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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Qiang ZENG~1,Hai-Tao ZHANG~2,Zhi-Ping LIU~1,Yi WANG~2,Zheng-Qin YIN~(2*),Shi-Gang HE~(1,*) 1 State Key Laboratory of Brain and Cognitive Sciences,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,china 2 southwest eye hospital,chongqing 400038,china

＜正＞Objective The Royal College of Surgeons（RCS） rats undergo a sustained degeneration of photoreceptors from the retinal pigment epithelial cell *** one kind of intemeurons,horizontal cells connect to cone and rod photoreceptors directly in the outer plexiform layer,which may be influenced by the loss of *** order to examine the remodeling of the surviving secondary neurons,here we investigated the lamination and morphology of horizontal cells （HCs） during photoreceptor degeneration in the RCS *** RCS rats were sampled at different degeneration stages and compared with age-matched control *** immunostaining of the cryosections and DiI labeling of the wholemount retinas were carried out to examine soma,dendritic and axonal *** were acquired by confocol microscopy and analyzed with *** The staining of photoreceptors shows that at P35,the beginning of the photoreceptor degeneration,the loss of photoreceptors is not significant and the morphology of the HCs is not changed. At P45 the loss of photoreceptors is obvious in the RCS *** the lamination and morphology of the HCs are not significantly *** 2 months,with 20%or less photoreceptors left,the area of dendrites and axon terminals are both reduced significantly and dendritic arbors become much *** the lamination of the HCs is still normal at this stage. At 3 months,nearly all the photoreceptors are *** dendritic arbor area is reduced and some of the dendrites tangle with each other;the axon terminals show a very simple morphology with only some main *** axon terminals show ectropic branches and the lamination is *** The morphology of HCs changes with the loss of the photoreceptors in the RCS *** the dendrites and axon terminals become simpler and smaller,but the modification is slower than the loss of *** lamination of the HC neurites is normal in the outer plexiform layer even at

关键词： RCS rat horizontal cell DiI labeling

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Morphology change of secondary neuron under fast and slow photoreceptor degeneration

Morphology change of secondary neuron under fast and slow ph...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Qiang ZENG~1,Hai-Tao ZHANG~2,Yan YIN~1,Zhi-Ping LIU~1,Yi WANG~2,Zheng-Qin YIN~(2,*),Shi-Gang HE~(1,*) 1 State Key Laboratory of Brain and Cognitive Sciences,Institute of Biophysics,Chinese Academy of Sciences,15 Da- tun Road,Beijing 100101,china 2 southwest eye hospital,chongqing 400038,china

＜正＞Objective To investigate the influence of photoreceptor degeneration on the morphology of secondary neurons（bipolar and horizontal cells） in the retina of Royal College of Surgeons（RCS） rat and light damaged（LD） albino *** RCS rats and LD mice retinas were sampled at different degeneration stages and compared with wild type（wt） retinas;Both immunohistochemistry and Dil labeling methods were used to examine lamination and morphology of the secondary *** were acquired by confocal microscopy and analyzed with ImageJ. Results Gradual loss of photoreceptors and ribbon synapses was detected from postnatal day 30（P30） to P90 in the RCS rat *** bipolar cells and horizontal cells kept the neurite lamination in outer plexiform layer（OPL） at P60 when 20%photoreceptors left;horizontal cells maintained their morphology at P45 when 50%photoreceptors *** induced fast loss of photoreceptors and ribbon synapses in albino mouse *** and morphology disruption of the bipolar cells happened at 1 day after light damage（DALD）.Morphology change of horizontal cells appeared at 5 *** Structure alternation of secondary neurons in RCS rat retina appears later than photoreceptor loss during the slow degeneration *** in LD mouse retina the alternation appears early following fast photoreceptor loss,indicating the morphology change could happen fast and the residual photoreceptors maintain the structure of secondary neurons.

关键词： retina Royal College of Surgeons light damage horizontal cell bipolar cell

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Effect of crystallines on survival and growth of rat RGCs in vitro

Effect of crystallines on survival and growth of rat RGCs in...

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The Third Asian Conference on Vision (ACV2004)

作者： Yanhua Wang Yi Wangsouthwest eye hospital southwest hospital Third Military Medical University chongqing 400038 china

＜正＞ Objective To study the effect of crystallins on survival and growth of rat retinal ganglion cells （RGCs） in vitro, and discussing the relation between crystallins and activated macrophage about their effect on rat RGCs in *** Crystallins were extracted from Long Evans rats, and macrophage-conditioned media were prepared by culturing enterocoelia macrophages of Long Evans rats for 24h. RGCs in Long Evans rats were cultured in DMEM, DMEM containing crystallins, and

关键词： Crystallins retinal ganglion cells

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Roles of nuclear receptors LXRs and ERs in the neuroprotection of dopaminergic neurons in the midbrain

Roles of nuclear receptors LXRs and ERs in the neuroprotecti...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Wen-Qiong GUO~1,Hong-Liang YI~1,Xiao-Tang FAN~2,Hai-Wei XU~(3,*) 1 Department of Physilogy,Third Military Medical University.chongqing 400038,china 2 Department of Histology and Embryology,Third Military Medical University,chongqing 400038,china 3 southwest eye hospital,southwest hospital,Third Military Medical University,chongqing 400038,china

＜正＞Objective To explore the roles of liver x receptors（LXRs） and estrogen receptors（ERs） in the activation of microglia and astrocyte in the substantia nigra（SN） of the midbrain and its relationship with the degeneration of dopaminergic *** The expression of LXRs subtypes（LXRa and LXRβ） and the ERs subtypes（ERa and ERp） in the midbrain of mice was detected with RT-PCR and ***α-/-,LXRβ-/-,LXRaβ-/- mice,ovariectomy mice and wildtype mice were used in this *** wildtype mice and ovariectomy mice were treated with agonist of LXR TO901317 and 17β-estradiol *** protein levels of ERK and AKt were detected by Western ***（1） Both LXRα,LXRβ,ERa and ERβare expressed in the midbrain of fourmonth old mice,and LXRβis expressed at higher levels than LXRα.Immunohistochemistry confirmed the expression of LXRs and ERs.（2） Compared with age-matched WT mice,microglia and astrocyte were over-activated in LXRβ-/- and LXRαβ-/- mice,of which glia over-activation are more remarkably in the LXRα-/-β-/- *** the number of TH-positive neurons in the SN and TH-ir fiber density in SNpr were decreased in the LXRβ-/-,and extremely reduced in the LXRα-/-β-/- mice.（3） Intraperitoneal injection of LPS to the 4-month-old female WT mice can trigger microglia activation and release inflammatory factors such as IL-1β,IL-6 and TNF-α.LXR agonist TO901317 can effectively block the activation of microglia and reduce mRNA levels of proinflammation factors including IL-1β, IL-6 and TNF-α.（4） The number of TH-IR neurons and the gene expression level of DAT significantly decreased in ovariectomized mice,and treatment with estrogen can prevent the reduction of *** derived neurotrophic factor was involved in the effect of *** By modulating the activation of microglia and astrocyte and their function of pro-inflammatory factors and neurotrophic factors level,both LXRβand ERβproduce neuroprotection effect on dopaminergic neu

关键词： liver x receptor estrogen receptor dopaminergic neuron microglia astrocyte

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THE RECORDING SENSITIVITY OF MULTIFOCAL ELECTRORETINOGRAMS IN PATIENTS WITH RETINITIS PIGMENTOSA

THE RECORDING SENSITIVITY OF MULTIFOCAL ELECTRORETINOGRAMS I...

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第十八届国际眼科研究大会

作者： Y.Liu Z.Q.Yin Y.J.Yu X.H.Meng southwest eye hospital/southwest hospital Third Military Medical University chongqing 400038 china

＜正＞To investigate the recording sensitivity of Multifocal Electroretinogram（mf-ERG） in patients with retinitis pigmentosa（RP）,predictive facets for recordable or nonrecordable mf-ERG were *** with RP and visual...

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Effect of BFD on inhibitory synaptic transmission of interneurons in rat visual cortex

Effect of BFD on inhibitory synaptic transmission of interne...

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The Third Asian Conference on Vision (ACV2004)

作者： Gao Pengfen. Yin Zhengqin Wang Shijun Yao Junpingsouthwest eye hospital southwest hospital Third Military Medical University chongqing 400038

＜正＞ Objective During a critical period of early postnatal development, the mammalian visual cortex is highly susceptible to experience-dependent modifications of its structural and functional architecture. The mechanism of this experience-dependent plasticity haven’t been interpreted clearly. GABAA inhibitory circuits is proposed to implicate in the start and ending of the critical period of visual cortex development. But how is inhibitory synaptic

关键词： GABA binocular form deprivation visual cortex

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A new real-time eye tracking based on nonlinear unscented Kalman filter for monitoring driver fatigue

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控制理论与应用（英文版） 2010年第2期8卷 181-188页

作者： Zutao ZHANG 1 , 2 , Jiashu ZHANG 2 (1.School of Mechanical Engineering, southwest Jiaotong University, Chengdu Sichuan 610031, china 2.Sichuan Key Lab of Signal and Information Processing, southwest Jiaotong University, Chengdu Sichuan 610031, china) School of Mechanical Engineering Southwest Jiaotong University Chengdu Sichuan China Sichuan Key Lab of Signal and Information Processing Southwest Jiaotong University Chengdu Sichuan China

A new scheme for driver fatigue detection is presented, which is based on the nonlinear unscented Kalman filter and eye tracking. Assuming a probability distribution than to approximate an arbitrary nonlinear function or transformation, eye nonlinear tracking can be achieved using an unscented transformation (UT), which adopts a set of deterministic sigma points to match the posterior probability density function of the eye movement. Driver fatigue can be detected using the percentage of eye closure (PERCLOS) framework in a realistic driving condition after the eye nonlinear tracking. This system was tested adequately in realistic driving environments with subjects of different genders, with/without glasses, in day/night driving, being commercial/noncommercial drivers, in continuous driving time, and under different road conditions. The last experimental results show that the proposed method not only improves the robustness for nonlinear eye tracking, but also can provide more accurate estimation than the traditional Kalman filter.

关键词： eye tracking Unscented Kalman filter (UKF) Fatigue detection PERCLOS

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维普期刊数据库

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RCS大鼠视网膜变性过程中二级神经元形态学变化的研究

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生物物理学报 2010年第5期26卷 389-396页

作者：张海涛曾强阴正勤王一何士刚第三军医大学西南医院西南眼科医院重庆400038 中国科学院生物物理研究所脑与认知科学国家重点实验室北京100101

用免疫组织化学方法研究RCS大鼠(Royal College of Surgeon's rat,RCS rat)视网膜变性过程中早、中、晚期二级神经元形态的变化。结果发现,P1MRCS大鼠各二级神经元未见明显的形态改变。P2M RCS大鼠视网膜外核层萎缩约85%,视杆双极细胞... 详细信息

用免疫组织化学方法研究RCS大鼠(Royal College of Surgeon's rat,RCS rat)视网膜变性过程中早、中、晚期二级神经元形态的变化。结果发现,P1MRCS大鼠各二级神经元未见明显的形态改变。P2M RCS大鼠视网膜外核层萎缩约85%,视杆双极细胞顶端树突萎缩;水平细胞的树突与轴突在外网状层的分层未见改变。P3M RCS大鼠视网膜外核层萎缩近95%,RCS大鼠视杆双极细胞顶端萌生新的神经突起;水平细胞的树突分支明显丢失,轴突在外网状层的分层发生改变,出现新生神经突起;无长突细胞的树突在内网状层的分层至变性晚期也未见改变。该研究表明RCS大鼠视网膜二级神经元形态的改变是继发性改变,是感光细胞变性后对传入缺失的一种反应,即重构反应。在进行视网膜功能救治时需要考虑重构反应带来的影响。

关键词：视网膜色素变性二级神经元形态学 RCS大鼠重构

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维普期刊数据库

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鲇和大口鲇同工酶比较研究

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西南师范大学学报（自然科学版） 2002年第4期27卷 572-575页

作者：方平王志坚高峰涪陵师范学院生命科学系重庆408003 西南师范大学生命科学学院重庆400715

采用聚丙烯酰胺垂直平板凝胶电泳技术 ,对鲇和大口鲇的肌肉、心脏、肝脏、肾脏、脑、眼等 6种组织器官乳酸脱氢酶 (LDH)和酯酶 (EST)同工酶进行了比较研究 .结果表明 :2种鲇的同种组织中乳酸脱氢酶 (LDH)同工酶的酶谱相同 ,但在不同组... 详细信息

采用聚丙烯酰胺垂直平板凝胶电泳技术 ,对鲇和大口鲇的肌肉、心脏、肝脏、肾脏、脑、眼等 6种组织器官乳酸脱氢酶 (LDH)和酯酶 (EST)同工酶进行了比较研究 .结果表明 :2种鲇的同种组织中乳酸脱氢酶 (LDH)同工酶的酶谱相同 ,但在不同组织中表现出明显的组织特异性 ;而 2种鲇的酯酶 (EST)同工酶谱表现出明显的组织特异性和物种特异性 .笔者还对

关键词：比较研究大口鲇鲇乳酸脱氢酶酯酶同工酶组织特异性物种特异性

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茂兰自然保护区蚱总科昆虫的初步调查

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陕西师范大学学报（自然科学版） 2003年第2期31卷 92-94页

作者：郑哲民石福明陕西师范大学动物研究所陕西西安710062 西南农业大学植物保护系重庆400716

对茂兰自然保护区蚱总科昆虫进行了初步研究,经鉴定共有7种,其中有一新种荔波波蚱Bolivaritettixliboensis.模式标本保存于陕西师范大学动物研究所昆虫标本室.

关键词：茂兰自然保护区蚱总科荔波波蚱模式标本形态结构直翅目昆虫调查

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