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Kinetics analysis of volume phase transition of intelligent neutral thermo-sensitive hydrogels

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science china(Physics,Mechanics & Astronomy) 2008年第5期51卷 532-540页

作者： WANG XiaoGui1 & LI YiQuan2 1 college of Mechanical Engineering,zhejiang university of technology,hangzhou 310032,china 2 School of Mechanical & Electronic Engineering,Changchun university of science and technology,Changchun 130022,china college of Mechanical Engineering Zhejiang University of Technology Hangzhou China School of Mechanical & Electronic Engineering Changchun University of Science and Technology Changchun China

In this work,utilizing the first law of thermodynamics and the Flory mean-field theory,the kinetic deformation studies concerning the volume phase transition of the neutral thermo-sensitive hydrogels were performed *** hydrogel was assumed as a biphasic mixture medium in the framework of the continuum mixture *** the energy conservation of the thermodynamics system of the hydrogel,the governing equations for the kinetics of the nonlinear large deforma-tion were *** explicit analytical expressions of the effective stress tensor and the chemical potential of the fluid of the thermo-sensitive hydrogel PNIPA were also obtained from the Helmholtz free energy,which can model the steady-static volume phase transition quantitatively.

关键词： thermo-sensitive hydrogel volume phase transition effective stress energy conservation

Enhanced sensitivity of hepatocellular carcinoma cells to chemotherapy with a Smac-armed oncolytic adenovirus

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Acta Pharmacologica Sinica 2007年第12期28卷 1996-2004页

作者： Qiu-wei PAN~(2,5),Su-yang ZHONG~(2,5),Bi-sheng LIU~2,Jin LIU~2,Rong CAI~2,Yi-gang WANG~2,Xin-yuan LIU~(2,3,4),Cheng QIAN~(2,4)~2 Xin Yuan Institute of Medicine and Biotechnology,life science college,zhejiang sci-tech university hangzhou 310018,china,~3 Instituteof Biochemistry and Cell Biology,Shanghai Institutes for Biological sciences,Chinese Academy of sciences,Shanghai 200031,china Xin Yuan Institute of Medicine and Biotechnology Life Science College Zhejiang Sci-Tech University Hangzhou China Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China

Aim:The aim of the present study was to further improve the therapeutic effectsfor human hepatocellular carcinoma (HCC) and reduce the damage in normal cellsusing a novel chemo-gene-virotherapeutic ***:An oncolyticadenoviral vector (ZD55) similar to the typical oncolytic adenovirus ONYX-015,with a deletion of ElB-55K gene,was employed to express the second mitochon-dria-derived activator of caspases (Smac) protein by constructing a *** *** enhanced cytotoxicity of the combined treatment of ZD55-Smac with cisplatin or 5-fluorouracil (5-FU) was evaluated in several HCC ***,the negative effects on normal cells have been tested in humannormal liver cell lines L-02 and QSG-7701 cell lines by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and apoptotic cell ***:According to our observation,ZD55-Smac is superior to ONYX-015 in sensitizingchemotherapy,ZD55-Smac used in conjunction with chemotherapy was found toexhibit obviously enhanced cytotoxicity in HCC cells,yet significantly abolishedthe negative toxicity in normal cells by utilizing the tumor selective replicationvector and reducing the ***:This chemo-gene-virotherapeutic(cisplatin or 5-FU+ZD55-Smac) strategy is superior to the conventional chemo-gene or chemo-viro approach.

关键词： oncolytic adenovirus inhibitor of apoptosis proteins second mitochondria-derived activator of caspases chemotherapy hepatocellular carcinoma

The three-dimensional structure of Infectious flacherie virus capsid determined by cryo-electron microscopy

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science china(life sciences) 2009年第12期52卷 1186-1191页

作者： XIE Li1,4, ZHANG QinFen2·, LU XingMeng3, DAI XinHong2, LI KunPeng2, HONG Jian1,4· & ZHOU XuePing11 Institute of Biotechnology, zhejiang university, hangzhou 310029, china 2 State Key Laboratory of Biocontrol, School of life sciences, Sun Yat-Sen university, Guangzhou 510275, china 3 college of Animal sciences, zhejiang university, hangzhou 310029, china 4 Center of Analysis and Measurement, zhejiang university, hangzhou 310029, china Institute of Biotechnology Zhejiang University Hangzhou China Center of Analysis and Measurement Zhejiang University Hangzhou China State Key Laboratory of Biocontrol School of Life Sciences Sun Yat-Sen University Guangzhou China college of Animal sciences Zhejiang University Hangzhou China

Cryo-electron microscopy and image reconstruction were used to determine the three-dimensional structure of Infectious flacherie virus (IFV). 5047 particles were selected for the final reconstruction. The FSC curve showed that the resolution of this capsid structure was 18 ·. The structure is a psuedo T=3 (P=3) icosahedral capsid with a diameter of 302.4 · and a single shell thickness of 15 ·. The density map showed that IFV has a smooth surface without any prominent protrude or depression. Comparison of the IFV structure with those of the insect picorna-like virus-Cricket paralysis virus (CrPV)and human picornavirus-Human rhinovirus 14 (HRV 14) revealed that the IFV structure resembles the CrPV structure. The "Rossmann canyon" is absent in both IFV and CrPV particles. The polypeptide topology of IFV VP2, IFV VP3 was predicted and the subunit location at the capsid surface was further analyzed.

关键词： Infectious flacherie virus cryo-electron microscopy three-dimensional structure polypeptide folding

Optical transfer function analysis of circular-pupil wavefront coding systems with separable phase masks

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Chinese Physics B 2012年第6期21卷 200-206页

作者：赵廷玉刘钦晓余飞鸿 Department of Physics Zhejiang Sci-Tech University Optical Engineering Department Zhejiang University

This paper proposes a simple method to achieve the optical transfer function of a circular pupil wavefront coding system with a separable phase mask in Cartesian coordinates. Based on the stationary phase method, the optical transfer function of the circular pupil system can be easily obtained from the optical transfer function of the rectangular pupil system by modifying the cut-off frequency and the on-axial modulation transfer function. Finally, a system with a cubic phase mask is used as an example to illustrate the way to achieve the optical transfer function of the circular pupil system from the rectangular pupil system.

关键词： wavefront coding circular pupil separable phase mask stationary phase method

Transport and deposition of nanoparticles in bend tube with circular cross-section

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Progress in Natural science:Materials International 2009年第1期19卷 33-39页

作者： Peifeng Lin a,Jianzhong Lin a,b,a State Key Laboratory of Fluid Power Transmission and Control,zhejiang university,hangzhou 310027,china b china Jiliang university,hangzhou 310018,china State Key Laboratory of Fluid Power Transmission and Control Zhejiang University Hangzhou 310027 China china Jiliang university Hangzhou 310018 China

Transport and deposition of nanoparticles in bend tube with circular cross-section were simulated numerically for different Reynolds numbers and Dean numbers.A finite-volume code and the SIMPLE scheme were used to solve the *** results show that the distribution of nanoparticle concentration is symmetrical with respect to the top and bottom sides of the *** diameter of the nanoparticles has a weak effect on the distribution of nanoparticle *** maximum and minimum of the deposition enhancement factor occur near the outside and inside walls of the bend tube,*** higher the Reynolds number is,the shorter is the time for nanoparticle *** bend curvature radius has a slight effect on the deposition enhancement factor.

关键词： Nanoparticles Transport Deposition Numerical simulation

Tetragonal Domain Switching via Reversible tm Phase Transformation

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Journal of Materials science & technology 1996年第4期12卷 255-260页

作者： Haiyan ZHU and Zhicheng XU(Dept. of Materials science and Engineering, zhejiang university, hangzhou 310027, china) Dept. of Materials science and Engineering Zhejiang University Hangzhou 310027 China

Grinding-induced tm phase transformation and the resultant texture in ceria-yttria-doped tetragonal zirconia polycrystals with varied tetragonality have been studied by XRD. It is observed that the reversible tm phase transformation occurs during grinding and the intensity ratio of I(002)t/I(200)t increases with the transformability. The author proposes that the texture induced by grinding at low temperatures is due to the tetragonal variant reorientation via cyclic,reversible tm phase transformation, termed 'transformational domain switching', instead of the ferroelastic one

关键词： Jun Am Chen Tetragonal Domain Switching via Reversible t m Phase Transformation

Does population increase alone ensure the long-term survival of endangered species?

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Chinese science Bulletin 2011年第24期56卷 2521-2522页

作者： FANG ShengGuo Special Topic Editor college of life sciences, zhejiang university, hangzhou 310058, china zhejiang Univ Coll Life Sci Hangzhou 310058 Zhejiang Peoples R China

Over the past three decades, wildlife conservation in china has achieved a number of successes. Endangered animals such as the Chinese alligator and the crested ibis, and plants such as the dawn redwood and Dysosma versipellis have recovered from the brink of extinction after considerable in situ and ex situ conservation efforts. However, population increase alone does not ensure the longterm survival of rare and endangered species, which also requires support from different fields of conservation biology.

关键词：人口增长濒危物种野生动物保护保护生物学濒危动物迁地保护扬子鳄朱鹮

Preparation and characterization of bis(dimolybdo-nonatungstogermanate)lanthanates of potassium

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Rare Metals 2003年第1期22卷 6-9页

作者： WU QingyinDepartment of Chemistry, zhejiang university, hangzhou 310027, china Department of Chemistry Zhejiang University Hangzhou 310027

The heteropoly complexes K_(13)[Ln(GeW_9Mo_2O_(39))_2] centre dot nH_2O (Ln =La, Ce, Pr, Nd, and Sm) were prepared for the first time and characterized by chemical analysis,infrared (IR) spectrum, ultraviolet (UV) spectrum, X-ray powder diffraction, and thermal ***, UV spectra, and X-ray powder diffraction studies show that the structure of the heteropolycomplexes is a square antiprism consisting of eight oxygen atoms of two GeW_9Mo_2O_(39)^(8-)heteropolyanions and a lanthanide ion. The thermostability of heteropoly complexes is lower thanthat of saturated Keggin structure dodecatungstogermanate.

关键词： inorganic chemistry heteropoly complex chemical synthesis lanthanates germanium

Understanding the endocrine disruption of chiral pesticides:The enantioselectivity in estrogenic activity of synthetic pyrethroids

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science china Chemistry 2010年第5期53卷 1003-1009页

作者： WANG Cui 1,ZHANG Quan 1,ZHANG XiaoFeng 1,LIU Jing 2 & LIU WeiPing 2 1college of Biological and Environmental Engineering,zhejiang university of technology,hangzhou 310032,china 2Key Laboratory of Environmental Remediation and Ecosystem Health,Ministry of Education college of Environmental and Resource sciences,zhejiang university,hangzhou 310029,china college of Biological and Environmental Engineering Zhejiang University of Technology Hangzhou China Key Laboratory of Environmental Remediation and Ecosystem Health Ministry of Education College of Environmental and Resource Sciences Zhejiang University Hangzhou China

Synthetic pyrethroids(SPs) ,a family of chiral insecticides consisting of multiple stereoismers,have been regarded as estrogenic endocrine-disrupting chemicals(EDCs) .In this study,we applied the yeast two-hybrid and molecular docking(MD) assay to assess the enantioselective estrogenic activities of three commonly used SPs,bifenthrin(cis-BF) ,permethrin(PM) and fenvalerate(Fen) .The β-galactosidase analyses indicated that all of the testing pyrethroids displayed significant(p2R-Fen and αS-2S-Fen also induced the β-galactosidase *** inability to initiate the reporter gene expression by the racemic chemicals may be due to the low ratios of these isomers or the antagonism among *** strong hydrophobic interaction and the hydrogen bond between positive estrogenic isomers and ERα support our biological testing *** research demonstrated that the enantioselective estrogenic activity of chiral SPs was due to selective binding between their isomers and the ERα*** data suggests that enantioselectivity of these chiral pesticides is significant to their estrogenic activities.

关键词： enantioselectivity synthetic pyrethroids (SPs) endocrine disruption yeast molecular docking