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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： xi-Yao GU,Ting-Ting LI,Yao-Yao FU,Zhi-Qi ZHAO,Yu-Qiu ZHANG~* institute of Neurobiology,institutes of brain Science and State Key Laboratory of medical Neurobiology,Fudan university,Shanghai,200032,china

＜正＞Objective Bone cancer pain is very common and a co-symptom in human bone-transfer,which causes allodynia and spontaneous *** studies suggest that the pain is related to the activation of astrocyte and microglia in the spinal *** express of glial fibrillary acidic protein（GFAP） is mainly caused by the overgrowth of astrocyte,thus it can be a marker of the activation of *** addition,activated microglia can participate in a wide range of production and transmission of nociceptive *** used the bone cancer pain model to investigate the role of astrocytes and microglia in the development of bone cancer pain and how it *** Rat model of bone cancer pain was built by injection of Walker256 mammary gland carcinoma cells into the tibia medullary *** Frey test and immunohistochemistry were used to reveal the allodynia and the expression of astrocytes and microglia from the native or bone cancer pain *** First of all,the Von Frey test showed the mechanical allodynia in ipsileteral hindpaw to bone cancer ***,immunohistochemistry results revealed either GFAP or OX-42（CD11b）,a specific protein expressed by microglia,was significantly ***,intrathecal injection of gliocyte inhibitor propentofylline（10μg/ 1μl） significantly attenuated the allodynia and the GFAP expression in the spinal *** the same time,intrathecal injection of minocycline,which can specifically inhibit microglia,also reduced the existed *** The results indicated that astrocytes and microglia play important roles in the generation and the maintenance of bone cancer pain.

关键词： bone caner pain astrocyte microglia GFAP OX-42 spinal cord intrathecal injection

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Advances in electrical impedance tomography-based brain imaging

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military medical Research 2022年第6期9卷 705-726页

作者： xi-Yang Ke Wei Hou Qi Huang Xue Hou Xue-Ying Bao Wei-Xuan Kong Cheng-xiang Li Yu-Qi Qiu Si-Yi Hu Li-Hua Dong Department of Radiation Oncology and Therapy the First Hospital of Jilin UniversityChangchun 130021China Jilin Provincial Key Laboratory of Radiation Oncology and Therapy the First Hospital of Jilin UniversityChangchun 130021China NHC Key Laboratory of Radiobiology School of Public HealthJilin UniversityChangchun 130021China CAS Key Laboratory of Bio-medical Diagnostics Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesSuzhou 215163JiangsuChina

Novel advances in the field of brain imaging have enabled the unprecedented clinical application of various imaging modalities to facilitate disease diagnosis and treatment. Electrical impedance tomography(EIT) is a functional imaging technique that measures the transfer impedances between electrodes on the body surface to estimate the spatial distribution of electrical properties of tissues. EIT offers many advantages over other neuroimaging technologies,which has led to its potential clinical use. This qualitative review provides an overview of the basic principles,algorithms, and system composition of EIT. Recent advances in the field of EIT are discussed in the context of epilepsy,stroke, brain injuries and edema, and other brain diseases. Further, we summarize factors limiting the development of brain EIT and highlight prospects for the field. In epilepsy imaging, there have been advances in EIT imaging depth,from cortical to subcortical regions. In stroke research, a bedside EIT stroke monitoring system has been developed for clinical practice, and data support the role of EIT in multi-modal imaging for diagnosing stroke. Additionally, EIT has been applied to monitor the changes in brain water content associated with cerebral edema, enabling the early identification of brain edema and the evaluation of mannitol dehydration. However, anatomically realistic geometry,inhomogeneity, cranium completeness, anisotropy and skull type, etc., must be considered to improve the accuracy of EIT modeling. Thus, the further establishment of EIT as a mature and routine diagnostic technique will necessitate the accumulation of more supporting evidence.

关键词： Electrical impedance tomography(EIT) brain diseases Tissue impedance Microelectrode array

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Small P values may not yield robust findings:an example using REST-meta-PD

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Science Bulletin 2021年第21期66卷 2148-2152,M0003页

作者： xi-Ze Jia Na Zhao Hao-Ming Dong Jia-Wei Sun Marek Barton Roxana Burciu Nicolas Carrière Antonio Cerasa Bo-Yu Chen Jun Chen Stephen Coombes Luc Defebvre Christine Delmaire Kathy Dujardin Fabrizio Esposito Guo-Guang Fan Federica Di Nardo Yi-Xuan Feng Brett W.Fling Saurabh Garg Moran Gilat Martin Gorges Shu-Leong Ho Fay BHorak xiao Hu xiao-Fei Hu Biao Huang Pei-Yu Huang Ze-Juan Jia Christina Jones Jan Kassubek Lenka Krajcovicova Ajay Kurani Jing Li Qing Li Ai-Ping Liu Bo Liu Hu Liu Wei-Guo Liu Renaud Lopes Yu-Ting Lou Wei Luo Tara Madhyastha Ni-Ni Mao Grainne McAlonan Martin J.McKeown Shirley Pang Andrea Quattrone Irena Rektorova Alessia Sarica Hui-Fang Shang James M.Shine Priyank Shukla Tomas Slavicek xiao-Peng Song Gioacchino Tedeschi Alessandro Tessitore David Vaillancourt Jian Wang Jue Wang Z.Jane Wang Lu-Qing Wei xia Wu xiao-Jun Xu Lei Yan Jing Yang Wan-Qun Yang Nai-Lin Yao De-Long Zhang Jiu-Quan Zhang Min-Ming Zhang Yan-Ling Zhang Cai-Hong Zhou Chao-Gan Yan xi-Nian Zuo Mark Hallett Tao Wu Yu-Feng Zang Center for Cognition and brain disorders the Affiliated HospitalHangzhou Normal UniversityHangzhou 310015China Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments Hangzhou 311121China National Basic Science Data Center Beijing 100190China State Key Laboratory of Cognitive Neuroscience and Learning&McGovern institute for brain Research Beijing Normal UniversityBeijing 100875China School of Information and Electronics Technology Jiamusi UniversityJiamusi 154007China Neuroscience Program Central European Institute of TechnologyCEITECMasaryk UniversityBrno 62500Czech Republic Department of Applied Physiology and Kinesiology University of FloridaGainesville FL 32611USA Univ.Lille InsermCHU LilleU1172-LilNCog-Lille Neuroscience&CognitionLille F-59000France The institute for biomedical Research and Innovation National Research CouncilMangone CS 87050Italy Department of Radiology The First Affiliated Hospital of China Medical UniversityShenyang 110001China Department of Radiology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China Department of Medicine Surgery and DentistryScuola Medica SalernitanaUniversity of SalernoFiscianoSA 132-84084Italy Department of Advanced medical and Surgery sciences University of Campania“Luigi Vanvitelli”Caserta 81100Italy Eye Center of the 2nd Affiliated hospital Medical College of Zhejiang UniversityHangzhou 310020China Zhejiang Provincial Key Lab of Ophthalmology Hangzhou 310020China Department of Health and Exercise Science Colorado State UniversityFort Collins CO 80523USA Pacific Parkinson’s Research Centre University of British ColumbiaVancouver BC V6E 2M6Canada Department of Medicine(Neurology)university of British Columbia Vancouver BC V6T 1B7Canada brain and Mind Center The University of SydneySydney NSW 2006Australia Department of Neurology Ulm UniversityUlm 89081Germany Division of Neurology Department of MedicineQueen Mary HospitalUniversity of Hong KongHong Kong 999077China Department of

Thousands of resting state functional magnetic resonance imaging(RS-f MRI)articles have been published on brain *** precise localization of abnormal brain activity,a voxel-level comparison is *** of the large number of voxels in the brain,multiple comparison correction(MCC)must be performed to reduce false positive rates,and a smaller P value(usually including either liberal or stringent MCC)is widely recommended[1].

关键词：帕金森病 precise correction

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