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Analysis and confirm of anabolic steroids in urine by GC/MS

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Analysis and confirm of anabolic steroids in urine by GC/MS

30th International Symposium on Capillary Chromatography、4th GC×GC Symposium、16th national Symposium and Exhibition on Chromatography,i.e. 1st Dalian International Symposium and Exhibition on Chromatography

作者： Liangmin Shangguan Wei Liu Qiaomei Lu Lan Zhang~* Guonan Chen The Ministry of Education Key Laboratory of Analysis and Detection Technology for food Safety(Fuzhou University),china The Sport Science Research Center,Fuzhou University,Fuzhou,Fujian,350002,china

＜正＞Anabolic steroids are currently a class of abused *** of their anabolic effects,they can enhance nitrogen retention and build-up of proteins result in improved muscle ***,based upon results of pharmacological and toxicological studies,they are harm to *** use of anabolic steroids in sports had been banned by the International Olympic Committee（IOC）since ***,detection of anabolic steroid misuse continues to be a significant fraction of the workload in athletic drug testing laboratories.

关键词： Anabolic steroids LLE Derivatization GC/MS

医疗器械行业人才需求与职业院校专业设置匹配分析

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中国职业技术教育 2020年第35期36卷 23-32页

作者：全国食品药品职业教育教学指导委员会唐红梅徐小萍张培茗全国食品药品职业教育教学指导委员会

医疗器械行业发展迅速,对人才需求量大,职业院校培养的技术技能型人才是医疗器械人才的重要组成部分。通过对我国医疗器械行业技术技能人才需求与职业院校人才培养的匹配分析,提出构建合理的医疗器械专业群,以专业教学标准为依据合理合... 详细信息

医疗器械行业发展迅速,对人才需求量大,职业院校培养的技术技能型人才是医疗器械人才的重要组成部分。通过对我国医疗器械行业技术技能人才需求与职业院校人才培养的匹配分析,提出构建合理的医疗器械专业群,以专业教学标准为依据合理合规设置专业;依据行业发展特点,动态调整专业核心课程;打通职业院校人才向上继续深造的通道,增强可持续发展能力等建议,为医疗器械行业人才培养和职业院校专业设置提供参考。

关键词：职业院校医疗器械行业行业人才需求专业设置匹配分析

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两种莲必治注射液急性和长期毒性研究

毒理学杂志 2010年第6期24卷 433-437页

作者：胡中慧吴纯启王全军王青秀骆永伟杨保华廖明阳军事医学科学院毒物药物研究所国家北京药物安全评价研究中心北京100850 兰州军区联勤部药品检验所

目的观察莲必治注射液A和B的急性毒性和长期毒性。方法上下法观察2种莲必治注射液对SD大鼠的急性毒性;连续30 d重复静脉给药观察其对SD大鼠的长期毒性,设置2种莲必治注射液高、中、低各3个剂量组(莲必治注射液A,450,150和50 mg/kg;B,150... 详细信息

目的观察莲必治注射液A和B的急性毒性和长期毒性。方法上下法观察2种莲必治注射液对SD大鼠的急性毒性;连续30 d重复静脉给药观察其对SD大鼠的长期毒性,设置2种莲必治注射液高、中、低各3个剂量组(莲必治注射液A,450,150和50 mg/kg;B,150,50和25 mg/kg)和生理盐水对照组,对一般生理指标、尿常规和尿酶、血液学、血液生化和组织病理进行学检查。结果急性毒性试验结果莲必治A注射液的LD50=2 101 mg/kg,莲必治B注射液的LD50=612.4 mg/kg;连续30 d重复静脉给药后结果,莲必治A和B高剂量组能够引起动物摄食量减少和体重降低,同时给药结束后莲必治A和B高剂量组尿素氮(BUN)、肌酐(CRE)有升高趋势,尿酶N-乙酰-β-D葡萄糖苷酶(NAG)活性升高,尿血红蛋白(ERY)增加,其他血液学、血液生化学、脏器系数及病理学检查均未见显著性变化。结论莲必治注射液对SD大鼠具有潜在肾毒性,推测可能影响肾小球滤过率和肾小管功能,毒性作用与其纯度和剂量有关。

关键词：莲必治注射液急性毒性长期毒性肾毒性

Development of Transgenic Sweet Potato(Ipomoea batatas) Plants Tolerant to Salt Stress

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Development of Transgenic Sweet Potato(Ipomoea batatas) Plan...

植物分子生物学与现代农业——2010全国植物生物学研讨会

作者： Weijuan Fan and Peng Zhang~* Shanghai Center for Cassava Biotechnology,Institute of Plant Physiology & Ecology,Shanghai institutes for Biological Sciences,Chinese Academy of Sciences,300 Fenglin Road,Shanghai 200032,china

Sweet potato is a herbaceous perennial root crop and provides major feedstock for food and biofuel industries in *** stresses,such as salinity,drought and low temperature,are critical delimiters for high productivity ... 详细信息

关键词： sweet potato over-expression Na+/H+ antiporter betaine aldehyde dehydrogenase

从国家抽验中看“高电位治疗设备”存在的问题

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中国医疗器械信息 2012年第6期18卷 25-28,34页

作者：齐丽晶国家食品药品监督管理局天津医疗器械质量监督检验中心天津300191

本文通过对2011年"高电位治疗设备"国家抽验中产品不合格项目的统计分析,深入探讨了此类设备在生产及注册管理中存在的问题,为进一步提升此类设备的产品质量、规范生产和注册管理提供了参考。

关键词：高电位治疗设备国家抽验

Genetic Engineering of Cassava and Sweet Potato for Industrial Applications

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Genetic Engineering of Cassava and Sweet Potato for Industri...

植物分子生物学与现代农业——2010全国植物生物学研讨会

作者： Jun Yang,Shanshan Zhao,Dong An,Huiping Bi,Jia Xu,Qiuxiang Ma,Min Zhang, Jia Liu,Peng Zhang~* Institute of Plant Physiology & Ecology,Shanghai institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200032,china

Cassava(Manihot esculenta Crantz) and sweetpotato(Ipomoea batatas) accumulate a lot of starch in their storage roots which can be processed to food,feed and bio-ethanol. The high yield potential and robustness against unfavorable environmental conditions make them the suitable energy crops for margin land cultivation,which will not highly compete with other food crops on arable *** are several key biological

关键词： Cassava sweetpotato genetic improvement transgenesis industrialization

Effect of histamine H1 receptor antagonist on the epileptogenesis and the involved mechanism related to astrocytes

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Effect of histamine H1 receptor antagonist on the epileptoge...

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Wei-Wei HU~1 Ping HE~1 Hai-Jing YAN~1 Zheng-Hao XU~1 Qi FANG~1 Kai ZHONG~1 Zhong CHEN~(1 2*) 1 Institute of Neuroscience Department of Pharmacology School of medicine Zhejiang University Hangzhou 310058 china 2 Department of Pharmacology College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 china

＜正＞Objective Histamine H1 receptor antagonists present epileptogenic activities such as inducing the seizure or promoting the progress of epilepsy during the ***,the effect of H1 receptor antagonists on the epileptogenesis after drug withdrawal is still unknown and the existed mechanism is *** our preliminary experiment,H1 receptor antagonist elevated the astrocyte extracelluar glutamate content,which is suggested to affect the neuron function and possibly involved in the *** the present study is to explore the effect of H1 receptor antagonists on the epileptogenesis after drug withdrawal and the astrocyte glutamate uptake related *** The afterdischarge threshold and behavioral stage of seizures during amygdaloid kindling acquisition was observed after 10- day drug withdrawal following two-week chronic diphenhydramine *** extracellular glutamate content,the expression,distribution and current of glutamate transporters,the expression of glutamine synthetase（GS）,and the morphology in astrocytes were investigated after administration of diphenhydramine and *** Chronic pretreatment of diphenhydramine reduced the afterdischarge threshold,accelerated the behavioral development of seizures, and decreased the number of stimulations required to seizure stage 2,3 or 4 during amygdaloid kindling acquisition after 10-day drug *** diphenhydramine and pyrilamine elevated the extracellular glutamate content,decreased the glutamate transporters GLT-1,GLAST and GS expression,but not affected the distribution of GLT-1 and *** withdrawal of drug did not recover the glutamate content and the protein expression during early *** glutamate transporter-mediated current was also decreased after diphenhydramine *** diphenhydramine and pyrilamine induced obvious vacuolization in cytoplasm,but without noticeable cytotoxicity at the same *** diphenhydramine and pyrilamin

关键词： H1 receptor antagonist epilepsy glutamate astrocyte

Research on Some Copper-Catalyzed Coupling Reactions

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Research on Some Copper-Catalyzed Coupling Reactions

中国化学会第十届全国有机合成化学学术研讨会

作者： Fengtao Zhou,Jiajie Yan,Jianguang Liu,Qian CaiKey Laboratory of Regenerative Biology and Institute of Chemical Biology,Guangzhou institutes of Biomedicine and Health,Chinese Academy of Sciences,No.190 Kaiyuan Avenue,Guangzhou Science Park,Guangzhou,510530,china

＜正＞As one of the most powerful tools for constructing aryl C-hetero bonds,copper-catalyzed Ullamnn-type coupling reactions have been extensively studied and applied both in academia and *** the last 15 years,Ullmann-type coupling reactions have received much attention with the development of mild conditions for such *** group has also focused our research on copper-catalyzed coupling reactions during the past two *** this presentation,we’d like to discuss our research on the development of novel copper-catalyzed tandem reactions by the combination of[3+2]cycloaddition reactions and Ullmann-type coupling reactions based on the conception of organocopper intermediate trapping,as well as the enantioselective Ullamnn-type coupling reactions based on the desymmetrization strategy.

关键词：

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何首乌安全用药指南

Acupuncture and Herbal Medicine 2024年第2期4卷 151-158,I0001页

作者：肖小河王伽伯宋海波欧阳冬生邹正升王睿林何婷婷景婧郭玉明柏兆方湛小燕牛明马致洁李春雨中华中医药学会中成药分会中华中医药学会肝胆病分会中国药学会临床中药学专业委员会中国药理学会药源性疾病学专业委员会肝病分委会中国毒理学会临床毒理专业委员会中国人民解放军总医院第五医学中心北京中南大学临床药理研究所长沙国家药品监督管理局药品评价中心北京不详

何首乌为常用中药,在临床治疗和日常保健中使用广泛,但近年来屡见有肝损伤报道,引起国内外广泛关注,部分含何首乌和首乌藤制剂肝损伤风险已被国家食品药品监督管理局多次通报。近年来相关研究已取得实质性进展,揭示了其特异质肝损伤的... 详细信息

何首乌为常用中药,在临床治疗和日常保健中使用广泛,但近年来屡见有肝损伤报道,引起国内外广泛关注,部分含何首乌和首乌藤制剂肝损伤风险已被国家食品药品监督管理局多次通报。近年来相关研究已取得实质性进展,揭示了其特异质肝损伤的基本属性、主要成因、物质基础和分子机制,发现其易感人群的基本特征和生物标志物,表明何首乌仅对极少数特定人群有肝损伤风险,对绝大多数人群是安全的。研究成果为正确客观地认识何首乌致肝损伤、合理制定何首乌及相关制剂安全用药措施提供了科学依据。为此,中华中医药学会组织全国相关领域专家,起草制定了《何首乌安全用药指南》,旨在帮助国内外公众和相关机构,科学认识、评估和规避何首乌肝损伤风险,指导何首乌及相关制剂的合理使用,保障广大消费者的健康权益,同时促进何首乌及相关产业的健康持续发展。该指南已通过中华中医药学会的审核,并进行了发布,编号T/CACM 1328-2019。

关键词：药物安全性肝损伤何首乌合理使用中药