检索结果-南通市图书馆

Two new cyclopeptides from stellaria yunnanensis

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of chemistry 1995年第3期13卷 267-272页

作者： ZHAO, Yu-Rui WANG, Xian-Kai ZHAO, Tong-Fangdepartment of medicinal chemistry of Natural Products, school of pharmacy, West china university of Medical Sciences, Chendu, Sichuan 610041, chinaZHOU, JunLaboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan 650204, chinaHUANG, Xiao-Lin WU, Hou-MingState Key Laboratory of Bio-Organic & Natural Products chemistry, shanghai Institute of Organic chemistry, Chinese Academy of Sciences, shanghai 200032,china department of medicinal chemistry of Natural Products School of Pharmacy West China University of Medical Sciences Chendu Sichuan 610041 China Laboratory of Phytochemistry Kunming Institute of Botany Chinese Academy of Sciences Kunming Yunnan 650204 China State Key Laboratory of Bio‐Organic & Natural Products chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 China

In the previous papers, we reported the isolation and structural elucidation of three new cyclopeptides, namely stellarin A, B and C, from the fresh roots of stellaria yunnanensis Franch. In a continued study on this plant, other two new cyclopeptides named stellarin D(1) and E(2) were obtained and their structures were established to be cyclo (Gly-Tyr-Leu-Phe-Pro-Ile-Pro)(1), cyclo(Gly-Ile-Pro-Tyr-Ile-Ala-Ala)(2), respectively.

关键词： Stellaria yunnanensis cyclopeptides stellarin.

Pharmacokinetic difference between S-(+)- and R-(-)-etodolac in rats

在线全文

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2004年第8期 22-25页

作者： Jing-min SHI, Shun-guo LAI, Chang-jiang XU, Geng-li DUAN, Duan LIdepartment of Pharmacology, department of Pharmaceutical Analysis, school of pharmacy, fudan university, shanghai 200032, chinaNow in shanghai Institute for Drug Control.

AIM: To study whether etodolac enantiomers have pharmacokinetic difference after oral administration. METHODS: Fourteen rats, divided into two groups randomly, were orally given S-(+)- or R-(-)-etodolac at a single dose of 20 mg/kg, respectively. Blood samples were collected before and at 5, 10, 20, 30 min and 1, 3, 6, 12, 24, 48, 72 h after treatment. The plasma samples were analyzed with a high-performance liquid chromatographic method. RESULTS: The calibration curves were linear in the range of 0.5-50.0 mg/L (r=0.9999) to S-(+)-etodolac and 2.0-200.0 mg/L (r=0.9999) to R-(-)-etodolac, respectively. The main pharmacokinetic parameters of S-(+)- and R-(-)-etodolac were as follows: t1/2(λz)18±4 h vs 19.4±2.2 h, tmax 3.3±2.6 h vs 4±4 h; Cmax 29±6 mg/L vs97±14 mg/L, AUC0-t 706±100 h·mg·L-1 vs 2940±400 h·mg·L-1, CL(s) 0.030±0.006 L·kg-1·h-1 vs 0.0065±0.0010 L·kg-1·h-1 and V/F 0.25±0.22 L·kg-1 vs 0.03±0.05 L·kg-1. There was no significant difference in t1/2(λz) and tmax between S-(+)-

关键词： etodolac non-steroidal anti-inflammatory agents pharmacokinetics stereoisomerism

dl-cis-和trans-4-乙酰氨基-2-正丁基-1-二甲氨基-5,6-亚甲二氧基茚满的合成

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

上海医科大学学报 1992年第6期19卷 413-418页

作者：周智善上海医科大学药学院合成药物化学教研室

以细胞内钙拮抗剂Bu-MDI为先导化合物,设计合成了具有弱钙拮抗作用的4-乙酰氨基取代的茚满衍生物。该目标化合物以胡椒醛为起始原料,经十一步反应制得。合成中对1的格氏反应、2的脱水消除和5的制备等均作了改进,使收率有所提高。对5的... 详细信息

以细胞内钙拮抗剂Bu-MDI为先导化合物,设计合成了具有弱钙拮抗作用的4-乙酰氨基取代的茚满衍生物。该目标化合物以胡椒醛为起始原料,经十一步反应制得。合成中对1的格氏反应、2的脱水消除和5的制备等均作了改进,使收率有所提高。对5的硝化产物6的硝基位置经NOE确证,并对目标化合物二对顺、反异构体的比例和生成机制作了讨论。

关键词： Bu-MDI 钙拮抗剂 MDIs

在线全文

学校读者我要写书评

暂无评论

严重急性呼吸道综合征冠状病毒疫苗研究现状

生物化学与生物物理进展 2003年第3期30卷 331-334页

作者：叶迅孟夏董继斌梁旻胡放陈红专上海第二医科大学药理学教研室上海200025 复旦大学药学院生物化学教研室上海200032 上海三维生物技术有限公司

冠状病毒被认为是新近爆发的严重急性呼吸道综合征的病原体 .迄今公共数据库中已发表了不同国家和地区分离的 12个SARS病毒株基因组完整序列 .突起蛋白是冠状病毒的主要抗原 ,包含许多抗原决定簇 .SARS冠状病毒突起蛋白的相对保守性为... 详细信息

冠状病毒被认为是新近爆发的严重急性呼吸道综合征的病原体 .迄今公共数据库中已发表了不同国家和地区分离的 12个SARS病毒株基因组完整序列 .突起蛋白是冠状病毒的主要抗原 ,包含许多抗原决定簇 .SARS冠状病毒突起蛋白的相对保守性为有效疫苗的开发奠定了很好的研究基础 .灭活或减毒的冠状病毒疫苗存在一定的局限性和危险性 .

关键词：严重急性呼吸道综合征冠状病毒疫苗突起蛋白 SARS 基因组

Total synthesis of lauroside B,a Megastigmane Glycoside from Laurus Nobilis（Bay Laurel） Leaves

在线全文

学校读者我要写书评

暂无评论

Total synthesis of lauroside B,a Megastigmane Glycoside from...

2011年全国药物化学学术会议——药物的源头创新

作者： Mingming Zhang,Ning Ding,Wei Zhang,Yingxia Li~3 department of medicinal chemistry,school of pharmacy,fudan university,shanghai 201203, china

＜正＞Lauroside B（1）,a megastigmane glycoside isolated from Laurus nobilis（bay laurel） leaves has antiproliferative propensity against human melanoma cell lines,namely,A375,WM115,and SK-Mel-28[1].Present study sho...

关键词：

Apolipoprotein A Ⅰdiminishes acute lung injury and sepsis in mice induced by Lipoteichoic acid

在线全文

cnki会议

学校读者我要写书评

暂无评论

Apolipoprotein A Ⅰdiminishes acute lung injury and sepsis i...

第四届全国血脂分析与临床学术研讨会暨第九届全国脂蛋白学术会议

作者： Yan-ling Jiao Man-Ping Wu department of Biochemistry,school of pharmacy,fudan university,shanghai,200032,china

Lipoteichoic acid (LTA),as a primary immunostimulus,triggers the systematic inflammatory responses. Our hypothesis is that apoA Ⅰ can neutralize LTA toxicity,like its effect on ***/c mice were chal- lenged with LTA,followed by human apoA Ⅰ *** found that apoA Ⅰ could attenuate LTA-in- duced acute lung injury and inflammation and significantly inhibit LTA-induced IL-1β and TNF-α accumu- lation in the serum (P29 cell mortali- ty caused by LTA-activated macrophages in a dose-dependent ***,apoA Ⅰ treatment could diminish LTA-mediated NFκB nuclear translocation in *** in vitro binding assay indicated that apoA Ⅰ can bind *** results clearly indicated that apoA Ⅰ can effectively protect against LTA-induced sepsis and acute lung *** mechanism might be related to the binding and neutralization of LTA.

关键词：

Development and Validation of a HPLC Method for Stimultaneous Quantitative Determination of Stilbene Oligomers in Caragana sinica

在线全文

cnki会议

学校读者我要写书评

暂无评论

Development and Validation of a HPLC Method for Stimultaneou...

第八届全国中药和天然药物学术研讨会与第五届全国药用植物和植物药学学术研讨会

作者： Na Shu, Changqi Hu (department of chemistry of Natural Drugs, school of pharmacy, fudan university, shanghai, china)

A HPLC method had been developed and validated in order to simultaneously quantify kobophenol A, (+)-α-viniferin and carasinol B, the main active stilbene oligomers in the medicinal herb Caragana sini

关键词：

Pharmacokinetics of esomeprazole in relation to genetic polymorphism of CYP2C19 in Chinese subjects

在线全文

cnki会议

学校读者我要写书评

暂无评论

Pharmacokinetics of esomeprazole in relation to genetic poly...

2006第六届中国药学会学术年会

作者： Zhong Longjin1, Cheng Nengneng2, Wang yongming2, 1 fudan university, Huashan Hospital, pharmacy department, shanghai 200040 2 fudan university, pharmacy school, shanghai 200032

Objective:To determine whether the pharmacokinetics of esomeprazole depend on the CYP2C19 genotype status in Chinese subjects. Methods:A single oral 40-mg dose of esomeprazole was administered to 5 subjects who were homozygous extensive metabolisers （homEMs）, 10 subjects who were heterozygous extensive metabolisers （hetEMs） and 8 subjects who were poor metabolisers （PMs） recruited from 93 healthy Chinese volunteers whose genotypes were predetermined by polymerase chain reaction-based amplification, followed by polymerase chain reaction-restriction fragment length polymorphism analysis （PCR-RFLP）. The plasma concentrations of esomeprazole and its two metabolites, hydroxyesomeprazole and esomeprazole sulphone, were determined by a reversed-phase HPLC method. Results: Twenty-nine subjects were homozygous （wt/wt） for the wt allele in both exon 5 and 4. Forty-five and six subjects were heterozygous for the CYP2C19m1 mutatiom （wt/m1） and the CYP2C19m2 mutatiom （wt/m2）, respectively. Nine and one subjects were homozygous with the defect in exon 5 （m1/m1） and exon 4 （m2/m2）, respectively. Three subjects were heterozygous with the two defects in exon 5 and 4 （m1/m2）. The pharmacokinetic parameters of esomeprazole AUC0-12, Cmax, CL and t1/2 in homEMs, hetEMs and PMs were （11.08±4.95） μmol.h.L-1, （15.65±6.55） μmol.h.L-1 and （26.21±4.96） μmol.h.L-1;（4.11±1.95） μmol.L-1, （4.36±1.28） μmol.L-1 and （7.28±2.30） μmol.L-1;（10.03±6.73） L.h-1, （7.29±4.08） L.h-1 and （3.92±0.98） L.h-1;（1.26±0.41） h-1, （1.71±0.46） h-1 and （2.43±1.08） h-1, respectively. The pharmacokinetic parameters of 5-hydroxyomeprazole AUC0-12 and Cmax in homEMs, hetEMs and PMs were （1.62±0.24） μmol.h.L-1, （1.60±0.34） μmol.h.L-1 and （1.58±0.46） μmol.h.L-1;（0.54±0.28） μmol.L-1, （0.47±0.21） μmol.L-1 and （0.45±0.16） μmol.L-1, respectively. The pharmacokinetic parameters of omeprazole sulphone AUC0-12 and Cmax in homEMs, hetEMs and PMs were （10.96±5.70） μmol.h.L-1, （15.53±6.35） μmol.h.L-1 and （25.44±6.37） μmol.h.L-1;（1.56±0

关键词：

Cardiac protection of new compounds from scientific Chinese medicine (SCM)

在线全文

cnki会议

学校读者我要写书评

暂无评论

沈阳药科大学学报 2008年第S1期25卷 9-9页

作者： ZHU Yi-zhun(department of Pharmacology,school of pharmacy,fudan university,shanghai 200032,china)

Objective Purification and Standardization of Chinese herbal extracts became a hot topic since last *** traditional Chinese medicine(TCM)has been used as a mixture from several herbs for centuries,it has been drawn much attention for studying the standardized Chinese herbs using modern *** Recently,we compared purified Salvia miltiorrhiza extract(PSME)with angiotensin-converting enzyme inhibitor,Ramipril,in in vitro experiments and also in vivo using animal model of myocardial *** PSME was found to have a significantly higher trolox equivalent antioxidant capacity which indicated a great capacity for scavenging free *** could also prevent pyrogallo red bleaching and DNA *** 2 weeks treatment with PSME or Ramipril,survival rates of rats with experimental myocardial infarction were marginally increased(68.2% and 71.4%)compared with saline(61.5%).In another recent study,we evaluated the cardioprotective effects of PSME on myocardial ischemia/reperfusion injury in isolated rat hearts and in hypoxic vascular smooth muscle *** found that PSME treated hearts showed significant postischemic contractile function recovery(develop pressure recovered to 44.2±4.9% versus 17.1±5.7%,P2±5.9% versus 15.1±6.3%,P<0.001;maximum relaxation restored to 69.3±7.3% versus 15.4±6.3%,P<0.001 in PSME and control group respectively).Conclusions Significant elevated in end-diastolic pressure,which indicated LV stiffening in PSME hearts might be resulted by exceed dose of PSME *** and standardized Chinese herb could provide an alternative regimen for the prevention of ischemic heart disease.

关键词： traditional Chinese medicine purified Salvia miltiorrhiza extract myocardial infarction ramipril