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Science china(Life Sciences) 2008年第11期51卷 1039-1044页

作者： DONG XiaoQing1, XU Jun2, WANG WeiCai1, Luo Hao1, LIANG XiaoFei1, Zhang Lei1, Wang HanJie1, Wang PengHua2 & CHANG Jin1 1 Institute of Nanobiotechnology, School of Materials Science and Engineering, Tianjin university, Tianjin 300072, china 2 department of Diabetic Foot, Tianjin Medical university Metabolic Disease Hospital, Tianjin 300070, china 1. Institute of Nanobiotechnology School of Materials Science and Engineering Tianjin University Tianjin 300072 China 2. department of Diabetic Foot Tianjin Medical University Metabolic Disease Hospital Tianjin 300070 China

In this study the w/o/w extraction–evaporation technique was adopted to prepare poly(lactic-co-glycolic acid) (PLGA) microspheres loading recombinant human epidermal growth factor (rhEGF). The micro-spheres were characterized for morphology by transmission electron microscopy (TEM) and particle size distribution. The release performances, the proliferation effects and therapeutic effects of rhEGF-loaded PLGA microspheres were all studied. The results showed that these spherical micro-spheres had a narrow size distribution and a high drug encapsulation efficiency (85.6%). RhEGF-loaded microspheres enhanced the growth rate of fibroblasts and wound healing more efficiently than pure rhEGF. The number of the proliferating cell nuclear antigen (PCNA) in the epidermis layer with the mi-crosphere treatment was significantly larger than those of the control groups. Overall locally sustained delivery of rhEGF from biodegradable PLGA microspheres may serve as a novel therapeutic strategy for diabetic ulcer repair.

关键词： rhEGF microspheres the diabetic ulcer recombinant human epidermal growth factor PLGA

High-Accuracy Measurement of the Dispersion of Chirped Fiber Gratings

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Chinese Journal of Lasers 2000年第4期9卷 32-37页

作者： SHU Xuewen 1 SHI Wei 2 JIANG Shan 2 HUANG Dexiu 1 ( 1 department of Optoelectronics, Huazhong university of Sciences and Technology, Wuhan 430074, china 2 Solid Devices Institute, Wuhan Research Institute of Posts and Telecommunica 华中理工大学湖北武汉武汉邮电科学研究院湖北武汉

A high accuracy test system for the dispersion measurement of chirped fiber gratings has been developed. The principle is based on converting the difficult measurement of the phase delay of light into the simple measurement of microwave. In our novel configuration, a lightwave component analyzer is used for the measurement of the phase delay with high resolution and as frequency tunable RF source. The test system has a wavelength resolution of 1 pm and a time delay resolution of <1 ps. A linearly chirped fiber reflection grating and a Gaussian apodized Bragg transmission grating have been tested with high resolution. Influences of noise in the measurements are also discussed and some new ideas are presented.

关键词： chirped fiber grating Bragg grating dispersion measurement

Effect of VKORC1 polymorphism on warfarin dose

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上海医学 2007年第S1期30卷 183-183页

作者： JIANG Lin-xin XU Biao department of Cardiology, Affiliated Drum Tower Hospital of nanjing university Medical School, nanjing 210008, china

Objective To analyze the association of polymorphism in C1173T of VKORC1 with warfarin dose. Methods There are 102 patients to be selected into the research ,who were treated with *** conducted a retrospective study to analyze the effect of C1173T polymorphism on warfarin dose. Results Of 102 patients,83(81.4%) patients with TT haplotypes,16(15.7%)

关键词： retrospective Polymorphism genotype

A NOVEL RESISTIVE HUMIDITY SENSOR BASED ON SODIUM POLYSTYRENESULFONATE/TiO_2 NANOCOMPOSITES

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Chinese Journal of Polymer Science 2002年第3期20卷 237-241页

作者： Yang Li Mu-jie Yang Yong She department of Polymer Science and Engineering Zhejiang university, Hangzhou 310027 china Zhejiang Univ Dept Polymer Sci & Engn Hangzhou 310027 Peoples R China

A resistive humidity sensor was prepared based on sodium polystyrenesulfonate (NaPSS)/TiO2 nanocomposites, and its electrical response to humidity was examined. The sensor exhibits better linearity, smaller hysteresis (2 s; desorption: less than 20 s) in comparison with sensor composed of NaPSS. The effect of concentration of NaPSS and TiO2 on humidity response of sensors was discussed.

关键词： humidity sensor nanocomposites TiO2 sodium polystyrenesulfonate

On Exponential Stability of Switched Systems with Delay: Multiple Lyapunov Functions Approach

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On Exponential Stability of Switched Systems with Delay: Mul...

Inflammatory responses to Hydroxyapatite implants in middle ear in rats

第二十六届中国控制会议

作者： Cong Shen1,3,Qian Wei2,Fei Shumin3 1.department of Automation,nanjing university of Science and Technology,nanjing 210094,P.R.china2.department of Computer Science and Technology,Henan Polytechnic university,Jiaozuo 454000,P.R.china3.Research Institute of Automation,Southeast university,nanjing 210096,P.R.china

The switched system composed of several linear time-delay systems is *** problem is to find the constraint conditions on subsystems and switching sequences to preserve the exponential *** multiple Lyapunov functions approach is generalized to the time-delay case,it is verified that the specified stability criterion for subsystems implies the exponential stability of whole system whenever the segments between two consecutive switching instants are greater than a prescribed *** results include the correpondent conclusion of stability analysis in the case without *** examples are given to demonstrate our results.

关键词： Switched Systems Time-Delay Exponential Stability Delay-Independence

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Journal of Otology 2008年第1期3卷 24-28页

作者： YE Qing 1, 2, JIANG Yi 1, 2, WANG Xiao-yan1, 2, ZHENG Ke-fei 1, 2 1 department of Otolaryngology, Fujian Provincial Hospital, Fuzhou 350001, china 2 department of Otolaryngology, Fujian Medical university, Fuzhou 350001, china department of Otolaryngology Fujian Provincial Hospital Fuzhou 350001 China department of Otolaryngology Fujian Medical University Fuzhou 350001 China

Objective To study local inflammatory response after implantation of hydroxyapatite synthetic ossicular prosthesis. Methods Hydroxyapatite granules were implanted in the bulla in 32 rats. Sham surgical procedures were performed in 10 rats as the control. Animals were sacrificed at 1 to 300 days after surgery. Bulla sections, stained with HE and Mallory’s azan, were examined for numbers and percentages of various inflammatory cell types. Results Slightly more inflammatory reaction was seen in animals with the implant than in the controls, mostly during the early stage following the implantation procedure. Few inflammatory cells were observed at later times. There were satisfactory fibrosis in both implanted and control ears. Conclusion The results indicate that hydroxyapatite synthetic prosthesis is a biocompatible implantation material in the middle ear. Nonetheless, the presence of inflammatory reaction immediately following implantation implies that control of infection is important in the early times after the implantation procedure.

关键词： Middle ear Hydroxyapatite Synthetic auditory prosthesis inflammatory response

Synthesis,characterization,structures and magnetic property of chiral oxalate-bridged dicopper(Ⅱ) complexes

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Science china Chemistry 2010年第6期53卷 1255-1260页

作者： WU Ling1,WANG Jun2,ZHU CaiFei1,LIN YiJi1,CHEN LeiQi1,FAN Jun2 & ZHANG Hui1 1State Key Laboratory of Physical Chemistry of Solid Surfaces department of Chemistry,College of Chemistry and Chemical Engineering,Xiamen university,Xiamen 361005,china 2School of Chemistry and Environment,South china Normal university,Guangzhou 510006,china 1. State Key Laboratory of Physical Chemistry of Solid Surfaces department of Chemistry College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China2. School of Chemistry and Environment South China Normal University Guangzhou 510006 China

The oxalato-bridged dicopper(II) complexes [Cu2(μ-ox)(LRR)2(H2O)2(ClO4)2] (1),[Cu2(μ-ox)(LRR)2(CH3COCH3)2(ClO4)2](1a),[Cu2(μ-ox)(LSS)2(H2O)2(ClO4)2] (2) and [Cu2(μ-ox)(LRR)(LSS)2(CH3COCH3)2(ClO4)2] (3) [LRR = (8R,10R)-(-)-[4,5]-pineno2,2′-bipyridine,LSS = (8S,10S)-(+)-[4,5]-pineno-2,2′-bipyridine;ox2= oxalate] were first prepared.A possible mechanism for the formation of the chial dicopper(II) complexes was *** on elemental analysis,conductance measurement,UV-Vis spectra,CD spectra and X-ray single-crystal diffraction,the oxalato-bridged structures of 1 and 2 were deduced to adopt two Cu(II) ions and the bridged oxalate lying in the nearly same *** crystal structures of 1a and 3 reveal that the coordination geometry around each Cu(II) ion is an elongated and distorted octahedron and two axial solvent molecules and two perchlorate ions are anti to each other respectively in both binuclear *** solution CD spectra of 1 and 2 in the visible d-d range show very weak Cotton effects with peaks at 588 and 779 nm,which are approximately of mirror image,suggesting the optical activities may be derived from the vicinal effects of the chiragenic centers at the pinene group of LRR and LSS,*** 1 has been characterized by variable-temperature magnetic susceptibility and the data was least-square fitted to the Blenaey-Bowers *** exchange integral J was found to be -338.41(4) cm-1,indicating a strong antiferromagnetic interaction between two copper(II) ions.

关键词： dicopper(II) complex chiral bipyridine μ-oxalate bridge crystal structure CD spectroscopy magnetic property

Non-paraxial Elliptical Gaussian Beam

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Chinese Journal of Lasers 2001年第6期10卷 33-39页

作者： WANG Zhaoying LIN Qiang NI Jie (Institute of Optics, department of Physics, Zhejiang university, Hangzhou 310028, china) 浙江大学物理系光学所浙江杭州 310028

By using the methods of Hertz vector and angular spectrum transormation, the exact solution of non-paraxial elliptical Gaussion beam with general astigmatism based on Maxwell′s equations is obtained. We discussed its propagation characteristics. The results show that the orientation of the elliptical beam spot changes continuously as the beam propagates through isotropic media. Splitting or coupling of beam spots may occur for different initial spot size. This is very different from that of paraxial elliptical Gaussian beam.

关键词： non-paraxial elliptical Gaussian beam propagation

Cloning and Overexpression of CYP6F1,a Cytochrome P450 Gene,from Deltamethrin-resistant Culex pipiens pallens

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Acta Biochimica et Biophysica Sinica 2005年第5期37卷 317-326页

作者： Mao-Qing GONG Yan GU Xiao-Bang HU Yan SUN Lei MA Xiu-Lan LI Li-Xin SUN Jing SUN Jin QIAN Chang-Liang ZHU department of Pathogenic Biology, nanjing Medical university: Key Laboratory of Modern Pathogenic Biology of Jiangsu Province, nanjing 210029, china departmentofPathogenicBiology NanjingMedicalUniversityKeyLaboratoryofModernPathogenicBiologyofJiangsuProvin

CYP6F1(GenBank/EMBL accession ***662654),a novel gene with a complete encodingsequence in the cytochrome P450 family 6,was cloned and sequenced from deltamethrin-resistant 4thinstar larvae of Culex pipiens *** cDNA sequence of CYP6F1 has an open reading frame of 1527bp,which encodes a putative protein of 508 amino acid *** deduced amino acid sequence ofCYP6F1 indicated that the encoded P450 has conserved domains of a putative membrane-anchoring signal,putative reductase-binding sites,a typical heme-binding site,an ETLR motif and substrate recognition ***-quantitative RT-PCR analysis indicated that the CYP6F1 gene was expressed to a greater extent in thedeltamethrin-resistant strain than in the susceptible strain of *** *** expression levels ofthe CYP6F1 gene in the deltamethrin-resistant 1 st,2nd,3rd,4th instar larvae and adult female mosquitoesdiffered,with highest expression levels in the 4th instar *** addition,the CYP6F1 gene was stablyexpressed in mosquito C6/36 cells,and the expected 61.2 kDa band was identified by Western *** transfected with CYP6F1 had an increased resistance to deltamethrin as compared with control *** results indicate that CYP6F1 is expressed at higher levels in the deltamethrin-resistant strain,and mayconfer some insecticide resistance in *** pallens.

关键词： Culex pipiens pallens insecticide resistance cytochrome P450 RT-PCR

Comparative analysis of temperature and CO2 fluxes for winter wheat in Tibetan Plain and North china Plain using the EMD method

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Progress in Natural Science:Materials International 2006年第10期16卷 1066-1071页

作者： JIANG Zhaoyang, YU Qiang, LEI Shuhe, WANG Tianduo, SUN Xiaomin and ZHANG Renhua ( Chinese Academy of Meteorological Science, Beijing 100081, china Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, china mathematics department, Ocean university of china, Qingdao 266071, china Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, china) [a]Chinese Academy of Meteorological Science Beijing China [b]Chinese Academy of Sciences Institute of Geographic sciences and Natural Resources Research Beijing China [c]mathematics department Ocean University of China Qingdao China [d]Chinese Academy of Sciences Shanghai Institute of Plant Physiology and Ecology Shanghai China

Comparative study of spectral properties of temperature and CO2 fluxes measured by eddy covariance method at Yucheng (36°57'N, 116°36'E, 28 m a.s.l., in the North china Plain) and at Lhasa (29°41'N, 91°20'E, 3688 m a.s. 1., on the Tibetan Plateau) is described using the empirical mode decomposition (EMD) method. The main results are: (1) The intrinsic oscillation modes or intrinsic mode functions (IMFs) were extracted from data of temperature ( T) and CO2 fluxes (F) measured at Yucheng ( T1 and F1) and Lhasa ( T2 and F2) . (2) Hilbert transform was applied to these IMF components, then the Hubert-Huang spectra and the marginal spectra of these data were obtained. (3) Comparison of temperature and CO2 fluxes in North china Plain and on Tibetan Plain illustrated that the characteristic frequencies corresponding to T1, F1, T2 and F2 are 0.05 Hz, 0.03 Hz, 0.014 Hz and 0.005 Hz, respectively.

关键词： empirical mode decomposition (EMD) intrinsic mode function (IMF) flux Hilbert transform wheat Tibet.