive summary of chinese expert consensus for topical application of anti-microbial agents for lower respiratory tract infection in adults

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chinese Medical Journal 2022年第22期135卷 2653-2655页

作者： Jing Zhang Qijian Cheng Yi Huang Hong Fan Guoxiang Lai Xiangdong Mu Wei Sha Danyang She Ning Shen Xin Su Jinfu Xu Feng Ye Xinlun Tian Tiantuo Zhang Hua Zhou Youning Liu Lixian He Heping Xiao Bei He Yi Shi Xiangyan Zhang Bin Cao Jieming Qu on behalf of Pulmonary Infection Assembly of chinese Thoracic Society Department of Pulmonary and Critical Care Medicine Zhongshan HospitalShanghai Medical CollegeFudan UniversityShanghai 200032China Department of Pulmonary and Critical Care Medicine Ruijin HospitalInstitute of Respiratory DiseasesShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Pulmonary and Critical Care Medicine Shanghai Changhai hospitalNavy Medical UniversityShanghai 200433China Department of Pulmonary and Critical Care Medicine West China HospitalSichuan UniversityChengduSichuan 610041China Department of Respiratory and Critical Care Medicine The Second Affiliated People's Hospital of Fujian University of Traditional Chinese MedicineFuzhouFujian 350003China Department of Respiratory and Critical Care Medicine Beijing Tsinghua Changgung HospitalBeijing 102218China Department of Pulmonary Tuberculosis Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghai 200433China Department of Pulmonary and Critical Care Medicine The First Medical Center of the General Hospital of Chinese People's Liberation ArmyBeijing 100853China Department of Respiratory Medicine Peking University Third HospitalBeijing 100191China Department of Pulmonary and Critical Care Medicine Nanjing Jinling HospitalSchool of MedicineNanjing UniversityNanjingJiangsu 210002China Department of Respiratory and Critical Care Medicine Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghai 200433China State key laboratory of Respiratory disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouGuangdong 510120China Department of Pulmonary and Critical Care Medicine Peking Union Medical College HospitalBeijing 100032China Department of Pulmonary and Critical Care Medicine The Third Affiliated HospitalSun Yat-Sen UniversityGuangzhouGuangdong 510630China Department of Pulmonary Medicine The First Affil

In recent years,with the increased prevalence of multi-drug resistant(MDR)bacterial infection and chronic pulmonary infection,the topical application of anti-microbial agents,mainly inhaled antibiotics,has come back to clinical *** formulations for nebulization and dry powder inhaler(DPI)have been approved for inhaled anti-infective ***,evidence and experience have been accumulated in the use of anti-microbial agents delivered via ***,the available studies in this field are heterogenous in the study population,drug delivery route and *** efficacy and safety of inhaled anti-infective therapy in various types of lower respiratory tract infections(LRTIs)need to be ***.

关键词： infection dosage application

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International Nuclear Medicine Consensus on the Clinical Use of Amyloid Positron Emission Tomography in Alzheimer’s disease

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Phenomics 2023年第4期3卷 375-389页

作者： Mei Tian Chuantao Zuo Ali Cahid Civelek Ignasi Carrio Yasuyoshi Watanabe Keon Wook Kang Koji Murakami Valentina Garibotto John OPrior Henryk Barthel Yihui Guan Jiaying Lu Rui Zhou Chentao Jin Shuang Wu Xiaohui Zhang Yan Zhong Hong Zhang Molecular Imaging-Based Precision Medicine Task Group of A3(china-Japan-Korea)Foresight Program PET center Huashan HospitalFudan UniversityShanghai 200235China human Phenome Institute Fudan UniversityShanghai 201203China Department of Nuclear Medicine and PET center The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009China national center for Neurological Disorders and national Clinical Research center for Aging and Medicine Huashan HospitalFudan UniversityShanghai 200040China Department of Radiology and Radiological Science Division of Nuclear Medicine and Molecular ImagingJohns Hopkins MedicineBaltimore 21287USA Department of Nuclear Medicine Hospital Sant PauAutonomous University of BarcelonaBarcelona 08025Spain laboratory for Pathophysiological and health Science RIKEN Center for Biosystems Dynamics ResearchKobeHyogo 650‑0047Japan Department of Nuclear Medicine Seoul National University College of MedicineSeoul 03080Korea Department of Radiology Juntendo University HospitalTokyo 113‑8431Japan Diagnostic Department University Hospitals of Geneva and NIMTlabUniversity of GenevaGeneva 1205Switzerland Department of Nuclear Medicine and Molecular Imaging Lausanne University HospitalLausanne 1011Switzerland Department of Nuclear Medicine Leipzig University Medical CenterLeipzig 04103Germany key laboratory of Medical Molecular Imaging of Zhejiang Province Hangzhou 310009China The College of Biomedical Engineering and Instrument Science of Zhejiang University Hangzhou 310007China key laboratory for Biomedical Engineering of Ministry of Education Zhejiang UniversityHangzhou 310007China 不详

Alzheimer’s disease(AD)is the main cause of dementia,with its diagnosis and management remaining *** positron emission tomography(PET)has become increasingly important in medical practice for patients with *** integrate and update previous guidelines in the field,a task group of experts of several disciplines from multiple countries was assembled,and they revised and approved the content related to the application of amyloid PET in the medical settings of cognitively impaired individuals,focusing on clinical scenarios,patient preparation,administered activities,as well as image acquisition,processing,interpretation and *** addition,expert opinions,practices,and protocols of prominent research institutions performing research on amyloid PET of dementia are *** the increasing availability of amyloid PET imaging,a complete and standard pipeline for the entire examination process is essential for clinical *** international consensus and practice guideline will help to promote proper clinical use of amyloid PET imaging in patients with AD.

关键词： Positron emission tomography(PET) Alzheimer’s disease Amyloid Brain imaging Expert consensus

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原发性干燥综合征诊疗规范

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中华内科杂志 2023年第9期62卷 1059-1067页

作者：张文陈竹厉小梅高洁赵岩代表中华医学会风湿病学分会中国医学科学院、北京协和医学院、北京协和医院风湿免疫科、国家皮肤与免疫疾病临床医学研究中心、疑难重症和罕见病国家重点实验室、风湿免疫病教育部重点实验室北京100730 中国科学技术大学附属第一医院安徽省立医院风湿免疫科合肥230001 海军军医大学第一附属医院风湿免疫科上海200433 不详

干燥综合征(SS)是一种以淋巴细胞增殖及进行性外分泌腺体损伤为特征的慢性炎症性自身免疫病。临床除有唾液腺、泪腺功能受损外,亦可出现多系统多脏器受累,血清中存在自身抗体和高免疫球蛋白血症。SS根据是否伴发其他结缔组织病分为继发... 详细信息

干燥综合征(SS)是一种以淋巴细胞增殖及进行性外分泌腺体损伤为特征的慢性炎症性自身免疫病。临床除有唾液腺、泪腺功能受损外,亦可出现多系统多脏器受累,血清中存在自身抗体和高免疫球蛋白血症。SS根据是否伴发其他结缔组织病分为继发性SS和原发性SS(pSS),前者常继发于系统性红斑狼疮、类风湿关节炎等。中华医学会风湿病学分会在借鉴国内外诊治经验和指南的基础上,制订了本规范,旨在规范SS诊断中关键指标(如血清抗SSA抗体和唇腺病理学)的检测和解读,采用公认的疾病活动指标评价疾病,规范局部和系统受累的合理诊治。

关键词：干燥综合征诊断治疗预后

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痛风诊疗规范

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中华内科杂志 2023年第9期62卷 1068-1076页

作者：徐东朱小霞邹和建林禾赵岩代表中华医学会风湿病学分会中国医学科学院、北京协和医学院、北京协和医院风湿免疫科、国家皮肤与免疫疾病临床医学研究中心、疑难重症及罕见病国家重点实验室、风湿免疫病学教育部重点实验室北京100730 复旦大学附属华山医院风湿免疫科上海200040 福建省立医院风湿免疫科福州350013 不详

痛风是一种单钠尿酸盐沉积在关节所致的晶体相关性关节病,属代谢性风湿病。我国痛风虽然并不少见,但其规范化诊疗的普及依然欠缺。中华医学会风湿病学分会查阅了该领域最新进展,在借鉴国内外诊治经验的基础上,制定了本规范,旨在规范痛... 详细信息

痛风是一种单钠尿酸盐沉积在关节所致的晶体相关性关节病,属代谢性风湿病。我国痛风虽然并不少见,但其规范化诊疗的普及依然欠缺。中华医学会风湿病学分会查阅了该领域最新进展,在借鉴国内外诊治经验的基础上,制定了本规范,旨在规范痛风的诊断、治疗时机和治疗方案,以减少误诊和漏诊。对患者短期与长期治疗予以建议,以减少不可逆损伤的发生,改善患者预后。

关键词：痛风高尿酸血症诊断治疗预后

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中国经导管二尖瓣缘对缘修复术临床路径(2022精简版)

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中国胸心血管外科临床杂志 2023年第3期30卷 333-343页

作者：吴永健林逸贤周达新宋光远中国医师协会心血管内科医师分会结构性心脏病学组亚太结构性心脏病俱乐部中国医学科学院、北京协和医学院、国家心血管病中心、阜外医院北京100037 香港嘉诺撒医院亚洲心脏病中心(香港) 中国复旦大学附属中山医院心内科上海200032 首都医科大学附属北京安贞医院心脏瓣膜病介入中心北京100029 不详

经导管二尖瓣缘对缘修复术(transcatheter mitral valve edge-to-edge repair,TEER)已成为外科手术高危的重度二尖瓣反流(mitral regurgitation,MR)患者的重要治疗选择。其手术流程复杂,团队协作要求高,但在中国尚缺乏规范的临床路径。... 详细信息

经导管二尖瓣缘对缘修复术(transcatheter mitral valve edge-to-edge repair,TEER)已成为外科手术高危的重度二尖瓣反流(mitral regurgitation,MR)患者的重要治疗选择。其手术流程复杂,团队协作要求高,但在中国尚缺乏规范的临床路径。基于当前循证医学证据,针对TEER团队建设、患者临床评估、影像评估、手术规范流程、复杂病变处理、围术期管理、全生命周期康复随访等临床关键问题,专家组撰写了此临床路径,以推动我国TEER技术规范、安全地开展和推广普及,促进我国MR患者诊疗水平和生活质量的提升。

关键词：经导管二尖瓣缘对缘修复术影像手术流程围术期管理康复

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蝙蝠体表蛛蝇中肯科伊病毒的分离鉴定

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病毒学报 2018年第4期34卷 461-470页

作者：冯云付士红张海林杨卫红章域震梁国栋云南省地方病防治所、云南省自然疫源性疾病防控技术重点实验室云南大理671000 中国疾病预防控制中心病毒病预防控制所、国家传染病预防和控制重点实验室北京102206

为调查云南省蝙蝠体表寄生虫蛛蝇中病原体的携带情况。采集蝙蝠体表蛛蝇标本,用细胞培养法分离病毒,对阳性分离物进行分子生物学鉴定,用RT-PCR（Reverse transcription PCR）、TCID（50）（Tissue culture infective dose）、免疫荧光... 详细信息

为调查云南省蝙蝠体表寄生虫蛛蝇中病原体的携带情况。采集蝙蝠体表蛛蝇标本,用细胞培养法分离病毒,对阳性分离物进行分子生物学鉴定,用RT-PCR（Reverse transcription PCR）、TCID（50）（Tissue culture infective dose）、免疫荧光等实验对病毒的特性进行研究。2012年从励腊县的棕果蝠（Rousettus leschenaulti）体表采集蛛蝇183只,利用节肢动物线粒体细胞色素氧化酶I（COI）的通用引物用PCR方法鉴定为蛛蝇科的Eucampsipoda sundaica。从这些蛛蝇中分离到1株阳性分离物MLBC1215,能引起金黄地鼠肾细胞（Golden hamster kidney cell,BHK-21）和非洲绿猴肾细胞（African green monkey kidney cell,VeroE6）出现圆缩、脱落的细胞病变（Cytopathic effect,CPE）。用RT-PCR方法扩增序列,测序结果显示MLBC1215病毒株为三节段RNA病毒,各基因组编码区序列长度分别为S基因为975核苷酸,M基因为4 568核苷酸,L基因为6 866核苷酸,3个基因节段核苷酸序列所形成的进化树拓扑构图相似,MLBC1215病毒株的S、M和L基因均与1970年泰国分离的肯科伊病毒（Kaeng Khoi orthobunyavirus,KKV）（PSC-19）处于同一进化分支。MLBC1215株的S、M、L片段与泰国PSC-19株的核苷酸的同源性分别为97.9%、94.4%和95.3%;氨基酸的同源性分别为98.7%、96.5%和98.4%。MLBC1215株在BHK-21细胞生长到60h达到最高滴度,TCID_（50）为10^（4.8）/0.1ml,随后病毒滴度逐渐下降,至144h TCID_（50）为10^（3.6）/0.1ml。MLBC1215株对小白鼠的主要器官均能引起病理改变,从而导致小白鼠发病死亡。采集的33份人血清中有9份IgG抗体与MLBC1215株有反应,检测结果为阳性,抗体滴度为4份1：20,4份1：40,1份1：80。本次研究证实云南省腊勐县蝙蝠体表吸血昆虫蛛蝇携带布尼亚病毒目KKV。

关键词：肯科伊病毒(KKV) 蛛蝇勐腊

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成人斯蒂尔病诊疗规范

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中华内科杂志 2022年第4期61卷 370-376页

作者：朱小霞李芹王悦赵令杨程德赵岩中华医学会风湿病学分会复旦大学附属华山医院风湿免疫科上海200040 云南省第一人民医院昆明理工大学附属医院风湿免疫科昆明650032 天津医科大学第二医院风湿免疫科天津300211 吉林大学第一医院风湿免疫科长春130031 上海交通大学医学院附属瑞金医院风湿免疫科上海200025 中国医学科学院北京协和医学院北京协和医院风湿免疫科国家皮肤与免疫疾病临床医学研究中心疑难重症及罕见病国家重点实验室风湿免疫病学教育部重点实验室北京100730 不详

成人斯蒂尔病是一种少见的全身性自身炎症性疾病。在我国,成人斯蒂尔病规范化诊疗的普及依然欠缺。中华医学会风湿病学分会查阅了该领域最新进展,在借鉴国内外诊治经验的基础上,制定了本规范,旨在规范成人斯蒂尔病的诊断,以减少误诊和漏... 详细信息

成人斯蒂尔病是一种少见的全身性自身炎症性疾病。在我国,成人斯蒂尔病规范化诊疗的普及依然欠缺。中华医学会风湿病学分会查阅了该领域最新进展,在借鉴国内外诊治经验的基础上,制定了本规范,旨在规范成人斯蒂尔病的诊断,以减少误诊和漏诊,并对其治疗原则、方案予以建议,以减少不可逆损伤的发生,改善患者预后。

关键词： Still病成年型诊断治疗

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Minimal improvement in coronary artery disease risk prediction in chinese population using polygenic risk scores:evidence from the china Kadoorie Biobank

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chinese Medical Journal 2023年第20期136卷 2476-2483页

作者： Songchun Yang Dong Sun Zhijia Sun Canqing Yu Yu Guo Jiahui Si Dianjianyi Sun Yuanjie Pang Pei Pei Ling Yang Iona YMillwood Robin GWalters Yiping Chen Huaidong Du Zengchang Pang Dan Schmidt Rebecca Stevens Robert Clarke Junshi Chen Zhengming Chen Jun Lv Liming Li On Behalf of the china Kadoorie Biobank Collaborative Group Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Department of Dermatology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Peking University center for Public health and Epidemic Preparedness&Response Beijing 100191China Fuwai Hospital chinese Academy of Medical Sciences Beijing 100730China Medical Research Council Population health Research Unit at the University of Oxford Oxford OX37LFUK Clinical Trial Service Unit and Epidemiological Studies Unit(CTSU) Nuffield Department of Population HealthUniversity of OxfordOxford OX37LFUK Qingdao center of disease Control and Prevention QingdaoShandong 266033China china national center for Food Safety Risk Assessment Beijing 100738China 不详

Background:Several studies have reported that polygenic risk scores(PRSs)can enhance risk prediction of coronary artery disease(CAD)in European ***,research on this topic is far from sufficient in non-European countries,including *** aimed to evaluate the potential of PRS for predicting CAD for primary prevention in the chinese ***:Participants with genome-wide genotypic data from the china Kadoorie Biobank were divided into training(n=28,490)and testing sets(n=72,150).Ten previously developed PRSs were evaluated,and new ones were developed using clumping and thresholding or LDpred *** PRS showing the strongest association with CAD in the training set was selected to further evaluate its effects on improving the traditional CAD risk-prediction model in the testing *** risk was computed by summing the product of the weights and allele dosages across genome-wide single-nucleotide *** of the 10-year first CAD events was assessed using hazard ratios(HRs)and measures of model discrimination,calibration,and net reclassification improvement(NRI).Hard CAD(nonfatal I21-I23 and fatal I20-I25)and soft CAD(all fatal or nonfatal I20-I25)were analyzed ***:In the testing set,1214 hard and 7201 soft CAD cases were documented during a mean follow-up of 11.2 *** HR per standard deviation of the optimal PRS was 1.26(95%CI:1.19-1.33)for hard *** on a traditional CAD risk prediction model containing only non-laboratory-based information,the addition of PRS for hard CAD increased Harrell’s C index by 0.001(-0.001 to 0.003)in women and 0.003(0.001 to 0.005)in *** the different high-risk thresholds ranging from 1%to 10%,the highest categorical NRI was 3.2%(95%CI:0.4-6.0%)at a high-risk threshold of 10.0%in *** association of the PRS with soft CAD was much weaker than with hard CAD,leading to minimal or no improvement in the soft CAD ***:In this chinese population sam

关键词： Coronary artery disease Polygenic risk score Risk prediction model chinese population

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