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Increased response to β2-adrenoreceptor stimulation augments inhibition of IKrin heart failure ventricular myocytes

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Increased response to β2-adrenoreceptor stimulation augment...

中华医学会心电生理和起搏分会第十次全国学术年会

作者： Hegui Wang1,Yanhong Chen2,HongjunZhu,Sen Wang2,Kejiang Cao,Jiangang Zou 2 1.Department of Cardiology,Yijishan Hospital of Wannan Medical College,241000 2.Department of Cardiology,the First Affiliated Hospital,nanjing Medical university,nanjing,china

Objective Increasing evidence indicates that the rapid component of delayed rectifier potassium current(I) is modulated byα- and β-adrenergic ***,the role and mechanism regulating I through β-adrenoreceptor( β-AR) stimulation in heart failure(HF) are unclear. Methods and Results In the present study,we investigated the effects of fenoterol,a highly selective β-AR agonist,on I in left ventricular myocytes obtained from control and guinea pigs with HF induced by descending aortic banding.I was measured by using whole cell patch clamp *** control myocytes,superfusion of fenoterol(10 uM) caused a 17%decrease in *** HF myocytes,the same concentration of fenoterol produced a significantly greater decrease(33%) in *** effects were not modified by the incubation of myocytes with CGP-20712A,a β-AR antagonist,but were abolished by pretreatment of myocytes with ICI-118551,a β-AR *** inhibitory cAMP analog, Rp-cAMPS and PKA inhibitor significantly attenuated fenoterol-induced inhibition of I in HF myocytes. Moreover,fenoterol markedly prolonged action potential durations at 90%(APD90) repolarization in HF ventricular myocytes. Conclusions The results indicate that inhibition of I induced by β-AR stimulation is increased in *** inhibitory effect is likely to be mediated through a cAMP/PKA pathway in HF ventricular myocytes.

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基于状态转换图的入侵检测模型STGIDM

计算机科学 2003年第11期30卷 99-101页

作者：姚立红黄皓谢立南京大学计算机科学与技术系南京210093 南京大学计算机软件新技术国家重点实验室南京210093

近年来,计算机系统的安全问题日益突出,相应的安全防范技术也成为了人们研究的热点.入侵检测技术作为一种重要的安全技术,从80年代中期就已经引起人们的注意[1],与其它安全技术相比(如身份认证、访问控制等),入侵检测技术具有鲜明的特点... 详细信息

近年来,计算机系统的安全问题日益突出,相应的安全防范技术也成为了人们研究的热点.入侵检测技术作为一种重要的安全技术,从80年代中期就已经引起人们的注意[1],与其它安全技术相比(如身份认证、访问控制等),入侵检测技术具有鲜明的特点:其它绝大多数安全技术主要强调预防或阻止外来入侵者进入系统,或者控制内部用户获取非法权限;而入侵检测主要在其它安全措施被突破、入侵者正在(或已经)进入系统的情况下发挥作用,该技术主要通过监视系统中的异常行为,及时发现入侵者,并采用相应措施(如断开网络连接、报告管理员等),以避免或尽可能减少入侵造成的损失[2].

关键词：网络安全状态转换图入侵检测模型 STGIDM 系统调用序列模式匹配性能分析

ATMOSPHERIC BOUNDARY LAYER IN EQUATORIAL AREA

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Science in china,Ser.B 1985年第4期28卷 410-419页

作者：伍荣生徐银梓宗金星 Department of Meteorology nanjing university

A system of linearized equations which describe the motion in the tropical boundary layer and their solutions are given in this paper. If the interaction between the boundary layer and the free atmosphere is taken into consideration, the potential height of the free atmosphere cannot be entirely independent of the character of the boundary layer. From this point of veiw, the continuous and bounded solutions of the boundary layer are obtained by imposing some suitable conditions to the field of potential height and thus the difficulty that the vertical velocity at the critical latitude tends to infinity can be overcome. Furthermore, a new result that the variation of the wind with height in the boundary layer at the critical latitude is not in the form of classical Ekman spiral is obtained. And this is also supported by the result obtained under the assumption of the so-called well-mlxed condition proposed by Mahrt.

关键词： ATMOSPHERIC BOUNDARY LAYER IN EQUATORIAL AREA 一彻

Preparation,Characterization and Properties of Conjugated Fc-Aq Complexes

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Preparation,Characterization and Properties of Conjugated Fc...

第十六届全国金属有机化学学术讨论会

作者： Ren-Jie Fan,Guan-lin Nie and Wen-Wei Zhang~* State Key Laboratory of Coordination Chemistry,School of Chemistry and Chemical Engineering, nanjing university,nanjing 210093,china

＜正＞Compounds with extendingπ-electron systems are of importance in a variety range of applications as optical, electronic,optoelectronic and magnetic ***,they are promising for generating new models for energy and...

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Pharmacokinetics study of three aromatic acids following oral administration of Shaofu Zhuyu decoction to normal and dysmenorrhea rats

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Pharmacokinetics study of three aromatic acids following ora...

中华中医药学会中药分析分会第五届学术交流会

作者： Shulan Su,Wenxia Cui,Yongqing Hua,Jinao Duan~*,Jianming Guo,Erxin Shang,Xinyue Jing,Pei Liu,Li Liu,Zhenhua Zhu,Yuping Tang Jiangsu Key Laboralory for TCM Formulae Research,nanjing university of Chinese Medicine,nanjing 210046,PR china

Shaofu Zhuyu decoction,a famous effective traditional Chinese formula,is commonly utilized for treating blood stasis syndrome of gynecology diseases in clinic for a long *** this paper,we compared the pharmacokinetics profile of three active aromatic acids in normal and dysmenorrhea rats plasma following oral administration of SFZYD and its ethanol supernatant. The rats were randomly divided to six groups and given the same dose of 2.1 mg/kg SFZYD and *** samples were collected at different time(0,0.083,0.25,0.5,1,2,4,6,8,12,24 h) after administration,the concentration of three aromatic acid components were then determined by ultra-performance liquid chromatography/time-of-flight mass spectrometry(UHPLC-QTOF/MS) and main pharmacokinetic parameters were estimated by DAS 2.0 *** aromatic acids were absorbed better in SFZYD than SFE, which was prepared of same amount of crude *** group has a better absorption than normal group which was benefit for therapy efficacy.

关键词： Shaofu Zhuyu decoction Aromatic acids Pharmacokinetics UHPLC-QTOF/MS

新生儿缺氧缺血性脑病血浆及脑脊液血小板活化因子的变化

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实用儿科临床杂志 2003年第12期18卷 972-974页

作者：郑帼徐英美南京医科大学附属南京儿童医院南京210008

目的　观察新生儿缺氧缺血性脑病 (HIE)血浆及脑脊液 (CSF)血小板活化因子 (PAF)的变化 ,探讨PAF在HIE发病中的作用。方法　于急性期和恢复期分别采集患儿血浆和CSF ,采用生物活性法检测血浆及CSF中PAF水平 ,并分析其与脑损伤和 1minAp... 详细信息

目的　观察新生儿缺氧缺血性脑病 (HIE)血浆及脑脊液 (CSF)血小板活化因子 (PAF)的变化 ,探讨PAF在HIE发病中的作用。方法　于急性期和恢复期分别采集患儿血浆和CSF ,采用生物活性法检测血浆及CSF中PAF水平 ,并分析其与脑损伤和 1minApgar评分的关系。结果　 ***患儿急性期CSF中PAF水平明显高于对照组患儿 (P 0 .0 5 ) ;恢复期与对照组比较无显著差异。 2 .血浆PAF水平与CSF中PAF水平呈正相关 ,血浆及CSF中PAF水平与脑损伤程度及 1minApgar评分呈明显正相关。结论　PAF可能参与新生儿HIE的发病机制。

关键词：婴儿新生脑缺氧脑缺血血小板活化因子

Tunable Filters with Narrow Band in Bulk SLA for DWDM Networks

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Chinese Journal of Lasers 1999年第6期 3-5页

作者： JIANG Yan CUI YipingTo whom correspondence should be addressed. PANG Shuming (Department of Electronic Engineering, Southeast university, nanjing 210096, china)

The filter mechanism of a tunable filter with narrow band in bulk semiconductor laser amplifier (SLA) is analyzed, which is suitable for dense wavelength division multiplexed (DWDM) optical fiber networks. The wavelength selectivity of the filter is derived from nondegenerate four wave mixing (NDFWM) in semiconductor gain medium. It uses the direction of propagation to separate the desired wave mixing product from the other light beams. The filters are shown to have very narrow passbands (subangstrom bandwidth) tunable over the entire semiconductor gain bandwidth. We gave the theoretical analysis of NDFWM effect in semiconductor gain medium is given and a set of nonlinear coupled wave equations is deduced, which are processed efficiently by Runge Kutta method in numerical simulation. The influences of various structural parameters of the filter on the output bandwidth and efficiency were also discussed.

关键词： DWDM networks wavelength filter nondegenerate four wave mixing

On the Relationship between Globalization and Modernity

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Social Sciences in china 2006年第1期27卷 171-172页

作者： Cheng Boqing, Associate Professor of the Department of Sociology, nanjing university Pan Jiabin

Discussions on globalization have been lively since the middle of 1990s. They have replaced, to a certain degree, past contentions on modernity and post-modernity to emerge as a hot topic in the mainstream world of learning. What then is the relationship between globalization and modernity? There are now three different viewpoints on this question in academic circles:

关键词：全球化现代化经济战略能源管理

MEASURING C PROGRAM COVERAGE BASED ON BINARY DECISION DIAGRAMS

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Journal of Electronics(china) 2005年第1期22卷 90-93页

作者： ShiLiang XuBaowen ChenLin DeptofComputerScience＆Eng. SoutheastUniversityNanjing210096China DeptofComputerScience＆Eng. SoutheastUniversityNanjing210096China／／JiangsuInstituteofSoftwareQualityNanjing210096China／／DeptofComputerNationalUniversityofDefenseTechnologyChangsha410073China

Test coverage analysis is a structural testing technique, which helps to evaluate the sufficiency of software testing. This letter presents two test generation algorithms based on binary decision diagrams to produce tests for the Multiple-Condition Criterion(M-CC) and the Modified Condition/Decision Criterion(MC/DC), and describes the design of the C program Coverage Measurement Tool (CCMT), which can record dynamic behaviors of C programs and quantify test coverage.

关键词： Software testing Test coverage Multiple-Condition Coverage(M-CC) Modified Condition/Decision Coverage(MC/DC)