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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Yang ZHANG~1 Wen-Sheng HOU~(1 *) Wei-Na LI~2 xiao-Ying WU~1 Guo-Cai WU~2 Hua FENG~2 Jun ZHENG~3 1 department of biomedical engineering Chongqing university Chongqing 400044 china 2 department of Neurosurgery Southwest Hospital Third military medical university Chongqing 400038 3 department of Computer Science New Mexico Institute of Mining and Technology Socorro NM 87801 USA

＜正＞Objective The present study is to obtain correlation between spatially separated brain regions,as well as the changes in time and frequency domain through analysis of the magnetoencephalography *** By means of the theory of coherence analysis,coherence coefficient of two signals corresponding to different cortical areas is computed, which reflects synchronization of the above two signals,as well as the correlation between spatially separated brain *** frequency analysis is also used to discuss the cortical correlation changes co-vary closely with time over the course of motor task in the three frequency band-α,βand lowγ.Results（1） By computing the coherence coefficient relative to the selected reference channel,it is suggested that channels with the most significant coherence are approximately in the same area,*** contralateral primary motor cortex and premotor ***,with the increase of frequency band both the coherence coefficient and the coupled area decline.（2） Changes of coherence co-varing with time inα,βand lowγband present the following characteristic:①The coherence shows such a trend that it increases firstly and then decreases over the course of motor task.②The most significant coherence,forαband,is observed from 0 to 0.3 second,while forβand lowγit appears at -0.2 *** The changes of coherence inα,βand lowγbands suggest that there are different neuronal modulations in the contralateral primary motor *** this modulation covaries with time,which consequently reflects the changes of correlation between different brain regions in time and frequency domain.

关键词： magnetoencephalography coherence time frequency analysis

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The laminated PLA/ β -TCP composite scaffold for calf bone repair

The laminated PLA/ β -TCP composite scaffold for calf bone ...

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The 6th International Conference on biomedical engineering and Rehabilitation engineering

作者： Shi Haitao Tang Shunqing Zhou Changren Chen Bing and Pei Guoxian biomedical Institute engineering of Jinan university Tel: 020-85220469 Fax: 020-85223742 E-mail: tshunqt@*** department of Orthopedics and traumatology Nanfang Hospital The First military medical university Guangzhou 510632 china

＜正＞In this paper, a laminated organic/inorganic composite material was prepared andwas used to repair calf bone defects. The composite had a high porosity, about 70%, and hadenough strength for bone tissue repair. ... 详细信息

关键词： Tissue engineering PLLA/ B -TCP composite calf bone repair

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RTEL1 gene variation and risk of glioma in a Chinese Han population

RTEL1 gene variation and risk of glioma in a Chinese Han pop...

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2011中华医学会神经外科学学术会议

作者： Gang Li1 Tian-Bo Jin2 Hong-Juan Liang1 Guo-Dong Gao1 1.department of Neurosurgery, Tangdu hospital, the fourth military medical university, xian 7 1 003 8 , china 2.National engineering Research Center for Miniaturized Detection Systems, School of Life Sciences, Northwest university, xi’an 7 1 006 9 , china

Background Previous studies have shown that common variants in multiple genes play a role in glioma progression, and certain single-nucleotide polymorphisms (SNPs) may be related to increased glioblastoma risk, indica... 详细信息

关键词： tagging single nucleotide polymorphism (tSNP) Glioma RTEL1 Haplotype case – control studies

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The effects of deep brain stimulation of the rat nucleus accumbens on morphine addiction

The effects of deep brain stimulation of the rat nucleus acc...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Hong-Yu LIU~(1,3),Jie JIN~1,Jing-Shi TANG~2,Wei-xin SUN~1,Hong JIA~2,xin-Ping YANG~1,Jian-Mei CUI~3,Chen-Guang WANG~3 1 Institute of medical Electronics in medical School,Key Laboratory of biomedical Information engineering,Ministry of Education,xi’an Jiaotong university,xi’an 710061,china 2 department of Physiology and Pathophysiology, School of Medicine,xi’an Jiaotong university,xi’an 710061,china 3Physiology Laboratory,North university of china,Taiyuan 030051,china

In order to explore a new method for treatment of drug addiction,we developed a device and an implant procedure for chronic deep brain stimulation(DBS) in *** device mainly consisted of an implantable pulse generator (IPG),a bipolar DBS electrode and an external *** was used for evaluation of the effect of the deep brain stimulation(DBS) of the rat nucleus accumbens(NAc) on morphine *** examined the effects of high frequency stimulation(HFS) on morphine-induced conditioned place preference(CPP).The DBS electrode was stereotaxically implanted into the core of unilateral nucleus accumbens and connected to the *** they were fixed to the rat skull with dental *** week later,the rats were administrated morphine hydrochloride intraperitoneally(i.p.) every day till craving for morphine ***,the rats in DBS group were administrated the high frequency stimulation. The stimulation "prescription" included a frequency of 130 Hz,pulse width of 0.21 ms,and current strength of 1.0 mA to 2.0 *** stimulator was turned on for 3 h with 1h task cycle every day in the period of morphine *** rats in sham DBS group were not administered any electronic *** time that the rats spent in the drug-paired side during 15min CPP paradigm was recorded to assess individual *** showed that 7-10 d later,administration of morphine with dose increase by degrees(10 mg/kg0 mg/kg) without electronic stimulation,led to increase in time spent in drug-paired side[(683±42.3) s,75.89%among 15 min],but exposure to 130 Hz high-frequency DBS led to decrease in time spent in drug-paired side[(199±61.2) s,22.11%among 15 min].There was a significant difference between the two groups[F(2,27) = 55.74;P2.1) s,11.67%among 15 min]as the original,which implied the rats preferred the black *** results indicate that the chro

关键词： deep brain stimulation(DBS) drug addiction nucleus accumbens(NAc) conditioned place preference(CPP) rat

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A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： xiao Liang xingping Quan xiaorui Geng Yujing Huang Yonghua Zhao Lei xi Zhen Yuan Ping Wang Bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina department of biomedical engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

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易于开启和维持自锁模的适度失谐腔克尔介质自锁模激光器

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中国激光 1995年第11期22卷 811-816页

作者：孙逊郗雪岭徐朗辛建国天津大学物理系天津大学电子工程系天津医科大学生物医学工程系北京理工大学信息工程学院光电工程系

提出工作于谐振腔适度失谐时的克尔介质自锁模激光器易于开启和维持自锁模的理论。根据克尔镜锁模原理和动态可饱和高斯增益特性，利用激光传输矩阵理论，对系统进行了数值模拟计算，确证了最佳腔镜失谐角的存在．结论与已有的实验结果... 详细信息

提出工作于谐振腔适度失谐时的克尔介质自锁模激光器易于开启和维持自锁模的理论。根据克尔镜锁模原理和动态可饱和高斯增益特性，利用激光传输矩阵理论，对系统进行了数值模拟计算，确证了最佳腔镜失谐角的存在．结论与已有的实验结果相符，并对它们赋予了新的合理解释。

关键词：自锁模激光器克尔镜锁模锁模激光器激光器

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压力诱导血管平滑肌细胞整合素β_3、桩蛋白和纽蛋白的变化

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解剖学报 2003年第2期34卷 150-154页

作者：杨向群严志强张炎姜宗来第二军医大学解剖学教研室生物医学工程研究所上海200433

目的　研究压力对大鼠颈总动脉血管平滑肌细胞整合素 β3、桩蛋白和纽蛋白的分布与表达的影响 ,探讨它们在血管平滑肌细胞的机械应力信号转导中的作用。　方法　不同压力 (16 0mmHg和 80mmHg)灌流大鼠颈总动脉 30min ,免疫组织化学和免... 详细信息

目的　研究压力对大鼠颈总动脉血管平滑肌细胞整合素 β3、桩蛋白和纽蛋白的分布与表达的影响 ,探讨它们在血管平滑肌细胞的机械应力信号转导中的作用。　方法　不同压力 (16 0mmHg和 80mmHg)灌流大鼠颈总动脉 30min ,免疫组织化学和免疫电镜观察整合素 β3、桩蛋白和纽蛋白在血管平滑肌细胞上的表达和分布变化。　结果　高压和常压灌流对大鼠颈总动脉平滑肌细胞的整合素 β3、桩蛋白和纽蛋白的表达无明显影响 ,但高压使整合素β3、桩蛋白和纽蛋白在平滑肌细胞膜上的分布发生改变 ,向离管腔面的平滑肌细胞膜聚集。　结论　高压诱导了整合素 β3、桩蛋白和纽蛋白向离管腔面的平滑肌细胞膜聚集。提示整合素 β3。

关键词：压力诱导血管平滑肌细胞整合素β3 桩蛋白纽蛋白免疫组织化学

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CLINICAL USE OF BIOLOGICALHEMOTATIC GLUE IN SURGERY

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Chinese Journal of biomedical engineering(English Edition) 1997年第3期6卷 195-196页

作者： xi Yamin（department for Surgery of First Teaching Hospital of medical Collegeof Jinan university）

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Visual pattern recognition based on spatio-temporal patterns of retinal ganglion cells’ activities

Visual pattern recognition based on spatio-temporal patterns...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Wei JING Hai-Qing GONG Pei-Ji LIANG~* department of biomedical engineering Shanghai Jiao Tong university Shanghai 200240 china

＜正＞Neural information is processed based on integrated activities of relevant *** the present study,the spike activities of bullfrog population retinal ganglion cells in response to three different visual patterns（vertical gratings, horizontal gratings,and pseudo-random binary checker-board） were recorded using multi-electrode array.A measurement of subsequence distribution discrepancy（MSDD） was applied to identify the spatio-temporal patterns of retina ganglion cells’ activities in response to different stimulation *** results showed that the population activity patterns were different under different stimulus patterns although the firing rates were similar,and such differences could be consistently detected in repeated experimental ***,the stimulation pattern can be discriminated according to the spatio-temporal patterns of the neuronal activities using the MSDD algorithm.

关键词： multi-unit recording population activity multiple spike train analysis pattern recognition

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线扫描直接数字化X线摄影原理与应用

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生物医学工程与临床 2003年第3期7卷 164-167页

作者：余厚军于红林第四军医大学西京医院放射科陕西西安710032 北京航天中兴医疗系统有限公司

目的　探讨线扫描直接数字化X线摄影的工作原理与实用价值。方法　以多丝正比室线扫描X线摄影系统为基础 ,分析线扫描直接数字化X线摄影的适用性。结果　线扫描成像技术克服了散射线造成的干扰 ,且探测灵敏度和精密度分辨率高。结论　... 详细信息

目的　探讨线扫描直接数字化X线摄影的工作原理与实用价值。方法　以多丝正比室线扫描X线摄影系统为基础 ,分析线扫描直接数字化X线摄影的适用性。结果　线扫描成像技术克服了散射线造成的干扰 ,且探测灵敏度和精密度分辨率高。结论　线扫描成像技术适合于除了动态摄影以外的各种数字X线摄影 ,对我国常规X线摄影逐步实现数字化开辟了美好的前景。

关键词：线扫描数字化X线摄影原理多丝正比室计算机辐射剂量

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