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Calcitonin gene-related peptide inhibits interleukin-1β-induced interleukin-8 secretion in human type Ⅱ alveolar epithelial cells

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Acta Pharmacologica Sinica 2006年第10期27卷 1340-1345页

作者： Wen-jing LI Teng-ke WANG Xian WANG~2 department of physiology,school of basic Medical Sciences,Peking university,Key Laboratory of Molecular Cardiovascular Science,Ministry of Education,Beijing 100083,china department of physiology School of Basic Medical Sciences Peking University Key Laboratory of Molecular Cardiovascular Science Ministry of Education Beijing 100083 China

Aim:Our previous data have shown that type Ⅱ alveolar epithelial(AEⅡ)cellsexpress neuropeptide calcitonin gene-related peptide(CGRP),and that pro-in-flammatory factor interleukin 1-β(IL-1β)induces CGRP secretion in the A549 hu-man AEⅡ cell *** the present study,we investigated the effect of endogenousand exogenous CGRP on IL-1β-induced chemokine interleukin-8(IL-8)***:We used enzyme-linked immunosorbent assay(ELISA)and RT-PCR todetect IL-8 protein and mRNA levels,respectively,siRNA and the stably trans-fected cell line were used to knock down and overexpress the CGRP gene,respectively,and chemiluminescence assay was used to detect reactive oxygenspecies(ROS)***:CGRP-1 receptor antagonist hCGRP8-37(0.1-1nmol·L-1)greatly amplified IL-1β-induced IL-8 *** inhibition of CGRPexpression by siRNA significantly increased IL-8 secretion upon IL-1β ***,cell clones stably transfected with CGRP showed significantly inhibitedmRNA and protein levels of IL-8 induced by 1L-1β.Conclusion:These data implythat AEⅡ cell-derived CGRP suppress IL-1β-induced IL-8 secretion in an autocrine/paracrine *** investigation showed that CGRP attenuated IL-1β-arousedROS formation,which is an early indication of pro-inflammatory factor signaling.

关键词： type Ⅱ alveolar epithelial cells interleukinl interleukin-8 calcitonin gene-related peptide anti-inflammation lung reactive oxygen species

COMPUTATION OF HOPF BRANCHES BIFURCATING FROM A HOPF/PITCHFORK POINT FOR PROBLEMS WITH Z_2-SYMMETRY

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Journal of Computational Mathematics 1998年第5期16卷 403-416页

作者： Bai－sheng Wu (department of Mathematics,jilin university, changchun 130023, china)Tassilo Kupper (Institute of Mathematics, university of Cologne, D-50931 Koln, Germany) jilin Univ Dept Math Changchun 130023 Peoples R China Univ Cologne Inst Math D-50931 Cologne Germany

This paper is concerned with the computation of Hopf branches emanating from a Hopf/Pitchfork point in a two-parametor nonlinear problem satisfying a Z2symnletry condition. Our aim is to present a new al,proach to the theoretical and computational analysis of the bifurcating Hopf branches at this singular point by using the system designed to calculate Hopf points and exploring its symmetry. It is shown that a Hopf/Pitchfork point is a pitchfork bifurcation point in the *** standard continuation and branch-switching can be used to compute these Hopf branches. In addition, an effect method based on the extended system of the singular points is developed for the computation of branch of secondary (nonsymmetric) Hopf points. The implementation of Newton's method for solving the extended system is also discussed. A numerical example is ***: Hopf/Pitchfork point, Z2-symmetry, Hopf point, bifurcation, Extended system

关键词： Hopf/pitchfork point Z_2-symmetry Hopf point bifurcation Extended system

Study on the Mode Losses and Bending Lossesof Hollow-core Optical Fiber of GeO2 andSiO2 Bases for Transmitting CO2 Laser Energy

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Chinese Journal of Lasers 1996年第1期B5卷 27-32页

作者： HOU Lantian (department of Physics,jilin university,changchun 130023 china)SUN Yingzhi (Light Communication department,changchun Poat and Telecommunication Institte,changchun 130012,china)ZHAO Bin(department of Physics,Science and Technology university of jilin Univ Changchun China

The transmitting losses of several lower modes for four kinds of straight and bent circular hollow optical fibers （waveguide） made up with GeO2 or SiO2 and doped with PbO or Sb2O3 respectively are calculated. The results show that the HE11 mode has the minimum loss in straight waveguide and the loss of TM01 mode in bent waveguide is the minimun.

关键词： hollow-core optical fiber low-order mode bending loss

The rate of convergence of the Lax-Oleinik semigroup-degenerate fixed point case

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Science china Mathematics 2011年第3期54卷 545-554页

作者： WANG KaiZhi1,2 & YAN Jun1 1school of Mathematical Sciences and Key Lab of Mathematics for Nonlinear Science, Fudan university, Shanghai 200433, china 2school of Mathematics, jilin university, changchun 130012, china 1. school of Mathematical Sciences and Key Lab of Mathematics for Nonlinear Science Fudan University Shanghai 200433 China2. School of Mathematics Jilin University Changchun 130012 China

For the standard Lagrangian in classical mechanics, which is defined as the kinetic energy of the system minus its potential energy, we study the rate of convergence of the corresponding Lax-Oleinik semigroup. Under the assumption that the unique global minimum point of the Lagrangian is a degenerate fixed point, we provide an upper bound estimate of the rate of convergence of the semigroup.

关键词： Hamiltonian system weak KAM theorem Lax-Oleinik semigroup

SYNTHESIS AND CHARACTERIZATION OF A SERIES OF NOVEL INORGANIC MICROPOROUS CRYSTALS,BePO_4-CIn(n=4-7).

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Chinese Chemical Letters 1991年第1期2卷 67-70页

作者： Long YU Wenqin PANG (department of Chemistry,jilin university,changchun,130021)

A series of novet beryllophosphate zeolites,named BePO_4-CIn(n=4-7), are synthesized hydrothermally and characterized with X-ray powder diffraction,IR spectra,SEM,thermat analysis and ion-exchange.

关键词： n=4-7 CJ SYNTHESIS AND CHARACTERIZATION OF A SERIES OF NOVEL INORGANIC MICROPOROUS CRYSTALS,BePO4-CIn n

A local spin evaluation into the active site models of [2Fe2S] ferrodoxin [Fe_2S_2(SR)_4]^(2-) (R=-H, -CH_3)

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Science china Chemistry 2007年第3期50卷 327-334页

作者： WEI JiChong1,2, WANG Yan3 & JU GuanZhi2,3 1 department of Chemistry, Hainan Normal university, Haikou 571158, china 2 State Key Laboratory of Theoretical and Computational Chemistry, jilin university, changchun 130023, china 3 department of Chemistry, Nanjing university, Nanjing 210093, china 1. department of Chemistry Hainan Normal University Haikou 571158 China 2. State Key Laboratory of Theoretical and Computational Chemistry Jilin University Changchun 130023 China 3. department of Chemistry Nanjing University Nanjing 210093 China

To test the feasibility of local spin theory of Davidson and Clark for ferrodoxin clusters, the models [Fe2S2(SR)4]2- (R=-H, -CH3) are chosen for evaluation. This purpose is realized by calculating the local spin expectation values , 2 >, and mA and discussing the connection between these expected values and the Heisenberg spin model (HSM) and the Noodleman broken-symmetry approach. In practical calculation, the spin-unrestricted Hartree-Fock (UHF) and spin-polarized density functional theory (DFT) are used and the calculational qualities of these two methods are also discussed. In addition, the theoretical magnetic coupling constants JAB of these models are calculated by various computational schemes for comparison with both theoretical and experimental results previously reported.

关键词： local spin iron-sulfur protein model density function theory magnetic coupling constant

Urotensin Ⅱ inhibits carotid sinus baroreflex in anesthetized male rats

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Acta Pharmacologica Sinica 2007年第2期28卷 216-220页

作者： Yu-ming WU Hong-mei XUE Lin XIAO Rui-rong HE~1 department of physiology Institute of basic medicine,Hebei Medical university,Shijiazhuang 050017,china department of physiology Institute of Basic Medicine Hebei Medical University Shijiazhuang China

Aim:To study the effects of urotensin Ⅱ(UⅡ)on the carotid sinus baroreflex(CSB).Methods:The functional curve of carotid sinus baroreflex was measuredby recording changes in arterial pressure in anesthetized male rats with perfusedisolated carotid ***:UⅡ at the concentration of 3 nmol/L had no effecton the CSB,while at the concentration of 30,300 and 3000 nmol/L inhibited theCSB,shifting the functional curve of the baroreflex upward and to the *** a marked decrease in peak slope and reflex decrease in blood *** of UⅡ were *** with verapamil(anantagonist of the L-type calcium channel,10 μmol/L)partially eliminated *** of UⅡ(300 nmol/L)on the *** with BIM-23127(3 μmol/L),an antagonist of human and rat UⅡ receptors,abolished the actions of UⅡ on *** with N~G-nitro-L-arginine methyl ester(L-NAME)100 μmol/L didnot affect the inhibitory effects of UⅡ(300 nmol/L)on the ***:These data suggest that UⅡ exerts an inhibitory action on the isolated *** action of UⅡ is predominantly mediated by the UⅡ receptors in vascular smoothmuscles,resulting in the opening of L-type calcium channels.

关键词： urotensin ]I carotid sinus baroreflex verapamil BIM-23127 L-NAME

A method of combining SE-tree to compute all minimal hitting sets

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Progress in Natural Science:Materials International 2006年第2期16卷 169-174页

作者： ZHAO Xiangfu and OUYANG Dantong (school of Computer Science and Technology, jilin university, changchun 130012, china Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, changchun 130012, china) [a]school of Computer Science and Technology Jilin University Changchun China

In model-based diagnosis, the candidate diagnostic results are generally characterized by all minimal hitting sets for the collection of all conflict sets. In this paper, a new method is proposed to judge a hitting set by the number of conflict sets corresponding to components, and the computing procedure is formalized by combining revised SE-tree (set enumeration tree) with closed nodes to generate all minimal hitting sets. Results show that because closed nodes are added into SE-tree, the search efficiency is highly improved. Furthermore, the proposed method is easy to be understood and implemented. Compared with other effective algorithms with completeness in some experimental tests, the diagnosis efficiency of our proposed method is higher, particularly for single- and double-fault diagnosis.

关键词： model-based diagnosis conflict set minimal hitting set set enumeration tree.

Acute pancreatitis as a complication of acute COVID-19 in kidney transplant recipients

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World Journal of Clinical Cases 2024年第6期12卷 1104-1110页

作者： Nikolina basic-Jukic Ivana Juric Lea Katalinic Vesna Furic-Cunko Vibor Sesa Anna Mrzljak department of Nephrology Arterial HypertensionDialysis and TransplantationUniversity Hospital Centre ZagrebZagreb 10000Croatia department of medicine School of MedicineZagreb 10000Croatia department of Gastroenterology and Hepatology University Hospital Centre ZagrebZagreb 10000Croatia

BACKGROUND Acute pancreatitis is a rare extrapulmonary manifestation of coronavirus disease 2019(COVID-19)but its full correlation with COVID-19 infection remains *** To identify acute pancreatitis’occurrence,clinical presentation and outcomes in a cohort of kidney transplant recipients with acute *** A retrospective observational single-centre cohort study from a transplant centre in Croatia for all adult renal transplant recipients with a functioning kidney allograft between March 2020 and August 2022 to record cases of acute pancreatitis during acute *** were obtained from hospital electronic medical *** acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection was proven by a positive SARS-CoV-2 real-time reverse transcriptase-polymerase chain reaction on the nasopharyngeal *** Four hundred and eight out of 1432(28.49%)patients who received a renal allograft developed COVID-19 *** analyzed cohort included 321 patients(57%males).One hundred and fifty patients(46.7%)received at least one dose of the anti-SARS-CoV-2 vaccine before the *** hundred twenty-five(39.1%)patients required hospitalization,141(44.1%)developed pneumonia and four patients(1.3%)required mechanical *** included immunosuppression modification in 233 patients(77.1%)and remdesivir in 53 patients(16.6%),besides the other supportive *** the study cohort,only one transplant recipient(0.3%)developed acute pancreatitis during acute COVID-19,presenting with abdominal pain and significantly elevated pancreatic *** survived without complications with a stable kidney allograft *** Although rare,acute pancreatitis may complicate the course of acute COVID-19 in kidney transplant *** mechanism of injury to the pancreas and its correlation with the severity of the COVID-19 infection in kidney transplant recipients warrants further research.

关键词： Acute pancreatitis COVID-19 Kidney transplant Angiotensin-converting enzyme-2 receptor Immunosuppressive agents