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北京城市副中心0701街区D#地块住房百年住宅示范项目

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建筑实践 2024年第3期 96-103页

作者： china Institute of Building Standard Design & research Co., Ltd. 中国建筑标准设计研究院有限公司

北京城市副中心是规划建设疏解北京非首都功能、推动京津冀协同发展的历史性工程。项目对于落实首都城市战略定位、建设国际—流的和谐宜居之都,对于建设以首都为核心的世界级城市群,都具有十分重大而深远的意义。项目规划设计打破传统...

北京城市副中心是规划建设疏解北京非首都功能、推动京津冀协同发展的历史性工程。项目对于落实首都城市战略定位、建设国际—流的和谐宜居之都,对于建设以首都为核心的世界级城市群,都具有十分重大而深远的意义。项目规划设计打破传统封闭社区规划模式,以小街区密路网、开放式社区的设计骨架,用半围合式住宅,院落内外高差处理等设计手法打造和谐、有序而具有活力的多元示范住区。

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Treatment with Vector-expressed Small Hairpin RNAs against Ki67 RNA-induced Cell Growth Inhibition and Apoptosis in Human Renal Carcinoma Cells

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Acta Biochimica et Biophysica Sinica 2006年第4期38卷 254-261页

作者： Jun-Nian ZHENG~(1,3*) Ya-Feng SUN~(2#) Dong-Sheng PEI~2 Jun-Jie LIU~1 Teng-Xiang MA~3 Rui-Fa HAN~3 Wang LI~1 Dian-Bao ZHENG~1 Jia-Cun CHEN~1 Xiao-Qing SUN~1 1 Laboratory of Urology,Affiliated Hospital of Xuzhou Medical College,Xuzhou 221002,china 2 research center for Biochemistry and Molecular Biology,Xuzhou Medical College,Xuzhou 221002,china 3 Institute of Urology,Medical University of tianjin,tianjin 300211,china LaboratoryofUrology AffiliatedHospitalofXuzhouMedicalCollegeXuzhou221002China researchcenterforBiochemistryandMolecularBiology XuzhouMedicalCollegeXuzhou221002China InstituteofUrology MedicalUniversityofTianjin

Short hairpin RNAs (shRNAs) transcribed *** polymerase Ⅲ promoters can triggersequence-selective gene silencing in mammalian *** virtue of their excellent function in knocking downexpression of cancer-associated genes,shRNAs could be used as new therapeutic agents for *** of Ki67 in renal cancer has been correlated to a more aggressive tumor phenotype,inhibitionof Ki67 protein expression by means of shRNAs seems to be a promising approach for the therapy of *** this study,we constructed an expression plasmid encoding shRNAs against the Ki67 gene,namedpSilencerKi67,and transfected it into human renal carcinoma *** pSilencerKi67 was shown to signifi-cantly knock down the expression of the Ki67 gene in human renal carcinoma cells,resulting in inhibitingproliferation and inducing apoptotic cell death that can be maintained for at least *** findings offer thepromise of using vector-based shRNAs against Ki67 in renal cancer gene therapy.

关键词： Ki67 gene shRNAs renal cell carcinoma proliferation apoptosis

Synthesis and Luminescence Properties of Pr^(3+) Doped Ca_xBa_(1-x)TiO_3 (0.3≤x<1) Fine Particles

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Journal of Wuhan University of Technology(Materials Science) 2009年第5期24卷 689-693页

作者：何声太 College of Materials Science and Engineering Tianjin Polytechnic University

CaxBa1-xTiO3 （CBT） fine particles doped with red luminescence center of Pr3＋ ions （Pr： CBT） were successfully synthesized by salt assisted spray pyrolysis （SASP） process. Scanning electronic microscope （SEM） and laser scattering analysis demonstrate that salt can be removed from the surface of particles by washing with Milli-Q water and the particles can be further separated by ball-milling to get well-dispersed Pr^3＋ ions doped CBT fine particles. The luminescence properties, such as photoluminescence （PL） and mechanoluminescence （ML）, of as-synthesized Pr： CBT particles were investigated. For Pr： CBT fine particles with different Ca molar ratios, all the samples show one emission at 612 nm, with increasing Ca molar ratio, PL intensity of Pr： CBT fine particles become stronger and stronger. When pressure was loaded on the Pr： CBT pellet, mechanoluminescence（ML） emission was measured. The results show that the ML intensity is proportional to the applied pressure.

关键词： synthesis luminescence mechanoluminescence photoluminescence Pr^3+ doped CaxBa1-xTiO3 fine particles

Molecular dynamics simulation study on zwitterionic structure to maintain the normal conformations of Glutathione

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Science china Chemistry 2007年第5期50卷 660-664页

作者： YAN Han1, ZHU HaoMiao2 & SHEN Jian1,2 1 Jiangsu research center of Surface and Interface Chemical Engineering and Technology, Nanjing University, Nanjing 210093, china 2 Jiangsu Engineering research center for Bio-medical function Materials, Nanjing Normal University, Nanjing 210097, china Jiangsu research center of Surface and Interface Chemical Engineering andTechnology Nanjing UniversityNanjing 210093China Jiangsu Engineering research center forBio-medical function Materials Nanjing Normal UniversityNanjing 210097China

Molecular dynamics simulations were applied to normal conformational Glutathione (GSH) and GSH over zwitterionic and hydrophobic surfaces respectively. Conformational analysis of GSH during the simulation time on RMSD, conformational flexibility and dihedral distribution were performed. The re- sults showed that zwitterionic structure maintains the normal conformations of GSH to a better extent, which should be a first good proof of the hypothesis of "maintain of normal structure".

关键词： protein-surface interactions, molecular dynamics simulation, zwitterionic structure, Glutathione, conformational changes, antithrombotic material

Explanation of the mechanism of carcinogenesis and syntheses of anticancer agents with high selectivity

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Science china Chemistry 2006年第1期49卷 44-62页

作者： DAI Qianhuan1,2 1. center of Chemistry and Bioengineering of Cancer research, Beijing Polytechnic University (Now known as Beijing Univer-sity of Technology), Beijing 100022, china 2. center of Environmental Sciences, Peking University, Beijing 100871, china 1. center of Chemistry and Bioengineering of Cancer research Beijing Polytechnic University Beijing 100022 China 2. center of Environmental Sciences Peking University Beijing 100871 China

In 1979, the mechanism of chemical carcinogenesis, a challenging anddifficult scientific problem pending for a number of years, was explained by Dai Qianhuan. Themechanism named di-region theory predicted that a carcinogen always metabolizes to form a specialbi-functional alky-lating agent. This agent induces cross-linkages between the complementary basepairs in DMA and switches on initial mutageneses in genomes including point and frameshiftmutations. This, in turn, induces further deep mutageneses including the production of variouschimeric chromosomes, deletions and other aberrations found in genomes. In the end this initiatescarcinogenesis of the whole cell through the reverse transcription mechanism after a lengthyincubation period. Recently, this laboratory has verified that physical carcinogenesis, includingthe oncogenesis induced by radiation and asbestos as well as the carcinogenesis induced byendogenous factors such as estrogen or diethyl-stilbestrol switch on carcinogenesis by inducing theformation of cross-linkages between the complementary base pairs in DNA. Di-region theory has nowbeen supported by many experimental observations such as mutational spectra of various *** potential for carcinogenesis, teratogenesis, sterility and mutagenesis lumped together asgenetic toxicity appears to originate almost uniformly from the cross-linking between complementarybases, i.e. malignant cross-linking, which is in accordance with di-region theory. Other forms ofcross-linking between non-complementary bases, benign cross-linkings, show bi-functional alkylationanticancer activity but lack genetic toxicity. The predictable design and synthesis of a highselectivity anticancer agent with high efficacy and low genetic toxicity, a goal long pursued incancer chemotherapy, have been realized for the first time in this laboratory by inhibitingmalignant and heightening benign cross-linking using the principles of di-region theory. A series ofpatented new anticanc

关键词： mechanism of carcinogenesis, di-region theory, minoplatin, selectivity of anticancer agent, cross-linking between DNA bases, anticancer platinum complexes, predictive design of anticancer agent, second generation anticancer agent.

Risk analysis model for landslide mass of high slope in dam area

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Science china(Technological Sciences) 2008年第S2期51卷 25-31页

作者： GU ChongShi1,2,HE XianFeng3,4,WU ZhongRu1,2 & SU HuaiZhi1,2 1 College of Water Conservancy and Hydropower Engineering,Hohai University,Nanjing 210098,china 2 National Engineering research center of Water Resources Efficient Utilization and Engineering Safety,Nanjing 210098,china 3 Yellow River Institute of Hydraulic research,Zhengzhou 450003,china 4 Embankment Security Defect Prevention and Control Engineering research center of MWR,Zhengzhou 450003,china 1. College of Water Conservancy and Hydropower Engineering Hohai University Nanjing 210098 China 2. National Engineering research center of Water Resources Efficient Utilization and Engineering Safety Nanjing 210098 China 3. Yellow River Institute of Hydraulic research Zhengzhou 450003 China 4. Embankment Security Defect Prevention and Control Engineering research center of MWR Zhengzhou 450003 China

In order to identify the threat of reservoir bank landslide to dam safety and reduce the risk of dam failure,impact factors of the landslide are *** concept of landslide risk degree is put forward to measure the threat of landslide to dam *** monotony of the landslide risk assessment function which changes with different affecting factors is analyzed *** on gene automatic programming,a data mining model of the landslide risk assessment function is constructed combined with impact factors of reservoir bank landslide on dam *** the assessment function of landslide risk has been excavated and established according to practical project information,which provides a valuable reference for analyzing the impact of landslide on dam risk.

关键词： landslide dam failure risk landslide risk

Sea surface temperature east of Australia:A predictor of tropical cyclone frequency over the western North Pacific?

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Chinese Science Bulletin 2011年第2期56卷 196-201页

作者： ZHOU BoTao 1,2 & CUI Xuan 3 1 National Climate center,china Meteorological Administration,Beijing 100081,china 2 Nansen-Zhu International research center,Institute of Atmospheric Physics,Chinese Academy of Sciences,Beijing 100029,china 3 National Meteorological center,china Meteorological Administration,Beijing 100081,china National Climate center China Meteorological Administration Beijing China Nansen-Zhu International research center Institute of Atmospheric Physics Chinese Academy of Sciences Beijing China National Meteorological center China Meteorological Administration Beijing China

The relationship between sea surface temperature (SST) east of Australia and tropical cyclone frequency over the western North Pacific (WNPTCF) is analyzed by use of observation *** WNPTCF from June to October is correlated negatively to spring SST east of *** the spring SST is in the positive phase,a cyclonic circulation anomaly in the upper troposphere and an anticyclonic circulation anomaly in the lower troposphere prevail over the western North Pacific from June to October,concurrent with an anomalous atmospheric subsidence and an enlarged vertical zonal wind *** conditions are unfavorable for tropical cyclone genesis,and thus WNPTCF *** negative phase of the spring SST east of Australia leads to more tropical cyclones over the western North *** spring SST east of Australia may give rise to simultaneous change in tropical atmospheric circulation via the teleconnection wave train,and then subsequently affect atmospheric circulation variation over the western North Pacific.

关键词：热带气旋北太平洋澳大利亚西部海面温度热带大气环流预测频率

Chinese consensus on the diagnosis and treatment of immunoglobulin light-chain cardiac amyloidosis

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Chinese Medical Journal 2024年第2期137卷 127-129页

作者： Kaini Shen Zhuang Tian Yajuan Gao Yining Wang Li Huo Jian Li Yun Zhang Shuyang Zhang On behalf of Chinese Society of Rare Diseases and Rare Diseases Branch of china research Hospital Association Department of Hematology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Cardiology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Clinical Medicine Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Radiology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Nuclear Medicine Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear MedicineState Key Laboratory of Complex Severe and Rare DiseasesCenter for Rare Diseases ResearchPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Cardiology The Key Laboratory of Cardiovascular Remodeling and Function ResearchChinese Ministry of EducationChinese National Health Commission and Chinese Academy of Medical SciencesThe State and Shandong Province Joint Key Laboratory of Translational Cardiovascular MedicineQilu HospitalCheeloo College of MedicineShandong UniversityJinanShandong 250012China Cardiovascular Disease research center of Shandong First Medical University Central Hospital Affiliated to Shandong First Medical UniversityJinanShandong 250013China 不详

Epidemiology of Amyloid Light-Chain Cardiac Amyloidosis(AL-CA)The annual incidence of amyloid light-chain(AL)amyloidosis is 3-5/million,and the incidence in men is slightly higher than that in ***,70%of patients with ... 详细信息

关键词： amyloid cardiac diagnosis

Analysis on Residents’ Travel Characteristics and Transport Policies: A Case Study on tianjin

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china City Planning Review 2008年第1期17卷 48-51页

作者： MA Keping,Engineer,research center of Transport,tianjin Urban Planning & Design Institute,tianjin,P.R.china.CAO Bohu,Senior Engineer,research center of Transport,tianjin Urban Planning & Design Institute,tianjin,P.R.china.FAN Xiaoyong,Engineer,research center of Transport,tianjin Urban Planning & Design Institute,tianjin,P.R.china.

The history of city development in china and other countries proves that the residents’ travel demand and characteristics apparently change in both time and space terms along with the process of rapid urbanization an... 详细信息

关键词： tianjin travel apparently urbanization thousand pr