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Large area mold fabrication for the nanoimprint lithography using electron beam lithography

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Science china(Technological Sciences) 2010年第1期53卷 248-252页

作者： CHU JinKui1,2,MENG FanTao1,2,HAN ZhiTao1,2 & GUO Qing1,2 1 key laboratory for Micro/Nano Technology and System of Liaoning province,Dalian University of Technology,Dalian 116024,china 2 key laboratory for Precision and Non-traditional Machining Technology of Ministry of Education,Dalian University of Technology,Dalian 116024,china key laboratory for Micro/Nano Technology and System of Liaoning province Dalian University of Technology Dalian China key laboratory for Precision and Non-traditional Machining Technology of Ministry of Education Dalian University of Technology Dalian China

The mold fabrication is a critical issue for the development of nanoimprint lithography as an effective low-cost and mass production *** paper describes the fabrication process developed to fabricate the large area nanoimprint molds on the silicon *** optimization of e-beam exposure dose and pattern design is *** overlayer process is developed to improve the field stitching accuracy of e-beam exposure,and around 10 nm field stitching accuracy is *** means of the optimization of the e-beam exposure dose,pattern design and overlayer process,large area nanoimprint molds having dense line structures with around 10 nm field stitching accuracy have been *** fabricated mold was used to imprint commercial imprinting resist.

关键词： nanoimprint lithography mold fabrication electron beam lithography

A novel method for evaluating and improving the 1H-MRSI glioma data quality

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Progress in Natural Science:Materials International 2005年第8期15卷 765-768页

作者： YUAN Kehong 1,2, LU Hongyu2, BAO Shanglian2*, CHEN Qiansheng1, LI Shaowu3 and DUAN Chaijie2(1. key laboratory of Pure and applied mathematics, School of Mathematical Sciences, Beijing 100871, china 2. The Research Center for Tumor Diagnosis and Therapeutical Physics & the Beijing key laboratory of Medical Physics and Engineering, Peking University, Beijing 100871, china 3. The Tian Tan Hospital, Beijing 100050, china) key laboratory of Pure and applied mathematics School of Mathematical Sciences Beijing 100871 China Beijing key laboratory of Medical Physics and Engineering Research Center for Tumor Diagnosis and Therapeutical Physics Peking University Beijing 100871 China Tian Tan Hospital Beijing 100050 China

Metabolic information obtained by proton magnetic resonance spectroscopic imaging (1H-MRSI) has been approved to be a powerful tool to identify either benign or malignant glioma, as well as to confirm the tumor level. However, 1H-MRSI data are affected by various factors, such as the thermal noise, eddy currents, susceptibility artifacts, and rigid body motion. To get accurate quantitative metabolic information, the key problem is to assess the 1H-MRSI data quality. In this paper, we introduce a new evaluating system to filter the data, and a new method, called wavelet denoising method, to improve the data quality under the evaluating system. Experimental results on 1H-MRSI glioma data demonstrate that preprocessing is prerequisite and the proposed algorithm with evaluating system is effective.

关键词： 1H-MRSI evaluating system glioma data quality wavelet denoising

Latent ancestral graph of structure vector autoregressive models

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Journal of Systems Engineering and Electronics 2010年第2期21卷 233-238页

作者： Wei Gao1,2and Zheng Tian2,3 1.School of Statistics,Xi’an University of Finance&Economics,Xi’an 710061,P.R.china 2.Department of applied mathematics,Northwestern Polytechnical University,Xi’an 710072,P.R.china 3.State key laboratory of Remote Sensing Science,Institute of Remote Sensing Applications,Chinese Academy of Sciences,Beijing 100101,P.R.china School of Statistics Xi'an University of Finance & Economics Xi'an 710061 P. R. China Department of applied mathematics Northwestern Polytechnical University Xi'an 710072 P. R. China Department of applied mathematics Northwestern Polytechnical University Xi'an 710072 P. R. China State key laboratory of Remote Sensing Science Institute of Remote Sensing Applications Chinese Academy of Sciences Beijing 100101 P. R. China

A class of latent ancestral graph for modelling the dependence structure of structural vector autoregressive （VAR） model affected by latent variables is proposed. The graphs are mixed graphs with possibly two kind of edges, namely directed and bidirected edges. The vertex set denotes random variables at dif- ferent times. In Gaussian case, the latent ancestral graph leads to a simple parameterization model. A modified iterative conditional fitting algorithm is presented to obtain maximum likelihood esti- mation of the parameters. Furthermore, a log-likelihood criterion is used to select the most appropriate models. Simulations are performed using illustrative examples and results are provided to demonstrate the validity of the methods.

关键词： multivariate time series latent ancestral graph itera- tive conditional fitting.

WAVE MOTION OVER TWO SUBMERGED LAYERS OF HORIZONTAL THICK PLATES

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Journal of Hydrodynamics 2009年第4期21卷 453-462页

作者： LIU Yong LI Yu-cheng TENG Bin key laboratory of Ocean Engineering Shandong Province Ocean University of China Qingdao 266100 China key laboratory of Water and Sediment Science and Water Hazard Prevention Hunan Province Changsha 410076 China State key laboratory of Coastal and Offshore Engineering Dalian University of Technology Dalian 116024 China

This study investigates the hydrodynamic performance of a submerged two layer horizontal plate breakwater. The plate thickness is considered as non-zero in the study. In the context of linear potential theory, an analytical solution for interaction of water waves with the plates is obtained using the matched eigenfunction expansion method. The solution consists of a symmetric part and an antisymmetric part. Its validity is confirmed by comparing the numerical results of reflection and transmission coefficients for limiting cases with previous predictions. Numerical examples are given to examine the major factors that affect the reflection and transmission coefficients of the plates. Some useful results are presented for engineering design.

关键词： submerged breakwater horizontal thick plate reflection coefficient transmission coefficient

Unfolding and unfolded states of small Proteins in the Physical Property Space

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生物物理学报 2009年第S1期25卷 361-362页

作者： key laboratory of Biophysics, Shandong province(Dezhou University), Dezhou 253023, china

In this work, multiple molecular dynamics simulations of protein G and protein L unfolding trajectories provide a direct demonstration of the diversity of unfolding pathway and give

关键词： GB1 Protein L Unfolding Unfolded state Physical property space Molecular dynamics simulation

A numerical study on Rayleigh-Taylor instability of aluminum plates driven by detonation

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Science china(Physics,Mechanics & Astronomy) 2010年第2期53卷 195-198页

作者： HE ChangJiang,ZHOU HaiBing & HANG YiHong Institute of applied Physics and Computational mathematics,laboratory of Computational Physics,Beijing 100088,china Institute of applied Physics and Computational mathematics Laboratory of Computational Physics Beijing China

The authors,using elastic-plastic hydrodynamic code,present the Rayleigh-Taylor (RT) instability of Al plates driven by high-explosive detonation. Our numerical study assumes the material is fluid,or it is an elastic-plastic solid,and we compare the results of these simulations with the experimental data. For the numerical simulation of Rayleigh-Taylor instability of the metal driven by high-explosive detonation,the elastic-plastic effect must be assumed. The result of the simulation is different from the experiment,using only equation of state. However,the growth of perturbation agrees well with the measured growth under the second assumption. There is a cutoff wavelength for RT instability of the metal. The growth of perturbation is stable for short wavelength. The growth increases rapidly as the wavelength increases.

关键词： interface instability elastic-plastic numerical simulation

Stacking interaction in metal complexes with compositions of DNA and heteroaromatic N-bases

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Chinese Science Bulletin 2002年第1期47卷 1-9页

作者： Jl Liangnian & LE XueyiDepartment of Chemistry, key laboratory for the Gene Engineering of the Ministry of Education of china, and State key laboratory of Ultrafast Laser Spectroscopy, Zhongshan University, Guangzhou 510275, china Department of applied C Department of Chemistry Key Laboratory for the Gene Engineering of the Ministry of Education of China and State Key Laboratory of Ultrafast Laser Spectroscopy Zhongshan University Guangzhou China Department of applied Chemistry South-China Agricultural University Guangzhou China

The current development in the intramolecular aromatic-ring stacking interactions in the complexes with compositions of DNA and heteroaromatic N-bases has been reviewed to a great extent, especially the significant contributions in several important systems about ternary mixed-ligand complexes, including nucleotide-metal ion-po-lyaromatic amine, amino acid-metal ion-polyaromatic amine, nucleotide-metal ion-pyridine-like aromatic amine, nucleo-tide-metal ion-amino acid, nucleotide-metal ion-nucleic acid base, nucleic acid base-metal ion, and the important factors affecting the intramolecular aromatic-ring stacking interac-tions in the complexes. Based on the study of stacking inter-action in the complexes, the mechanism of interaction be-tween DNA molecules and complexes of heteroaromatic N-bases has been established, which is crucial for the design and synthesis of the complexes acting as molecular devices of DNA.

关键词： ternary mixed-ligand complexes stacking interaction transition metal ion heteroaromatic N-base nucleotide amino acid.

Reappraisal of phylogenetic status and genetic diversity analysis of Asian population of Lentinula edodes

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Progress in Natural Science:Materials International 2006年第3期16卷 274-280页

作者： XU Xuefeng, LI Anzheng, CHENG Shuiming, LIN Fanxue and LIN Fangcan (State key laboratory of Agricultural Microbiology and Institute of applied Mycology, Huazhong Agricultural University, wuhan 430070, china) State key laboratory of Agricultural Microbiology and Institute of applied Mycology Huazhong Agricultural University Wuhan 430070 China

Phylogenetic relationship within the Lentinula genus is constructed based on the sequenced ITS fragments of the 60 Chinese wild L. edodes isolates and the sequence data of 48 isolates of different species from other districts downloaded from the Gen-Bank. The 108 isolates of Lentinula genus are divided into two branches and seven groups, one branch and two groups in the New World, and the other branch and five groups in the Old World, and the isolates clustering of different groups corresponds obviously with the classification of the morphological species. Asian isolates are partitioned in group Ⅰ and Ⅴ, two of the five groups of the Old World, by which the germplasm resources status represented is of great importance shown by the phylogenetic analysis. Group Ⅴ which fills up the blank of geographic distribution has become one of the mainstream groups with an increased isolate number, while group Ⅰ has a tendency to dissimilate into two subgroups (Ia and Ib) with a huge isolate quantity and a coverage of most tested districts, suggesting that china (or Asia) is an important genetic diversity center of the natural population of Lentinula genus. Genetic analysis of Asian isolates based on groups Ia, Ib and group Ⅴ indicates that the diversity of the east coastal-land, northwestern highland and southwestern china and Himalayas districts is the most plentiful, which is the three priorities in diversity protection of Asian Lentinula population.

关键词： Asia Lentinula ITS (internal transcribed spacer) phytogeny genetic diversity.

Interaction of cellular-localized signature modules in response to prostate cancer

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Progress in Natural Science:Materials International 2007年第11期17卷 1368-1375页

作者： Zhu Jing1, Guo Zheng1,2, Zhang Min2, Yang Da2, Wang Jing2 and Wang Chenguang2(1. School of Life Science and Bioinformatics Centre, University of Electronic Science and Technology of china, Chengdu 610054, china 2. Department of Bioinformatics, Bio-Pharmaceutical key laboratory of Heilongjiang province, Harbin Medical University, Harbin 150081, china) School of Life Science and Bioinformatics Centre University of Electronic Science and Technology of China Chengdu 610054 China Bio-Pharmaceutical key laboratory of Heilongjiang province Department of Bioinformatics Harbin Medical University Harbin 150081 China

Rapid progress in high-throughput biotechnologies (e.g. microarrays) and exponential accumulation of gene functional knowledge makes it promising for systematic understanding of complex human diseases at the functional modules level. Current modular categorizations can be defined and selected more specifically and precisely in terms of both biological processes and cellular locations, aiming at uncovering the modular molecular networks highly relevant to cancers. Based on Gene Ontology, we identifed the functional modules enriched with differentially expressed genes and characterized by biological processes and specific cellular locations. Then, according to the ranking of the disease discriminating abilities of the pre-selected functional modules, we further defined and filtered signature modules which have higher relevance to the cancer under study. Applications of the proposed method to the analysis of a prostate cancer dataset revealed insightful biological modules.

关键词： microarray analysis Gene Ontology classification analysis cellular location functional module