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2023.chinese national clinical practice guideline on diagnosis and management of ulcerative colitis

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中华医学杂志(英文版) 2024年第14期137卷 1642-1646页

作者： Inflammatory Bowel Disease Group, chinese Society of Gastroenterology, chinese Medical Association Inflammatory Bowel Disease Quality Control center of{3. Inflammatory Bowel Disease Group Chinese Society of Gastroenterology Chinese Medical Association Inflammatory Bowel Disease Quality Control center of china

The role of chinese expert consensus in standardization and improvement of the clinical diagnosis and treatment of inflammatory bowel disease (IBD) is self-evident. As clinical and basic research in china becomes standardized under a better understanding of IBD, more data on chinese patients have become available to develop a consensus and guideline. This guideline, collaboratively developed by the IBD Group, chinese Society of Gastroenterology, incorporates the latest international consensus statements, domestic research findings, and practical considerations, as an update based on the 2018 chinese consensus on IBD management. The IBD guideline consists of two parts: ulcerative colitis (UC) and Crohn's disease, and this manuscript presented the UC part. The evidence used in this guideline was collected and analyzed by the standard of guideline, and the contents were organized as problem statements, for clarity. The formulation of this guideline aimed to reflect the latest progress in IBD, providing comprehensive and valuable guidance for the clinical management of IBD.

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IL-8-induced L-selectin shedding regulates its binding kinetics to PSGL-1

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chinese Science Bulletin 2009年第16期54卷 2786-2793页

作者： JIA XiaoLing1,2,3. CHEN Juan1,2 & LONG Mian1,2 1 National Microgravity Laboratory, institute of mechanics, chinese academy of sciences, Beijing 100190, china {3., institute of mechanics, chinese academy of sciences, Beijing 100190, china 3.School of Biological Science and Medical Engineering, Beihang University, Beijing 100083. china National Microgravity Laboratory Institute of Mechanics Chinese Academy of Sciences Beijing 100190 China center of biomechanics and bioengineering Institute of Mechanics Chinese Academy of Sciences Beijing 100190 China School of Biological Science and Medical Engineering Beihang University Beijing 100083 China

L-selectin plays a crucial role in inflammation cascade by initiating the tethering and rolling of leukocytes on endothelium wall. While many L-selectin molecules are rapidly shed from the cell surface upon activation, the remaining membrane-anchored L-selectin may still play an important role in regulating leukocyte rolling and adhesion with different binding kinetics. Here we developed an in vitro model to activate Jurkat cells via interlukin-8 (IL-8) and quantified the two-dimensional (2D) binding kinetics, using a micropipette aspiration assay, of membrane-anchored L-selectin to P-selectin glycoprotein ligand 1 (PSGL-1) ligand coupled onto human red blood cells (RBCs). The data indicated that L-selectin shedding reduced the amount of membrane-anchored L-selectin and lowered both its reverse and forward rates. These results suggested that the rolling dynamics of activated leukocytes was determined by two opposite impacts: reducing the surface presentation would enhance the rolling but lowering the kinetic rates would decrease the rolling. This finding provides a new insight into under-standing how L-selectin shedding regulates leukocyte rolling and adhesion.

关键词：结合动力学选择素配体白细胞介素8 Jurkat细胞诱导细胞表面微管吸吮

Dynamics of morphological changes for mitochondrial fission and fusion

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Science china(Physics,mechanics & Astronomy) 2010年第4期53卷 680-689页

作者： WANG ShiQi 1,2,4 , FU ChangLiang 1,2 , ZHANG Yan 1,2 , CHEN Quan 3.& LONG Mian 1,2 1 Key Laboratory of Microgravity (National Microgravity Laboratory), Beijing 100190, china 2 center for biomechanics and{3., institute of mechanics, chinese academy of sciences, Beijing 100190, china 3.State Key Laboratory of Biomembrane and Membrane Biotechnology, institute of Zoology, chinese academy of sciences, Beijing 100101, china 4 institute of Vertebrate Paleontology and Paleoanthropology, chinese academy of sciences, Beijing 100044, china 1. Key Laboratory of Microgravity (National Microgravity Laboratory) Beijing 100190 China2. Center for Biomechanics and Bioengineering Institute of Mechanics Chinese Academy of Sciences Beijing 100190 China4. Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of Sciences Beijing 100044 China3. State Key Laboratory of Biomembrane and Membrane Biotechnology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China

Mitochondria experience continuous fusion and fission in a living cell, but their dynamics remains poorly quantified. Here a theoretical model was developed, upon a simplified population balance equation (PBE), to predict the morphological changes induced by mitochondrial fission and fusion. Assuming that both fission and fusion events are statistically independent, the survival probability of mitochondria staying in the fission or fusion state was formulated as an exponentially-decayed function with time, which depended on the time-dependent distribution of the mitochondrial volume and the fission and fusion rates. Parametric analysis was done for two typical volume distributions. One was Gamma distribution and the other was Gaussian distribution, derived from the measurements of volume distribution for individual mitochondria in a living cell and purified mitochondria in vitro. The predictions indicated that the survival probability strongly depended on morphological changes of individual mitochondria and was inversely correlated to the fission and fusion rates. This work provided a new insight into quantifying the mitochondrial dynamics via monitoring the evolution of the mitochondrial volume.

关键词： mitochondria morphology fission fusion dynamics modeling

Spectral analysis of quasi-stationary sea surface topography from GRACE mission

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Science china Earth sciences 2005年第11期48卷 2040-2048页

作者： ZHANG Zizhan1,2 & LU Yang1,3.1. institute of Geodesy and Geophysics, chinese academy of sciences, Wuhan 43.077, china 2. Graduate School of the chinese academy of sciences, Beijing 10003., china 3. Unite center for Astro-geodymics Research, chinese academy of sciences, Shanghai 20003., china 1. institute of Geodesy and Geophysics Chinese Academy of Sciences 430077 Wuhan China 2. Graduate School of the chinese academy of sciences 100039 Beijing China 3. Unite center for Astro-geodymics Research Chinese Academy of Sciences 200030 Shanghai China

During the last two decades satellite altimetry has offered an abundance of meas-urements of the sea surface resulting in the improvement of global mean sea surface height (MSSH) and marine geoid determination. On the other hand, with the launching of new genera-tion gravity satellites, some high accuracy long-wavelength gravity models are available. These breakthroughs give us a great opportunity for new estimation of quasi-stationary sea surface topography (QSST). In this paper, the new gravity model GGM01C derived from GRACE mission is briefly presented, and a new global high precision and high-resolution QSST is determined based on the GGM01C model and the global MSSH. The spectral features of the QSST esti-mated by GGM01C and EGM96 gravity model to degree/order 200 are discussed by spectral analysis. As a result, the QSST is mainly composed of long waves, medium waves partially and short waves scarcely, its power spectral structures are different between the zonal direction and the meridional direction, there are great differences between the two models, which maybe ex-plain why the ocean currents derived from the two gravity models by Tapley show different pat-terns.

关键词： quasi-stationary sea surface topography, mean sea surface height, GGM01, fast Fourier transform, spectral analysis

Strong decays of N~*(153.) in an extended chiral quark model

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Science china(Physics,mechanics & Astronomy) 2009年第10期52卷 1452-1457页

作者： AN ChunSheng1,2,3.& ZOU BingSong1,2,3.1 institute of High Energy Physics,chinese academy of{3.,Beijing 100049,china 2 Theoretical Physics center for Science Facilities,chinese academy of{3.,Beijing 100049,china 3.Graduate University of chinese academy of sciences,Beijing 100049,china institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China Theoretical Physics center for Science Facilities Chinese Academy of Sciences Beijing 100049 China Graduate University of chinese academy of sciences Beijing 100049 China

The strong decays of the N*(153.) resonance are investigated in an extended chiral quark model by including the low-lying $ qqqq\bar q $ components in addition to the qqq component. The results show that these five-quark components in N*(153.) contribute significantly to the N*(153.) → Nπ and N*(153.) → Nη decays. The contributions to the Nη decay come from both the lowest energy and the next-tolowest energy five-quarks components, while the contributions to the Nπ decay come from only the latter one. Taking these contributions into account, the description for the strong decays of N*(153.) is improved, especially for the puzzling large ratio of the decays to Nη and Nπ.

关键词： N*(153.) strong decays five-quark components

Compression behavior of Zr_(41)Ti_(14)Cu_(12.5)Ni_(10)Be_(22.5) bulk metallic glass up to 24 GPa

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Science china(Physics,mechanics & Astronomy) 2005年第3期48卷 319-324页

作者： LI Gong 1, 2 , ZHAN Zaiji 2 , LIU Jing 3., YUN Jinku 1 , SUN Liling 2 , LIU Riping 1 , ZHANG Jun 2 & WANG Wenkui 1, 2 1. Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao 066004, china 2. center for Condensed Matter Physics, institute of Physics,{3., Beijing 100080, china 3. BSRF, institute of High Energy Physics,{3., Beijing 10003., china 1. Key Laboratory of Metastable Materials Science and Technology Yanshan University 066004 Qinhuangdao China 2. center for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences 100080 Beijing China 3. BSRF Institute of High Energy Physics Chinese Academy of Sciences 100039 Beijing China

The compression of a Zr41Ti14Cu12.5Ni10Be22.5 bulk metallic glass (BMG) is investigated at room temperature up to 24 GPa using in-situ high pressure energy dispersive X-ray diffraction with a synchrotron radiation source. The pressure-induced structural relaxation is exhibited. It is found that below about 8 GPa, the existence of excess free volume contributes to the rapid structural relaxation, which gives rise to the rapid volumetric change, and the structural relaxation results in the structural stiffness under higher pressure.

关键词： bulk metallic glass, high pressure, structural relaxation, synchrotron radiation.

Interannual variability of Antarctic Oscillation and its influence on East Asian climate during boreal winter and spring

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Science china Earth sciences 2006年第5期49卷 554-560页

作者： FAN Ke1,2,3.& WANG Huijun2 1. Nansen-Zhu International Research center, institute of Atmospheric Physics, chinese academy of sciences, Beijing 100029,{3. 2. Department of Atmospheric Science, Yunnan University, Kunming 650091,{3. 3. Graduate University of the chinese academy of sciences, Beijing 100049,{3. 1. Nansen-Zhu International Research center Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China 2. Department of Atmospheric Science Yunnan University Kunming 650091 China 3. Graduate University of the chinese academy of sciences Beijing 100049 China

The interannual variability of Antarctic Oscillation (AAO) and its influence on East Asian climate during both boreal winter and spring are addressed. The results show that the positive AAO anomaly decreases the cold activity over East Asia during both boreal winter and spring. AAO-related barotropic meridional teleconnection from Antarctic to Arctic is found through analysis of mean me- ridional circulations. This meridional teleconnection is remarkable over Eurasia during boreal winter and over the Pacific Ocean during boreal spring. The results also show that zonal mean zonal wind at high latitudes in Southern Hemisphere has well positive correlation with that of Eurasia during boreal winter and has negative correlation with Pacific North American teleconnection (PNA) during boreal spring, which again display the meridional teleconnection. Thus, local meridional teleconnection is a possible linkage for interaction of circulations at mid-high latitudes between both hemispheres.

关键词： Antarctic Oscillation, Eurasian west wind, meridional teleconnection, mean meridional circulation.

Developing a microfluidic-based system to quantify cell capture efficiency

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Science china(Life sciences) 2009年第2期52卷 173-181页

作者： YANG Fan, GAO YuXin, ZHANG Yan, CHEN Juan & LONG Mian National Microgravity Laboratory and center for biomechanics and bioengineering,{3., chinese academy of sciences, Beijing 100080, china 1. National Microgravity Laboratory and center for biomechanics and bioengineering Institute of Mechanics Chinese Academy of Sciences Beijing 100080 China

Micro-fabrication technology has substantial potential for identifying molecular markers expressed on the surfaces of tissue cells and viruses. It has been found in several conceptual prototypes that cells with such markers are able to be captured by their antibodies immobilized on microchannel substrates and unbound cells are flushed out by a driven flow. The feasibility and reliability of such a microflu- idic-based assay, however, remains to be further tested. In the current work, we developed a microflu- idic-based system consisting of a microfluidic chip, an image grabbing unit, data acquisition and analysis software, as well as a supporting base. Specific binding of CD59-expressed or BSA-coupled human red blood cells (RBCs) to anti-CD59 or anti-BSA antibody-immobilized chip surfaces was quan- tified by capture efficiency and by the fraction of bound cells. Impacts of respective flow rate, cell concentration, antibody concentration and site density were tested systematically. The measured data indicated that the assay was robust. The robustness was further confirmed by capture efficiencies measured from an independent ELISA-based cell binding assay. These results demonstrated that the system developed provided a new platform to effectively quantify cellular surface markers effectively, which promoted the potential applications in both biological studies and clinical diagnoses.

关键词： cell surface marker microfluidic capture efficiency

Mass Spectrometric Evidence of Heparin Disaccharides for the Catalytic Characterization of A Novel Endolytic Heparinase

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Acta Biochimica et Biophysica Sinica 2004年第12期36卷 840-844页

作者： Yapeng CHAO1,3. Shaoxiang XIONG2, Xiulan CHENG1, and Shijun QIAN1* 1institute of Microbiology, chinese academy of sciences, Beijing 100080, china 2{3. of Mass Spectrometry, institute of Chemistry, chinese academy of sciences, Beijing 100080, china 3.raduate School of the chinese academy of sciences, Beijing 10003., china institute of Microbiology Chinese Academy of SciencesBeijing 100080 China Graduate School of the chinese academy of sciencesBeijing 10003. China center of Mass Spectrometry Institute of Chemistry Chinese Academy of SciencesBeijing 100080 China

Heparinase from different sources can eliminate heparin or/and heparan sulfate into various low-molecular weight heparins with different characteristics. Porcine intestinal mucosa heparin was de- graded into a series of oligosaccharides by a novel heparinase from the species Sphingobacterium. Disaccha- ride components from the digests were separated and purified by ultrafiltration and HPLC. Five major peaks appeared as three types according to their retention time. The mass spectrometry of peak I mainly gave the non-sulfated disaccharide with the mass of 3.9 Da. Peak II and III were indicated as two major monosulfated disaccharides with molecular mass of 417 and 459 Da respectively. Moreover, the peak III represented an N- acetyl disaccharide. Both peak IV and V showed the same mass of 496 Da, hinting that they were disulfate- substituted disaccharides. No trisulfate-substituted disaccharides were detected in the mixture of the heparin digest though they were abundant in the heparin structure. The results revealed that the heparinase might specifically cut the sites with low sulfated domain in heparin.

关键词： electrospray ionization-mass spectrometry heparin disaccharides heparinase high perfor- mance liquid chromatography Sphingobacterium sp.