检索结果-南通市图书馆

北京山地系统的土地利用控制与景观生态环境建设规划

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

山地学报 2001年第S1期19卷 92-97页

作者：李红孙丹峰林培北京市农林科学院植物营养与资源研究所中国农业大学土地资源系中国农业大学土地资源系北京100089

在分析北京山地系统的三大景观生态区域的现状和土地利用特点以及存在的生态环境问题基础上提出北京市景观生态环境建设的规划分区原则 ,那立北京市的三个一级规划分区和 8个类型区 ,指出各区的土地利用调整和类型区的景观生态环境建设... 详细信息

在分析北京山地系统的三大景观生态区域的现状和土地利用特点以及存在的生态环境问题基础上提出北京市景观生态环境建设的规划分区原则 ,那立北京市的三个一级规划分区和 8个类型区 ,指出各区的土地利用调整和类型区的景观生态环境建设方向。本文建立土地利用控制分区与生态环境建设相结合的规划模式 ,体现两个《规划》的基本要求 ,从而将人类经济活动、土地资源利用和生态环境建设融合在一起 ,实现土地利用规划“一保吃饭 ,二保建设 ,三保生态环境”的原则。

关键词：山地系统土地利用控制景观生态规划分区

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

克山病病区粮及硒补充对小鼠免疫功能的影响

卫生研究 1989年第1期18卷 30-34页

作者：曹来福闻芝梅中国预防医学科学院营养与食品卫生研究所中国预防医学科学院营养与食品卫生研究所卫生部食品卫生监督检验所

用克山病病区粮和在病区粮中补加不同水平硒的饲料喂养C57BL/6J断乳小鼠7周,病区粮组小鼠脾脏免疫特异玫瑰花形成细胞（RFC）数、溶血空斑形成细胞（PFC）数、脾脏淋巴细胞介导的体外绵羊红细胞溶血反应（QHS）均明显低于非病区粮组,病... 详细信息

用克山病病区粮和在病区粮中补加不同水平硒的饲料喂养C57BL/6J断乳小鼠7周,病区粮组小鼠脾脏免疫特异玫瑰花形成细胞（RFC）数、溶血空斑形成细胞（PFC）数、脾脏淋巴细胞介导的体外绵羊红细胞溶血反应（QHS）均明显低于非病区粮组,病区粮补硒各组小鼠的上述免疫反应虽有增强,但未达到非病区粮对照组水平。提示补硒只能部分改善病区粮致病因素对免疫功能的抑制作用。

关键词：克山病硒免疫功能

Adjust the reaction conditions of enzyme catalysis to product fructooligosaccharides containing different components proportions

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Adjust the reaction conditions of enzyme catalysis to produc...

2010 First International Conference on Cellular,Molecular Biology, Biophysics and Bioengineering(CMBB 2010)

作者： Ding Jicheng Key Laboratory of nutrition and safety Ministry of Education Tianjin University of Science & Technology Tianjin china 300457Lv xiaoling Key Laboratory of nutrition and safety Ministry of Education Tianjin University of Science & Technology Tianjin china 300457

Fructooligosaccharides （FOSs）, as a mixture of 1-kestose, nystose, and 1F-fructofuranosylnystose oligosaccharides, exhibit lots of beneficial effects on our health and have been used as food ingredients. There have been a lot of reports on how to raise FOSs yield in different ways, but almost nobody did any deeply studies on the composition of FOSs—proportion of each component. However, different components may have different functions and some even show side-effects. In this research, we employed immobilized fructosyltransferase to produce FOSs and got a maximum yield of 56.12 %. Then we successfully produced FOSs of different components proportions by adjusting the reaction parameters—pH, temperature, and fermentation time. We designed six groups to investigate the relationship between reaction parameters and components proportions, and the results showed that pH condition mainly affects the yield while reaction time mainly affects components proportions. It is the first time that the components proportions of FOSs are systemically investigated, and we finally figured out six protocols for producing different FOSs. This is a basic investigation on the relationship between FOSs components proportions and reaction conditions. We hope this research can be helpful for other researchers who are interested in this area.

关键词： Fructooligosaccharides Components proportions Reaction conditions Optimization

Threonine and tryptophan supplementation mitigate porcine respiratory and reproductive syndrome(PRRS) vaccination induced growth slowness of growing pigs

在线全文

cnki会议

学校读者我要写书评

暂无评论

Threonine and tryptophan supplementation mitigate porcine re...

低碳经济与高效养殖——第六次全国饲料营养学术研讨会暨动物营养学分会成立三十周年大会

作者： Shen Jie,Zhengfeng Fang,Yingfei Zhao,Yan Lin,De Wu~* (Key Laboratory for Animal disease Resistance nutrition of Ministry of Education of china,institute of Animal nutrition,Sichuan Agricultural University,Ya’an 625014,china)

The objective of this study was to determine whether Thr and Trp-rich(TTR) diet would benefit growing pigs vaccinated with porcine respiratory and reproductive syndrome(PRRS) ***-six growing pigs(29 kg BW) were fed either a conventional(CON) diet with Lys:Thr:Trp at 100:64:18(n=13),or a TTR diet with Lys:Thr:Trp at 100:80:26(n=13),for 70The objective of this study was to determine whether Thr and Trp-rich(TTR) diet would benefit growing pigs vaccinated with porcine respiratory and reproductive syndrome(PRRS) ***-six growing pigs(29 kg BW) were fed either a conventional(CON) diet with Lys:Thr:Trp at 100:64:18(n=13),or a TTR diet with Lys:Thr:Trp at 100:80:26(n=13),for 70

关键词： growing pigs PRRS vaccination growth performance blood parameters

EFFECT OF FEED INTAKE LEVELS ON EMBRYONIC SURVIVAL AND IMPORTANT DEVELOPMENTAL GENE EXPRESSION DURING EARLY PREGNANCY IN GILTS

在线全文

cnki会议

学校读者我要写书评

暂无评论

EFFECT OF FEED INTAKE LEVELS ON EMBRYONIC SURVIVAL AND IMPOR...

中国畜牧兽医学会动物营养学分会第八届全国会员代表大会暨第十次动物营养学术研讨会

作者： Xu Shengyu Wu De Zhang Guo Zheng Airong Guo Haiyan Key Laboratory for Animal disease Resistance nutrition of the Ministry of Education of china,institute of Animal nutrition,Sichuan Agricultural University,Ya’an 625014,china

In this study, fifty-four gilts at an average weight of 80kg in Landrace × Large white two-way crossbred were used. The crossbred gilts were allotted to three treatment groups of high ( H, 2 × maintenance), medium ( M, 1.2 × maintenance), and low ( L, 0. 6 × maintenance) after mating to study the effect of feed intake lev- el on embryonic survival, hormone secretion and mRNA expression of leptin, obesity receptor ( ob-R), signal

关键词： Feed intake level Gilts Embryonic survival Gene expression

胰高糖素样肽-1受体激动剂类药物结合生活方式干预减重专家共识(2024版)

在线全文

cnki会议

学校读者我要写书评

暂无评论

中华糖尿病杂志 2024年第9期16卷 945-958页

作者：中国民族卫生协会中国健康管理协会健康体检分会翁建平曾强包巍苏枫张惠杰郑雪瑛不详安徽医科大学第一附属医院中国科学技术大学附属第一医院合肥230001 解放军总医院第二医学中心健康管理研究院北京100853 中国科学技术大学公共卫生研究院浙江中医药大学南方医科大学南方医院中国科学技术大学附属第一医院

肥胖是由遗传因素和不良生活方式共同引发的代谢性疾病,是多种慢性病的高危因素。超重和肥胖问题已成为我国重大公共卫生问题。体重管理的手段包括生活方式干预、药物治疗及代谢手术。目前,多款胰高糖素样肽-1受体激动剂(GLP-1RA)类药... 详细信息

肥胖是由遗传因素和不良生活方式共同引发的代谢性疾病,是多种慢性病的高危因素。超重和肥胖问题已成为我国重大公共卫生问题。体重管理的手段包括生活方式干预、药物治疗及代谢手术。目前,多款胰高糖素样肽-1受体激动剂(GLP-1RA)类药物被批准用于体重管理。生活方式干预是所有体重管理手段的基础措施,其应贯穿于GLP-1RA类药物治疗等其他管理手段的始终,药物与生活方式干预如何科学有效地结合成为一个重要临床问题。内分泌、营养、公共卫生等领域专家,依据国内外临床研究提供的循证医学证据并结合临床实践,撰写了《胰高糖素样肽-1受体激动剂类药物结合生活方式干预减重专家共识(2024版)》,内容涵盖超重和肥胖的定义、诊断、流行病学、相关并发症,超重和肥胖的体重管理目标、减重策略以及患者使用GLP-1RA类药物减重的管理流程,并提出推荐意见,以期为从事体重管理工作的临床医师提供指导。

关键词：减重胰高糖素样肽-1受体激动剂生活方式干预体重管理流程

维普期刊数据库

Long-term ginsenoside administration prevents memory loss in aged female C57BL/6J mice by modulating the redox status and up-regulating the plasticity-related proteins in hippocampus

在线全文

学校读者我要写书评

暂无评论

Long-term ginsenoside administration prevents memory loss in...

北京市营养学会第四届会员代表大会暨膳食与健康研讨会

作者： Haifeng Zhao~(ab),Qiong Li~a,Yong Li~(a*) a Department of nutrition and food Hygiene,School of Public Health,Peking University,beijing 100191,P.R. china b Department of nutrition and food Hygiene,School of Public Health,Shanxi Medical University,Taiyuan, Shanxi 030001,P.R.china

Memory impairment is considered to be one of the most prominent consequences of aging. Deterioration of memory begins in advance of old age in animals,including ***,it is extremely important to prevent memory decline for increasing healthy *** generation of reactive oxygen species(ROS) and/or free radicals-induced oxidative stress which is the major age-related changes,can lead to hippocampus damage and increase vulnerability to impaired learning and ***,the effective ingredient of ginseng,has been reported to have a neuron beneficial *** the present study,C57BL/6J mice aged 12 months were chronically treated with ginsenoside(3 dose groups were given ginsenoside in drinking water for 8 months). The three groups were treated with ginsenoside 50,100 and 200 mg/kg per day,respectively. Placebo-treated aged mice and young ones(4 months old) were used as *** efficacious effect of ginsenoside was manifested in the amelioration of memory impairment in aged mice by Morris water maze and step-down *** ginsenoside treated groups,the activities of GSH-Px and T-SOD markedly increased,and the levels of TBARS and the content of protein carbonyl decreased significantly in serum and in *** activation of lipofuscin formation, disruption or loss of cristae in the mitochondria,the irregular nucleus and condensed chromatin laid against the nuclear membrane in pyramidal cells of hippocampal CA1 region,which are all related to oxidative stress,were also reduced after ginsenoside *** also found that long-term ginsenoside treatment prevented age-related reductions of post-synaptic density 95 (PSD-95),protein kinase Cγsubunit(PKCγ) and brain derived neurotrophic factor(BDNF) in the *** results demonstrated that long-term ginsenoside administration may prevent memory loss in aged C57BL/6J mice by modulating the redox status and up-regulating the plasticity-related proteins in hippocampus.

关键词： Ginsenoside Hippocampus Memory prevention Antioxidation Plasticity-related proteins

Endothelial PPARγmediates anti-inflammatory actions of rosiglitazone through dissociation of NF-κB

在线全文

cnki会议

学校读者我要写书评

暂无评论

Endothelial PPARγmediates anti-inflammatory actions of rosi...

中国生理学会心血管生理学术研讨会

作者： Shengzhong Duan Key Laboratory of nutrition and Metabolism,institute for nutritional Sciences, Shanghai institutes for Biological Sciences,chinese Academy of Sciences, Shanghai 200031,china

＜正＞Objective:Endothelial inflammation is important in the initiation and progression of cardiovascular disease and ***（TZDs） are a class of anti-diabetic drugs that can inhibit inflammation in endothelial cells（ECs）.This study was designed to investigate whether these effects of TZDs are mediated by peroxisome proliferator activated receptorγ（PPARγ） and explore the regulatory ***:We created endothelial cell-specific PPARy knockout（ENDO-PGKO） mouse model and isolated ECs from ENDO-PGKO and floxed control（FC） *** gene expression was analyzed using quantitative PCR （QPCR） in these cells at baseline and with stimulation of tumor necrosis factorα（TNFα）. Western blotting was used to evaluate protein *** immunoprecipitation（ChIP） was used to detect interactions between transcription factors and their response elements on the promoters of their target *** was used to detect nuclear translocation of p65,a member of ***:ECs from ENDO-PGKO mice have higher mRNA levels of pro-inflammatory gene targets of nuclear factor（NF）-kB relative to ECs from FC mice. Stimulation of ENDO-PGKO ECs with TNFa induced greater expression of pro-inflammatory genes relative to ***（Rosi）,a TZD,inhibited expression of NF-kB target genes in FC but failed to do so in ENDO-PGKO ECs,an effect rescued by adenoviral re-expression of PAPRγ.No changes in mRNA or protein of NF-kB subunits p50,p65 or the inhibitor of NF-kB, IkBαwere observed in ECs from either ENDO-PGKO or FC ***,in ChIP analysis, Rosi decreased binding of p65 to the NF-kB response element on the promoter of intercellular adhesion molecule 1（ICAM1） in a PAPRγdependent ***,Rosi increased the binding of PPARγto its response element on the ICAM-1 promoter and increased recruitment of histone deacetylase ***:We conclude that the inhibitory effects of TZDs on NF-kB target genes are PPARγ*** of the m

关键词：

Magnesium modulates amyloid precursor protein processing in vitro

在线全文

cnki会议

学校读者我要写书评

暂无评论

Magnesium modulates amyloid precursor protein processing in ...

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Jia YU~(1,2),Miao SUN~1,Yi LIU~1,Zheng CHEN~2,Guo-Song LIU~3,De-Hua CHUI~(1,*) 1 Neuroscience Research institute and Key Laboratory of Neuroscience,Ministry of Education,Peking University, beijing 100083,china 2 beijing Geriatric Hospital,beijing 100095,china 3 center for Learning and Memory,School of Medicine,Tsinghua University,beijing 100084,china

Objective Alzheimer’s disease,the most common form of dementia,is characterized by the presence of excessive deposits of aggregated P-amyloid(Aβ) peptides,which are derived from the P-amyloid precursor protein(APP) following processing byβ-secretase andγ-*** environmental factors are involed in the pathogenesis of AD, including nutrition and metal *** content have been reported to decrease in AD brain ***, the exact role of mg on the neurodegenerative process in AD brain remains to be clearly *** In this study, we investigate the effects of various concentration of magnesium on APP cleavage,Aβformation and degradation. Results Here we show that varying[Mg]o induced both dose and time dependent effect on APP *** 24 h treatment,[Mg]o at high doses favored a-secretase pathway,increased CTFαlevel and sAPPαrelease,and promoted retention of APP on cell *** contrast,[Mg]o at low doses resulted in accumulation of amyloidogenic fragments(i. ***) increased secreted Aβin conditioned media,and reduced the distribution of APP on plasma *** levels of full length APP,insulin degrading enzyme and neprilysin were not changed under any ***,complete deficiency of magnesium in media for 24 h decreased total intracellular magnesium level,impaired cell viability and reduced neprilysin enzyme *** 24 h incubation with physical concentration of magnesium(i.e.0.8 mM),restored normal APP *** These findings demonstrate that APP processing can be modulated by magnesium, with[Mg]o at high doses promotingα-cleavage of APP and suggest that supplementation of this element might have a therapeutic potential in Alzheimer’s disease.

关键词： magnesium amyloid precursor protein(APP) CTF sAPP Aβ