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A template of rat brain based on fMRI T2* imaging

Progress in Natural science:materials International 2005年第6期15卷 502-506页

作者： HU Zhenghui1, WU Yigen2, WANG Xiaochuan3, WANG Jianzhi3, CHEN Feiyan1 and TANG Xiaowei1*(1. department of physics and Bio-X Laboratory, Zhejiang university, Hangzhou 310027, china 2. institute of High energy physics and Key Laboratory of nuclear Analysis Techniques, Chinese Academy of sciences,beijing 100039, china 3. department of Pathophysiology, Tongji Medical College, Huazhong university of science and Technology, Wuhan 430030, china) department of physics and Bio-X Laboratory Zhejiang University Hangzhou 310027 China institute of High energy physics and Key Laboratory of nuclear Analysis Techniques Chinese Academy of Sciences Beijing 100039 China department of Pathophysiology Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

The development of functional magnetic resonance imaging (fMRI) technology has made it possible to carry out functional brain imaging experiments in small animals. Usually, group data is required to form the assessment of population, which can not only increase the sensitivity of the overall experiment, but also allow the generalization of the conclusion to the whole population. In order to average the signals of functional brain images from different subjects, it is necessary to put all the mapping images into the same standard space (template image). However, up to now, most animal brain templates remain unavailable and it must be done by ourselves. In this study, a template image based on the brains of eight male Wistar rats is obtained, and it is successfully used in our present Alzheimer disease (AD)-like rat model studies as template for spatially normalizing images to the same stereotaxical space. The fMRI results processed with statistical parametric mapping (SPM99) software are in agreement with the results from immunohistochemical experiment, which proves that this method is universally applicable to the pathologic models of other small animals and to human brain lesion studies.

关键词： fMRI animal model atlas template normalization T*2.

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Track Fading and Its Applications in Archaeology, Tectonics and Geothermal Chronology in china

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Journal of Earth science 2013年第4期24卷 645-651页

作者：郭士伦袁万明陈宝流黄慰文刘顺生 department of nuclear physics China Institute of Atomic Energy School of Earth sciences and Resourses China University of Geosciences department of Radioisotopes China Institute of Atomic Energy institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of Sciences Guangzhou institute of Geochemistry Chinese Academy of Sciences

Track fading is a basic phenomenon in track science and has been the source of informa- tion in geosciences. This article summarizes the knowledge of track fading and gives some examples of successful applications of track fading in archaeology, tectonics and geothermal chronology in china. The applications of track fading are classified into 5 modes：（1） mode of complete fading （annealing）; （2） mode of partial fading; （3） use of the dependence of track fading on time and temperature; （4） use of the differences of track fading between coexisting minerals; and （5） use of fading-reduced track length. Track fading mechanisms hints that scientists in geothermal chronology should adopt microprobes for quantitative elemental analysis to determine the detailed chemical compositions of each mineral grain or at least of the grains from each position of geological structures in order that one becomes well aware of the relation between the track fading behavior and chemical compositions of the mineral used.

关键词： track fading archaeology tectonics geothermal chronology.

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Fabrication of atomically smooth SrRuO_3 thin films by laser molecular beam epitaxy

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science china(physics,Mechanics & Astronomy) 2008年第7期51卷 745-749页

作者： LIU GuoZhen1, HE Meng1, JIN KuiJuan1, YANG GuoZhen1, Lü HuiBin1, ZHAO Kun2, ZHENG ShiJian3 & MA XiuLiang3 1 beijing National Laboratory for Condensed Matter physics, institute of physics, Chinese Academy of sciences, beijing 100080, china 2 department of Mathematics and physics, china university of Petroleum, beijing 102249, china 3 Shenyang National Laboratory for {13.s science, institute of Metal Research, Chinese Academy of sciences, Shenyang 110016, china 1. beijing National Laboratory for Condensed Matter physics Institute of Physics Chinese Academy of Sciences Beijing 100080 China 2. department of Mathematics and physics China University of Petroleum Beijing 102249 China 3. Shenyang National Laboratory for materials science Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

High-quality SrRuO3 (SRO) thin films and SrTiO3/SRO bilayer were grown epitaxially on SrTiO3 (STO)(001) substrates by laser molecular beam epitaxy. The results of in situ observation of reflection high-energy electron diffraction and ex situ X-ray diffraction θ -2θ scan indicate that the SRO thin films have good crystallinity. The measurements of atomic force microscopy and scan tunneling microscopy reveal that the surface of the SRO thin film is atomically smooth. The resistivity of the SRO thin film is 300 μΩ·cm at room temperature. Furthermore, the transmission electron microscopy study shows that the interfaces of STO/SRO and SRO/STO are very clear and no interfacial reaction layer was observed. The experimental results show that the SRO thin film is an excellent electrode material for devices based on perovskite oxide materials.

关键词： SrRuO3 thin film laser molecular beam epitaxy surface morphology

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Measurement of Double Differential Cross Section for ^(93)Nb(n,xp) Reaction at E_n=14.6 MeV

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Chinese journal of nuclear physics 1994年第2期16卷 120-126页

作者： Ye Bangjiao Fan Yangmei Wang Zhongmin Han Rongdian(department of Modern physics,university of science and Technology of china,Hefei 230026)Xiao Zhenxi(institute of Management,university of science and Technology of china,beijing 100080) 中国科学技术大学近代物理系安徽合肥 230026 中国科学技术大学近代物理系安徽合肥中国科学技术大学管理学院北京 100080

-The energy spectrum and angular distributions of protons from 93Nb（n,xp）reactions are measured by means of the USTC（university of science and Technologyof china）multitelescope *** total proton production cross sections are in fairagreement with the results of other *** energy spectrum is well explained by thesum of the spectra calculated on the basis of the preequilibrium and the H-F *** from the previous measurement at the high energy end of the angle-inte-grated proton spectrum are *** angular distributions which show a stronglyenergy-dependent forward-backward asymmetry are in fair agreement with thephenomenological model of Kalbach-Mann.

关键词： Double differential cross section Neutron induced reaction Preequilibrium

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Correlation of Behavior Changes and BOLD Signal in Alzheimer-like Rat Model

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Acta Biochimica et Biophysica Sinica 2004年第12期36卷 803-810页

作者： Zheng-Hui HU#, Xiao-Chuan WANG1#, Li-Yun LI3, Mai-Li LIU3, Rong LIU1, Zhiqun LING1, Qing TIAN1, Xiao-Wei TANG, Yi-Gen WU2*, and Jian-Zhi WANG1* department of physics and Bio-X disciplinary Laboratory, Zhejiang university, Hangzhou 310027,china 1 department of Pathophysiology, Tongji Medical College, Huazhong university of science and Technology, Wuhan 430030, china 2institute of High energy physics and Key Laboratory of nuclear Analysis Techniques, Chinese Academy of sciences, P.O. Box 918, {13. 100039, china 3Wuhan institute of physics and Mathematics, State Key Laboratory of Magnetic Resonance and Atomic and Molecular physics, Chinese Academy of sciences, Wuhan 430071, china department of physics and Bio-X disciplinary Laboratory Zhejiang UniversityHangzhou 310027China department of Pathophysiology Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030 China Wuhan institute of physics and Mathematics State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Chinese Academy of SciencesWuhan 430071 China institute of High energy physics and Key Laboratory of nuclear Analysis Techniques Chinese Academy of SciencesP.O. Box 918 Beijing 100039 China

To explore a potential means for the early diagnosis of Alzheimer disease, we studied the relationship of resting T2* signal and tau hyperphosphorylation/spatial memory deficit. The rat model with tau hyperphosphorylation and spatial memory deficit was established by bilateral hippocampi injection of isoproterenol (IP). Then, the correlative alteration between resting T2* signal and spatial memory retention was assessed with blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) study and Morris Water Maze test, and Western blot was employed to confirm tau hyperphosphorylation. The analysis showed following results. (1) Tau phosphorylation at Ser396/Ser404 and Ser199/Ser202 was signifi- cantly increased in IP-injected rats as detected by PHF-1 and tau-1, respectively. (2) An AD-like spatial memory retention disturbance was induced at 24 h after isoproterenol injection. (3) A sensitivity threshold of resting T2* signal intensity, which separated the IP-treated rats from vehicle control, was obtained by applying linear regression analysis, and an estimated sensitivity statistical threshold was at 32.62. These results suggest that resting T2* signal may serve as a noninvasive quantitative marker in predicting AD-like spatial memory deficits and tau hyperphosphorylation.

关键词： Alzheimer disease (AD) functional magnetic resonance imaging (fMRI) isoproterenol (IP) Morris Water Maze diagnosis

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PIXE and INAA studies on ancient potteries from Guangfulin relics in Shanghai

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Progress in Natural science:materials International 2007年第11期17卷 1348-1356页

作者： Lin Jiawei1, Cheng Huansheng1, Zhang Zhengquan1, Zhang Bin1, Feng Songlin2, Song Jian3, Gao Menghe4 and Zhu Dan1(1. Applied Ion Beam physics Laboratory, Key Laboratory of the Ministry of Education, institute of Modern physics, Fudan university, Shanghai 200433, china 2. Key Laboratory of nuclear Analytical Techniques, institute of High energy physics, beijing 100039, china 3. Shanghai Museum, Shanghai 200003, china 4. department of Cultural Heritage and Museology, Fudan university, Shanghai 200433, china) Applied Ion Beam physics Laboratory Key Laboratory of the Ministry of Education Institute of Modern Physics Fudan University Shanghai 200433 China Key Laboratory of nuclear Analytical Techniques Institute of High Energy Physics Beijing 100039 China Shanghai Museum Shanghai 200003 China department of Cultural Heritage and Museology Fudan University Shanghai 200433 China

This paper reports the study of ancient potteries unearthed from the Guangfulin site in Shanghai. From the external features of these potteries, archeologists can classify them into two different cultural types: Liangzhu culture (local culture) and a new culture which might be derived elsewhere, but they can not recognize whether they were produced in the same place. Proton induced X-ray emission (PIXE) and instrumental neutron activation analysis (INAA) were used to measure the chemical compositions of the samples and the results were analyzed using multivariate statistics. We found that the two methods can complement each other and their database can be mutually referenced in the study of ancient potteries. Experimental results show that the compositions of the potteries from the two cultural types are different, which means that the materials for ancient potteries of new culture originate from elsewhere. This supports the archaeologists’ speculation that a group of ancient people migrated to Shanghai from some other places 4000 years ago.

关键词： PIXE INAA factor analysis Guangfulin ancient pottery

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The study of energy bands in nucleus ^(102)Zr

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science china(physics,Mechanics & Astronomy) 2010年第1期53卷 106-110页

作者： DONG GuoXiang 1,2 , YU ShaoYing 1,2,3 , LIU YanXin 1 , SHEN CaiWan 1,2,4 & DONG YongSheng 1,2,5I School of science, Huzhou Teachers College, Huzhou 313.00, china 2 School of science and Information engineering, Zhejiang Normal university, Jinhua 321000, china 3 institute of Theoretical physics, Chinese Academy of sciences, beijing 100080, china 4 Center of Theoretical nuclear physics, National Laboratory of Heavy Ion Accelerator of Lanzhou, Lanzhou 730000, china 5 department of physics, Jining Teachers College, Jining 012000, china 1. School of science Huzhou Teachers College Huzhou 313000 China2. School of Science and Information Engineering Zhejiang Normal University Jinhua 321000 China3. Institute of Theoretical Physics Chinese Academy of Sciences Beijing 100080 China4. Center of Theoretical Nuclear Physics National Laboratory of Heavy Ion Accelerator of Lanzhou Lanzhou 730000 China5. Department of Physics Jining Teachers College Jining 012000 China

Theoretical calculations of the energy bands in nucleus 102 Zr are carried out by taking the projected shell model approach, which has reproduced the experimental data. In addition, by analyzing band-head energies, corresponding configurations of yrast band, quasi-particle rotational bands and side bands, we have worked out the microscopic formation mechanism of axially symmetric deformation bands: The low-excitation deformation bands are attributed to the high-j intruder states 1g 7/2 and 1h 11/2 in the N=4, 5 shells; the quasi-particles in the orbit v5/2-[532], v3/2+[411] and v3/2+[413. in particular play an important role in the deformation of 102 Zr.

关键词： projected shell model yrast band quasi-particle rotational band side band

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XMM-Newton observation of the eclipsing binary Algol

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Research in Astronomy and Astrophysics 2011年第4期11卷 457-470页

作者： Xue-Juan Yang Fang-Jun Lu Bemd Aschenbach Li Chen Faculty of materials Optoelectronics and Physics Xiangtan University Xiangtan 411105China Particle Astrophysics Center Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China Max-Planck-Institut fur Extraterrestrische Physik 85741 Garching Germany department of Astronomy Beijing Normal University Beijing 100875 China

We present an XMM-Newton observation of the eclipsing binary Algol which contains an X-ray dark B8V primary and an X-ray bright K2IV secondary. The observation covered the optical secondary eclipse and captured an X-ray flare that was eclipsed by the B star. The XMM-Newton European Photon Imaging Camera and Reflection Grating Spectrometer spectra of Algol in its quiescent state are described by a two-temperature plasma model. The cool component has a temperature around 6.4× 106 K while that of the hot component ranges from 2 to 4.0× 107 K. Coronal abundances of C, N, O, Ne, Mg, Si and Fe were obtained for each component for both the quiescent and the flare phases, generally with upper limits for S and Ar, and upper limits for C, N, and O from the hot component. F-tests show that the abundances do not need to be different between the cool and the hot component and between the quiescent and the flare phase with the exception of Fe. Although the Fe abundance of the cool component remains constant at -0.14, the hot component shows an Fe abundance of -0.28, which increases to -0.44 during the flare. This increase is expected from the chromospheric evaporation model. The absorbing column density NH of the quiescent emission is 2.5 - 1020 cm-2, while that of the flare-only emission is significantly lower and consistent with the column density of the interstellar medium. This observation substantiates earlier suggestions of the presence of X-ray absorbing material in the Algol system.

关键词： stars abundance -- star binaries eclipsing -- stars flare -- stars indi-vidual Algol

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X（3872） and Bound State Problem of D0*0（0 D*0）

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原子核物理评论 2009年第S1期 16-21页

作者： LIU Yan-rui1,LIU Xiang2,3,DENG Wei-zhen2 (1 institute of High energy physics,Chinese Academy of sciences,beijing 100049,china 2 department of physics,Peking university,beijing 100871,china 3 Centro de Física Terica,Departamento de Física,Universidade de Coimbra,P-3004-516,Coimbra,Portugal)

We have performed a dynamical calculation of the bound state problem of D0D*0 by considering the pion and sigma meson exchange potential. Our preliminary analysis disfavors the molecular interpretation of X(3872) if we use the experimental D*Dπ coupling constant g=0.59 and a reasonable cutoff around 1 GeV,which is the typical hadronic scale. In contrast,there probably exists a loosely bound S-wave BB* molecular state. Such a molecular state would be rather stable since its dominant decay mode is the radiative decay through B*→Bγ.

关键词： X(3872) bound state molecule

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Long range implantation by MEVVA metal ion source

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nuclear science and Techniques 2001年第1期12卷 16-20页

作者： ZHANG Tong-He WU Yu-Guang MA Fu-Rong LIANG Hong (Key Laboratory in university for Radiation Beam Technology and material modification, institute of low energy nuclear physics, beijing Normal university beijing Radiation Center, beijing 100875) Key Laboratory in university for Radiation Beam Technology and material modification Instituteof Low Energy Nuclear Physics Beijing Normal University beijing Radiation Center

Metal vapor vacuum arc (MEVVA) source ion implantation is a new technology used for achieving long range ion *** is very important for research and application of the ion beammodification of materials. The results showthat the implanted atom diffusion coefficient increases in Mo implanted Al with high ion flux andhigh dose. The implanted depth is 311.6 times greater than that ofthe corresponding ion range. The ionspecies, doses and ion fluxes play an important part in the long-range implantation. Especially,thermal atom chemistry have specific effect on the long-range implantation during high ion fluximplantation at transient high target temperature.

关键词： MEVVA离子源离子移植扩散技术

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