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Inhibition of Tumor Growth in Mice by Endostatin Derived from Abdominal Transplanted Encapsulated Cells

Acta Biochimica et Biophysica Sinica 2007年第4期39卷 278-284页

作者： Huaining TENG~(1.3) Ying ZHANG~2 Wei WANG~2 Xiaojun MA~2* Jian FEI~1* 1 laboratory of Molecular Cell Biology,institute of Biochemistry and Cell Biology,Model Organism Research Center,Shanghai institutes for Biological sciences,chinese academy of sciences,Shanghai 200031,china 2 laboratory of biomedical material engineering,dalian institute of chemical physics,chinese academy of sciences,dolian 116023,china 3 Department of Urology,Changzheng Hospital,Second Military Medical University,Shanghai 200003,china laboratory of Molecular Cell Biology Institute of Biochemistry and Cell Biology Model Organism Research Center Shanghai Institutes for Biological Sciences Chinese Academy of SciencesShanghai 200031 China Department of Urology Changzheng Hospital Second Military Medical UniversityShanghai 200003 China laboratory of biomedical material engineering Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023 China

Endostatin,a C-terminal fragment of collagen 18a,inhibits the growth of established tumorsand metastases in vivo by inhibiting ***,the purification procedures required for large-scale production and the attendant cost of these processes,together with the low effectiveness in clinicaltests,suggest that alternative delivery methods might be required for efficient therapeutic use of *** the present study,we transfected chinese hamster ovary(CHO)cells with a human endostatin geneexpression vector and encapsulated the CHO cells in alginate-poly-L-lysine *** release ofbiologically active endostatin was confirmed using the chicken chorioallantoic membrane *** encap-sulated endostatin-expressing CHO cells can inhibit the growth of primary tumors in a subcutaneous B 16tumor model when injected into the abdominal cavity of *** results widen the clinical applicationof the microencapsulated cell endostatin delivery system in cancer treatment.

关键词： microencapsulation endostatin CHO tumor gene therapy

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Optical characteristics and environmental pollutants detection of porous silicon microcavities

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Science china Chemistry 2011年第8期54卷 1348-1356页

作者： HUANG JianFeng, LI Sha, CHEN QingWei & CAI LinTao CAS Key laboratory of Health Informatics Shenzhen Key laboratory of Cancer Nanotechnology institute of biomedical and Health engineering, Shenzhen institute of Advanced Technology, chinese academy of sciences, Shenzhen 518055, china CAS Key laboratory of Health Informatics Shenzhen Key laboratory of Cancer Nanotechnology institute of biomedical and Health engineering Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen China

Porous silicon microcavities (PSM) optical crystals consisting of a Fabry-Perot microcavity embedded between two distributed Bragg reflectors have been fabricated by electrochemical etching. Scanning electron microscopy (SEM) clearly depicted their physical sandwich construction. The optical feature of the PSM structure was tuned by varying the anodization parameters. Through proper thermal oxidation and surface chemical modifications, the resulting structures were employed as optical sensors for the detection of environmental pollutants including volatile organic vapors (i.e. acetonitrile, toluene, cyclohexane, chloroform, acetone and ethanol) and interior decoration gases (i.e. toluene, ammonia and formaldehyde). Fourier transform infrared spectroscopy (FTIR) spectra confirmed the effective thermal annealing and surface modification chemistry, and the sensing process was accompanied by recording the modified structures' optical responses when exposed to target analytes. The PSM optical sensors showed good stability, sensitivity and selectivity, implying promising applications in gas sensing and en- vironmental monitoring.

关键词： porous silicon microcavity optical sensor thermal oxidation surface modification environmental pollutants detection

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Wet-chemical synthesis and characteristics of Au nanoshell

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Science china Chemistry 2005年第5期48卷 431-435页

作者： LIU Zhongxin1,2, SONG Hongwei1, YU Lixin1,2, YANG Linmei1,2 & PAN Guohui1,2 1. Key laboratory of Excited State physics, Changchun institute of Optics, Fine Mechanics and physics, chinese academy of sciences, Changchun 130033, china 2. Graduate School of the chinese academy of sciences, Beijing 100039, china Key laboratory of Excited State physics Changchun Institute of Optics Fine Mechanics and Physics Chinese Academy of Sciences Changchun China Graduate School of the chinese academy of sciences Beijing China

Gold nanoshells were prepared by an easy wet-chemical method, with Ag nanoparticles used as the templates. Transmission electron microscopy (TEM) indicated that the shells were sphere in shape, the size was homogenous, being about 20 nm, and no hard ag-glomerates were observed. The plasma resonance absorption of gold was tuned from visible to near-infrared (NIR) with the increased volume of HAuCl4. The temperature grads (?T) of the gold nanoshell hydrosol under the exposure of an 808-nm optical fiber laser with different power den-sities were measured. The highest ?T was 30℃ (5 W/cm2, irradiation area was 2 cm2). This kind of gold nanoshell hydrosol is a promising material to be used in biomedicine such as photo-thermal cancer therapy, and its special photothermal convert property will photothermally trigger drug release.

关键词： wet-chemical synthesis, Au, nanoshell, NIR absorption, photothermal conversion.

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Carbon isotope composition of the Lower Triassic marine carbonates, Lower Yangtze Region, South china

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Science china Earth sciences 2006年第3期49卷 225-241页

作者： ZUO Jingxun1,2, TONG Jinnan3, QIU Haiou4 & ZHAO Laishi3 1. Nanjing institute of Geology and Palaeontology, chinese academy of sciences, Nanjing 210008, china 2. Henan institute of Geological Survey, Zhengzhou 450007, china 3. State Key laboratory of Geological Processes and Mineral Resources at china University of Geosciences, Wuhan 430074, china 4. Faculty of material sciences and chemical engineering, china University of Geosciences, Wuhan 430074, china Nanjing institute of Geology and Palaeontology Chinese Academy of Sciences Nanjing China Henan institute of Geological Survey Zhengzhou China State Key laboratory of Geological Processes and Mineral Resources at china University of Geosciences Wuhan China Faculty of material sciences and chemical engineering China University of Geosciences Wuhan China

Studies on three Lower Triassic sections located on the shallow water platform, the deep water slope and in the deep water basin in the Lower Yangtze Region, South china, show the similar trend of carbon isotope evolution. Biostratigraphic correlations among the Lower Triassic sections on the basis of standard conodont zones indicate that three negative shifts occurred in the Griesbachian, the Smithian and the late Spathian stages respectively, and one distinctly positive shift occurred in the early Spathian stage. Trend of carbon isotope evolution of the Lower Triassic reflects some significant changes in the global carbon cycle. Moreover, δ 13C background values are intensively controlled by palaeogeographic environment. In general, δ 13C values from deep-water slope carbonates are lighter than those from carbonate platform and heavier than those from deep-water basin carbonates. The positive carbon isotope excursion may be induced by a significant amount of organic carbon burial in marine sediments and increase in primary productivity. The large negative carbon isotope excursions during the Early Triassic in Lower Yangtze Region are interpreted to relate to volcano eruptions based on tuffaceous claystone interlayers observed near the Permian-Triassic boundary, the Induan- Olenekian boundary and the Lower Triassic-Middle Triassic boundary.

关键词： Lower Triassic, carbon isotope compositions, palaeogeography, volcanic eruptions, Lower Yangtze Region.

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The Crystallization of Poly (3-dodecyltbiophene) in an Oriented Solidification Environment

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chinese chemical Letters 2000年第4期11卷 361-364页

作者： Xiu Ying QIAO~1 Xian Hong WAN~1 Zhao Bin QIU~1 Zhi Shen MO~1 Wen Kui WANG~2 ( 1 Polymer physics laboratory. Changchun institute of Applied Chemistry. chinese academy of sciences, Changchun 130022 2 institute of material engineering. Yanshan University, Polymer physics laboratory Changchun Inst. of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China institute of material engineering Yanshan University Qinhuangdao 066004 China

The crystallization behaviors of poly (3-dodecylthiophene) (P3DDT) under two different oriented solidification conditions. i e..' two different relative relations (90° and 180°) between the directions of gravity and solidification. were investigated. X-ray diffraction results reveal that although similar layered structures are formed, under the condition of the relative relation 180°. temperature; gradient has greater effects on the perfect degree of the layered structures of P3DDT. It also can be concluded that after recrystallization. the layered structures of P3DDT can be improved at relative relation 90°, but the orderly degree of the arrangements of alkyl side chains are not improved yet, even is reduced for both of the oriented solidification conditions.

关键词： Crystallization poly (3-dodecylthiophene) oriented solidification.

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Support vector machine for SAR/QSAR of phenethyl-amines

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Acta Pharmacologica Sinica 2007年第7期28卷 1075-1086页

作者： Bing NIU~2,Wen-cong LU~(2,3,6),Shan-sheng YANG~2,Yu-dong CAI~(3,4,6),Guo-zheng LI~5 ~2 College of material Science and engineering,Shanghai University,Shanghai 200444,china ~3 laboratory of chemical Data Mining,Department of Chemistry,College of sciences,Shanghai University,Shanghai 200444,china ~4 Department of Combinatorics and Geometry,CAS-MPG Partner institute for Computational Biology,Shanghai institutes for Biological sciences,chinese academy of sciences,Shanghai200031,china ~5 School of Computer Science and engineering,Shanghai University,Shanghai 200072,china 2College of material Science and engineering Shanghai University Shanghai 200444 China 3laboratory of chemical Data Mining Department of Chemistry College of Sciences Shanghai University Shanghai 200444 China 2College of material Science and engineering Shanghai University Shanghai 200444 China 4Department of Combinatorics and Geometry CAS-MPG Partner Institute for Computational Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China 5School of Computer Science and engineering Shanghai Univeristy Shanghai 200072 China

Aim:To discriminate 32 phenethyl-amines between antagonists and agonists,and predict the activities of these ***:The support vectormachine (SVM) is employed to investigate the structure-activity relationship(SAR)/quantitative structure-activity relationship (QSAR) of phenethyl-aminesbased on molecular ***:By using the leave-one-out cross-vali-dation (LOOCV) test,1 optimal SAR and 2 optimal QSAR models for agonists andantagonists were *** accuracy of prediction for the classification ofphenethyl-amines by using the LOOCV test is 91.67%,and the accuracy of predic-tion for the classification of phenethyl-amines by using the independent test is100%;the results are better than those of the Fisher,the artificial neural network(ANN),and the K-nearest neighbor models for this real world *** RMSE(root mean square error)of antagonists' QSAR model is 0.5881,and the RMSE ofagonists' QSAR model is 0.4779,which are better than those of the multiple linearregression,partial least squares,and ANN models for this real world ***:The SVM can be used to investigate the SAR and QSAR of phenethyl-amines and could be a promising tool in the field of SAR/QSAR research.

关键词： support vector machine QSAR phenethylamines antagonists agonists

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A New High Efficiency Green Luminescent material──the System Al_2O_3-B_2O_3 Containing Ce^(3+) and Tb^(3+) Ions

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chinese chemical Letters 1998年第9期9卷 877-880页

作者： Hong Peng YOU Guang Yan HONG (laboratory of Rare Earth Chemistry and physics, Changchun institute of Applied Chemistry,chinese academy of sciences, Changchun 130022) Lab. of Rare Earth Chem. and physics Changchun Inst. of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China

To obtain high efficiency luminescent materials, the system Al2O3-B2O3 containing Ce3+ andTb3+ ions with variation of B2O3-content, has been prepared by Al2O3, H3BO3, CeO2 and Tb4O7 underreducing atmosphere at 1250i . It is notable that the brightness of the sample with appropriatecomposition is similar to that of commercial phosphorous containing Ce3+ and Tb3+, indicating that a newhigh efficency green luminescent material was obtained with appropriate B2O3-content.

关键词： the system Al_2O_3-B_2O_3 Ce^(3+) and Tb^(3+) ions a new high efficent green phosphorous

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Photoresponsive organogel and organized nanostructures of cholesterol imide derivatives with azobenzene substituent groups

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Progress in Natural Science:materials International 2012年第1期22卷 64-70页

作者： Tifeng Jiao a,b,c,Yujin Wang a,Fengqing Gao a,Jingxin Zhou a,Faming Gao a a Hebei Key laboratory of Applied Chemistry,College of Environmental and chemical engineering,Yanshan University,Qinhuangdao 066004,china b College of Chemistry & materials engineering,Wenzhou University,Wenzhou 325027,china c State Key laboratory of Solid Lubrication,Lanzhou institute of chemical physics,chinese academy of sciences,Lanzhou 730000,china Hebei Key laboratory of Applied Chemistry College of Environmental and Chemical Engineering Yanshan University Qinhuangdao 066004 China College of Chemistry & materials engineering Wenzhou University Wenzhou 325027 China State Key laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences Lanzhou 730000 China

Two new cholesterol imide derivatives with azobenzene substituent groups have been *** compounds possess headgroups of hydrogen or methyl units,*** gelation test revealed that a subtle change in the headgroup of azobenzene segment produced a dramatic change in the gelation behavior of both *** compound with headgroups of hydrogen units only gelated N,N-Dimethylformamide(DMF),while the other compound with headgroups of methyl units cannot gelate any solvent tested *** DMF gel and solution of the gelator,the reversible photoisomerization transitions by irradiation with ultraviolet(UV) and visible light are investigated by UV-vis absorption spectra,Fourier transform infrared spectrometer,scanning electron microscope,atomic force microscope,and X-ray diffraction *** UV irradiation of the gel,trans-cis photoisomerization of the azobenzene groups occurs,the change in molecular polarity leads to the breaking of van der Waals interactions,resulting in the gel-sol *** gel can be recovered by the reverse cis-trans photoisomerization after exposure to visible *** and spectral studies reveal that the gelator molecules selfassemble into one-dimensional fibers,which further crossed-linked to form regular *** results afford useful information for the development of new versatile low molecular mass gelators and soft matter.

关键词： Organogel Cholesterol Azobenzene Photoisomerization Soft material

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Regulation mechanism of EM parameters in natural ferrite and its application in microwave absorbing materials

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Science china(Technological sciences) 2006年第1期49卷 38-49页

作者： ZHENG Yongchun1,2, WANG Shijie2, FENG Junming2, LI Chunlai1, OUYANG Ziyuan1,2, LIU Jianzhong1 & LI Xiaobiao2 1. National Astronomical Observatories, chinese academy of sciences, Beijing 100012, china 2. State Key laboratory of Environmental Geochemistry, institute of Geochemistry, chinese academy of sciences, Guiyang 550002, china National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China

Electromagnetic (EM) parameters (ε ′, ε ″, μ ′, μ″ ) of several M2+Fe2O4 and Fe2O3 type natural ferrites with different geological occurrences are measured in this pa-per. The measurement results show that EM parameters of a magmatic-occurring natural ferrite is very different from other types occurring from sedimentary-metamorphic iron deposit, hydrothermal vein iron deposit, outer contact of magmatic iron deposit. It has potential to be used as magnetic absorbent in microwave absorbing materials. After min-eral separation and concentration, this magmatic-occurring natural ferrite was processed into type A ferrite absorbent. Type A natural ferrite absorbent is a kind of magnetic material with low dielectric constants, high magnetic conductivity and high EM loss. Its EM pa-rameters are ε ′ = 58.60, ε ″ = 10.0, μ ′ = 1.2-1.5, μ ″ = 1.0-1.2, respectively. In order to illuminate the regulation mechanism of EM parameters, we studied the chemical and mineral composition of type A ferrite absorbent. There is high concentration of natural impurities, which regulate the EM parameters of type A ferrite greatly. For comparison, the other types of natural ferrite, single-phase magnetite and two-phase iron minerals (ilmen-ite and magnetite), have few impurity. Thus regulation mechanism of EM parameters was absent in these ferrites. As a result, the regulation of EM parameters is advantageous to develop type A natural ferrite as excellent absorbent, lowers the reflectivity coefficients and enhances the absorbing efficiency of MAM made from it. Furthermore, the impurities in type A natural ferrite and its effects on EM parameters are very difficult to simulate in the synthesize ferrite. The carbonyl-iron powder is another kind of absorbent that is used ex-tensively in MAM. To compare the absorbing properties of these two absorbent, type A natural ferrite and carbonyl-iron powder were mixed with rubber and processed into mi-crowave absorbing sheets with the same procedures and tec

关键词： natural impure ferrite, complex permittivity, complex permeability, microwave absorbing materials.

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Growth and characterization of high-quality Mn-doped LiAlO_2 single crystal

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chinese Optics Letters 2010年第4期8卷 414-417页

作者：滕浩周圣明林辉贾婷婷侯肖瑞王军 Key laboratory of material Science and Technology for High Power Lasers Shanghai institute of Optics and Fine Mechanics Chinese Academy of Sciences Graduate University of chinese academy of sciences

The growth of a Mn-doped LiAlO_2 single crystal by the Czochralski（CZ） method and the characterization of its spectroscopy and thermoluminescence（TL） are *** X-ray rocking curve and chemical etching analysis show that the as-grown crystal has good *** full-width at half-maximum （FWHM） of the LiAlO_2（200）ωrocking curve is 23.2 arcsec and the etching pits density of the（100） plane is（1.6-4.0）×10~4 cm^（-2）.The transmission spectrum indicates that the crystal is highly transparent in the 200-1500-nm wavelength *** emission spectrum of the crystal consists of a peak around 579 nm when excited with 428-nm *** TL spectra show that the LiAlO_2：Mn crystal has glow peaks at 150 and 172℃.The change of TL characteristics of the crystal before and after thermal annealing in the air is discussed,and the effect of annealing and irradiation on the evolution of defect types is analyzed.

关键词： Emission spectroscopy Etching Lithium alloys Manganese compounds Single crystals Thermoluminescence

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