检索结果-南通市图书馆

Deferiprone protects the isolated atria from cardiotoxicity induced by doxorubicin

2011年全国药物化学学术会议——药物的源头创新

作者： Peng Zhu and Minyong Li department of medicinal chemistry,{3.,Shandong university,Shandong 250012, china

＜正＞Quorum sensing is a cell-cell communication mechanism that coordinate gene expression according to bacterial population *** has been implicated that QS can regulate bacterial behaviors such as the secretion of virulence factors,biofilmformation,bioluminescence production, conjugation,sporulation,and *** 2（AI-2）,proposed to be involved in

关键词： Quorum sensing AI-2 LuxPQ inhibitors triazole

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2006年第10期27卷 1333-1339页

作者： Ling-jie XU~(1,4) Liang JIN~1 Hong PAN~1 Ao-zhen ZHANG~2 Gang WEI~1 Ping-ping LI~3.Wei-yue LU~(1,5) ~1fudan-PharmCo Drug Targeting Research Center,department of Pharmaceutics,~2department of Pharmacology,~3.3.,fudan university,Shanghai 20003.,china ~4department of Pharmaceutics,{3.,Guiyang Medical university,Guiyang 550004,china fudan-PharmCo Drug Targeting Research Center Department of Pharmaceutics Fudan University Shanghai 200032 China

Aim:To investigate the effects of deferiprone on doxorubicin-inducedcardiotoxicity and determine its protection on cardiac contractility in vivo at tis-sue ***:Spontaneously-beating isolated atria from rats were pre-treated with deferiprone for 10 min at 1.2 mmol/L or 0.3.mmol/L,respectively beforeco-incubation with doxorubicin(DOX)at 0.03.mmol/L for 60 ***(dF/dt)was assessed every 10 min during the *** that,the tissuesaround the sinuatrial nodes were fixed for ultrastructural study;succinate dehy-drogenase(SDH)and Cu,Zn superoxide dismutase(Cu,Zn-SOD)activity,as wellas malondialdehyde(MDA)level of the atria were ***:Treatmentwith DOX alone resulted in a 49.3.% reduction of the contractility,mitochondriaswelling,disruption of mitochondrial crista and decreased electron density of ***,with the presence of deferiprone,the negative inotropiceffect and lesions in the cardiac mitochondria structure induced by DOX ***,Zn-SOD activity increased by 12.97%-12.11%,the MDA leveldecreased by 29.12%-3..82% and succinate dehydrogenase(SDH)activity wasameliorated by 25.15%-3..76%.Conclusion:Deferiprone can efficiently pre-serve cardiac ***,the results of this study indicate thatdeferiprone is able to protect mitochondrial function and structure form damageinduced by *** cardiac protective potential of deferiprone could be due toits defense capability against oxidative damage.

关键词： deferiprone doxorubicin cardiotoxicity cardiac protection isolated atria

Difference in oral absorption of ginsenoside Rg1 between in vitro and in vivo models

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2006年第4期27卷 499-505页

作者： Min HAN Xiao-ling FANG~1 department of Pharmaceutics,school of pharmacy.fudan university.Shanghai {3..china departmentofPharmaceutics SchoolofPharmacyFudanUniversityShanghai200032China

Aim:To clarify the cause of poor oral absorption of ginsenoside Rg1(Rg1),theactive ingredient in Panax notoginseng saponins(PNS)used for ***:Caco-2 cell monolayers were used as an in vitro model tostudy the transport mechanism of Rg1across the intestinal ***,the serum concentration-time profiles after peroral(po),intraduodenal(id),portalvenous(pv)and tail venous(iv)administration of Rg1in rats were compared toevaluate the first-pass effects in the stomach,intestine,and ***:Up-take of Rg1by Caco-2 cell monolayers was temperature-dependent,but was notinfluenced by cyclosporin *** change in the apical pH produced no obviouseffect on the uptake of *** uptake and transport of Rg1was non-saturable;whereas the flux from the apical compartment to the basolateral compartment(A-B)increased in a linear manner with the increase in concentration,indicatingpassive *** apparent permeability coefficient of(2.59±0.17)×10-7cm/s(C0=1 mg/mL)predicted incomplete absorption.A significant difference was ob-served between the po(Fpowas 3.29% at a dose of 1500 mg/kg),id(Fidwas 6.60%at a dose of 1200 mg/kg)and pv(Fpvwas 50.56%)administration methods,and thebarrier function of the intestine was more significant than those of the stomachand liver in the absorption ***:Elimination in the stomach,largeintestine and liver contributed to the low oral bioavailability of Rg1,but low mem-brane permeability might be a more important factor in determining the extent ofabsorption.

关键词： ginsenoside Rgl Panax Caco-2 bioavailability pharmacokinetics

Preparation of ion-activated in situ gel systems of scopolamine hydrobromide and evaluation of its antimotion sickness efficacy

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2007年第4期28卷 584-590页

作者： Shi-lei CAO Qi-zhi ZHANG Xin-guo JIANG department of Pharmaceutics,school of pharmacy,fudan university,Shanghai {3.,china departmentofPharmaceutics SchoolofPharmacyFudanUniversityShanghai200032China

Aim:To develop a novel,in situ gel system for nasal delivery of scopolaminehydrobromide (SCOP) and study its efficacy on motion ***:SCOPin situ gels at 0.2%,0.5%,and 1.0% gellan gum concentration (w/v) were prepared,respectively,and characterized in terms of viscosity,in vitro release,and *** photon emission computing tomography technique was usedto evaluate the nasal residence time of gel containing ~99mTc *** antimotionsickness efficacy produced by the in situ gel formulation was investigated in ratsand compared with those achieved after subcutaneous and oral ***:The viscosity of the gellan gum formulations either in solution or in gelincreased with increasing concentrations of gellan *** release in vitro wasmoderate in artificial nasal *** micrographic results showed that in situ gelswere safe,without nasal *** comparison with phosphate buffer saline,a prolonged radioactivity of99mTc in the rabbit nasal cavity was observed afteradministration of the gellan gum *** SCOP in situ gel at a doseof 100 pg/kg decreased symptoms of motion sickness significantly in comparisonwith subcutaneous and oral administration (P<0.01).Conclusion:SCOP nasal insitu gel is a safe and promising therapeutic alternative to existing medications formotion sickness.

关键词： scopolamine gellan gum nasal delivery motion sickness residence time nasal ciliotoxicity

Oxidation of the Norditerpenoid Alkaloids Isotalatisidine and 6-Epiforsticine

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2000年第5期11卷 421-424页

作者： Zheng Bang LI Qiao Hong CHEN Feng Peng WANG Bo Gang LI (department of chemistry of medicinal Natural Products, {3., West china university of Medical Sciences, Chengdu 610041 Chengdu Institute of Biology, Chinese Academy of Sciences, Cheng Dept. of Chem. of Med. Nat. Products School of Pharmacy W. China Univ. of Medical Sciences Chengdu 610041 China Chengdu Institute of Biology Chinese Academy of Sciences Chengdu 610041 China

Oxidation of 1 with KMnO_4 in acetone-H_2O (1:1) for 1h gave nevadenine 2 (3.%). But. 3.was formed in 98% yield when prolonging time and raising temperature (40℃). Reaction of 1 and 10 with Conforth reagent afforded the ketones 11 (55%), 12 (3.%), and 13.(13.), 14 (20%). respectively. While oxidation of 7 and 15 with a variety of the oxidizing agents gave 17 only in low 20% of yield besides the minor 16. In addition. 1 was converted to 2 by the fungi Curvularia lunata.

关键词： Norditerpenoid alkaloid. oxidation. isotalatizidine. 6-epiforsticinc. Curvularia lunata

维普期刊数据库

Modification of Norditerpenoid Alkaloids:Ⅱ.A Simple andConvenient Preparation of the Imine Derivatives of Norditerpenoid Alkaloids

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1999年第6期10卷 453-456页

作者： Feng Peng WANG Zheng Bang LI Jin Song YANG and Bo Gang LI(department of chemistry of medicinal Natural Products {3.West china university of Medical Sciences. Chengdu 610041 Chengdu Institute of Biology. Chinese Academy of Sciences. Chengd Dept. of Chem. of Med. Nat. Products School of Pharmacy W. China Univ. of Medical Sciences Chengdu 610041 China Chengdu Institute of Biology Chinese Academy of Sciences Chengdu 610041 China

Treatment of 3.acetylpseudaconie 6 and 3. 13.diacetylyunnaconitine 9 withNBS/acetone-H2O(2:1) at room temperature produced corresponding imine derivatives & and ***. in good yields. This is a novel simple and conveni... 详细信息

关键词： Norditerpenoid alkaloids imine

维普期刊数据库

Development and Validation of a HPLC Method for Stimultaneous Quantitative Determination of Stilbene Oligomers in Caragana sinica

在线全文

学校读者我要写书评

暂无评论

Development and Validation of a HPLC Method for Stimultaneou...

Small-molecule fluorescent probes for theα1-adrenergic receptors

第八届全国中药和天然药物学术研讨会与第五届全国药用植物和植物药学学术研讨会

作者： Na Shu, Changqi Hu (department of chemistry of Natural Drugs, school of pharmacy, {3., Shanghai, china)

A HPLC method had been developed and validated in order to simultaneously quantify kobophenol A, (+)-α-viniferin and carasinol B, the main active stilbene oligomers in the medicinal herb Caragana sini

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Small-molecule fluorescent probes for theα1-adrenergic rece...

A novel homospermidine conjugate inhibits growth and induces apoptosis in human hepatoma cells

2011年全国药物化学学术会议——药物的源头创新

作者： Wenhua Li,Lupei Du and Minyong Li~* department of medicinal chemistry,{3.,Shandong university,Shandong 250012, china

＜正＞ai-adrenergic receptors（ARs）,as the crucial members of G protein-coupled receptors（GPCRs）, draw more attention of the medicinal chemists because they mediate a number of physiological responses of the sympat... 详细信息

关键词： ai-adrenergic receptors small-molecule fluorescent probes

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2007年第11期28卷 1827-1834页

作者： Song-qiang XIE~(2,3.,Ying-liang WU~2,Peng-fei CHENG~4,Min-wei WANG~2,Guang-chao LIU~5,Yuan-fang MA~5,Jin ZHAO~4,Chao-jie WANG~(4,6)~2 department of Pharmacology,Shenyang Pharmaceutical university,Shenyang 110016,china ~3.{3. College,Henan university,Kaifeng 475001,china ~4 Institute of Natural Products and medicinal chemistry,Henan university,Kaifeng 475001,china:~5 MedicalCollege,Henan university,Kaifeng 475001,china ment of Pharmacology Shenyang Pharmaceutical University Shenyang 110016 China. wcjsxq@***.

Aim:To elucidate the mechanism responsible for the antiproliferative effects of anovel homospermidine conjugate,anthracenylmethyl homospermidine(ANTMHspd),in the human hepatoma BEL-7402 cell ***:The viabilityof the cells was assessed by MTT assay and the trypan blue dye exclusion *** changes were observed by fluorescence microscopy with Hoechst3.258 *** cycle distribution,apoptosis,and mitochondrial membranepotential were measured by flow *** expression was detected byWestern blot ***:ANTMHspd strongly decreased BEL-7402 cellproliferation in a dose-and time-dependent *** 3.258 staining andthe flow cytometry assay showed that ANTMHspd induced cell apoptosis andcell cycle ***,ANTMHspd could induce mitochondrialmembrane potential loss and cytochrome c release and enhance cleaved caspase-3.cleaved caspase-9,and Bax protein expression without caspase-8 *** could also decrease the expression of Bcl-2 and cytochrome c *** addition,the specific inhibitors of caspase-9 and caspase-3.lmost abolished the ANTMHspd-induced caspase-9 and caspase-3.activation,***:ANTMHspd could induce BEL-7402 cell apoptosis viathe mitochondrial/caspase-dependent pathway and the Bcl-2 family was involvedin the control of apoptosis.

关键词： polyamine apoptosis cell cycle mitochondrial membrane potential caspase Bcl-2

Pharmacokinetics and biodistribution of polymeric micelles of paclitaxel with Pluronic P123

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2006年第6期27卷 747-753页

作者： Li-mei HAN Jie GUO Li-jun ZHANG Qing-song WANG Xiao-ling FANG~2 department of Pharmaceutics.school of pharmacy,fudan university,Shanghai {3.,china departmentofPharmaceutics SchoolofPharmacyFudanUniversityShanghai200032China

Aim:To investigate the preparation,in vitro release,in vivo pharmacokineticsand tissue distribution of a novel polymeric micellar formulation of paclitaxel(PTX)with Pluronic ***:The polymeric micelles of paclitaxel with PluronicP123.were prepared by a solid dispersion *** characteristics of micellesincluding particle size distribution,morphology and in vitro release of PTX frommicelles were carried ***-loaded micellar solutions were administered throughthe tail vein to healthy Sprague-Dawley rats and Kunming strain mice to assessthe pharmacokinetics and tissue distribution of PTX,***,thecommercially available intravenous formulation of PTX,was also administered ***:By using a dynamic light scattering sizer and a transmissionelectron microscopy,it was shown that the PTX-loaded micelles had a mean sizeof approximately 25 nm with narrow size distribution and a spherical *** continuously released from Pluronic P 123.micelles in release medium contain-ing 1 mol/L sodium salicylate for 24 h at 3.℃.In the pharmacokinetic assessment,t1/2βand AUC of micelle formulation were 2.3.and 2.9-fold higher than that of *** the PTX-loaded micelles increased the uptake of PTX in the plasma,ovary and uterus,lung,and kidney,but decreased uptake in the liver and brain inthe biodistribution ***:Polymeric micelles using Pluronic P123.an effectively solubilize PTX,prolong blood circulation time and modify thebiodistribution of PTX.

关键词： paclitaxel micelle Pluronic P123 pharmacokinetics biodistribution