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下肢步行机器辅助训练对痉挛型偏瘫脑性瘫痪患儿步态改善的效果分析

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中国中西医结合儿科学 2024年第4期16卷 286-290页

作者：孙胜月周大勇卢伟娜房贵巍刘宁杜丽哈尔滨医科大学附属第四医院儿童康复中心哈尔滨150023

目的探讨下肢步行机器辅助训练对痉挛型偏瘫脑性瘫痪(简称脑瘫)患儿步态改善的效果分析。方法2022年5月至2023年11月哈尔滨医科大学附属第四医院儿童康复中心门诊收治偏瘫脑瘫儿童16例,随机分为对照组和观察组各8例。对照组给予患儿常... 详细信息

目的探讨下肢步行机器辅助训练对痉挛型偏瘫脑性瘫痪(简称脑瘫)患儿步态改善的效果分析。方法2022年5月至2023年11月哈尔滨医科大学附属第四医院儿童康复中心门诊收治偏瘫脑瘫儿童16例,随机分为对照组和观察组各8例。对照组给予患儿常规康复训练,观察组在此基础上联合下肢步行机器辅助训练,训练时间均为30 min,每周6次。对训练前后儿童步长、单侧支撑时间、步态周期、摆动时间的步态参数进行采集,对干预前后8周数据变化进行分析。结果治疗后两组治疗方法对偏瘫患儿患侧步长长度变长、患侧单侧支撑时间变长、患侧和健侧步态周期、摆动时间的差异有统计学意义(P<0.05),且常规康复训练联合下肢步行机器辅助训练优于常规康复训练,更趋向于正常步态。结论下肢步行机器辅助训练可以改善偏瘫患儿患侧步态周期,增加患侧步长、单侧支撑时间,延长患侧摆动时间,缩短健侧摆动时间,改善偏瘫步态。

关键词：脑性瘫痪偏瘫下肢步行机器辅助训练步态儿童

Beneficial effects of deep cryogenic treatment on mechanical properties of additively manufactured high entropy alloy:cyclic vs single cryogenic cooling

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Journal of Materials Science & Technology 2022年第20期115卷 40-51页

作者： Hongge Li Wenjie Zhao Tian Chen Yongjiang Huang Jianfei sun Ping Zhu Yunzhuo lu Alfonso H.W.Ngan Daqing Wei Qing Du Yongchun Zou School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China School of Materials Science and Engineering Dalian Jiaotong UniversityDalian 116028China Department of Mechanical Engineering The University of Hong KongHong KongChina Center of Analysis Measurement and Computing Harbin Institute of TechnologyHarbin 150001China

Additively manufactured(AM)metallic materials commonly possess substantial tensile surface residual stress,which is detrimental to the load-bearing service ***,we demonstrated that deep cryogenic treatment(DCT)is an effective method for improving the tensile properties of CoCrFeMnNi high-entropy alloy(HEA)samples fabricated by laser melting deposition(LMD),by introducing high compressive residual stress and deformation microstructures without destroying the AM ***,carrying out the DCT in a single-step mode does not improve the residual stress gradients inherent from the LMD process,which are undesirable as the mechanical properties will not be homogeneous within the *** this work,we show that carrying out the DCT in a cyclic mode with repeated cryogenic cooling and reheating can significantly homogenize the residual stress in LMD-fabricated Co Cr Fe Mn Ni HEA,and improve tensile strength and ductility,compared with single-step DCT of the same cryogenic soaking *** cyclic DCT,the thermal stress is re-elevated to a high value at each cryogenic cooling step,leading to the formation of denser and more intersecting reinforcing crystalline defects and hcp phase transformation,compared to single-step DCT of the same total cryogenic soaking duration in which the thermal stress relaxes towards a low value over *** enhancement of defect formation in the cyclic mode of DCT also leads to more uniform residual stress distribution in the sample after the *** results here provide important insights on optimizing DCT processes for post-fabrication improvement of mechanical properties of AM metallic net shapes.

关键词： Additive manufacturing High entropy alloy Deep cryogenic treatment Residual stress Mechanical properties

Morphological and phylogenetical analysis reveals that a new tapeworm species (Cestoda: Hymenolepididae) from whooper swan belongs to Cloacotaenia not Hymenolepis

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Journal of Forestry Research 2020年第6期31卷 2581-2587页

作者： Zhijun Hou Lei Han Ying sun Dongdong Shen Zhiwei Peng Lixin Wang Qian Zhai Yanqiang Zhou Yaxian lu Liwei Teng Hongliang Chai College of Wildlife Resource Northeast Forestry UniversityHarbin 150040People’s Republic of China

During a helminthological study of waterfowl in China,a new species(Cloacotaenia cygnimorbus ***.)of hymenolepidid cestodes(tapeworm)was found in the small intestine of whooper swan(Cygnus cygnus,Linnaeus,1758).The rudimentary rostellum and four unarmed muscular suckers,proglottids with distinct craspedote and three spherical testes were coincident with the characters of Cloacotaenia or Hymenolepis,but phylogenetic analysis of 28S rRNA and cox1 gene revealed that the new species is Cloacotaenia rather than *** morphology was also clearly diff erentiated from *** in the arrangement of its testes in a triangle instead of in line and the cirrus unarmed rather than *** with ***,the new species has more elongated neck,much larger mature proglottids and much smaller testes,cirrus sac,ovary,vitellarium and uterine *** addition,it infected the host intestine not the *** analysis of cox1 gene of the new species shows that it had a level of sequence variation(10.52–23.06%)with the sequences of *** considerable morphological and molecular diff erences between those two parasites support *** *** a new species.

关键词： Cloacotaenia Hymenolepididae Hymenolepis Whooper swan 28S rRNA cox1

CaO_(2)/Fe^(2+)协同控制污水管道硫化物的效能

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中国环境科学 2024年第10期44卷 5649-5657页

作者：张志强刘雨欣孙逸帆赵磊任晓卫杨静宋姗姗任亚婷卢金锁西安建筑科技大学环境与市政工程学院陕西西安710055 哈尔滨工业大学城市水资源与水环境国家重点实验室黑龙江哈尔滨150090

针对污水管道硫化物的生成和积累导致管道腐蚀、臭味逸散问题,提出CaO_(2)/Fe^(2+)协同控制方法.研究了不同CaO_(2)和Fe^(2+)投加量条件下硫化物氧化动力学和作用机制,分析了pH值、温度、无机离子对硫化物氧化去除效能的影响,通过连续... 详细信息

针对污水管道硫化物的生成和积累导致管道腐蚀、臭味逸散问题,提出CaO_(2)/Fe^(2+)协同控制方法.研究了不同CaO_(2)和Fe^(2+)投加量条件下硫化物氧化动力学和作用机制,分析了pH值、温度、无机离子对硫化物氧化去除效能的影响,通过连续流反应评估了CaO_(2)/Fe^(2+)协同控制方法对污水管道硫化物控制效能.结果表明CaO_(2)/Fe^(2+)协同氧化去除硫化物符合伪一级反应动力学,反应过程中生成的HO·是氧化硫化物的主要活性物种,当CaO_(2)和Fe^(2+)物质的量比为4:1时,氧化速率最优;硫化物氧化速率与pH值呈现负相关,与温度呈现正相关,水中常见阴离子和铵离子对氧化速率无显著影响;CaO_(2)/Fe^(2+)协同投加可有效控制硫化物生成,当药剂投加量与污水比例(W/V)为0.30%时,硫化物50%生成率恢复周期达8.34d.

关键词：管道腐蚀恶臭气体协同效应反应动力学控制效能

超干处理对菜豆种子活力及生理生化活性的影响

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中国农学通报 2024年第15期40卷 66-72页

作者：韩济民孙璐冯国军刘大军刘畅杨晓旭黑龙江大学现代农业与生态环境学院哈尔滨150080

本研究旨在应用硅胶干燥的方法对菜豆进行超干处理,分析其主要生理活性相关指标,以期为菜豆种子的长期储藏提供科学依据和实践参考。超干处理后,应用考马斯亮蓝G-250染色法、TTC法、硫代巴比妥酸(TBA)法等测定蛋白质含量、脱氢酶(ADH)... 详细信息

本研究旨在应用硅胶干燥的方法对菜豆进行超干处理,分析其主要生理活性相关指标,以期为菜豆种子的长期储藏提供科学依据和实践参考。超干处理后,应用考马斯亮蓝G-250染色法、TTC法、硫代巴比妥酸(TBA)法等测定蛋白质含量、脱氢酶(ADH)含量等指标。结果表明‘将军’含水量在6.95%时,种子活力及生理指标均高于对照,而抗氧化酶的活性显著低于对照;‘紫冠’含水量在6.89%时,各项生理指标均高于对照,O2-含量下降;‘热那亚’含水量在6.15%时,发芽率最高,蛋白含量、ADH活性明显上升,O2-含量、MDA不显著。这表明适度超干处理对‘将军’种子影响较大,对‘紫冠’、和‘热那亚’影响较小或者没有影响。通过试验结果可知,超干处理对于保存菜豆种子是可行的,为菜豆种子的长期储藏奠定下基础。

关键词：超干处理菜豆种子活力生理活性贮藏期

Echocardiographic Measurements in Normal Chinese Adults(EMINCA)II focusing on left ventricular and left atrial size and function by three-dimensional echocardiography

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Frontiers of Medicine 2024年第4期18卷 649-663页

作者： Yingbin Wang Yu Zhang Guihua Yao Hong Tang Lixin Chen Lixue Yin Tiangang Zhu Jianjun Yuan Wei Han Jun Yang Xianhong Shu Ya Yang Yulin Wei Yanli Guo Weidong Ren Dongmei Gao Guilin lu Ji Wu Hongning Yin Yuming Mu Jiawei Tian Lijun Yuan Xiaojing Ma Hongyan Dai Yunchuan Ding Mingyan Ding Qing Zhou Hao Wang Di Xu Mei Zhang Yun Zhang State Key Laboratory for Innovation and Transformation of luobing Theory Key Laboratory of Cardiovascular Remodeling and Function ResearchChinese Ministry of EducationChinese National Health Commission and Chinese Academy of Medical SciencesDepartment of CardiologyQilu Hospital of Shandong UniversityJinan250012China Department of Cardiology Qilu Hospital of Shandong University(Qingdao)Qingdao266000China Department of Ultrasonography West China HospitalSichuan UniversityChengdu610041China Department of Ultrasonography Shenzhen People’s Hospital/The Second Clinical Medical College of Jinan UniversityShenzhen518020China Department of Ultrasonography Electronic Science and Technology University of ChinaThe Affiliated Sichuan Provincial People’s HospitalChengdu610072China Department of Cardiology Peking University People’s HospitalBeijing100044China Department of Ultrasonography Henan Provincial People’s HospitalZhengzhou463599China Department of Cardiology The First Affiliated Hospital of Harbin Medical UniversityHarbin150007China Department of Echocardiology The First Affiliated Hospital of China Medical UniversityShenyang110001China Department of Echocardiology Zhongshan HospitalFudan UniversityShanghai200032China Department of Echocardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing100029China Department of Cardiology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou510120China Department of Ultrasonography The Southwest Hospital of AMUChongqing400038China Department of Ultrasonography Shengjing Hospital of China Medical UniversityShenyang110136China Department of Ultrasonography China-Japan Union hospital of Jilin UniversityChangchun130033China Department of Ultrasonography First Affiliated HospitalSchool of MedicineShihezi UniversityShihezi832000China Department of Ultrasonography The First Affiliated Hospital of Guangxi Medical UniversityNanning537406China Department of Echocardiology The Second Hospital of Hebei Medical Uni

Current guidelines encourage large studies in a diverse population to establish normal reference ranges for three-dimensional(3D)echocardiography for different ethnic *** study was designed to establish the normal values of 3D-left ventricular(LV)and left atrial(LA)volume and function in a nationwide,population-based cohort of healthy Han Chinese adults.A total of 1117 healthy volunteers aged 18–89 years were enrolled from 28 collaborating laboratories in *** sets of 3D echocardiographic instruments were used,and full-volume echocardiographic images were recorded and transmitted to a core laboratory for image analysis with a vendor-independent off-line ***,866 volunteers(mean age of 48.4 years,402 men)were qualified for final *** parameters exhibited substantial differences between different sex and age groups,even after indexation by body surface *** normal ranges of 3D-LV and 3D-LA volume and function differed from those recommended by the American Society of Echocardiography and the European Association of Cardiovascular Imaging guidelines,presented by the World Alliance Societies of Echocardiography(WASE)study,and from the 2D values in the EMINCA *** normal reference values of 3D echocardiography-derived LV and LA volume and function were established for the first time in healthy Han Chinese *** ranges of 3D-LV and 3D-LA echocardiographic measurements stratified with sex,age,and race should be recommended for clinical applications.

关键词： three-dimensional echocardiography left ventricle left atrium normal reference values Chinese adults

Relationship between Modulator Recognition Factor 2/AT-rich Interaction Domain 5B Gene Variations and Type 2 Diabetes Mellitus or Lipid Metabolism in a Northern Chinese Population

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Chinese Medical Journal 2017年第9期130卷 1055-1061页

作者： lu-lu sun Si-Jia Zhang Mei-Jun Chen Kazakova Elena Hong Qiao Department of Endocrinology The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150000 China

Background： Four single nucleotide polymorphisms （SNPs） in the modulator recognition factor 2/AT-rich interaction domain 5B （MRF2/ARID5B） gene located at chromosome 10q21,2 have been shown to be associated with both type 2 diabetes mellitus （T2DM） and coronary artery disease in a Japanese cohort. This study aimed to investigate the relationship between these SNPs （rs2893880, rs10740055, rs7087507, rs10761600） and new-onset T2DM and lipid metabolism in a Northern Chinese population. Methods： This was a case-control study. The rs2893880, rs10740055, rs7087507, and rs10761600 genetic variants were genotyped by SNPscan and analyzed in relation to T2DM susceptibility in 2000 individuals （090 with newly diagnosed T2DM and 1001 controls without diabetes mellitus）. Associations between the MRF2/ARID5B genetic models and T2DM were determined by multivariate logistic regression. Results： Regarding the rs 10740055 SNP, AA was associated with a higher risk of T2DM compared with codominant-type CC （adjusted by sex, age, and body mass index [BMI], P = 0.041, odds ratio [OR] = 1.421, 95% confidence interval [C1 ] 1.014-1.991）. Meanwhile, AA individuals were at increased risk of presenting with T2DM compared with individuals with CC or a single C （adjusted by sex, age, and BMI, P = 0.034, OR = 1.366, 95% CI 1.023-1.824）. With respect to rsl0761600, AT contributed to a higher risk of T2DM compared with AA （adjusted by sex, age, and BMI, P = 0.013, OR = 1.585, 95% CI 1.101-2.282）, while TT also increased the risk of presenting with T2DM compared with AA or A （adjusted by sex, age, and BMI, P = 0.004, OR = 1.632, 95% CI 1.166-2.284）. High-density lipoprotein cholesterol （HDL-C） levels were significantly different among the three genotypes of rs7087507 in the controls （P = 0.048）（GG〉GA）. Conclusions： The present results identified MRF2/AR1D5B as a potential susceptibility gene for new-onset T2DM in a Northern Chinese population, while the rs7087507 SNP was associated with HDL-C levels

关键词： Diabetes Mellitus Type 2 Lipid Metabolism Polymorphism Single-nucleotide

鲤PPARγ基因序列特征及其与脂肪沉积的相关性

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水产学杂志 2024年第2期37卷 18-25页

作者：周佳刘天奇孙志鹏吉宇丹鲁翠云曹顶臣郑先虎中国水产科学研究院黑龙江水产研究所淡水鱼类育种国家地方联合工程实验室农业农村部淡水水产生物技术与遗传育种重点实验室黑龙江哈尔滨150070 上海海洋大学农业农村部淡水水产种质资源重点实验室上海201306

为探讨过氧化物酶体增殖物激活受体γ(peroxisome proliferator activated receptor,PPARγ)对鲤(Cyprinus carpio)脂肪沉积的调控机制,采用RACE和实时荧光定量PCR技术克隆体质量(215.20±8.21)g鲤的PPARγ基因,分析其组织表达特征。结果显示,PPARγ基因c DNA全长为3 077 bp,包括233 bp的5′非编码区、1 311bp的3′非编码区和编码510个氨基酸的开放阅读框。鲤PPARγ包括4个功能结构域,即A/B区,DNA结合区(DNA binding domain,DBD区),铰链区和配体结合区(ligand binding domain,LBD区)。鲤PPARγ与鲫(Carassius auratus)、斑马鱼(Danio rerio)的氨基酸序列相似性最高,分别为98.63%和87.28%。PPARγ基因在各组织均有表达,肝脏中相对表达量最高,脑次之,脾和心脏中最少。腹腔脂肪中PPARγ基因表达量多脂鲤显著高于少脂鲤(P<0.05),背部肌肉中PPARγ基因表达量多脂鲤极显著高于少脂鲤(P<0.01)。推测PPARγ具有促进脂肪沉积的作用,PPARγ基因可以作为鲤脂肪沉积候选基因用于分子选择。本研究为进一步解析鲤PPARγ基因调控脂肪沉积分子机制研究奠定了理论基础。

关键词：鲤 PPARγ基因基因表达脂肪沉积

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改进量子位初始映射的综合SWAP优化策略

计算机工程与应用 2024年第14期60卷 66-73页

作者：李晖韩子傲卢凯刘述娟鞠明媚哈尔滨商业大学计算机与信息工程学院哈尔滨150028 黑龙江省电子商务与信息处理重点实验室哈尔滨150028

在嘈杂的中尺度量子时代,传统的初始映射策略忽略了后续操作中可能出现的邻接性的问题。针对这一挑战,综合考虑量子比特间的距离、交互时间和门操作的错误率,设计了一个多因素交互成本函数,并提出综合SWAP优化策略(comprehensive SWAP o... 详细信息

在嘈杂的中尺度量子时代,传统的初始映射策略忽略了后续操作中可能出现的邻接性的问题。针对这一挑战,综合考虑量子比特间的距离、交互时间和门操作的错误率,设计了一个多因素交互成本函数,并提出综合SWAP优化策略(comprehensive SWAP optimization strategy,CSOS)。该策略包括最佳SWAP选择和基于SWAP的批量更新策略,用于优化量子电路的局部量子位映射。最佳SWAP选择通过对比SWAP操作的效益,选择最佳收益的SWAP门;批量更新策略在映射阶段考虑即将执行的量子操作序列,预先执行批量的SWAP操作。二者综合可以减少整个电路执行过程中的SWAP数量,以最大程度减少映射开销。实验结果显示,CSOS优化方式可以平均减少38.1%的插入SWAP门数量,并降低约12%的硬件门计数开销。

关键词：量子计算初始映射综合SWAP优化策略最佳SWAP选择批量更新