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Expert consensus on endodontic therapy for patients withsystemic conditions

International Journal of Oral Science 2024年第3期16卷 390-397页

作者： Xin Xu Xin Zheng Fei Lin Qing Yu Benxiang Hou Zhi Chen Xi Wei Lihong Qiu Wenxia Chen Jiyao Li Lili Chen Zuomin Wang Hongkun Wu Zhiyue lu Jizhi Zhao Yuhong Liang Jin Zhao Yihuai Pan Shuang Pan Xiaoyan Wang Deqin Yang Yanfang Ren Lin Yue Xuedong Zhou State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Cariology and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina Department of Cariology and Endodontology Peking University School and Hospital of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research of Oral Biomaterials and Digital Medical Devices&Beijing Key Laboratory of Digital StomatologyPeking UniversityBeijingChina State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Key Laboratory of Oral DiseasesDepartment of Operative Dentistry&EndodonticsSchool of StomatologyThe Fourth Military Medical UniversityXi’anChina Center for Microscope Enhanced Dentistry Beijing Stomatological HospitalCapital Medical UniversityBeijingChina State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyWuhan UniversityWuhanChina Department of Operative Dentistry and Endodontics Hospital of StomatologyGuanghua School of StomatologySun Yat-Sen University&Guangdong Provincial Key Laboratory of StomatologyGuangzhouChina Department of Endodontics School of StomatologyChina Medical UniversityShenyangChina College&Hospital of Stomatology Guangxi Medical UniversityNanningChina Department of Stomatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Stomatology Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Geriatric Dentistry West China Hospital of StomatologySichuan UniversityChengduChina Beijing Hospital National Center of GerontologyBeijingChina Department of Stomatology Peking Union Medical College Hospit

The overall health condition of patients significantly affects the diagnosis, treatment, and prognosis of endodontic diseases. Asystemic consideration of the patient’s overall health along with oral conditions holds the utmost importance in determining thenecessity and feasibility of endodontic therapy, as well as selecting appropriate therapeutic approaches. This expert consensus is acollaborative effort by specialists from endodontics and clinical physicians across the nation based on the current clinical evidence,aiming to provide general guidance on clinical procedures, improve patient safety and enhance clinical outcomes of endodontictherapy in patients with compromised overall health.

关键词： patients diagnosis prognosis

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非洲猪瘟病毒的流行与遗传演化:变与不变

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中国兽医学报 2024年第7期44卷 1545-1555页

作者：陈盛媚王涛陆战豪蓝靖罗瑞付强孙元仇华吉佛山科学技术学院生命科学与工程学院广东佛山528231 中国农业科学院哈尔滨兽医研究所动物疫病防控全国重点实验室黑龙江哈尔滨150069

非洲猪瘟(African swine fever,ASF)是由非洲猪瘟病毒(African swine fever virus,ASFV)感染家猪和野猪而引起的一种烈性传染病。ASFV在欧洲暴发流行过程中,已演化出无红细胞吸附特性的弱毒株。2018年,基因Ⅱ型ASFV强毒株传入我国后,相... 详细信息

非洲猪瘟(African swine fever,ASF)是由非洲猪瘟病毒(African swine fever virus,ASFV)感染家猪和野猪而引起的一种烈性传染病。ASFV在欧洲暴发流行过程中,已演化出无红细胞吸附特性的弱毒株。2018年,基因Ⅱ型ASFV强毒株传入我国后,相继出现了基因Ⅱ型弱毒株、基因Ⅰ型弱毒株以及基因Ⅰ型和Ⅱ型重组的ASFV强毒株。这表明ASFV在流行过程中出现了复杂、多样的遗传演化,给疫苗研发和疫病的监测带来了严峻的挑战。本文首先对ASFV在我国和全球流行的新特点进行了总结;重点分析了ASFV在流行过程中的遗传变异和致病性的改变;在此基础上,探讨了ASFV遗传变异对病毒免疫逃逸和致病性的影响,以及对疫苗研发、疫病检测和监测带来的挑战;旨在加深对ASFV遗传演化规律与变异机制的认知,从而为疫苗和诊断技术研究提供理论依据。

关键词：非洲猪瘟非洲猪瘟病毒基因突变重组遗传演化疫苗

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Dynamic Accuracy Design Method of Ultra-precision Machine Tool

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Chinese Journal of Mechanical Engineering 2018年第1期31卷 167-175页

作者： Guo-Da Chen Ya-Zhou sun Fei-Hu Zhang Li-Hua lu Wan-Qun Chen Nan Yu Center for Precision Engineering Harbin Institute of Technology Key Laboratory of E&M Ministry of Education & Zhejiang Province Zhejiang University of Technology Precision Engineering Institute Cranfield University

Ultra-precision machine tool is the most important physical tool to machining the workpiece with the frequency domain error requirement, in the design process of which the dynamic accuracy design(DAD) is indispensable and the related research is rarely available. In light of above reasons, a DAD method of ultra-precision machine tool is proposed in this paper, which is based on the frequency domain error *** basic procedure and enabling knowledge of the DAD method is introduced. The application case of DAD method in the ultra-precision flycutting machine tool for KDP crystal machining is described to show the procedure detailedly. In this case, the KDP workpiece surface has the requirements in four different spatial frequency bands, and the emphasis for this study is put on the middle-frequency band with the PSD specifications. The results of the application case basically show the feasibility of the proposed DAD method. The DAD method of ultra-precision machine tool can effectively minimize the technical risk and improve the machining reliability of the designed machine tool. This paper will play an important role in the design and manufacture of new ultra-precision machine tool.

关键词： Dynamic accuracy design Ultra-precision machine tool Frequency domain Error allocation

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铜-锌合金电沉积及脱合金化法制备多孔铜箔

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电镀与涂饰 2024年第6期43卷 23-32页

作者：郭翡翔杨斌凌羽宋克兴卢伟伟安茂忠戎万孙梁河南科技大学材料科学与工程学院河南洛阳471023 河南省科学院材料研究所河南郑州450052 哈尔滨工业大学化工与化学学院黑龙江哈尔滨150038 西北有色金属研究院陕西西安710016 华为技术有限公司广东深圳518116

[目的]纳米多孔铜由于其开放的多孔结构、较高的比表面积、较低的密度等独特的理化性能,在储能、催化剂、传感器等领域有巨大的应用潜力。为了解决金属锂作为锂离子电池负极材料时存在的锂枝晶及安全问题,采用脱合金化法制备多孔铜箔成... 详细信息

[目的]纳米多孔铜由于其开放的多孔结构、较高的比表面积、较低的密度等独特的理化性能,在储能、催化剂、传感器等领域有巨大的应用潜力。为了解决金属锂作为锂离子电池负极材料时存在的锂枝晶及安全问题,采用脱合金化法制备多孔铜箔成为近年来的研究热点。[方法]先以钛板为基体电沉积铜箔基底,接着电沉积Cu-Zn合金,再脱合金化处理得到多孔铜箔。重点研究了工艺参数对Cu-Zn合金镀层形貌、结构和性能的影响。[结果]Cu-Zn合金电沉积的较优工艺条件为:电流密度1.0 A/dm^(2),温度40℃,时间20 min。该条件下所得Cu-Zn合金镀层表面平整、结构均匀、形成单一合金相,经脱合金化处理后Zn元素的去除率为70.6%。[结论]采用电沉积+脱合金化的方法有望制得孔径均匀的多孔铜箔,但会产生裂纹,有待进一步研究和改善。

关键词：多孔铜箔铜-锌合金电沉积脱合金化微观结构

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基于生命周期评价的定制家具碳足迹与减排策略研究

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林业机械与木工设备 2024年第5期52卷 47-51页

作者：孙晨颖杨超路金涛朱晓冬东北林业大学家居与艺术设计学院黑龙江哈尔滨150000

基于生命周期评价方法对定制家具生产过程中的碳足迹进行研究,分析定制家具在生产过程中不同阶段碳排放数量。从原材料使用、生产工艺优化以及零部件三方面提出了不同的优化方案,降低板式家具在生产过程中造成的环境污染,达到定制家具... 详细信息

基于生命周期评价方法对定制家具生产过程中的碳足迹进行研究,分析定制家具在生产过程中不同阶段碳排放数量。从原材料使用、生产工艺优化以及零部件三方面提出了不同的优化方案,降低板式家具在生产过程中造成的环境污染,达到定制家具“减量化”设计的目的。

关键词：定制家具板式家具生命周期评价碳足迹减量化

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Cutting path-dependent machinability of SiCp/Al composite under multi-step ultra-precision diamond cutting

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Chinese Journal of Aeronautics 2021年第4期34卷 241-252页

作者： Shijin lu Junjie ZHANG Zengqiang LI Jianguo ZHANG Xiaohui WANG Alexander HARTMAIER Jianfeng XU Yongda YAN Tao sun Center for Precision Engineering Harbin Institute of TechnologyHarbin 150001China State Key Laboratory of Digital Manufacturing Equipment and Technology School of Mechanical Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China School of Mechanical Engineering University of JinanJinan 250022China Interdisciplinary Centre for Advanced Materials Simulation Ruhr-University BochumBochum 44780Germany

Particle-tool interactions,which govern the synergetic deformation of SiC particle reinforced Al matrix composites under mechanical machining,strongly depend on the geometry of particle position residing on cutting *** the present work,we investigate the influence of cutting path on the machinability of a SiCp/Al composite in multi-step ultra-precision diamond cutting by combining finite element simulations with experimental observations and *** consistent with experimentally characterized microstructures,the simulated SiCp/Al composite is considered to be composed of randomly distributed polygonally-shaped SiC particles with a volume fraction of 25 vol%.A multi-step cutting strategy with depths of cut ranging from 2 to 10 lm is adopted to achieve an ultimate depth of cut of 10 *** material parameters and extrinsic cutting conditions utilized in finite element simulations of SiCp/Al cutting are consistent with those used in corresponding *** results reveal different particle-tool interactions and failure modes of SiC particles,as well as their correlations with machining force evolution,residual stress distribution and machined surface topography.A detailed comparison between numerical simulation results and experimental data of multi-step diamond cutting of SiCp/Al composite reveals a substantial impact of the number of cutting steps on particle-tool interactions and machined surface *** findings provide guidelines for achieving high surface finish of SiCp/Al composites by ultra-precision diamond cutting.

关键词： Cutting path Diamond cutting Finite element simulation Particle-tool interaction SiCp/Al composites

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Vapor deposition of aluminium oxide into N-rich mesoporous carbon framework as a reversible sulfur host for lithium-sulfur battery cathode

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Nano Research 2021年第1期14卷 131-138页

作者： Fei sun Zhibin Qu Hua Wang Xiaoyan Liu Tong Pei Rui Han Jihui Gao Guangbo Zhao Yunfeng lu School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001China Department of Chemistry Shanghai Normal UniversityShanghai 150001China Department of Chemical and Biomolecular Engineering University of CaliforniaLos AngelesCA 90095USA

Restraining the shuttle effects of lithium polysulfides is the key to improve the cycling reversibility and stability of lithium-sulfur(Li-S)batteries for which design of robust sulfur hosts has been regarded as the most effective *** this work,we report a new type of hybrid sulfur host which is composed of Al_(2)O_(3) homogenously decorated in nitrogen-rich mesoporous carbon framework(NMC-Al_(2)O_(3)).The NMC-Al_(2)O_(3) hybrid host features a poly-dispersed spherical morphology and a mesoporous configuration with high surface area and large pore volume that can accommodate a high sulfur content up to 73.5 wt.%.As a result,the fabricated NMC-Al_(2)O_(3)-S cathode exhibits all-round improvements in electrochemical properties in term of capacities(1,212 mAh·g^(-1)at 0.2 C;755 mAh·g^(-1)at 2 C),cycling charge-discharge reversibility(sustainably 100%efficiencies)and stability(1,000 cycles with only 0.023%capacity decay per cycle at 0.5 C).By contrast,the Al_(2)O_(3)-free NMC-S cathode shows both decreased capacities and rapidly descending Coulombic efficiencies during *** functional theory(DFH")calculations further reveal that the implanted Al_(2)O_(3) can greatly enhance the chemical adsorption and catalytic conversion for various lithium polysulfides and thereby effectively prevent the polysulfide shuttling and significantly improve the utilizability,reversibility and stability of sulfur cathode.

关键词： lithium-sulfur battery aluminium oxide sulfur host nitrogen-rich carbon mesoporous structure

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Ti-6Al-4V-5Cu synthesized for antibacterial effect in vitro and in vivo via contact sterilization

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Journal of Materials Science & Technology 2021年第31期90卷 133-142页

作者： Duo Xu Tianyu Wang Zhiyuan lu Yuanqi Wang Bin sun Shudan Wang Qiang Fu Zhenggang Bi Shuo Geng Department of Orthopedics First Affliated Hospital of Harbin Medical UniversityHarbin 150001Chinal Department of Cardiology First Affliated Hospital of Harbin Medical UniversityHarbin 150001China Center of Testing and Analysis College of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001China Department of Ophthalmology First Affliated Hospital of Harbin Medical UniversityHarbin 150001China Department of General Surgery Beihai People’s HospitalBeihai 536000China

Implant-related infection is one of the most catastrophic complications after surgery,since it may trigger osteomyelitis and necessitate reoperation,increasing the pain suffered by and the burden placed on the *** a new alloy with an antibacterial effect for use as a biomedical material is an urgent *** this article,Ti-6 Al-4 V-5 Cu was synthesized under two different heat treatment schemes(solution temperatures of 850℃and 950℃).Through comprehensive observation of the microstructure,phase,copper ion release,biocompatibility,corrosion resistance and antibacterial effect in vitro and in vivo,it was determined that cell viability and corrosion resistance of Ti-6 Al-4 V-5 Cu was better than Ti-6 Al-4 *** importantly,the obtained alloy,especially samples treated at 850℃,showed prominent antibacterial ***,we also found that the main antibacterial mechanism of the alloy was contact sterilization via the extensive precipitation of Ti_(2)Cu instead of Cu ion release,and the content,surface area of Ti_(2)Cu could affect the antibacterial *** findings provide a very promising scheme by which to balance the biocompatibility and antibacterial effect of Ti-based,Cu-bearing alloys,which could improve their performance in orthopedic and dental applications.

关键词： Antibacterial effect Ti-based alloy Copper Ti_(2)Cu In vivo

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Effect of a nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester on invasion of human colorectal cancer cell line SL-174T

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World Journal of Gastroenterology 2005年第40期11卷 6385-6388页

作者： Li-Bo YU Xin-Shu Dong Wen-Zhou sun Dong-lu Zhao Yue Yang Department of GeneralSurgery the Affiliated Tumor Hospital of Harbin MedicalUniversity Harbin 150040 Heilongiiang Province China Cancer Research Institute of harbinMedical university Harbin 150040 Heilongjiang Province China

AIML To investigate the effect and mechanism of action of the nitric oxide synthase （NOS） inhibitor NG-nitro-L-arginine methyl ester （L-NAME） on invasion and metastasis of human colorectal cancer cell line SL-174T. METHODS： Human colorectal cancer cel4 line SL-174T was cultured and treated separately with four different dosages of L-NAME for 72 h, Nitric oxide （NO） production was measured with Griess reagent, The effect of L-NAME on invasion and migration of SL-174T cells were evaluated by using Transwell chambers attached with polycarbonate filters and reconstituted basement membrane （Matrigel）, RT-PCR was performed to determine the mRNA levels of matrix metalloproteinase-2 （MMP-2） and tissue inhibitor metalloproteinase-2 （TIMP-2）,RESULTS： L-NAME could significantly inhibit NO production of SL-174T in a dose-dependent manner. After being treated for 72 h with 0.2, 0.4, 0.8, and 1.0 mmol/L L- NAME, respectively, the ability of the L-NAME treated SL- 174T cells to invade the reconstituted basement membrane decreased significantly （t = 8.056, P〈0.05; t= 14.467, P〈0.01; t= 27.785, P〈0.01; and t= 29.405, P〈0.01, respectively） and the inhibition rates were 10.29%, 19.62%, 34.08%, and 42.23%, respectively. Moreover, L-NAME could inhibit migration of SL-174T cells, and the inhibition rates were 20.76%, 24.95%, 39.43%, and 46. 85% for L-NAME at 0.2, 0.4, 0.8, and 1.0 mmol/L, respectively （t = 15.116, P〈0.01）. In addition, after treatment with L-NAME, expression of MMP-2 mRNA was significantly decreased （t = 71.238, P〈0.01） and that of TIMP-2 mRNA was markedly increased （t = -13.020, P〈0.01）. CONCluSION： L-NAME exerts anti-invasive and anti- metastatic effects on SL-174T cell line via downregulating MNP-2 mRNA expression and upregulating TIMP-2 mRNA expression.

关键词： Colorectal Neoplasms Neoplasm Invasiveness Cell Line, Tumor Cell Movement Dose-Response Relationship, Drug Female Gelatinase A Humans Male NG-Nitroarginine Methyl Ester Nitric Oxide Nitric Oxide Synthase inhibitors Tissue Inhibitor of Metalloproteinase-2

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智能仓货架返回位置分配动态优化策略研究

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工程管理科技前沿 2024年第5期43卷 41-48页

作者：李腾张茹兰孙艳哈尔滨商业大学管理学院黑龙江哈尔滨150028

智能仓被广泛用于高频拣选场景,其效率受制于货架摆放位置。由于季节性需求变化、营销策略、促销活动等导致的订单波动,驱使货架摆放位置按需动态调整。本文利用智能仓特点,以移动机器人完成任务时间最短为目标,在任务周期中建立动态调... 详细信息

智能仓被广泛用于高频拣选场景,其效率受制于货架摆放位置。由于季节性需求变化、营销策略、促销活动等导致的订单波动,驱使货架摆放位置按需动态调整。本文利用智能仓特点,以移动机器人完成任务时间最短为目标,在任务周期中建立动态调度模型。构建由三种位置分配策略形成的策略空间,将货架热度、货架间关联度和货架现存位置综合形成状态值,设计加权双Q学习算法,得到适应订单状态波动的货架位置分配动态优化策略。仿真实验表明:与返回原位置相比,动态策略在大订单波动环境下的效率提升约31.36%,能够在感知订单波动后及时调整策略,提高智能仓拣选效率。

关键词：智能仓货架返回位置分配加权双Q学习两阶段分配策略动态优化

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