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Rat CC chemokine receptor 4 is the functional homologue of human CC chemokine receptor 4 and can interact with human CCL17 and CCL22

国际材料科学与工程学术研讨会

作者： MA Hai-Long~(1,2), JIN Guo-Qiang, GUO Xiang-Yun~1 (1.State Key Laboratory of Coal Conversion, Institute of Coal Chemistry, chinese academy of sciences,,Taiyuan 030001,china 2.Graduate School of chinese academy of sciences, beijing, 100039, china

＜正＞ Considerable efforts have been made to explore the unique physical, chemical and electronic properties of carbon nanotubes over past decades. It has been shown that the nanotubes can be used in a wide range of applications such as the storage of gases[1], nano-and micro-electronic devices[2], and composite fillers[3]. However, the application of the carbon nanotubes as microscopic reactors or channels is significantly hampered due to their nanometer-sized diameters[4]. Therefore, a micron-sized carbon tube might be an alternative. Recently, different routes have been employed to produce carbon microtubes. Hu et al. reported the preparation of a crystalline graphitic structure-uniform diameter, thin-walled carbon microtubes via a thermal reaction between ZnS and activated carbon[4]. Mitchell et al. discribed the carbon microtubes produced with both laser and electric

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chinese Science Bulletin 2010年第14期55卷 1388-1395页

作者： TIAN LinJie1,2, QI Hui1,2, XIE Yuan1,2, ZHANG YingMei1,2, ZHANG WenJuan1,2, SUN XiangYu1,2, WANG Ying1,2 & MA DaLong1,2 1 Laboratory of Medical Immunology, School of Basic Medical Science, Peking University Health Science Center, beijing 100191, china 2 Human Disease Genomics Center, Peking University, beijing 100191, china Laboratory of Medical Immunology School of Basic Medical Science Peking University Health Science Center Beijing China Human Disease Genomics Center Peking University Beijing China

Human CCL17/TARC (hCCL17) and CCL22/MDC (hCCL22) interact with their receptor CCR4, playing pivotal roles in various Th2 cell-dominant diseases. Rat Ccl17, Ccl22 and Ccr4 share 63.4%, 65.2% and 87.5% homology at the amino acid level, respectively, compared with their human homologues. Rat Ccl22 has been demonstrated to interact with rat Ccr4. However, it is not known whether rat Ccl17 is a functional ligand for rat Ccr4 and whether rat Ccr4 can interact with hCCL17 and hCCL22. In this study, we cloned rat Ccl17 and Ccr4 cDNA from rat thymus and expressed the recombinant rat Ccl17. The binding assay indicated rat Ccl17 could saturably bind rat Ccr4, and this binding could be competitively inhibited by unlabeled rat Cc17, hCCL17 or hCCL22. Both rat and human CCL17 or CCL22 could induce the chemotactic migration and calcium mobilization in rat Ccr4-transfected cells. They could also desensitize each other’s effect on chemotaxis and calcium mobilization. Furthermore, both rat Ccl17 and hCCL17 could induce significant receptor internalization in rat Ccr4-EGFP transfected cells. These results demonstrated the conserved CCL17/CCR4 interaction in rats and the further cross-species interaction of rat Ccr4 with hCCL17 and hCCL22. Likewise, they provided the molecular basis for the investigation of physiological and pharmacological roles of CCR4, its ligands, and their antagonists in rat disease models.

关键词：趋化因子受体同源性大鼠人类基因转染细胞绿色荧光蛋白相互作用疾病模型

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超热电子在非均匀磁场中的运动轨迹

物理学报 2002年第4期51卷 843-846页

作者：苍宇张杰邱阳张军彭练矛中国科学院物理研究所光物理开放实验室北京100080 中国科学院物理研究所电子显微镜实验室北京100080

在电子磁谱仪中实际的磁场强度分布是不均匀的 ,这就造成电子束在探测器上的位置和分布与均匀磁场假设下的结果的不同 .

关键词：电子磁谱仪超热电子非均匀磁场运动轨迹激光等离子体相互作用诊断仪器

From Physical Space to Visual Image Space

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Geo-Spatial Information Science 2003年第2期6卷 42-47页

作者： YE Zetian LIN Hui LIU Xianlin YE Zetian, Ph.D, chinese academy of Surveying and Mapping, 16 Beitaiping Road, Haidian District, beijing 100039, china. academy of Surveying and Mapping Haidian District Beijing China

The theoretical framework of visual simulation in virtual reality is discussed. The new concept of visual image space is supposed. On the basis of visual image space, in visual perceptive sense, VR is considered as a spatial simulation. The objective of the spatial simulation is to transform physical space to visual image space. Last, the prototype system, surveying & mapping virtual Reality (SMVR), is developed, and the space simulation above is realized. By use of SMVR, the real 3D representation, 3D visual analysis, virtual plan and designs can be implemented.

关键词： virtual reality physical space visual image space space of earth surface space simulation

On the existence of Absolute Instability in Bluff Body Wakes

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Communications in Nonlinear Science and Numerical Simulation 1996年第3期1卷 4-8页

作者： Chuanping SHAO Xuequan E & Wei WANG (Laboratory of Applied Fluid Mechanics, Institute of Mechanics, chinese academy ofsciences, 15 Zhong Guan Cun Road, beijing 100080, china)E-mail: shaocp@cc5 . Imech .ac. cn Laboratory of Applied Fluid Mechanics Institute of Mechanics Chinese Academy of Sciences 15 Zhong Guan Cun Road Beijing 100080 China

The wake stability of steady flow past a circular cylinder has been studiedexperimentally An impulse perturbation signal（very short in time, finite in amplitude） wasgiven to the wake from a small hole on the back of the cylinder, and its long time evolution inthe wake was detected by a hot film probe at a fixed point. The test Reynolds number rangeRe=30 ~ 320. The restult shows that （1）ahsolute instability exists in the wake when Re=55～320. （2） The absolute region extends from 0.5 2.3 ~ 2.5as Reynlods number increases from 55 to 200.

关键词： absolute Instability wake circular cylinder

Study on the denoising method for the electromagnetic ultrasonic echoes from multiple interfaces

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chinese Journal of Acoustics 2008年第1期27卷 75-84页

作者： SONG Weihua WANG Xiaomin LI Mingxuan Institute of Acoustics Chinese Academg of Sciences Beijing 100080 Graduate School of the chinese academy of sciences beijing 100029

The electromagnetic ultrasound is used in the detection of interfaces of the adhesive multilayer structures to solve the unstable coupling problem in ultrasonic testing by traditional piezoelectric transducers. Based on the analysis of the transforming mechanism of electromag-netic ultrasound energy and the resultant dead zone from mutual inductance of the transducer, the wavelet filtering by soft-thresholding and adaptive noise canceling methods are used simul-taneously to the detected electromagnetic ultrasonic signals to overcome the drawbacks of the low signal to noise ratio （SNR） and the wide intrinsic dead zone of the transducer. Processed results in the interface detection of a three layered adhesive sample of steel and rubber materials demonstrate that the wavelet filtering enhances the SNR about 12dB while the adaptive noise canceling narrows the dead zone effectively.

关键词： Study on the denoising method for the electromagnetic ultrasonic echoes from multiple interfaces

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交感神经系统在应激免疫调节中的作用

心理学报 2003年第4期35卷 559-562页

作者：邵枫林文娟肖健北京大学心理学系北京100871 中国科学院心理研究所脑-行为研究中心北京100101

目前 ,越来越多的研究资料表明交感神经系统 (SNS)参与了应激的免疫调节作用。有关研究主要集中在SNS与免疫系统间的解剖基础及相互作用、SNS参与应激的免疫调节作用的实验研究以及SNS与下丘脑 -垂体 -肾上腺轴 (HPA)间的相互作用等几... 详细信息

目前 ,越来越多的研究资料表明交感神经系统 (SNS)参与了应激的免疫调节作用。有关研究主要集中在SNS与免疫系统间的解剖基础及相互作用、SNS参与应激的免疫调节作用的实验研究以及SNS与下丘脑 -垂体 -肾上腺轴 (HPA)间的相互作用等几个方面。综合阐述这些研究结果 ,并着重分析SNS、应激与免疫系统间的相互作用及其机制。

关键词：交感神经系统应激免疫

UNIFORM PERSISTENCE AND GLOBAL ATTRACTIVITY FOR NONAUTONOMOUS COMPETITIVE SYSTEMS WITH DISPERSION

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Journal of Systems Science & Complexity 2002年第3期15卷 307-314页

作者： SONGXinyu CHENLansun DepartmentofMathematics XingangTeachersCollegeHenan464000China InstituteofMathematics AcademyofMathematicsandSystemsScienceChinesAcademyofSceiencesBeijing100080China

In this paper, we consider a nonautonomous competitive model with dispersion and a finite number of discrete delays. The system, which consists of two Lotka-Volterra patches, has two competitors: one can disperse between the two patches, but the other is confined to one patch and cannot disperse. Our purpose is to demonstrate that the dispersion rates have no effect on the uniform persistence of the solutions of the system. Furthermore, we establish the conditions under which the system admits a positive periodic solution which attracts all solutions.

关键词： Uniform persistence global attractivity dispersion.

Planation Surfaces on the Tibet Plateau,china

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Journal of Mountain Science 2008年第4期5卷 310-317页

作者： ZHANG Xinbao HE Xiubin WANG Yangchun LONG Yi Institute of Mountain Hazards and Environment CAS Chengdu 610041 China State Key Laboratory of Loess and Quaternary Geology Institute of Earth Environment GAS Xi＇an 710075 China Graduate University of the chinese Academic of sciences Beijing 100039 China

A planation hypothesis is proposed to explain landform evolution of the Tibet Plateau. A denudation threshold （T）, the maximum potential denudation rate for a certain type of rock, is introduced to explain the combined effects of lithology and tectonics on landform evolution. If the tectonic uplifting rate （U） is equal to or less than the threshold rate （U ≤ T）, the tectonic uplifting and terrain denudation are in dynamic equilibrium, and landforms are in a steady state. The end product should be planation surfaces whether the original landforms are flat plains or deeply dissected mountains. If U 〉 T, uplift and denudation are not able to reach a dynamic equilibrium state. The plateau surface is mostly underlain by soft rocks, such as the Mesozoic epimetamorphic argillites and Tertiary sedimentary rocks, while the mountain ranges comprise hard rocks, such as granite, gneiss and limestone. In soft rock regions, hills are low with a relative relief of mostly less than 100 m and the slopes are gentle at a gradient of 〈200. In contrast, hills can maintain steep slopes in hard rock regions. The Tibet Plateau has been under an equilibrium condition between tectonic uplifting and denudation except for the mountain ranges. The plateau might have reached the present altitudes before the Quaternary.

关键词： planation denudation threshold landform evolution Tibet Plateau china