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The in vitro reconstitution of nucleosome and its binding patterns with HMG1/2 and HMG14/17 proteins

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Cell research 2003年第5期13卷 351-359页

作者： SHU BING ZHANG, JIAN HUANG, HUI ZHAO, YI ZHANG, CHUN HuI HOU, XIAO DONG CHENG, CHU JIANG, MIN QIAN LI, JUN HU, RUO LAN QIAN 1 Group of Globin Gene Expression and Regulation, State Key Laboratory of Molecular Biology, institute of Biochemistry and Cell Biology, shanghai institutes for Biological sciences, chinese academy of sciences, shanghai 200031, china. 2 shanghai institute of nuclear research, chinese academy of sciences, shanghai 201800, china Group of Globin Gene Expression and Regulation State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China

Using atomic force microscopy (AFM), the dynamic process of the in vitro nucleosome reconstitution followed by slow dilution from high salt to low salt was visualized. Data showed that the histone octamers were dissociated from DNA at 1M NaCl. When the salt concentration was slowly reduced to 650 mM and 300 mM, the core histones bound to the naked DNA gradually. Once the salt concentration was reduced to 50 mM the classic 'beads-on-astring' structure was clearly visualized. Furthermore, using the technique of the in vitro reconstitution of nucleosome, the mono- and di- nucleosomes were assembled in vitro with both HS2core (-10681 to -10970 bp) and NCR2 (-372 to -194 bp) DNA sequences in the 5’flanking sequence of human b-globin gene. Data revealed that HMG 1/2 and HMG 14/17 proteins binding to both DNA sequences are changeable following the assembly and disassembly of nucleosomes. We suggest that the changeable binding patterns of HMG 14/17 and HMG1/2 proteins with these regulatory elements may be criti

关键词： atomic force microscopy HMG proteins (HMG1/2 and HMG14/17) human β-globin gene in vitro reconstitution nucleosome.

Top 10 Influential Events in carbon neutrality and climate change response for 2023

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Frontiers in Energy 2024年第1期18卷 1-3页

作者： research institute of Carbon Neutrality of shanghai Jiao Tong University research institute of Carbon Neutrality Shanghai Jiao Tong UniversityShanghai 200240China

In 2023, the global community intensified its efforts towards achieving carbon neutrality and addressing climate change, witnessing several impactful events. research institute of Carbon Neutrality, shanghai Jiao Tong University compiled the Top 10 Events (in chronological order) in the field of global carbon neutrality and climate change response for 2023, to share with readers these significant moments that document the ongoing ambition and collective efforts of human society.

关键词： neutral collective intensified

^3H示踪法研究来乐司酮在动物体内的分布与排泄

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同位素 2002年第1期15卷 20-23页

作者：董墨李惠源吴元芳陆宏祺严惠芳中国科学院上海原子核研究所上海201800 上海医药工业研究院上海200437

进行了来乐司酮的氚标记,所得标记物的比活度为3.61TBq/g,纯化后放化纯度>95%;同时对该标记物在大白鼠体内的分布与排泄进行了研究。结果表明:来乐司酮能分布到大白鼠的各组织脏器中;其在卵巢中的分布量仅次于肝脏和肾上腺,其吸收量在0... 详细信息

进行了来乐司酮的氚标记,所得标记物的比活度为3.61TBq/g,纯化后放化纯度>95%;同时对该标记物在大白鼠体内的分布与排泄进行了研究。结果表明:来乐司酮能分布到大白鼠的各组织脏器中;其在卵巢中的分布量仅次于肝脏和肾上腺,其吸收量在0.5h时达到高峰,且在子宫中24h内可以保持一定的浓度,即可达到止早孕的目的;其在脊髓、脑和小脑中的分布较少,表明来乐司酮对中枢神经系统影响不大;来乐同酮主要经粪便排出,72h经粪和尿排出量占负荷量的62.84%,表明该药在体内没有积累致毒,可作为新药开发。

关键词：来乐司酮生物分布排泄止早孕药物氚示踪法氚标记药理实验

Productions of kaon and lambda by 50 GeV protons incident on nuclear targets

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nuclear Science and Techniques 1998年第2期9卷 74-77页

作者： Xu Xiao-Ming (shanghai institute of nuclear research, the chinese academy of sciences, shanghai 201800) shanghai institute of nuclear research Chinese Academy of Sciences Shanghai 201800 China

A Glauber multiple scattering theory in terms of pations and nucleons is applied to study productions of kaon, lambda and antilambda ill 50 GeV proton-nucleus scatterings at JHF (the Japan Hadron Facility). Tile ratios of tile differential cross sections of nucleontungsten to nucleon-beryllium are calclutated versus the transverse momentum at central rapidity. The cancellation between the single and double scattering amplitudes leads to nuclear enhancement of strangeness production at central rapidity.

关键词：质子核子靶 K介子 Α粒子

Filtering-efficiency measurement of chinese-made filter 1by double-filter method

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nuclear Science and Techniques 1999年第3期10卷 168-170页

作者： ZHI Min (shanghai institute of nuclear Rcsearrh, the chinese academy of sciences, shanghai 201800) shanghai institute of nuclear research Chinese Academy of sciences Shanghai 201800 China

Filtering efficiency of the chinese-made filter 1 has been measured by the double-filter method with only one set of measurement equipment. The β counts of the two filters are measured in turn for every 3 minutes, from which the decay constants are extracted to be 0.0131 min-1 and 0.0129 min-1 for the first and second filter respectively. After correcting the β counts of the second filter, the filtering efficiency of the filter is obtained to be (87.4±0.7)% in average.

关键词：滤波器双重滤波方法滤波效率

Regular behaviors in SU(2) Yang-Mills classical mechanics

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nuclear Science and Techniques 1997年第3期8卷 139-143页

作者： Xu Xiao Ming (shanghai institute of nuclear research, the chinese academy of sciences, shanghai 201800) shanghaiinstituteofnuclearresearch theChineseAcademyofSciencesShanghai201800

ＲｅｇｕｌａｒｂｅｈａｖｉｏｒｓｉｎＳＵ（２）ＹａｎｇＭｉｌｓｃｌａｓｉｃａｌｍｅｃｈａｎｉｃｓＸｕＸｉａｏＭｉｎｇ（ＳｈａｎｇｈａｉＩｎｓｔｉｔｕｔｅｏｆＮｕｃｌｅａｒＲｅｓｅａｒｃｈ，ｔｈｅＣｈｉｎｅｓｅＡ... 详细信息

ＲｅｇｕｌａｒｂｅｈａｖｉｏｒｓｉｎＳＵ（２）ＹａｎｇＭｉｌｓｃｌａｓｉｃａｌｍｅｃｈａｎｉｃｓＸｕＸｉａｏＭｉｎｇ（ＳｈａｎｇｈａｉＩｎｓｔｉｔｕｔｅｏｆＮｕｃｌｅａｒＲｅｓｅａｒｃｈ，ｔｈｅＣｈｉｎｅｓｅＡｃａｄｅｍｙｏｆＳｃｉｅｎｃｅｓ，...

关键词： SU(2) 杨-Mills经典力学正则行为

Simulation of Isotopic Angular Effects under Ion Bombardment of a^(92)Mo-^(100)Mo Target

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Journal of Materials Science & Technology 1997年第1期13卷 65-68页

作者： Liping ZHENG (shanghai institute of nuclear research, chinese academy of sciences, shanghai 201800, china)Risheng LI and Shuyou LI(Lab. of Atomic Imaging of Solids, institute of Metal research, chinese academy of sciences,Shenyang 110015, china) shanghai institute of nuclear research Chinese Academy of Sciences Shanghai 201800 China Lab. of Atomic Imaging of Solids Institute of Metal Research Chinese Academy of Sciences Shenyang 110015 China

Under 5 keV Ar ion bombardment of a 92Mo-100Mo target, we have investigated isotopic angular effects by means of the static and the dynamic Monte Carlo programs. Our calculated results are in quantitative agreement with the measured and other calculated results. The conclusion consistences among theories. simulations and measurements are also discussed.

关键词： Mo Target Simulation of Isotopic Angular Effects under Ion Bombardment of a Target

Transverse patterns and spatiotemporal instability of a photorefractive oscillator

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chinese Science Bulletin 1997年第9期42卷 724-729页

作者： ZHUANG Jun and TAN Weihan1. shanghai institute of Optics and Fine Mechanics, chinese academy of sciences, shanghai 201800, china 2. shanghai University, shanghai 201800, china shanghai institute of Optics and Fine Mechanics Chinese Academy of Sciences Shanghai China shanghai University Shanghai China

IN time realm,instability and chaos phenomena of a nonlinear optical system have been dis-cussed *** recent years,as much interest was attracted to the transverse ef-fects in nonlinear optics,the study was developed t... 详细信息

关键词： photorefractive oscillator spatiotemporal instability transverse patterns.

Mathematical feature of photon spectra produced in ultra-relativistic heavy-ion collision

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nuclear Science and Techniques 1997年第1期8卷 18-22页

作者： Ai Xiao Bai(Ai Hsiao Bai) ( shanghai institute of nuclear research, the chinese academy of sciences, shanghai 201800 ) shanghaiinstituteofnuclearResarch theChineseAcademyofSciencesShanghai201800

ＭａｔｈｅｍａｔｉｃａｌｆｅａｔｕｒｅｏｆｐｈｏｔｏｎｓｐｅｃｔｒａｐｒｏｄｕｃｅｄｉｎｕｌｔｒａｒｅｌａｔｉｖｉｓｔｉｃｈｅａｖｙｉｏｎｃｏｌｉｓｉｏｎＡｉＸｉａｏＢａｉ（ＡｉＨｓｉａｏＢａｉ）（Ｓｈａｎ... 详细信息

ＭａｔｈｅｍａｔｉｃａｌｆｅａｔｕｒｅｏｆｐｈｏｔｏｎｓｐｅｃｔｒａｐｒｏｄｕｃｅｄｉｎｕｌｔｒａｒｅｌａｔｉｖｉｓｔｉｃｈｅａｖｙｉｏｎｃｏｌｉｓｉｏｎＡｉＸｉａｏＢａｉ（ＡｉＨｓｉａｏＢａｉ）（ＳｈａｎｇｈａｉＩｎｓｔｉｔｕｔｅｏｆＮｕ...

关键词：重离子碰撞夸克-胶子等离子体光子谱