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GBE50对高脂大鼠脑缺血再灌注损伤的保护作用

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复旦学报（医学版） 2004年第5期31卷 502-504页

作者：朱桂荣潘家祜复旦大学药学院药理学教研室上海200032

目的　研究新型银杏叶提取物制剂GBE5 0对高脂血症大鼠脑缺血再灌注损伤的保护作用。方法　在高脂血症大鼠上 ,建立大脑中动脉栓塞 (McAO)再灌注损伤模型 ,观察灌胃给予GBE5 0 (5 0、10 0、2 0 0mg/kg) 2周 ,对大鼠脑梗死体积、神经行... 详细信息

目的　研究新型银杏叶提取物制剂GBE5 0对高脂血症大鼠脑缺血再灌注损伤的保护作用。方法　在高脂血症大鼠上 ,建立大脑中动脉栓塞 (McAO)再灌注损伤模型 ,观察灌胃给予GBE5 0 (5 0、10 0、2 0 0mg/kg) 2周 ,对大鼠脑梗死体积、神经行为学、血液流变学等指标的影响。结果　高脂McAO模型组大鼠脑梗死体积为(31± 5 ) % ,神经行为评分为 2 .7± 0 .8;给予GBE5 0小、中、大剂量三组的高脂McAO大鼠的脑梗死体积分别为(13± 4 ) %、(14± 4 ) %和 (13.0± 2 .6 ) % ,与模型组比较差异有显著意义 (P cAO大鼠的脑梗死体积 ,改善神经行为障碍和血液流变学。

关键词：大鼠高脂脑梗死体积保护作用脑缺血再灌注损伤 McAO 神经行为学新型还原降低

cardiac protection of new compounds from scientific chinese medicine (ScM)

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Cardiac protection of new compounds from scientific Chinese ...

两岸三地药理学与临床药理学术会议

作者： ZHU Yi-zhun (department of Pharmacology, school of pharmacy, fudan university, shanghai 200032, c.ina)

Objective Purification and Standardization of chinese herbal extracts became a hot topic since last *** traditional chinese medicine(TcM)has been used as a mixture from several herbs for cen- turies,it has been drawn much attention for studying the standardized chinese herbs using modern technolo- *** Recently,we compared purified Salvia miltiorrhiza extract(PSME)with angiotensin-con- verting enzyme inhibitor,Ramipril,in in vitro experiments and also in vivo using animal model of myocar- dial *** PSME was found to have a significantly higher trolox equivalent antioxidant capacity which indicated a great capacity for scavenging free *** could also prevent pyrogalto red bleach- ing and DNA *** 2 weeks treatment with PSME or Ramipril,survival rates of rats with experi- mental myocardial infarction were marginally increased(68.2% and 71.4%)compared with saline (61.5%).In another recent study,we evaluated the cardioprotective effects of PSME on myocardial is- chemia/reperfusion injury in isolated rat hearts and in hypoxic vascular smooth muscle *** found that PSME treated hearts showed significant postischemic contractile function recovery(develop pressure recov- ered to 44.2±4.9% versus 17.1±5.7%,Pcontraction recovered to 57.2±5.9% ver- sus 15.1±6.3%,Pcontrol group respectively).conclusions Significant elevated in end-diastolic pressure, which indicated LV stiffening in PSME hearts might be resulted by exceed dose of PSME *** and standardized chinese herb could provide an alternative regimen for the prevention of ischemic heart disease.

关键词： traditional chinese medicine purified Salvia miltiorrhiza extract myocardial infarction ramipril

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5-单硝基异山梨酯制剂的合理选用

中国新药与临床杂志 2004年第4期23卷 243-245页

作者：李端复旦大学药学院药理学教研室上海200032

本文根据 5 单硝基异山梨酯口服片剂和静脉滴注制剂药动学的性质和参数差异。

关键词：硝酸盐类剂型药物疗法异山梨酯硝酸

HPLc-ELSD法测定小百部中小百部苷B的含量

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复旦学报（医学版） 2004年第5期31卷 521-523页

作者：白桦冯举陈道峰复旦大学药学院生药学教研室上海200032

目的　建立测定小百部 (AsparagusfilicinusBuch . Ham)中小百部苷B含量的方法 ,评价不同产地药材的质量。方法　高效液相色谱法。色谱柱 :ZorbaxEclipseXDB c18柱 (5 μm ,15 0mm× 4 .6mm) ;流动相 :甲醇水(82∶18) ;流速 :1.0mL/mi... 详细信息

目的　建立测定小百部 (AsparagusfilicinusBuch . Ham)中小百部苷B含量的方法 ,评价不同产地药材的质量。方法　高效液相色谱法。色谱柱 :ZorbaxEclipseXDB c18柱 (5 μm ,15 0mm× 4 .6mm) ;流动相 :甲醇水(82∶18) ;流速 :1.0mL/min ;柱温 :35℃ ;ELSD参数 ;漂移管温度为 10 0℃ ,气体流量 1.5L/min。结果　小百部苷B在 1.0～ 10 .0 μg范围内呈良好的线性关系 ,r =0 .9997,平均加样回收率为 96 .74 % ,RSD =1.90 % (n =5 )。结论　以HPLc ELSD法测定小百部中小百部苷B含量的方法可行。

关键词： HPLc-ELSD法含量百部生药不同产地指标成分高效液相色谱法甲醇回收率色谱柱

Pharmacokinetics of esomeprazole in relation to genetic polymorphism of cYP2c19 in chinese subjects

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Pharmacokinetics of esomeprazole in relation to genetic poly...

2006第六届中国药学会学术年会

作者： Zhong Longjin1, cheng Nengneng2, Wang yongming2, 1 fudan university, Huashan Hospital, pharmacy department, shanghai 200040 2 fudan university, pharmacy school, shanghai 200032

Objective:To determine whether the pharmacokinetics of esomeprazole depend on the cYP2c19 genotype status in chinese subjects. Methods:A single oral 40-mg dose of esomeprazole was administered to 5 subjects who were homozygous extensive metabolisers （homEMs）, 10 subjects who were heterozygous extensive metabolisers （hetEMs） and 8 subjects who were poor metabolisers （PMs） recruited from 93 healthy chinese volunteers whose genotypes were predetermined by polymerase chain reaction-based amplification, followed by polymerase chain reaction-restriction fragment length polymorphism analysis （PcR-RFLP）. The plasma concentrations of esomeprazole and its two metabolites, hydroxyesomeprazole and esomeprazole sulphone, were determined by a reversed-phase HPLc method. Results: Twenty-nine subjects were homozygous （wt/wt） for the wt allele in both exon 5 and 4. Forty-five and six subjects were heterozygous for the cYP2c19m1 mutatiom （wt/m1） and the cYP2c19m2 mutatiom （wt/m2）, respectively. Nine and one subjects were homozygous with the defect in exon 5 （m1/m1） and exon 4 （m2/m2）, respectively. Three subjects were heterozygous with the two defects in exon 5 and 4 （m1/m2）. The pharmacokinetic parameters of esomeprazole AUc0-12, cmax, cL and t1/2 in homEMs, hetEMs and PMs were （11.08±4.95） μmol.h.L-1, （15.65±6.55） μmol.h.L-1 and （26.21±4.96） μmol.h.L-1;（4.11±1.95） μmol.L-1, （4.36±1.28） μmol.L-1 and （7.28±2.30） μmol.L-1;（10.03±6.73） L.h-1, （7.29±4.08） L.h-1 and （3.92±0.98） L.h-1;（1.26±0.41） h-1, （1.71±0.46） h-1 and （2.43±1.08） h-1, respectively. The pharmacokinetic parameters of 5-hydroxyomeprazole AUc0-12 and cmax in homEMs, hetEMs and PMs were （1.62±0.24） μmol.h.L-1, （1.60±0.34） μmol.h.L-1 and （1.58±0.46） μmol.h.L-1;（0.54±0.28） μmol.L-1, （0.47±0.21） μmol.L-1 and （0.45±0.16） μmol.L-1, respectively. The pharmacokinetic parameters of omeprazole sulphone AUc0-12 and cmax in homEMs, hetEMs and PMs were （10.96±5.70） μmol.h.L-1, （15.53±6.35） μmol.h.L-1 and （25.44±6.37） μmol.h.L-1;（1.56±0

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2-甲氧基雌二醇合成方法的改进

复旦学报（医学版） 2003年第5期30卷 494-495页

作者：张蓓娜王宏博张倩陈瑛夏鹏复旦大学药学院药物化学教研室上海200032

目的　合成抗肿瘤新药新生血管形成抑制剂 2 甲氧基雌二醇。方法　以雌二醇为原料经 2 位溴代 ,继而甲氧基化直接合成 2 甲氧基雌二醇。结果　改进的合成方法割除了文献报道方法中的 3,17 双乙酰化及水解二个反应步骤 ,合成获得的 2 ... 详细信息

目的　合成抗肿瘤新药新生血管形成抑制剂 2 甲氧基雌二醇。方法　以雌二醇为原料经 2 位溴代 ,继而甲氧基化直接合成 2 甲氧基雌二醇。结果　改进的合成方法割除了文献报道方法中的 3,17 双乙酰化及水解二个反应步骤 ,合成获得的 2 甲氧基雌二醇成品进行了结构确证。结论　通过有效地纯化 2 溴雌二醇中间体 ,可缩短二步反应直接制得成品。

关键词： 2-甲氧基雌二醇合成方法抗肿瘤药 2-溴雌二醇中间体雌二醇

Total synthesis of grassystatin A,a linear peptide from marine cyanobacteria

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Total synthesis of grassystatin A,a linear peptide from mari...

2011年全国药物化学学术会议——药物的源头创新

作者： Siming Yang,Wei Zhang,Ning Ding,Yingxia Li~* department of medicinal chemistry,school of pharmacy,fudan university,shanghai 201203, c.ina

＜正＞cathepsin E（cat E） is an intracellular aspartic protease that is mainly present in the immune system. cat E is highly homologous to the analogous aspartic protease cathepsin D（cat D）.So far,the physiological...

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cYcLOPEPTIDES FROM STELLARIA DELAVAYI

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chinese chemical Letters 1996年第2期7卷 149-152页

作者： Yu Rut ZHAO Jun ZHOU Xiang Kai WANG Hou Ming WU Xiao Lin HUANG (department of medicinal chemistry of Natural Products,school of pharmacy. West c.ina university of Medical Sciences, chengdu 610041)(Laboratory of Phytochemistry, Kunming Institute of Botan W c.ina UNIV MED ScI SCH PHARMDEPT MED CHEM NAT PRODCHENGDU 610041PEOPLES R CHINA cHINESE AcAD ScI KUNMING INST BOTLAB PHYTOCHEMKUNMING 650204PEOPLES R CHINA cHINESE AcAD ScI SHANGHAI INST ORGAN CHEMSTATE KEY LAB BIOORGAN & NAT PROD CHEMSHANGHAI 200032PEOPLES R CHINA

Further chemical study on Stellaria delavayi led to the isolation of two ether new cyclopeptides, namely stelladelin B and c. On the basis of spectroscopic analysis and chemical evidence, their structures were established as cyclo(Gly-Ile-Pro(2)-Pro(1)-Ala-Tyr-Asp-Leu) and cylo(Val-Pro(3)-Tyr(2)-Pro(2)-Pro(1)-Phe-Tyr(1)-Ser), respectively.

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Apolipoprotein A-I attenuates renal ischemia/reperfusion injury in rats

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Apolipoprotein A-I attenuates renal ischemia/reperfusion inj...

第四届全国血脂分析与临床学术研讨会暨第九届全国脂蛋白学术会议

作者： Ning Shi Man-Ping Wu department of Biochemistry,school of pharmacy,fudan university,shanghai,200032,c.ina

Introduction Renal ischemia,occurring during transplantation,shock,vascular surgery,is a major cause in the devel- opment of ischemic acute renal failure,which has been known to result in high morbidity and ***-

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