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Hepatitis C virus genotypes, HLA-DRB alleles and their response to interferon-α and ribavirin in patients with chronic hepatitis C

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Hepatobiliary & Pancreatic Diseases International 2005年第1期4卷 80-83页

作者： Jian Jiao and Jiang-Bin Wang changchun, china Digestive department, china-Japan Union Hospital, jilin university, changchun 130031 , china Digestive department China-Japan Union Hospital Jilin University Changchun 130031 China. zxyjj@***

BACKGROUND: Hepatitis C virus (HCV) is a worldwide common disease. Some predictive factors influencing the response to interferon alpha (IFN-α) therapy have been identified, but the conclusions differ in various counties and areas. The aim of this study was to study the associa- tions between HCV genotypes, HLA-DRB alleles and their response to IFN-α and ribavirin in Chinese patients with chronic hepatitis C in Northeast china. METHODS: HCV genotypes of 113 patients with HCV were investigated. Gene chips were used to analyze the fre- quency of HLA-DRB in 25 of these patients and their re- sponse to IFN-α and ribavirin. The associations of HCV genotypes, HLA-DRB alleles and their response to IFN-α and ribavirin were also studied. RESULTS: The response rates differed in several types of HCV, with HCV 2b being the highest (57.78% ), HCV 1a and 2a lower (46.15% and 47.62% ) and HCV 1b the low- est (11.76% ). The response rates to IFN-α and ribavirin in patients with DRB1 07 were higher than those with DRB1 04. Sex, HCV type and HLA-DRB were all related to the response. Most female patients with HCV 2b and HLA- DRB1 07 presented complete response, whereas male pa- tients with HCV 1b and HLA-DRB1 04 usually demon- strated no response. DRB1 07 allele and HCV 2b were the factors closely related to the response. CONCLUSIONS: The response rate of HCV 1b may be the lowest even IFN-α and ribavirin are combined in treat- ment. Not only virus but also the host plays an important role in anti-virus therapy. Thus, it is necessary to adjust the host's immune status to accelerate the clearance of HCV.

关键词： chronic hepatitis C genotype HLA interferon-α ribavirin

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Robust observer-based control for uncertain discrete-time piecewise affine systems

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控制理论与应用（英文版） 2012年第2期10卷 236-243页

作者： Yahui GAO 1 , Zhiyuan LIU 2 , Hong CHEN 3 1.AVIC (Aviation Industry Corporation of china) china Aviation Motor Control System Institute, Wuxi Jiangsu 214063, china 2.department of Control Science and Engineering, Harbin Institute of Technology, Harbin Heilongjiang 150001, china 3.department of Control Science and Engineering, jilin university, changchun jilin 130025, china AVIC (Aviation Industry Corporation of china) china Aviation Motor Control System Institute Wuxi Jiangsu China department of Control Science and Engineering Harbin Institute of Technology Harbin Heilongjiang China department of Control Science and Engineering Jilin University Changchun Jilin China

The main contribution of this paper is to present a novel robust observer-based controller design method for discrete-time piecewise affine systems with norm-bounded uncertainties. The key ideas are to construct a piecewise quadratic Lyapunov function to guarantee the stability of the closed-loop systems, approximate polytopic operating regions by ellipsoids, and use the singular value decomposition technique to treat the constraint of matrix equality. It is shown that the suggested control method can be formulated as linear matrix inequalities that are numerically feasible with commer- cially available software. A numerical example is also given to verify the proposed approach.

关键词： Piecewise affine systems Robust control Observer Linear matrix inequality

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SOME RESULTS ON A DEGENERATE AND SINGULAR DIFFUSION EQUATION

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Acta Mathematica Scientia 2007年第3期27卷 581-601页

作者：姚正安周文书 department of Mathematics Zhongshan University

In this article, a degenerate and singular diffusion problem is studied. The existence of solutions is established by parabolic regularization. Some properties of solutions, for instance, asymptotic behavior, are also... 详细信息

关键词： Degenerate and singular diffusion equation weak solution existence asymptotic behavior

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On the studies of the vibrational spectra of cluster [Mo2O2S2（S2）2]2-

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Chinese Journal of Chemistry 1986年第1期4卷 42-47页

作者： LIANG Ying-Qiu ZHAO Wen-Yun XU Wei-Qing ZHANG Zhi-Gui Institute of Theoretical Chemistry, jilin university, changchun, china department of Chemistry, jilin university, changchun, china Institute of Theoretical Chemistry Jilin University Changchun China department of Chemistry Jilin University Changchun China

IR and Raman spectra of [Mo2O2S2（S2）2]2-were reported. The resonance Ramanspectra and the depolarization ratios in CH3CN solution were measured. By using the data of crystalstructure, the simplified normal coordinate calculation of the stretching vibrations for anion[Mo2O2S2（S2）2]2-was performed. The results obtained are useful to assign the vibrational bands ofsome Mo-Fe-S clusters.

关键词： Mo2O2S2 On the studies of the vibrational spectra of cluster

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PARTICLE DISTRIBUTION IN CENTRIFUGAL ACCELERATING FIELDS

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Chinese Journal of Mechanical Engineering 2003年第3期16卷 329-333页

作者： Yu SirongZhang XinpingHe ZhenmingLiu YaohuiCollege of Materials Scienceand Engineering,jilin university,changchun 130025, china College of Materials Science and Engineering Jilin University Changchun 130025

Based on continuum theory and moving law of particles, a model is presentedto obtain gradient distribution of particles in centrifugal accelerating field, by which theparticle distribution in gradient composite material can be predicted. The simulation shows withincreases in rotating time, four regions gradually appear from the internal periphery to theexternal one, they are free region, transition region, steady region and surface reinforced region,and the latest three regions are defined as a rich region. Finally, the steady region disappears,and the rich region only includes transition region and surface reinforced region. The influences ofcentrifugal acceleration coefficient G, primary volume fraction phi_0, pouring temperature theta_pand density difference between the particle and the metal matrix on particles gradient distributionare studied in detail. The results of the theoretical analysis agree with experiment ones. Both ofanalysis and experiment results indicate that with the increase in G and theta_p the particledistribution becomes more centralized and the consistence of particle in the surface peripherybecomes larger.

关键词： Centrifugal accelerating field Particles Numerical simulation Functionalgradient material

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Autoantibody against Cardiac β1-Adrenoceptor Induces Apoptosis in Cultured Neonatal Rat Cardiomyocytes

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Acta Biochimica et Biophysica Sinica 2006年第7期38卷 443-449页

作者： Yan GAO~1 Hui-Rong LIU~1 Rong-Rui ZHAO~1 Jian-Ming ZHI~(2*) 1 department of Cardiovascular physiology Shanxi Medical university,Taiyuan 030001,china 2 department of physiology,Shanghai Jiaotong university,College of basic medicine,Shanghai 200025,china departmentofCardiovascularphysiology ShanxiMedicalUniversityTaiyuan030001China departmentofphysiology ShanghaiJiaotongUniversityCollegeofBasicMedicineShanghai200025China

To clarify whether apoptosis is involved in the injury processes induced by autoantibodyagainst cardiac β1-adrenoceptor,we investigated the biological and apoptotic effects of antibodies on culturedneonatal rat *** rats were immunized with peptides corresponding to the second extra-cellular loop of the β1-adrenoceptor to induce the production of anti-β1-adrenoceptor antibodies in the ***（Ig）G in the sera was detected using synthetic antigen enzyme-linked immunosorbentassay and purified using the diethylaminoethyl cellulose ion exchange *** of cardiomyo-cytes was evaluated using agarose gel electrophoresis and flow *** results showed that thepositive serum IgG greatly increased the beating rates of cardiomyocytes and showed an"agonist-like"***,positive serum IgG induced cardiomyocyte apoptosis after treatment with β1-adrenoceptor overstimulation for *** effects of monoclonal antibody against β-adrenoceptor werealso found to be similar to those of positive serum *** was suggested that the autoantibody could inducecardiomyocyte apoptosis by excessive stimulation of β1-adrenoceptor.

关键词： β1-adrenoceptor rat cardiomyocyte autoantibody apoptosis

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Rotation-invariant Target Detection Using a Hybrid Optical Circular Harmonic Joint Transform Correlator with DC Bias

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Chinese Journal of Lasers 1999年第1期8卷 50-55页

作者： HUANG Xiaojing (department of basic Science, Fisheries College, Jimei university, Xiamen 361021, china)HUANG Xianlie (department of Physics, Xiamen university, Xiamen 361005, china) 集美大学渔业学院福建厦门 361021 厦门大学物理系福建厦门

１ＩｎｔｒｏｄｕｃｔｉｏｎＦｏｒｒｏｔａｔｉｏｎｉｎｖａｒｉａｎｔｐａｔｅｒｎｒｅｃｏｇｎｉｔｉｏｎ，ｔｈｅｓｐａｔｉａｌｍａｔｃｈｅｄｃｏｒｅｌａｔｏｒｉｓｏｆｔｅｎｕｓｅｄｂｙｔａｋｉｎｇａｃｉｒｃｕｌａｒｈａｒ... 详细信息

１ＩｎｔｒｏｄｕｃｔｉｏｎＦｏｒｒｏｔａｔｉｏｎｉｎｖａｒｉａｎｔｐａｔｅｒｎｒｅｃｏｇｎｉｔｉｏｎ，ｔｈｅｓｐａｔｉａｌｍａｔｃｈｅｄｃｏｒｅｌａｔｏｒｉｓｏｆｔｅｎｕｓｅｄｂｙｔａｋｉｎｇａｃｉｒｃｕｌａｒｈａｒｍｏｎｉｃｃｏｍｐｏｎｅｎｔ（ＣＨ...

关键词： optical pattern recognition circular harmonic function joint transform correlator

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Effect of Cycloheximide on the Adaptive Response Induced by Low Dose Radiation

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Biomedical and Environmental Sciences 1992年第1期5卷 46-52页

作者： CAI Lu AND LIu SHUZHENGdepartment of Radiation Biology, Institute of Radiation medicine, Norman Bethune university of Medical Sciences, changchun 130021, china Corresponding author department of Radiation Biology Norman Bethune University of Medical Sciences Changchun China.

Human lymphocytes pre-exposed to 10 mGy or 50 mGy of X-rays become less sensitive to subsequent large dose irradiation, exhibited lower rate of chromosome aberration than expected. This adaptive response could be inhibited by cycloheximide, a protein synthesis inhibitor for successive 2 h period ranging from 0.5h before to 4h after the low dose exposure, indicating that the adaptive response was directly related with the protein synthesis.

关键词： In Effect of Cycloheximide on the Adaptive Response Induced by Low Dose Radiation

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Database of open-framework aluminophosphate syntheses:introduction and application(Ⅰ)

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Science china Chemistry 2009年第11期52卷 1734-1738页

作者： YAN Yan1,LI JiYang1,QI Miao2,ZHANG Xiao1,YU JiHong1 & XU RuRen1 1 State Key Laboratory of Inorganic Synthesis and Preparative Chemistry,jilin university,changchun 130012,china 2 department of Chemistry,Northeast Normal university,changchun 130117,china 1. State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin University Changchun 130012 China 2. department of Chemistry Northeast Normal University Changchun 130117 China

The database of open-framework aluminophosphate(AlPO) syntheses has been established,which includes about 1600 synthetic *** analysis has been done on the basis of the framework composition,structure dimension,pore ring,and organic *** database will serve as useful guidance for the rational synthesis of microporous functional materials.

关键词： aluminophosphates open framework synthesis database

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Complete quantum circuit of Haar wavelet based MRA

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Chinese Science Bulletin 2005年第16期50卷 1796-1798页

作者： HE Yuguo1,2 & SUN Jigui1,3 1. College of Computer Science and Technology, jilin university, changchun 130012, china 2. department of Computer Science and Engineering, Beijing Institute of Technology, Beijing 100081, china 3. Key Laboratory of Computation and Knowledge Engineering of Min-istry of Education, jilin university, changchun 130012, china College of Computer Science and Technology Jilin University Changchun 130012 China

Wavelet analysis has applications in many ar- eas, such as signal analysis and image processing. We pro- pose a method for generating the complete circuit of Haar wavelet based MRA by factoring butterfly matrices and con- ditional perfect shuffle permutation matrices. The factoriza- tion of butterfly matrices is the essential part of the design. As a result, it is the key point to obtain the circuits of I 2t ⊕ W ⊕ I 2n ? 2t ?2. In this paper, we use a simple means to de- velop quantum circuits for this kind of matrices. Similarly, the conditional permutation matrix is implemented entirely, combined with the scheme of Fijany and Williams. The cir- cuits and the ideas adopted in the design are simple and in- telligible.

关键词：量子计算量子算法量子电路 Haar微波 MRA

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