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Exon 3 polymorphisms and haplotypes of O6-methylguanine-DNA methyltransferase and risk of bladder cancer in southern china:a case-control analysis

Exon 3 polymorphisms and haplotypes of O6-methylguanine-DNA ...

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第四届全国环境与职业医学研究生学术研讨会

作者： Chunping Li, Jia Liu, Aiping Li, Lixin Qian, Xinru Wang, Qingyi Wei, Jianwei Zhou, MD,PhD Zhengdong Zhang MD,PhD department of molecular Cell Biology and Toxicology, Jiangsu Provincial Key Laboratories of Human Functional Genomics and of applied Toxicology School of Public Health, Nanjing Medical university, Nanjing 210029, People’s Republic of china department of Urological Surgery, The First Affiliated Hospital, Nanjing Medical university, Nanjing 210029, china department of Epidemiology, The university of Texas M. D. Anderson Cancer center, Houston, TX 77030, USA

Methylating agents are involved in bladder carcinogenesis. O6-methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein that removes methyl group from O6-methylguanine and thus plays an important role in the etiology of cancer. We hypothesized that two MGMT polymorphisms in exon 3, C16195T (or MGMT L53L) and C16286T (or MGMT L84F), are associated with risk of bladder cancer. In a hospital-based case-control study of 167 patients with bladder cancer and 204 cancer-free controls frequency-matched by age, sex, smoking status, and alcohol use, we genotyped these two MGMT polymorphisms. We found that these two polymorphisms alone had a nonsignificant main effect on risk of bladder cancer. However, when these two polymorphisms were evaluated together, individuals with the combined genotypes or haplotypes with one or more variant alleles (i.e., the 16195T and 16286T alleles) had statistically significantly increased risk of bladder cancer (adjusted odd ratio [OR] = 1.67, 95% confidence interval [CI], 1.01-2.77) compared with those with no variant allele. In the stratification analysis, the risk of bladder cancer was increased in a dose-response manner as the age increased (Ptrend - 0.010), and the increased risk was more pronounced among old subjects (> 65 years) (adjusted OR = 2.51, 95% CI, 1.05-6.04), men (1.76, 1.00-3.10), and non-drinkers (1.91, 1.08-3.36). In conclusion, these two MGMT polymorphisms may jointly play a role in the etiology of bladder cancer in southern Chinese population. Larger studies are warranted to validate our findings.

关键词： MGMT Polymorphism Bladder cancer Genetic susceptibility molecular epidemiology Southern Chinese

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A correlative analysis on the social disability and the criminal responsibility of the alcohol-related offender

A correlative analysis on the social disability and the crim...

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2010 First International Conference on Cellular,molecular Biology, Biophysics and Bioengineering(CMBB 2010)

作者： Zhang Dong-jun1 Yao Gui-ying2 Deng Xiao-hui3 Yang Shi-chang1 Li Yan4 Hu Ze-qing4 1. department of Psychology Xinxiang Medical university Xinxiang 453003 china 2. School of Nursing Xinxiang Medical university Xinxiang 453003 china 3. School of basic medicine Xinxiang Medical university Xinxiang 453003 china 4. department of Forensic Psychiatry of Sichuan university Chengdu 610041 china

In order to explore social disability of the alcohol-related offence and to investigate the relationship between social disability and criminal responsibility,we conducted a statistic analysis between the two groups of drunkenness （Abbreviation for D）（72 cases） and chronic alcoholism（Abbreviation for CA）（34 cases）. In the study,we applied the forensic psychiatric expertise registration scale and social disability screening schedule （SDSS）. The rate of social disability of D was 41.7%,and the rate of CA was 82.4%.There were statistic disparity between the two groups in the score of SDSS. After logistic regression analysis,we found that occupation,work,social withdrawal,family function,responsibility,planning were correlate with criminal responsibility. The CA’s score of all items of SDSS was higher than the D’s except the item of interest and care. Occupation and work,social withdrawal,family function,responsibility,planning affected the assessment of criminal responsibility.

关键词： Forensic Psychiatry Drinking Offense Social Ability Criminal Responsibility

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Advancing early warning and surveillance for zoonotic diseases under climate change:interdisciplinary systematic perspectives

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Advances in Climate Change Research 2023年第6期14卷 814-826页

作者： Chen-Xi WANG Le-Shan XIU Qin-Qin HU tung-Chun LEE Jia LIU Leilei SHI Xiao-Nong ZHOU Xiao-Kui GUO Liyuan HOU Kun YIN School of Global Health Chinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghai 200025China One Health center Shanghai Jiao Tong University-The University of EdinburghShanghai 200025China institute for Materials Discovery University College London(UCL)BloomsburyLondon WCIE 7JEUnited Kingdom Deparment of chemistry University College London(UCL)London WCIH OAJ.United Kingdm School of Arts and sciences Carolina UniversityWinston-Salem NC2710lUSA Civil and Environmental Engineering department Utah State UniversityLogan UT 84322USA Utah Water Research Laboratory Logan UT 84321USA

Zoonoses account for the majority of emerging infectious diseases and pose a serious threat to human and animal *** global warming and climate change,zoonoses are significantly affected by influencing hosts,vectors,and pathogen dynamics as well as their *** zoonoses surveillance relies on molecular or serological diagnostic methods to monitor pathogens from animal or patient samples,which may miss the early warning signs of pathogens spillover from the ***,new technologies such as remote sensing,environment-based screening,multi-omics,and big data science facilitate comprehensive active surveillance,offering great potential for early warning and *** the recent technological advances,there is few reviews that explores the integration of cutting-edge technologies aimed at constructing a robust early warning ***,we discussed the opportunities,barriers,and limitations of interdisciplinary emerging technologies for exploring early warning and surveillance of *** systematic review summarized a practical framework for early surveillance integrated with a modified SEIR model for zoonoses in the context of climate *** also outlined challenges and future prospects in terms of data sharing,early detection of unknown zoonoses and the move towards global surveillance.

关键词： Zoonoses Surveillance system Early warning Climate change interdisciplinary

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Nanotrap-enabled quantification of KRAS-induced peptide hydroxylation in blood for cancer early detection

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Nano Research 2019年第6期12卷 1445-1452页

作者： Zaian Deng Zhen Zhao Bo Ning Jeffery Basilio Karen Mann Jie Fu Yajun Gu Yuanqing Ye Xifeng Wu Jia Fan Paul chiao Tony Hu College of Health science and Environmental Engineering Shenzhen Technology UniversityShenzhen 518118 China School of Biological and Health Systems Engineering Virginia G. Piper Biodesign Center for Personalized DiagnosticsThe Biodesign InstituteArizona State UniversityTempeArizona 85287USA department of Nanomedicine Houston Methodist Research InstituteHoustonTexas 77030USA Pathology and Laboratory Medicine Weill Cornell Medical CollegeNew York New York 10065USA center for molecular Design and Biomimetics The Biodesign InstituteArizona State UniversityTempeArizona 85287USA department of Laboratory Medicine Clinical CenterNational Institutes of HealthBethesdaMaryland 20892USA department of molecular Oncology H. Lee Moffitt Cancer CenterTampaFlorida 33612USA department of molecular and Cellular Oncology The University of Texas MD Anderson Cancer CenterHoustonTexas 77030USA School of Medical Laboratory Tianjin Medical UniversityTianjin 300203China department of Epidemiology The University of Texas MD Anderson Cancer CenterHoustonTexas 77030USA

Circulating peptide is a potential source of biomarkers for cancer ***,the existence of large molecular weight proteins in plasma have a disastrous effect on circulating peptides isolating and ***,nanotrap fractionation following by mass spectrometry have been applied to quantify the levels of bradykinin (BK) and hydroxylated bradykinin (Hyp-BK) as a relative measure of KRAS-regulated prolyl-4-hydroxylase alpha-1 (P4HA1) which may serve as early diagnosis marker for pancreatic ductal adenocarcinoma (PDAC).We found that P4HA1 can be upregulated by KRASG12v,which is a PDAC driver mutation,using HPNE/KRAS and HPNE *** we revealed that P4HA1 is overexpressed in PDAC tumors,compared to normal and inflamed pancreatic *** interference revealed that P4HA1 activity was primarily responsible for Hyp-BK *** spectrometry analysis revealed that plasma Hyp-BK/BK ratio was higher in PDAC than pancreatitis patients and healthy controls,while the area under the receiver operating characteristic (ROC) curve (AUC) is 0.8209 (95%Cl,0.7269-0.9149).The Hyp-BK/BK association with PDAC was reproduced in another cohort,where this ratio was found to increase with advancing tumor *** novel findings paved the way for wider applications of Nanotrap coupled mass spectrometry as a powerful tool for revealing biosignatures from plasma.

关键词： nanotrap hydroxylation level bradykinin pancreatic ductal adenocarcinoma

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Effective N-methyl-2-pyrrolidone wet cleaning for fabricating highperformance monolayer MoS2 transistors

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Nano Research 2019年第2期12卷 303-308页

作者： Po-Chun Chen Chih-Pin Lin Chuan-Jie Hong Chih-Hao Yang Yun-Yan Lin Ming-Yang Li Lain-Jong Li tung-Yuan Yu Chun-Jung Su Kai-Shin Li Yuan-Liang Zhong Tuo-Hung Hou Yann-Wen Lan department of Physics "National Taiwan Normal University" Taipei 11677 Taiwan China department of Electronics Engineering and institute of Electronics "National Chiao Tung University' Hsinchu 30010 Taiwan China department of Physics and center for Nanotechnology Chung Yuan Christian University Chungli 32023 Taiwan China Research center for applied sciences Academia Siriica: Taipei 11529 Taiwan China Physical Sci. and Eng. King Abdullah University of Sci.and Technology Thuwal 23955 Kingdom of Saudi Arabia "national Nano Device Laboratories:"national applied Research Laboratories" Hsinchu 30078 Taiwan China

Two-dimensional semiconductors,such as MoS2 are known to be highly susceptible to diverse molecular adsorbates on the surface during fabrication,which could adversely affect device *** ensure high device yield,uniformity and performance,the semiconductor industry has long employed wet chemical cleaning strategies to remove undesirable surface contaminations,adsorbates,and native oxides from the surface of Si wafers.A similarly effective surface cleaning technique for two-dimensional materials has not yet been fully *** this study,we propose a wet chemical cleaning strategy for MoS2 by using *** cleaning process not only preserves the intrinsic properties of monolayer MoS2,but also significantly improves the performance of monolayer MoS2 *** device on current of 12 μA·μm-1 for a channel length of 400 nm,contact resistance of 15 kΩ·μm,field-effect mobility of 15.5 cm^2·V^-1·s^-1,and the average on-off current ratio of 10^8 were successfully demonstrated.

关键词： monolayer M0S2 devices standard wet cleaning field-effect transistors N-methyl-2-pyrrolidone

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新世纪中推动生物科学发展的“Bio-X”

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生物物理学报 2001年第1期17卷 1-9页

作者：张志鸿复旦大学生命科学学院生理学和生物物理学系立人实验室上海200433

近二年国际上正掀起建立以生物科学为中心的交叉学科研究中心或研究所等实体的热潮。其中最引人注目的是美国斯坦福大学以诺贝尔物理学奖获得者朱棣文教授等人组建的“Bio -X”研究中心。Bio -X中的Bio为生物学 ,X泛指物理学、化学、工... 详细信息

近二年国际上正掀起建立以生物科学为中心的交叉学科研究中心或研究所等实体的热潮。其中最引人注目的是美国斯坦福大学以诺贝尔物理学奖获得者朱棣文教授等人组建的“Bio -X”研究中心。Bio -X中的Bio为生物学 ,X泛指物理学、化学、工程学、医学等其它学科。在新世纪到来之时 ,生物科学中有不少迅速发展的领域迫切需要多学科交叉共同研究和参与 ,特别是 :后基因组、基于同步辐射的结构生物学、单分子测量、纳米技术、脑科学、生物医学工程等。

关键词： Bio-X 交叉学科后基因组单分子测量脑科学物理学

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Novel CagA ELISA exhibits enhanced sensitivity of Helicobacter pylori CagA antibody

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World Journal of Gastroenterology 2017年第1期23卷 48-59页

作者： Yuichi Matsuo Yasutoshi Kido Junko Akada Seiji Shiota Tran Thanh Binh Tran Thi Huyen Trang Ho DQ Dung Pham Huu tung Tran Dinh Tri Ngo P Minh Thuan Le Quang Tam Bui Chi Nam Vu Van Khien Yoshio Yamaoka department of Environmental and Preventive Medicine Oita University Faculty of Medicine department of General Medicine Oita University Faculty of Medicine department of Endoscopy Cho Ray Hospital department of molecular Biology 108 Military Central Hospital department of Endoscopy Daklak Hospital department of Endoscopy Lao Cai Hospital department of Hepatogastroentrology 108 Military Center Hospital department of Medicine-Gastroenterology Baylor College of Medicine and Michael E.De Bakey Veterans Affairs Medical Center

AIM To develop a novel Helicobacter pylori(***)CagA antibody enzyme-linked immunosorbent assay(ELISA)suitable for detecting serum anti-CagA antibodies with high *** Recombinant East Asian-type CagA protein was purified and immobilized for *** samples from 217Vietnamese individuals(110 ***-infected and107 uninfected individuals)were *** ELISA from Western-type CagA and our East Asian-type CagA ELISA were evaluated by comparing 38 subjects with the Western-type genotype and 72 subjects with the East Asian-type cagA *** scores of the gastric mucosa were determined using the updated Sydney System to examine the relationship with anti-CagA antibody *** Recombinant 70-100 k Da fragments were immobilized on the ELISA *** ROC analysis,the area under the curve of our East Asian-type CagA ELISA was comparable to that of conventional CagA *** sensitivity of the two ELISAs differed depending on the cagA *** sensitivity of East Asian-type Cag A ELISA was higher for subjects infected with East Asiantype cagA ***(P25,P=0.058)and was inversely correlated with *** density(r=-0.26,P=0.043).CONCLUSION The novel ELISA is useful to detect anti-CagA antibodies in East Asian countries,and the titer may be a marker for predicting chronic gastritis.

关键词： Helicobacter pylori cagA 遗传型 Anti-CagA 抗体连接酶的 immunosorbent 试金发炎胃炎

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应用机器学习加速新材料的研发

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中国科学：物理学、力学、天文学 2018年第10期48卷 54-66页

作者：吴炜孙强北京大学工学院材料系北京100871 北京大学应用物理与技术研究中心北京100871

材料不仅是国民经济的基础,而且也是高新技术的载体.超越常规手段、应用新方法加速新材料的研发已成为全世界的研究热点.随着数据驱动方法取得的巨大成功,机器学习受到了日益高度的关注.它结合计算机科学、数据库理论、统计学、计算数... 详细信息

材料不仅是国民经济的基础,而且也是高新技术的载体.超越常规手段、应用新方法加速新材料的研发已成为全世界的研究热点.随着数据驱动方法取得的巨大成功,机器学习受到了日益高度的关注.它结合计算机科学、数据库理论、统计学、计算数学和工程学,不仅能展现出更快的计算速度和可靠的预测能力,大幅度提升材料计算效率,而且还能有效地处理一些难以运用传统模拟计算方法解决的体系和问题,这为研发具有特殊功能和特殊结构的新材料以满足日益提升的新技术的要求提供了契机.本文将简要概述机器学习的基本原理,介绍机器学习模型中的几种典型算法以及机器学习在新材料研究中的应用进展,并对机器学习在材料科学领域中的未来的发展前景做出展望.

关键词：新材料机器学习材料计算模拟

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First-principles study on the mechanics, optical, and phonon properties of carbon chains

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Chinese Physics B 2018年第11期27卷 559-567页

作者：李金平孟松鹤陆汉涛遠山貴巳 national Key Laboratory of science and Technology on Advanced Composites in Special Environments Center for Composite Materials and Structure Harbin Institute of Technology center for interdisciplinary Studies & Key Laboratory for Magnetism and Magnetic Materials of the Ministry of Education Lanzhou University department of applied Physics Tokyo University of Science

Besides graphite, diamond, graphene, carbon nanotubes, and fullerenes, there is another allotrope of carbon, carbyne,existing in the form of a one-dimensional chain of carbon atoms. It has been theoretically predicted that carbyne would be stronger, stiffer, and more exotic than other materials that have been synthesized before. In this article, two kinds of carbyne, i.e., cumulene and polyyne are investigated by the first principles, where the mechanical properties, electronic structure, optical and phonon properties of the carbynes are calculated. The results on the crystal binding energy and the formation energy show that though both are difficult to be synthesized from diamond or graphite, polyyne is more stable and harder than cummulene. The tensile stiffness, bond stiffness, and Young＇s modulus of cumulene are 94.669 eV/？A,90.334 GPa, and 60.62 GPa, respectively, while the corresponding values of polyyne are 94.939 eV/？A, 101.42 GPa, and60.06 GPa. The supercell calculation shows that carbyne is most stable at N = 5, where N is the supercell number, which indicates that the carbon chain with 10 atoms is most stable. The calculation on the electronic band structure shows that cumulene is a conductor and polyyne is a semiconductor with a band gap of 0.37 eV. The dielectric function of carbynes varies along different directions, consistent with the one-dimensional nature of the carbon chains. In the phonon dispersion of cumulene, there are imaginary frequencies with the lowest value down to-3.817 THz, which indicates that cumulene could be unstable at room temperature and normal pressure.

关键词： carbyne first-principles calculation electronic structure physical properties

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维度调控策略提升铂基纳米晶氧还原催化研究进展（英文）

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物理化学学报 2018年第4期34卷 361-376页

作者：骆明川孙英俊秦英楠杨勇吴冬郭少军北京大学工学院材料科学与工程系北京100871 青岛科技大学化学与分子工程学院山东青岛266042 北京大学前沿交叉学科研究院北京100871 北京大学工学院工程科学与新兴技术高精尖中心北京100871

燃料电池技术的商业化进程主要受制于其阴极动力学缓慢的氧还原反应(ORR)所需的高铂量电催化剂,因此急需开发更高活性的电催化剂。过去十年里,人们在提高铂基催化剂ORR活性的研究取得了极大进展。本文概述了通过结构调控提升铂基纳米晶... 详细信息

燃料电池技术的商业化进程主要受制于其阴极动力学缓慢的氧还原反应(ORR)所需的高铂量电催化剂,因此急需开发更高活性的电催化剂。过去十年里,人们在提高铂基催化剂ORR活性的研究取得了极大进展。本文概述了通过结构调控提升铂基纳米晶氧还原电催化性能的最新进展,依据纳米晶的空间维度展开讨论,同时列举各类电催化材料的优缺点。基于理论和实验结果,本文重点讨论铂基纳米晶应用于氧还原电催化的构效关系,以及其对下一代电催化材料结构设计方面的潜在指导意义。最后,我们对此领域未来的研究方向做了展望。

关键词：燃料电池氧还原铂基纳米晶维度调控

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