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Changes in Autoantibodies against β1-Adrenoceptor and M2-Muscarinic Receptor during Development of Renovascular Hypertension in Rats

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Acta Biochimica et Biophysica Sinica 2004年第12期36卷 793-797页

作者： Jian-Ming ZHI*, Rong-Fang CHEN1, Heng WU2, Hui-Rong LIU2, and Rong-Rui ZHAO2 department of physiology, Shanghai Second medical university, Shanghai 200025, china 1department of Toxicology, Second Military medical university, Shanghai 200433, china 2 department of physiology, shanxi medical university, taiyuan 030001, china department of physiology Shanghai Second Medical UniversityShanghai 200025 China department of Toxicology Second Military Medical UniversityShanghai 200433 China department of physiology Shanxi Medical UniversityTaiyuan 030001 China

In an experimental rat’s renovascular hypertension model, we studied the genesis of anti- cardiac β1-adrenoceptor and M2-muscarinic receptor autoantibodies in relation to the changes in immunological function during the development of renal hypertension. The biological activities of these autoantibodies were also examined. It was shown that after two weeks of operation both the frequency of occurrence and the titre of autoantibodies to cardiac β1-adrenoceptor and M2-muscarinic receptor were significantly increased as compared with the control of pre-treatment. The increased autoantibodies lasted for several weeks and then automatically decreased gradually to the pre-clipping level at 10 weeks. Meanwhile the ratio of CD4 /CD8 + + was also undergone an initial increase followed by gradual recovery and correlated well with the changes in antibody titre. The biological effects of these autoantibodies displayed an “agonistic-like” activities on the beating frequency of cultured neonatal cardiomyocyte. It is suggested that autoimmune mechanisms are involved in the pathogenesis of renal hypertension and the cardiac receptor autoantibodies might be one of the mechanisms leading to cardiac dysfunction.

关键词： autoantibody renal hypertension cardiac receptor immunology

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Autoantibody against Cardiac β1-Adrenoceptor Induces Apoptosis in Cultured Neonatal Rat Cardiomyocytes

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Acta Biochimica et Biophysica Sinica 2006年第7期38卷 443-449页

作者： Yan GAO~1 Hui-Rong LIU~1 Rong-Rui ZHAO~1 Jian-Ming ZHI~(2*) 1 department of Cardiovascular physiology shanxi medical university,taiyuan 030001,china 2 department of physiology,Shanghai Jiaotong university,College of Basic Medicine,Shanghai 200025,china departmentofCardiovascularphysiology ShanxiMedicalUniversityTaiyuan030001China departmentofphysiology ShanghaiJiaotongUniversityCollegeofBasicMedicineShanghai200025China

To clarify whether apoptosis is involved in the injury processes induced by autoantibodyagainst cardiac β1-adrenoceptor,we investigated the biological and apoptotic effects of antibodies on culturedneonatal rat *** rats were immunized with peptides corresponding to the second extra-cellular loop of the β1-adrenoceptor to induce the production of anti-β1-adrenoceptor antibodies in the ***（Ig）G in the sera was detected using synthetic antigen enzyme-linked immunosorbentassay and purified using the diethylaminoethyl cellulose ion exchange *** of cardiomyo-cytes was evaluated using agarose gel electrophoresis and flow *** results showed that thepositive serum IgG greatly increased the beating rates of cardiomyocytes and showed an"agonist-like"***,positive serum IgG induced cardiomyocyte apoptosis after treatment with β1-adrenoceptor overstimulation for *** effects of monoclonal antibody against β-adrenoceptor werealso found to be similar to those of positive serum *** was suggested that the autoantibody could inducecardiomyocyte apoptosis by excessive stimulation of β1-adrenoceptor.

关键词： β1-adrenoceptor rat cardiomyocyte autoantibody apoptosis

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Changes in autoantibodies against β3-adrenoceptor during development of congestive heart failure in rats

Changes in autoantibodies against β3-adrenoceptor during de...

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2008北京国际生理科学学术大会

作者： YAO Hong~(1,2),WU Ye~2,MA Xiu-Rui~2,YAN Li~2,LI Xiao-Yu~2,ZHAO Huan-Xin~2,TIAN Jue~2,WANG Ye-Hong~2, ZHAO Rong-Rui~2,LIU Hui-Rong~2 1 department of Microbiology and Immunology,shanxi medical university,taiyuan,shanxi,030001,china 2 department of physiology shanxi medical university,taiyuan,shanxi 030001,china

Introduction Autoimmune mechanisms have been regarded as one of the important pathogenesis of congestive heart failure(CHF).In our previous study,the autoantibody agaistβ-adrenoceptor(βAR)had been demonstrated to be present in the patients with CHF and exhibited remarkable negative inotropic and chronotropic effects on *** clarify the relations of myocardial pathologic state to the genesis ofβAR autoantibodies may deepen our understanding of the autoimmune mechanism in the pathogenesis and development of some heart *** Male Wistar rats were divided into 2 groups:aortic banding group(AB group)and sham operated control group(sham group).Throughout the experiment,rat blood samples were taken before and 2,4,6, 8,10,12,14 and 16 week *** detection for the autoantibodies againstβAR was done by ELISA using the synthesized peptide corresponding to the second extracellular loop of ratβAR as *** 4,8,12 and 16 weeks post-treatment,left ventricular(LV)function of 8 animals were measured invasively and the hearts were excised each *** cardiac structure was examined by routine light microscopy and theβAR contents of heart tissues were detected by Western *** In AB group,levels of autoantibodies againstβAR in the sera were slightly increased at 2 to 6 weeks *** 8weeks post-treatment,it reached the peak and keeped for 4 weeks then began to *** 14 and 16 weeks post-treatment,there were no any differences in the OD value of autoantibodies between AB and sham ***,on the basis of cardiac anatomic measurements and light microscopic examination,it was shown that the experimental models underwent remarkable myocardial remodeling at 8 weeks to 16 weeks *** this period,the expression of cardiacβAR protein in AB group was exceedingly increased as compared with pre-treatment,suggesting the consistency of function betweenβAR and their ***,no significant changes we

关键词： receptor adrenergic β3 autoantibody heart failure animal model

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Construction of tissue-engineered cartilage using human placenta-derived stem cells

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Science china(Life Sciences) 2010年第2期53卷 207-214页

作者： LIU DaShun1,2,HUI HuangFu3,CHAI XiangBin3,WANG BinQuan3 & QIU JianHua1 1 department of ENT,Xijing Hospital,the Foruth Military medical university of PLA,Xi’an 710032,china 2 department of ENT,264 Hospital of PLA,taiyuan 030001,china 3 department of ENT,the First Hospital of shanxi medical university,taiyuan 030001,china 1. department of ENT Xijing Hospital the Foruth Military Medical University of PLA Xi’an 710032 China2. Department of ENT 264 Hospital of PLA Taiyuan 030001 China3. Department of ENT the First Hospital of Shanxi Medical University Taiyuan 030001 China

Human placenta-derived stem cells (hPDSCs) were isolated by trypsinization and further induced into cartilage cells in *** engineered cartilage was constructed by combining hPDSCs with collagen sponge and the cartilage formation was observed by implantation into nude *** showed that hPDSCs featured mesenchymal stem cells and maintained proliferation in vitro for over 30 passages while remaining *** results indicated that hPDSCs have the potential to differentiate into functional cartilage cells in vitro when combined with collagen sponge,which provided experimental evidence for prospective clinical application.

关键词： human placenta-derived stem cells collagen sponge cartilage tissue engineering

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Karyotypic analysis of intersexuality in Chinese from taiyuan

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Asian Journal of Andrology 2000年第2期2卷 155-157页

作者： Zhen-Guo MI Xiao-Feng YANG Tao LAN department of Urology, First Affiliated Hospital, shanxi medical university, taiyuan 030001, china department of Urology First Affiliated Hospital Shanxi Medical University Taiyuan China

Aim: To analyze the kayrotypic patterns of 33 cases of intersexuality in Chinese from taiyuan, china in order tofurther clarify its mechanism of development and the interrelationship between karyotype and phenotypic sex. Meth-ods: High-resolution GTG-banding chromosome technique was used to analyze the karyotype patterns. Results:In these patients, 57.58% were male pseudohermaphrodites (46, XY), 18.18%, female pseudohermaphrodites (46,XX), 12.12%, true hemaphrodites, and 12.12%, other karyotypes, Although testes can be seen in 88.8% of kary-otypes with Y chromosome, 73.68% of the patients were of female social sex. In 42.82% of patients the social sex isin conformity with their karyotypes. There were 2 cases of male pseudohennaphrodites, where the sex chromosome wasnormal, but abnormalities were found in chromosomes 9, 13, or 14. Conclusion: Sex chromosomes determine thedirection of gonadal and sex differentiation, while the development of the normal gonad and extemal genitalia shouldhave the participation of many autosomal chromosomes as well.

关键词： pseudobermaphroditism hermaphroditism karyotyping gene chromosome

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Amyloid β-protein differentially affects NMDA receptor-and GABAA receptor-mediated currents in rat hippocampal CA1 neurons

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Progress in Natural Science:Materials International 2009年第8期19卷 963-972页

作者： Junfang Zhanga, Lei Houb, Xiuping Gao a, Fen Guoa, Wei Jingc, Jinshun Qia, Jiantian Qiaoa a department of Neurobiology, shanxi medical university, taiyuan 030001, china b Anesthesiology department, shanxi Tumor Hospital, taiyuan 030013, china c department of Biomedical Engineering, Shanghai Jiao Tong university, Shanghai 200240, china [a]department of Neurobiology Shanxi Medical University Taiyuan 030001 China [b]Anesthesiology Department Shanxi Tumor Hospital Taiyuan 030013 China [c]Department of Biomedical Engineering Shanghai Jiao Tong University Shanghai 200240 China

Although the aggregated amyloid b-protein (Ab) in senile plaques is one of the key neuropathological features of Alzheimer’s disease (AD), soluble forms of Ab also interfere with synaptic plasticity at the early stage of AD. The suppressive action of acute application of Ab on hippocampal long-term potentiation (LTP) has been reported widely, whereas the mechanism underlying the effects of Ab is still mostly unknown. The present study, using the whole-cell patch clamp technique, investigated the effects of Ab fragments (Ab25–35 and Ab31–35) on the LTP induction-related postsynaptic ligand-gated channel currents in isolated hippocampal CA1 neurons. The results showed a rapid but opposite action of both peptides on excitatory and inhibitory receptor currents. Glutamate application-induced currents weresuppressed by Ab25–35in a dose-dependent manner,andfurtherN-methyl-D-aspartate(NMDA)receptor-mediated currents were selectively inhibited. In contrast, pretreatment with Ab fragments potentiated c-aminobutyric acid (GABA)-induced whole-cell currents. As a control, Ab35–31, the reversed sequence of Ab31–35, showed no effect on the currents induced by glutamate, NMDA or GABA. These results may partly explain the impaired effects of Ab on hippocampal LTP, and suggest that the functional down-regulation of NMDA receptors and up-regulation of GABAA receptors may play an important role in remodeling the hippocampal synaptic plasticity in early AD.

关键词： Amyloid b-protein Glutamate-induced current GABA-induced current Whole-cell patch clamp Hippocampus

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An algebraic invariant for Jordan automorphisms on B(H):The set of idempotents

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Science china Mathematics 2005年第12期48卷 1585-1596页

作者： CUI Jianlian & HOU Jinchuan department of Mathematical Science, Tsinghua university, Beijing 100084, china department of Applied Mathematics, taiyuan university of Technology, taiyuan 030024, china department of Mathematics, shanxi Teachers university, Linfen 041004, china department of Mathematical Science Tsinghua University Beijing 100084 China department of Applied Mathematics Taiyuan University of Technology Taiyuan 030024 China department of Mathematics Shanxi Teachers University Linfen 041004 China

Let H be an infinite dimensional complex Hilbert space. Denote by B(H) the algebra of all bounded linear operators on H, and by I(H) the set of all idempo-tents in B(H). Suppose that Φ is a surjective map from B(H) onto itself. If for every λ ∈ {-1,1,2,3,1/2,1/3} and A, B ∈ B(H), A - λB ∈ I(H) (?) Φ(A) - λΦ(B) ∈ I(H), then Φ is a Jordan ring automorphism, i.e. there exists a continuous invertible linear or conjugate linear operator T on H such that Φ(A) = TAT-1 for all A ∈ B(H), or Φ(A) = TA*T-1 for all A ∈ B(H); if, in addition, A-iB ∈ I(H) (?) Φ(A) -ιΦ(B) ∈ I(H), here ι is the imaginary unit, then Φ is either an automorphism or an anti-automorphism.

关键词： Hilbert space operators,Jordan automorphisms,idempotents.

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Relationship between platelet P-selectin and severity of acute coronary syndromes

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Journal of Geriatric Cardiology 2008年第3期5卷 146-149页

作者： Rui Wang~1 Jiyuan Lu~1 Yongping Jia~1 Yuping Gao~1 Chunyu Fan~1 Fang Li~2 1 department of Cardiology, The First Hospital of shanxi medical university. 2 department of Biochemisry and Molecular Biology, shanxi medical university. taiyuan, shanxi 030001, china department of Cardiology First Hospital Shanxi Medical University 85 Jiefang South Rode Taiyuan 030001 Shanxi China department of Biochemisry and Molecular Biology Shanxi Medical University Taiyuan Shanxi 030001 China

Objective Recent studies reveal important roles ofplatelet P-selectin on progression of *** the present study, we examine the relation between platelet P-selectin expression and severity of acute coronary *** One hundred and eighty-four consecutive patients with proven or clinically suspected acute coronary syndromes (ACS) were enrolled in the study. Level of P-selectin expression was determined by flow *** P-selectin level was expressed as the percentage of P- selectin positive *** The level of P-selectin was higher in patients with a single diseased coronary artery or multiple diseased arteries compared to those with normal coronary arteries.P-selectin expression was significantly and positively correlated with angiographic Gensini score (r=0.323,P=0.029).Multiple regression analyses showed that the association of the percentage of P- selectin-positive platelets with ACS was independent of other clinical *** Platelet P-selectin is associated with severity of acute coronary syndromes in patients with acute coronary syndromes.

关键词： platelets P-selectin acute coronary syndromes

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Contribution of an Auxin to the Uptake of Nickel and Cadmium in Maize Seedlings

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Biomedical and Environmental Sciences 1999年第3期12卷 170-176页

作者： GUO DONG-SHENG XI Yv-YINC WANG AI-YING ZHANG JUN AND YUAN XIAO-YING(department of Environmentel Science, shanxi university, taiyuan, china Analyzingand Detecting Center, shanxi university, taiyuan, china) department of Environmentel Science Shanxi University Taiyuan China

Maize seedlings were cultured in nickel or cadmium contaminated sand treated with α-naphthylacetic acid (NAA). The effeets of NAA on nickel and cadmium uptake in roots, shoots, and subcellular fractions (cell wall, nuclei and remained parts of seedling cells) were determined. The data showed growth promotion when NAA was applied at low concentrations and inhibition at high concentrations. Uptake of nickel and cadmium content increased concurmntly in roots and shoots. In thesubcellular fraction, nickel and cadmium was greatest in the cell wall. The changes in growth had greatest cormlation Wtih nickel and cadmium content in the subeellular fraction.

关键词： Ni Contribution of an Auxin to the Uptake of Nickel and Cadmium in Maize Seedlings

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Quantum statistical entropy corresponding to cosmic horizon in five-dimensional spacetime

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Science china(Physics,Mechanics & Astronomy) 2008年第2期51卷 140-146页

作者： ZHAO Ren1,2 & ZHANG ShengLi1 1 department of Applied Physics, Xi’an Jiaotong university, Xi’an 710049, china 2 department of Physics, shanxi Datong university, Datong 037009, china department of Applied Physics Xi’an Jiaotong University Xi’an 710049 China department of Physics Shanxi Datong University Datong 037009 China

The generalized uncertainty relation is introduced to calculate the quantum statis-tical entropy corresponding to cosmic horizon. By using the new equation of state density motivated by the generalized uncertainty relation, we discuss entropies of Bose field and Fermi field on the background of five-dimensional spacetime. In our calculation, we need not introduce cutoff. There is no divergent logarithmic term in the original brick-wall method. And it is obtained that the quantum statistical en-tropy corresponding to cosmic horizon is proportional to the area of the horizon. Further it is shown that the entropy corresponding to cosmic horizon is the entropy of quantum state on the surface of horizon. The black hole's entropy is the intrinsic property of the black hole. The entropy is a quantum effect. In our calculation, by using the quantum statistical method, we obtain the partition function of Bose field and Fermi field on the background of five-dimensional spacetime. We provide a way to study the quantum statistical entropy corresponding to cosmic horizon in the higher-dimensional spacetime.

关键词： quantum statistical entropy generalized uncertainty relation high-dimensional spacetime

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