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Pharmacokinetic and Pharmacodynamic Study of PEG-G-CSF in cancer patients with chemotherapy-induced neutropenia

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Pharmacokinetic and Pharmacodynamic Study of PEG-G-CSF in ca...

OPENING NEW HORIZONS FOR VEHICLE SYSTEM DYNAMICS

第十三次全国临床药理学学术大会

作者： Zhengli1 HouMei2 Wangjin2 QiuMeng2 WuQi3 1.GCP center,West china hospital of sichuan University,chengdu 61004. china 2.Tumor department,West china hospital of sichuan University,chengdu 61004. china 3.Tumor department,sichuan province hospital,chengdu 61004. china

BACKGROUND/AIMS:The newly developed generic PEG-G-CSF,a long-acting granulocyte colony-stimulating factor was established in china,the aim of this study was to investigate the safety, pharmacokinetic and pharmacodynamic profiles of PEG-G-CSF in cancer patients with chemotherapy-induced neutropenia. METHODS:This open-label,randomized-sequence,2-way crossover study was conducted at two Hospitals, *** Chinese cancer patients(eight patients with nonsmall-cell lung cancer and two patients with lymphoma) who had experienced severe neutropenia were *** received the same chemotherapy regimen in their each *** were randomly assigned at a 1:1 ratio to received a single subcutaneous dose of 60 ug/kg PEG-G-CSF or with daily subcutaneous dose of 5μg/kg filgrastim at the 48 hours after chemotherapy ended in the first chemotherapy cycle and administration of the alternate formulation in the second cycle. Pharmacokinetic,pharmacodynamic and safety analyses were *** samples for PEG-G-CSF concentration measurement were collected before PEG-G-CSF administration and froml to 432 hours after the injection of ***:PEG-G-CSF and filgrastim were similar for all efficacy and safety end *** main pharmacokinetic parameters of PEG-G-CSF are as follow:T:21.0±11.0 h,C:138.4±31.3μg/L,t:64.2±11.0h,CL:0.006±0.002 L/h/kg,AUC(0-t):11105±2643ug/L/*** concentrations of PEG-G-CSF began to decrease after day 5 at the end of chemotherapy and returned to baseline levels on day 15. CONLUSION:The tolerance,pharmacokinetic and pharmacodynamic characteristics of PEG-G-CSF supported that a single dose of 60ug/kg subcutaneous injection once per treatment cycle for prevention of severe neutropenia.

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Bulletin of the Chinese Academy of Sciences 1995年第3期9卷 274-275页

作者： Shen Zhiyun(Southwest Jiaotong University in chengdu, sichuan province)

The non-linear wheel-rail motional model is the first research breakthrough I have made in the field of vehicle system dynamics. The main external interference to a vehicle system in rail-borne transportation comes from the dynamic interaction between the wheel and the rail. To determine the forces exerted on the rail-contacting patches of a railcar is known to be one of the most complicated problems in rail haulage, expecially in its unsaturated state, i.e. before overall sliding occurs. Since the 1960s, many scholars, including K.L. Johnson and ***, have considered it a problem in rolling contact mechanics. However, none of the presented

关键词： work OPENING NEW HORIZONS FOR VEHICLE SYSTEM DYNAMICS high

Determination of metabolite of nicergoline in human plasma by high-performance liquid chromatography and its application in pharmacokinetic studies

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Journal of Pharmaceutical Analysis 2012年第1期2卷 62-66页

作者： Rong Zheng, Yi-Hong Wu, De-Xi Jiang, Dan Zhang West china School of Pharmacy, sichuan University, chengdu 61004., china West china School of Pharmacy Sichuan University Chengdu 610041 China.

A fast, simple and sensitive high performance liquid chromatographic (HPLC) method has been developed for determination of 10a-methoxy-6-methyl ergoline-8b-methanol (MDL, a main metabolite of nicergoline) in human plasma. One-step liquid–liquid extraction (LLE) with diethyl ether was employed as the sample preparation method. Tizanidine hydrochloride was selected as the internal standard (IS). Analysis was carried out on a Diamonsil ODS column (150 mm 4.6 mm, 5 mm) using acetonitrile–ammonium acetate (0.1 mol/L) (15/85, v/v) as mobile phase at detection wavelength of 224 nm. The calibration curves were linear over the range of 2.288–73.2 ng/mL with a lower limit of quantitation (LLOQ) of 2.288 ng/mL. The intra-and inter-day precision values were below 13% and the recoveries were from 74.47% to 83.20% at three quality control levels. The method herein described was successfully applied in a randomized crossover bioequivalence study of two different nicergoline preparations after administration of 30 mg in 20 healthy volunteers.

关键词： Nicergoline 10a-methoxy-6-methy- lergoline-8b-methanol (MDL) HPLC Plasma-drug concentration Bioequivalence study

银证分业与合业经营模式评析──兼论我国银证分业经营体制下的银证合作

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四川大学学报（哲学社会科学版） 2002年第1期 31-34页

作者：汝莹四川大学工商管理学院四川成都610064

国际银行业与证券业关系演变与现状为我国WTO环境下银证体制的构建提供了重要的借鉴。分业体制下的银证合作是我国应对入关后激烈金融竞争的积极主动策略。除了继续拓展经纪业等一般业务外，更应以合作创新为基础，彼此建立起在经营... 详细信息

国际银行业与证券业关系演变与现状为我国WTO环境下银证体制的构建提供了重要的借鉴。分业体制下的银证合作是我国应对入关后激烈金融竞争的积极主动策略。除了继续拓展经纪业等一般业务外，更应以合作创新为基础，彼此建立起在经营理念、资金实力、经营人才等方面的战略伙伴关系，实现更深层次如组织结构和股权层面上的合作。

关键词：银行银证分业经营体制银证合作

白刺属植物的川西新记录和澳大利亚间断分布途径的探讨

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山地学报 2006年第2期24卷 137-143页

作者：杨钦周四川省林业调查规划院四川省林业勘察设计研究院四川成都610081

四川西部干旱河谷新记录两种白刺属植物（柴达木白刺和西伯利亚白刺）,从它们的地理分布可以反射出干旱河谷现代植物区系起源古老,具有历史植物区系“活化石”意义,该区系与古地中海在时间上、与现代中亚（草原和荒漠）在空间上有着渊... 详细信息

四川西部干旱河谷新记录两种白刺属植物（柴达木白刺和西伯利亚白刺）,从它们的地理分布可以反射出干旱河谷现代植物区系起源古老,具有历史植物区系“活化石”意义,该区系与古地中海在时间上、与现代中亚（草原和荒漠）在空间上有着渊源联系。这两种白刺在川西是中生而不是旱生植物,生于干旱河谷灌丛（近似于中亚草原灌丛）而不是草原或荒漠中。根据植物地理学和地质学研究的一些例证,探讨了远离白刺属发生地和分布中心的比拉底白刺（或其祖型）,从非洲北部-阿拉伯地区经由印度和缅甸至马来西亚直达澳大利亚形成现代洲际间断分布的迁移途径。

关键词：白刺属四川西部新记录中生植物干旱河谷澳大利亚间断分布迁移途径

The fundamental theory of abstract majorization inequalities

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Science china Mathematics 2009年第10期52卷 2287-2308页

作者： YANG DingHua College of Mathematics and Software Sciences, sichuan Normal University, chengdu 610066, chinaAbstract College of Mathematics and Software Sciences Sichuan Normal University Chengdu 610066 China

Using the axiomatic method, abstract concepts such as abstract mean, abstract convex function and abstract majorization are proposed. They are the generalizations of concepts of mean, convex function and majorization, respectively. Through the logical deduction, the fundamental theorems about abstract majorization inequalities are established as follows: for arbitrary abstract mean Σ and $ \Sigma ' $ and abstract ∑ ? $ \Sigma ' $ strict convex function f(x) on the interval I, if x i , y i ∈ I (i = 1, 2,..., n) satisfy that $ (x_1 ,x_2 , \ldots ,x_n ) \prec _n^\Sigma (y_1 ,y_2 , \ldots ,y_n ) $ then $ \Sigma ' $ {f(x 1), f(x 2),..., f(x n )} ? $ \Sigma ' $ {f(y 1), f(y 2),..., f(y n )}. This class of inequalities extends and generalizes the fundamental theorem of majorization inequalities. Moreover, concepts such as abstract vector mean are proposed, the fundamental theorems about abstract majorization inequalities are generalized to n-dimensional vector space. The fundamental theorem of majorization inequalities about the abstract vector mean are established as follows: for arbitrary symmetrical convex set $ \mathcal{S} \subset \mathbb{R}^n $ , and n-variable abstract symmetrical $ \overline \Sigma $ ? $ \Sigma ' $ strict convex function $ \phi (\bar x) $ on $ \mathcal{S} $ , if $ \bar x,\bar y \in \mathcal{S} $ , satisfy $ \bar x \prec _n^\Sigma \bar y $ , then $ \phi (\bar x) \geqslant \phi (\bar y) $ ; if vector group $ \bar x_i ,\bar y_i \in \mathcal{S}(i = 1,2, \ldots ,m) $ satisfy $ \{ \bar x_1 ,\bar x_2 , \ldots ,\bar x_m \} \prec _n^{\bar \Sigma } \{ \bar y_1 ,\bar y_2 , \ldots ,\bar y_m \} $ , then $ \Sigma '\{ \phi (\bar x_1 ),\phi (\bar x_2 ), \ldots ,\phi (\bar x_m )\} \geqslant \Sigma '\{ \phi (\bar y_1 ),\phi (\bar y_2 ), \ldots ,\phi (\bar y_m )\} $ .

关键词： abstract mean abstract convex function abstract majorization abstract majorization inequality 26A51 26B25 39B62 52A01 60E15

Effect of recombinant human growth hormone and interferon gamma on hepatic collagen synthesis and proliferation of hepatic stellate cells in cirrhotic rats

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Hepatobiliary & Pancreatic Diseases International 2012年第3期11卷 294-301页

作者： Yong-Hua Chen, Bing-Qing Du, Zhen-Jiang Zheng, Guang-Ming Xiang, Xu-Bao Liu and Gang Mai Department of Hepatobiliopancreatic Surgery, West china Hospital, sichuan University, chengdu 61004., china Department of Hepatobiliopancreatic Surgery West China Hospital Sichuan University Chengdu 610041 China

BACKGROUND: Fibrosis plays a key role in the development of liver cirrhosis. In this study, we investigated the effect of growth hormone and interferon gamma on hepatic collagen synthesis and the proliferation of hepatic stellate cells in a cirrhotic rat model. METHODS: Cirrhosis was induced in rats using carbon tetrachloride. Rats were simultaneously treated with daily subcutaneous injections of recombinant human growth hormone or interferon gamma combined with recombinant human growth hormone. The control group was given saline. The relative content of type I and type IV collagen was assessed by indirect immunofluorescence analysis. Activated hepatic stellate cells were prepared from cirrhotic rats. The 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2H-tetrazolium bromide (MTT) method was used to assess the effects of recombinant human growth hormone and interferon gamma on these cells in vitro. RESULTS: Both qualitative and quantitative analysis showed that type I and type IV collagen secretion increased with time after recombinant human growth hormone administration and was significantly higher than control and recombinant human growth hormone combined with interferon gamma administration. In vitro, recombinant human growth hormone significantly stimulated hepatic stellate cell proliferation in a concentration-dependent manner (10 -3 -10 -1 mg/100 μL), andinterferon gamma (10 -2 -10 -1 μg/100 μL) significantly inhibited their growth compared to the control group. Interferon gamma combined with recombinant human growth hormone eliminated this growth-promoting effect to a certain degree in a concentration-dependent manner (10 -1 μg/100 μL, P2 -10 -3 μg/100 μL, P>0.05) and a time-dependent manner (P<0.05). CONCLUSIONS: Recombinant human growth hormone increased collagen secretion in cirrhotic rats in vivo and promoted the proliferation of hepatic stellate cells from cirrhotic rats in vitro. It is possible that concurrent interferon gamma therapy can offset

关键词： growth hormone interferon gamma hepatic stellate cell liver cirrhosis collagen

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岷江上游干旱河谷灌丛研究

山地学报 2007年第1期25卷 1-32页

作者：杨钦周四川省林业调查规划院四川省林业勘察设计研究院四川成都610081

岷江上游干旱河谷灌丛现代植物区系的基本特征是温带分布属占优势而含有较多的热带分布属,以及拥有许多古地中海残遗种和本地特有种,其与古地中海在时间上、与现代中亚(草原和荒漠)在空间上有着渊缘联系,热带属的种与温带荒漠、草原种... 详细信息

岷江上游干旱河谷灌丛现代植物区系的基本特征是温带分布属占优势而含有较多的热带分布属,以及拥有许多古地中海残遗种和本地特有种,其与古地中海在时间上、与现代中亚(草原和荒漠)在空间上有着渊缘联系,热带属的种与温带荒漠、草原种在此巧妙地聚集和组合是干旱河谷的特有现象,它可能是古地中海植物区系的延续和残遗的反映,在某种意义上可能是历史植物区系的'活化石'。幽深而封闭的峡谷地貌和青藏高原亚热带山地半干旱的暖温气候,以及干燥而贫瘠的山地(碱性)灰褐土是干旱河谷灌丛生境的基本特征。土壤湿度(水分相对含量)和肥力(有机质相对含量)的梯度分析,显示出半干旱-半贫瘠的土壤为其代表性的也是主要的生境类型。一种既无乔木群落(森林)又无草本群落(草原或草甸),而仅有矮灌木和半灌木占优势的灌木群落(矮灌丛),盖满了干旱河谷沿岸干燥山坡的荒凉景观,是岷江上游干旱河谷自然植被的现状概貌和基本特征。干旱河谷灌丛形成于特定的生态环境和地质历史的时空中,是一种处于森林与草原之间的而近似于草原灌丛的隐域性(非地带性或超地带性)植被。其含有的众多中亚荒漠、草原种,在干旱河谷多为中生或中生耐旱特性。因此,干旱河谷灌丛不是草原也更不是荒漠,而是中国-喜马拉雅地区夏雨性的冬旱灌丛(群系纲),它与地中海型气候的冬雨性夏旱灌丛(群系纲:如地中海的Macehia和北美洲的Chaparral等)同属于干旱(季节性)灌丛植被型的两个群系纲(Formation class)。从干旱河谷灌丛数量分析的样地相关性半矩阵中,析出的具有三角形网眼的灌丛之群系关联网(Relative net)和群系之样地关联网,显示了灌丛核心群系和群系的典型样地在关联网中的相关位置。干旱河谷灌丛沿着地质历史的长河在地貌形成与演化过程中,大约在上新世(或许更早)青藏高原尚处于夷平面发育时期,早先的干热性古植被(森林草原)中,就可能已经孕育着干旱河谷灌丛的雏型,至少与邻近的横断山区干旱河谷及中亚的荒漠、草原区(或泛、古地中海区)拥有许多共有种,继而在整个第四纪中不断发展和逐渐形成。在全新世最新的深切河谷中生存着第三纪古老植被的残遗类型和衍生后裔,是现代干旱河谷灌丛起源古老的历史性反映和植被现状的基本特征,它应该是一种原生性的植被(或顶极群落)。建立封山、禁止放牧和樵采以及保护自然植被的有效管理机制,综合开发干旱河谷自然环境中水、热优势资源的直接和间接的多种效益,是岷江上游干旱河谷保护和建设生态环境与发展区域经济的基本途径。岷江上游干旱河谷灌丛拥有十分特殊的古老植物区系和非常稀有的原始植被类型,在有限的地域内保存着古地中海植物区系的残遗成分和衍生后裔,在广阔的湿润森林地带的特定环境中生存着典型的冬旱灌丛,这些都是十分宝贵而稀有的自然遗产,对于研究我国西部的历史植物区系和自然地理,以及保护和建设现代生态环境和区域经济,都有着非常宝贵的科学价值和十分重要的现实意义。因此,特建议在岷江上游干旱河谷划出一定的面积建立自然保护区。保护地段可选设在杂谷脑河的甘堡至龙溪地区(包括主要支流的一部分河段)和岷江干流的飞虹桥至黑水河的沙坝(干旱中心)地区。

关键词：岷江上游干旱河谷植物区系植物群落冬旱灌丛草原灌丛关联网隐域植被自然保护区

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专家荐股信息的实证研究

四川大学学报（哲学社会科学版） 2003年第3期 51-54页

作者：李昆四川大学工商管理学院四川成都610064

对荐股信息发布后股票回报率的研究,显示分析师并没有预测股票未来走势的能力,依照他们的推荐来买卖股票不能提供超额的回报。荐股信息对投资人的投资决策有显著的影响。

关键词：有效市场专家荐股超额回报