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Generation and Characterization of a Panel of Monoclonal Antibodies Against Distinct Epitopes of Human CD146

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生物物理学报 2009年第S1期25卷 231-232页

作者： Ping Wang1, Xiyun Yan.National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 datun road, Beijing 100101, China

CD146 (MUC18, Mel-CAM/MCAM) is a transmembrane protein, originally identified as a biomarker of melanoma, and plays an important role in cancer invasion and metastasis.

关键词： human CD146 antibody different epitopes

Intrinsic peroxidase-like activity of ferromagnetic nanoparticles and its application in immunoassay and environment treatment

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生物物理学报 2009年第S1期25卷 304-305页

作者： Lizeng Gao, Jie Zhuang, Xiyun Yan National Laboratory of Biomacromolecules and Institute of Biophysics, Chinese Academy of Sciences, 15 datun road, Beijing 100101, China.

Nanoparticles that contain magnetic materials, such as magnetite (Fe3O4), are particularly useful for imaging and separation techniques. Since these nanoparticles are

关键词： Nanoparticles Peroxidase immunoassay

Bid mediates lysosomal membrane permeabilization and the consequent mitochondrial outer membrane permeabilization in RH-35 hepatoma cells

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生物物理学报 2009年第S1期25卷 247-248页

作者： Xingyu Zhao, Kai Zhao, Taotao Wei, Fuyu Yang Institute of Biophysics, Chinese Academy of Sciences, 15 datun road, Chaoyang District, Beijing, 100101, China,

We reported previously that chymotrypsin B is cached in the lysosomes of rat hepatocytes and mediates apoptosis induced by TNF-alpha (1) and H2O2. However, the mechanism

关键词： Bid mediates lysosomal membrane permeabilization and the consequent mitochondrial outer membrane permeabilization in RH-35 hepat RH MOMP

Chymotrypsin-dependent cleavage and activation of calcineurin

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生物物理学报 2009年第S1期25卷 246-247页

作者： Kai Zhao, Taotao Wei, Fuyu Yang National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 datun road, Chaoyang District, Beijing, 100101, China

We have reported that chymotrypsin B is not just a digestive enzyme secreted by the pancreas, but also cached in rat liver lysosomes and mediates extrinsic apoptotic pathway (1). Herein,

关键词： Chymotrypsin-dependent cleavage and activation of calcineurin

Insulin/PI3K/AKt Signaling Pathway Mediates Cardiac Hypertrophy in FKBP12.6 Deficient Male Mice

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生物物理学报 2009年第S1期25卷 206-207页

作者： Zheng Chen, Zheng-Zheng Li, Wen-Xuan Yin, Guangju Ji Institute of Biophysics, Chinese Academy of Sciences, 15 datun road, Chaoyang District, Beijing 100101

Male mice deficient in FKBP12.6 display cardiac hypertrophy, but the underlying mechanism is still unclear. Here we report that the cardiac hypertrophy is a physiological response

关键词： AKT, insulin cardiac hypertrophy male FKBP12.6 null mice

A further study on the role of lysosomal chymotrypsin B in apoptosis

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生物物理学报 2009年第S1期25卷 233-234页

作者： Xingyu Zhao, Kai Zhao, Taotao Wei, Fuyu Yang National Laboratory of Bio macromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 datun road, Chaoyang District, Beijing, 100101, China

We have reported that chymotrypsin B is not just a digestive enzyme secreted by the pancreas, but also cached in rat liver lysosomes and mediates extrinsic apoptotic pathway (1). Herein,

关键词： digestive pancreas cathepsin secreted extrinsic intestine cytosolic ovary hairpin stomach

Identification of LepA as PPIase reveals a common molecular mechanism of translational GTPases regulating L11 switch on the ribosome

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Identification of LepA as PPIase reveals a common molecular ...

Reconstitution Demonstrates that Cytoskeletal Disassembly can Power Cell Body Retraction in Amoeboid Cell Motility

第十一次中国生物物理学术大会暨第九届全国会员代表大会

作者： Yan Qin Institute of Biophysics,Chinese,15 datun road,Chaoyang District,Beijing,100101,China

＜正＞LepA,the highly conserved translational GTPase（trGTPase）,triggers one-codon back-movement of the elongating *** we identify a new enzymatic activity of

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Reconstitution Demonstrates that Cytoskeletal Disassembly ca...

Identification of LepA as PPIase reveals a common molecular mechanism of translational GTPases regulating L11 switch on the ribosome

中国遗传学会“发育、遗传和疾病”研讨会

作者： Long Miao 15 datun road,Chaoyang District Institute of Biophysics,Chinese Academy of Sciences,Beijing,100101

Amoeboid motility requires both extension of the leading edge and retraction of the cell body but it is not known how these processes are *** motility of Ascaris sperm is driven by an extensive meshwork of major sperm protein(MSP)filaments,which are assembled at the leading edge and disassembled at the base of the *** can be reconstituted in vitro using cell-free extracts of *** derived from the leading edge membrane trigger the assembly of a fiber comprised of a columnar meshwork of MSP filaments,that pushes the vesicle forward as it *** can be reconstituted in the same in vitro motility system by treating fibers with tyrosine phosphatase(YOP).The enzyme causes a dramatic shortening and disassembly of fibers that does not occur upon treatment with assembly buffer *** YOP-induced retraction generates sufficient force to move epoxy coated beads attached to shortening *** also blocks fiber protrusion by dephosphorylating the integral membrane protein that orchestrates fiber *** effects of YOP on both fiber protrusion and retraction are blocked by sodium orthovanadate,a potent tyrosine phosphatase *** results indicate cytoskeletal disassembly can produce a contractile force without using molecular ***,in this motility system retraction is essentially the reciprocal of protrusion;that is,protrusion is generated by cytoskeletal assembly and regulated by phosphorylation while retraction is powered by cytoskeletal disassembly triggered by *** prepared sperm extracts also induce orthovanadate-sensitive fiber *** are underway to identify the native phosphatase and its target in these extracts.

关键词： Reconstitution Demonstrates that Cytoskeletal Disassembly can Power Cell Body Retraction in Amoeboid Cell Motility

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生物物理学报 2009年第S1期25卷 226-226页

作者： Yan Qin Institute of Biophysics, Chinese, 15 datun road, Chaoyang District, Beijing, 100101, China

LepA, the highly conserved translational GTPase (trGTPase), triggers one-codon back-movement of the elongating ribosome. Here we identify a new enzymatic activity

关键词： PPIase Identification of LepA as PPIase reveals a common molecular mechanism of translational GTPases regulating L11 switch on the ribosome