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Reduning Injection versus Neuraminidase Inhibitors in Treatment of Influenza:A Systematic Review and Meta-Analysis

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Chinese Journal of Integrative Medicine 2022年第11期28卷 1023-1031页

作者： ZHAO Guo-zhen LI Bo wang Ya-fan GUO shi-qi DU yuan MA qiu-xiao GUO yu-hong liu Qing-quan School of Clinical Medicine Beijing University of Chinese MedicineBeijing(100029)China Department of Emergency Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing(100010)China Beijing Evidence-Based Chinese Medicine Center Beijing(100010)China Beijing Institute of Chinese Medicine Beijing(100010)China School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing(100029)China Department of Respiratory Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing(100700)China

Objective:To perform a systematic review to assess the effectiveness and safety of Reduning Injection versus neuraminidase inhibitors in treatment of ***:The MEDLINE,Embase,the Cochrane Central Register of Controlled Trials(CENTRAL),Chinese Bio-medical Literature and Retrieval System(Sinomed),China National Knowledge Infrastructure Database(CNKI),China Science and Technology Journal Database(VIP),Wanfang Data Knowledge Service Platform and *** were systematically searched from inception dates to May 2021 for randomized controlled trials(RCTs)exploring Reduning Injection alone or in combination with neuraminidase inhibitors in patients with *** analysis was performed using RevMan 5.4 and Stata *** qualities of the involved studies were assessed by the risk of bias according to the Cochrane *** evidence quality of each outcome was evaluated by GRADEpro ***:Twelve trials with 1,460 patients were *** included studies had a certain unclear or high risk of *** Injection appeared to be more effective in shortening the fever clearance time(MD:-16.20 h,95%CI:-19.40 to-12.99,7 trials,814 patients,I^(2)=94%,very low certainty),fever alleviation time(MD:-4.09 h,95%CI:-4.22 to-3.96,3 trials,366 patients,I^(2)=0%,low certainty),cough alleviation time(MD:-21.34 h,95%CI:-41.56 to-1.11,2 trials,228 patients,I^(2)=89%,very low certainty),fatigue alleviation time(MD:-31.83 h,95%CI:-36.88 to-26.77,2 trials,270 patients,I^(2)=0%,low certainty),sore throat alleviation time(MD:-28.66 h,95%CI:-32.23 to-25.10,1 trial,150 patients,low certainty),and improving the total effective rate(RR:1.15,95%CI:1.06 to 1.25,10 trials,1,074 patients,I^(2)=76%,very low certainty).Besides,Reduning Injection seemed generally ***:This study provided low or very low evidence indicating Reduning Injection may be effective in the treatment of influenza and might be *** rigorously designed studies are need

关键词： Chinese patent medicine Reduning Injection influenza meta-analysis systematic review

Nature and timing of a prehistoric giant landslide on the eastern margin of the Tibetan Plateau

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Journal of Mountain Science 2020年第6期17卷 1438-1451页

作者： ZHAO Xun wang yun-sheng wang shi-yuan ZHAO Bo ZENG Lu liu yu FENG qian-qian State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu 610059China Sichuan Earthquake Agency Chengdu 610041China Key Laboratory of Mountain Hazards and Earth Surface Processes Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu 610041China

Studying the characteristics of a prehistoric giant landslide and ascertaining its relationship with palaeo-seismic events could provide useful information on the role of regional tectonic activities in hillslope ***,a giant palaeoseismic landslide(GPSL),namely,the Luanshibao(LSB)landslide,located on the eastern margin of the Qinghai-Tibet Plateau,was investigated to ascertain its characteristics and occurrence *** relationship between occurrence age and palaeoseismic episodes was also discussed by using 14 C dating on the adjacent active faults,including the regional Yidun-Litang-Dewu(YD-LT-DW)fault zone,which crossed the LSB *** dating of multiple samples acquired from palaeo-seismic trenches revealed that at least 5 palaeo-seismic episodes had occurred in the vicinity of the LSB landslide over the last 5000 *** occurrence age of the LSB landslide(3635±387 a BP)coincides with palaeo-seismic episode I,and the LSB landslide is convincingly inferred to have been triggered during episode I,which reached a seismic intensity(Chinese scale)of at least degree VII near the LSB landslide during *** timing of a second reactivation phase coincides with palaeo-seismic episode IV,which occurred at 2100-2200 a *** study could provide reference for studying the regional palaeoseismic activities and palaeo landslide evolution near the Litang area.

关键词： Prehistoric landslide Active fault zone Palaeo-seismic episode Dating

2023年重庆市高中学生结核分枝杆菌潜伏感染现状及影响因素分析

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现代预防医学 2024年第16期51卷 2960-2965+3009页

作者：钱金山余雅吴成果石亚玲刘英尹进苏倩黄学勇王梅曾庆吴波重庆医科大学公共卫生学院重庆市结核病防治所

目的探索重庆市高中学生结核分枝杆菌潜伏感染现状及影响因素，为重庆市学校结核病防控提供参考。方法采用分层整群抽样方法，抽取2023年重庆市高一、高二年级学生为研究对象，用重组结核分枝杆菌融合蛋白皮肤试验检测结核分枝杆菌潜... 详细信息

目的探索重庆市高中学生结核分枝杆菌潜伏感染现状及影响因素，为重庆市学校结核病防控提供参考。方法采用分层整群抽样方法，抽取2023年重庆市高一、高二年级学生为研究对象，用重组结核分枝杆菌融合蛋白皮肤试验检测结核分枝杆菌潜伏感染情况，收集结核分枝杆菌潜伏感染的相关信息，采用logistic回归模型分析影响因素。结果共纳入重庆市高一、高二年级学生9 161人，检出结核分枝杆菌潜伏感染543人，结核分枝杆菌潜伏感染率为5.93%。多因素logistic回归分析显示，既往结核病史(OR:4.244,95%CI:2.239～8.044)、结核病密切接触史(OR:2.096,95%CI:1.123～3.914)、吸烟(OR:6.819,95%CI:3.562～13.053)、熬夜(OR:1.665,95%CI:1.154～2.402)是学生结核分枝杆菌潜伏感染的危险因素。结论重庆市高一、高二年级学生结核分枝杆菌潜伏感染率较低。做好个人防护措施，加强身体锻炼，提高自身免疫力，可降低学生感染结核分枝杆菌的风险。

关键词：结核病学生结核分枝杆菌潜伏感染影响因素皮肤试验

An Unprecedented Record Low Antarctic Sea-ice Extent during Austral Summer 2022

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Advances in Atmospheric Sciences 2022年第10期39卷 1591-1597页

作者： Jinfei wang Hao LUO Qinghua YANG Jiping liu Lejiang yu qian shi Bo HAN School of Atmospheric Sciences Sun Yat-sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Department of Atmospheric and Environmental Sciences University at Albany State University of New YorkNew York 12222USA Ministry of Natural Resources Key Laboratory for Polar Science Polar Research Institute of ChinaShanghai 200136China

Seasonal minimum Antarctic sea ice extent(SIE)in 2022 hit a new record low since recordkeeping began in 1978 of 1.9 million km^(2) on 25 February,0.17 million km^(2) lower than the previous record low set in *** negative anomalies in the Bellingshausen/Amundsen Seas,the Weddell Sea,and the western Indian Ocean sector led to the new record *** sea ice budget analysis presented here shows that thermodynamic processes dominate sea ice loss in summer through enhanced poleward heat transport and albedo-temperature *** spring,both dynamic and thermodynamic processes contribute to negative sea ice ***,dynamic ice loss dominates in the Amundsen Sea as evidenced by sea ice thickness(SIT)change,while positive surface heat fluxes contribute most to sea ice melt in the Weddell Sea.

关键词： Antarctic record low sea ice budget atmospheric circulation

Diagnostic value of two dimensional shear wave elastography combined with texture analysis in early liver fibrosis

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World Journal of Clinical Cases 2019年第10期7卷 1122-1132页

作者： Zhao-Cheng jian Jin-Feng Long yu-jiang liu Xiang-Dong Hu Ji-Bin liu Xian-quan shi Wei-Sheng Li Lin-Xue qian Department of Ultrasound Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Medical Imaging Center Affiliated Hospital of Weifang Medical UniversityWeifang 261031Shandong ProvinceChina Institute of Ultrasound Thomas Jefferson University HospitalPhiladelphiaPA 19107United States

BACKGROUND Staging diagnosis of liver fibrosis is a prerequisite for timely diagnosis and therapy in patients with chronic hepatitis *** recent years,ultrasound elastography has become an important method for clinical noninvasive assessment of liver fibrosis stage,but its diagnostic value for early liver fibrosis still needs to be further *** this study,the texture analysis was carried out on the basis of two dimensional shear wave elastography(2D-SWE),and the feasibility of 2D-SWE plus texture analysis in the diagnosis of early liver fibrosis was *** To assess the diagnostic value of 2D-SWE combined with textural analysis in liver fibrosis *** This study recruited 46 patients with chronic hepatitis *** underwent 2DSWE and texture analysis;Young's modulus values and textural patterns were obtained,*** pattern was analyzed with regard to contrast,correlation,angular second moment(ASM),and *** results of biopsy specimens were the gold standard;comparison and assessment of the diagnosis efficiency were conducted for 2D-SWE,texture analysis and their *** 2D-SWE displayed diagnosis efficiency in early fibrosis,significant fibrosis,severe fibrosis,and early cirrhosis(AUC>0.7,P23(0.678-0.921),0.808(0.662-0.911),0.920(0.798-0.980),and 0.855(0.716-0.943).Contrast and homogeneity displayed independent diagnosis efficiency in liver fibrosis stage(AUC>0.7,P10)and 0.925(0.805-0.983),0.789(0.639-0.897),0.736(0.582-0.858),0.705(0.549-0.883)and 0.798(0.650-0.904)in four liver fibrosis stages,which exhibited equivalence to 2D-SWE in diagnostic efficiency(P>0.05).Combined diagnosis(PRE)displayed diagnostic efficiency(AUC>0.7,P1)for all fibrosis stages with respective AUC of 0.952(0.841-0.994),

关键词： Elastography Two-dimensional shear wave Texture analysis Liver fibrosis,Staging

重庆市农村居民2018—2021年健康素养及预测研究

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现代预防医学 2024年第3期51卷 476-483页

作者：杨倩茹刘薇薇陈鑫雨师英杰王思媛郭田雷迅重庆医科大学公共卫生学院/医学与社会发展研究中心/重庆市新型建设智库公共卫生安全研究中心重庆市健康教育所

目的了解2018—2021年重庆市农村居民健康素养水平变化情况及影响因素，预测2022—2024年该人群的健康素养水平，为今后制定重庆市农村地区的健康促进战略提供基础。方法采用全国统一的健康素养调查问卷，分析了2018—2021年重庆市农... 详细信息

目的了解2018—2021年重庆市农村居民健康素养水平变化情况及影响因素，预测2022—2024年该人群的健康素养水平，为今后制定重庆市农村地区的健康促进战略提供基础。方法采用全国统一的健康素养调查问卷，分析了2018—2021年重庆市农村居民健康素养监测资料，对全市抽取的39个区县的农村监测点的73 478名居民健康素养状况进行调查。运用多因素logistic回归法分析居民健康素养的影响因素。应用灰色预测模型GM(1,1)对2022—2024年重庆市农村居民健康素养水平进行预测。结果 2018—2021年重庆市农村居民健康素养水平呈现出稳步上升的趋势(χ趋势2=280.989,P1)。四年的健康素养水平分别为17.14%、21.68%、22.50%、24.15%。多因素回归分析显示，年龄越大，健康素养水平越低:45～59岁，OR=0.761(95%CI:0.725～0.800);60～69岁，OR=0.455(95%CI:0.426～0.485)；文化程度越高，健康素养水平就越高:初中，OR=2.551(95%CI:2.432～2.675)；高中/职高/中专，OR=4.435(95%CI:4.145～4.746)；大专/本科及以上，OR=6.890(95%CI:6.261～7.582)。GM(1,1)预测结果显示，到2024年重庆市农村居民的总健康素养将上升至28.54%。三方面健康素养均呈上升趋势。六方面健康素养中，有四方面的健康素养持续上升：传染病防治素养升至37.54%、健康信息素养升至32.39%、慢性病防治素养升至29.88%、基本医疗素养升至28.59%；两方面的健康素养持续下降：科学健康观素养降至33.42%、安全与急救素养则降至38.57%。结论重庆市农村居民的健康素养在2018—2021年间持续提升。对高龄、低文化程度、低收入的农村居民亟需采取针对性的干预措施以提高其健康素养。预测结果显示，未来三年科学健康观素养水平、安全与急救素养水平呈下降趋势，应加强对其关注。

关键词：健康素养农村居民预测健康教育

Helicobacter pylori-induced Th17 responses modulate Thl cell responses,benefit bacterial growth and contribute to pathology in mice

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Helicobacter pylori-induced Th17 responses modulate Thl cell...

Treatment of upper gastrointestinal fistula and leakage with personal stage nutrition support

重庆微生物学会第九届会员代表大会暨学术年会

作者： yun shi~(1*),Xiao-Fei liu~(1*),yuan Zhuang~1,Jin-yu Zhang~1,Tao liu~1,Chao Wu~1,Xu-Hu Mao~1, Ke-Ran Jia~1,Feng-Jun wang,~2 Hong Guo,~3 Zhuo Zhao~1,Kai-yun liu~1,Bin Xiao~1,~*Guo Ying~1, Wei-Jun Zhang~1,Wei-Ying Zhou~1,Gang Guo~(1+),quan-Ming Zou~(1+) (1 Department of Clinical Microbiology and Immunology,2 Institute of Burn Research,Southwest Hospital,and 3 Department of Gastroenterology,Xinqiao Hospital,Third Military Medical University,Chongqing,China.)

CD4 T cell responses are critical for the pathogenesis of *** *** present study evaluated the role of the Th17 subset in *** *** infection induced significant expression of IL-17 and IFN-γin mouse gastric ***-23 and IL-12 were increased in the gastric tissue and in ***-stimulated *** responses were examined by intracellular staining for IFN-γ, IL-4 and *** infected with *** developed a mixed Th17/Th1 response:Th17 responses preceded Th1 *** of mice with an anti-IL-17 antibody but not a control antibody significantly reduced the *** burden and inflammation in the *** colonization and gastric inflammation were also lower in IL-17 ***,administration of AdmIL-17 increased both the *** load and *** analysis showed that the Thl cell responses to *** were down-regulated when IL-17 is *** results together suggest that *** infection induces a mixed Th17/Th1 cell response,and the Th17/IL-17 pathway modulates Th1 cell responses and contributes to pathology.

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World Journal of Gastroenterology 2008年第32期14卷 5073-5077页

作者： Qun wang Zhi-Su liu Qun qian quan sun Ding-yu Pan yue-Ming He Department of General Surgery Zhongnan Hospital Wuhan University Wuhan 430071 Hubei Province China Department of Digestive Disease Research Center of Zhongnan Hospital Wuhan University Wuhan 430071 Hubei Province China

AIM： To investigate the feasibility of treatment for upper gastrointestinal fistula and leakage with personal stage nutrition support. METHODS： Forty-three patients with upper gastrointestinal fistula and leakage were randomly divided into two groups. Patients in group A were treated with personal stage nutrition support and patients in group B were treated with total parental nutrition （TPN） in combination with operation. Nutritional states of the candidates were evaluated by detecting albumin （AIb） and pre-AIb. The balance between nutrition and hepatic function was evaluated by measurement of aspartate aminotransferase （AST）, alanine aminotransferase （ALT） and total bilirubin （Tbill） before and after operation. At the same time their complications and hospitalized time were surveyed. RESULTS： Personal stage nutrition support improved upper gastrointestinal fistula and leakage. The nutrition state and hepatic function were better in patients who received personal stage nutrition support than in those who did not receive TPN. There was no significant difference in the complication and hospitalized time in the two groups of patients. CONCLUSION： Upper gastrointestinal fistula and leakage can be treated with personal stage nutrition support which is more beneficial for the post-operation recovery and more economic than surgical operation.

关键词： Personal stage nutrition support Treatment Upper gastrointestinal fistula and leakage Totalparental nutrition Enteral nutrition

High Energy Terahertz Parametric Oscillator Based on Surface-Emitted Configuration

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Chinese Physics Letters 2013年第2期30卷 139-142页

作者： XU De-Gang ZHANG Hao jianG Hao wang yu-Ye liu Chang-Ming yu Hong LI Zhong-Yang shi Wei YAO jian-quan Institute of Laser and Optoelectronics College of Precision Instrument and Optoelectronics EngineeringTianjin UniversityTianjin 300072 Key Laboratory of Optoelectronics Information Science and Technology(Ministry of Education) Tianjin UniversityTianjin 300072 North China University of Water Resources and Electric Power Zhenzhou 450011

We experimentally demonstrate a high power nanosecond pulsed terahertz(THz)-wave parametric oscillator(TPO)by using a wide pump beam.A surface emitted cavity configuration is employed to reduce the THz absorption in MgO:LiNbO_(3) *** THz wave can be tuned from 1 THz to 3 THz.A maximum THz output energy of 438 nJ/pulse is achieved at 1.56 Hz using a 4.5-mm-diameter pump beam with a pulse energy of 226 mJ pump energy with the repetition of 10 Hz,corresponding to the energy conversion efficiency of 1.94×10^(-6).

关键词： pump Configuration repetition