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Journal of Energy Chemistry 2024年第1期88卷 513-520,I0011页

作者： Feng Zhou Xiaofeng Ke Yihuang chen Mei Zhao yun Yang Youqing Dong Chao Zou Xi’an chen Huile Jin Lijie Zhang Shun Wang Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325000ZhejiangChina Zhejiang Engineering Research center for Electrochemical Energy Materials and Devices Institute of New Materials&Industry TechnologyWenzhou UniversityWenzhou 325000ZhejiangChina

The scarcity,high cost and susceptibility to CO of Platinum severely restrict its application in alkaline hydrogen oxidation reaction(HOR).Hybridizing Pt with other transition metals provides an effective strategy to modulate its catalytic HOR performance,but at the cost of mass activity due to the coverage of modifiers on Pt ***,we constructed dual junctions'Pt/nitrogen-doped carbon(Pt/NC)andδ-MoC/NC to modify electronic structure of Pt via interfacial electron transfer to acquire Pt-MoC@NC catalyst with electron-deficient Pt nanoparticles,simultaneously endowing it with high mass activity and durability of alkaline ***,the unique structure of Pt-MoC@NC endows Pt with a high COtolerance at 1,000 ppm CO/H_(2),a quality that commercial Pt-C catalyst *** theoretical calculations not only confirm the diffusion of electrons from Pt/NC to Mo C/NC could occur,but also demonstrate the negative shift of Pt d-band center for the optimized binding energies of*H,*OH and CO.

关键词： Hydrogen oxidation reaction Dual junctions CO-tolerance Platinum

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FLNB haploinsufficiency-related short stature:a new syndrome or an expanded spectrum of Larsen syndrome

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World Journal of Pediatrics 2024年第9期20卷 976-980页

作者： Qing Wang Hong-Ying Wang Shui-Yan Wu Xue-Qian Wang Hai-Ying Wu Rong-Rong Xie Feng-yun Wang Xiu-Li chen Lin-Qi chen Hai-Tao Lv Ting chen Department of Endocrinology Genetics and MetabolismChildren’s Hospital of Soochow UniversitySuzhouChina Suzhou Clinical center for Rare diseases in Children Children’s Hospital of Soochow UniversitySuzhouChina Intensive Care Unit Children’s Hospital of Soochow UniversitySuzhouChina Department of Cardiology Children’s Hospital of Soochow UniversitySuzhouChina Department of Pediatrics Kunshan Sixth People’s HospitalSuzhouJiangsuChina

FLNB encodes the protein filamin B(FLNB),which is expressed in chondrocytes of the human growth plate[1].To date,pathogenic mutations in the FLNB gene have solely been found to cause skeletal deformities,indicating th... 详细信息

关键词： insufficiency skeletal expanded

RNA modifications in cellular metabolism:implications for metabolism-targeted therapy and immunotherapy

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1565-1594页

作者： Wei-Wei Liu Si-Qing Zheng Tian Li yun-Fei Fei chen Wang Shuang Zhang Fei Wang Guan-Min Jiang Hao Wang Department of Laboratory Medicine The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina School of Clinical Medicine Shandong UniversityJinanChina Core Unit of National Clinical Research center for Laboratory Medicine HefeiChina Neurosurgical Department The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina Department of Clinical Laboratory The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhaiChina

Cellular metabolism is an intricate network satisfying bioenergetic and biosynthesis requirements of *** studies have been constantly making inroads in our understanding of pathophysiology,and inspiring development of *** a crucial component of epigenetics at post-transcription level,RNA modification significantly determines RNA fates,further affecting various biological processes and cellular *** be noted,immunometabolism defines the metabolic alterations occur on immune cells in different stages and immunological *** this review,we characterize the distribution features,modifying mechanisms and biological functions of 8 RNA modifications,including N6-methyladenosine(m6A),N6,2'-O-dimethyladenosine(m6Am),N1-methyladenosine(m1A),5-methylcytosine(m5C),N4-acetylcytosine(ac4C),N7-methylguanosine(m7G),Pseudouridine(V),adenosine-to-inosine(A-to-l)editing,which are relatively the most studied *** regulatory roles of these RNA modification on metabolism in diverse health and disease contexts are comprehensively described,categorized as glucose,lipid,amino acid,and mitochondrial *** we highlight the regulation of RNA modifications on immunometabolism,further influencing immune *** all,we provide a thorough discussion about clinical implications of RNA modification in metabolism-targeted therapy and immunotherapy,progression of RNA modification-targeted agents,and its potential in RNAtargeted ***,we give legitimate perspectives for future researches in this field from methodological requirements,mechanistic insights,to therapeutic applications.

关键词： metabolism targeted alterations

A novel clinical data management platform for acute pancreatitis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第8期25卷 711-718页

作者： Shiyin chen cheng ZHANG Zhi’en WANG Jian ZHANG Wenqiao YU Yanshuai WANG Weiwei SI Tingbo LIANG yun ZHANG Department of Hepatobiliary and Pancreatic Surgery Zhejiang Provincial Key Laboratory of Pancreatic Diseasethe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Rehabilitation Medicine the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Comprehensive Intensive Care Unit the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

This study presents a multi-center clinical data management platform that facilitates unified and structured management of real-world data and serves as an ideal tool to enhance the quality and progress of clinical research related to severe acute pancreatitis(SAP).The use of the platform enables clinical teams to obtain safe,accurate,structurally unified,traceable,sceneclear,and fully functional real-world medical data in the diagnosis,treatment,and research of acute pancreatitis(AP).

关键词： clinical pancreatitis acute

SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl^(-)concentration

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1745-1759页

作者： Jian-Bang Xu Wei-Jie Guan Yi-Lin Zhang Zhuo-Er Qiu Lei chen Xiao-Chun Hou Junqing Yue Yu-yun Zhou Jie Sheng Lei Zhao yun-Xin Zhu Jing Sun Jincun Zhao Wen-Liang Zhou Nan-Shan Zhong State Key Laboratory of Respiratory disease National Clinical Research Center for Respiratory DiseaseNational Center for Respiratory MedicineDepartment of Respiratory and Critical Care MedicineGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Department of Thoracic Surgery Guangzhou Institute for Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Guangzhou National Laboratory GuangzhouP.R.China School of Life Sciences Sun Yat-sen UniversityGuangzhouP.R.China Guangdong provincial Key Laboratory of Pharmaceutical Functional Genes School of Life SciencesSun Yat-sen UniversityGuangzhouP.R.China Department of Physiology School of Basic Medical SciencesGuangzhou Medical UniversityGuangzhouP.R.China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection disrupts the epithelial barrier and triggers airway *** envelope(E)protein,a core virulence structural component of coronaviruses,may play a role in this *** could interfere with transepithelial Cl^(-)transport via impairment of the cystic fibrosis transmembrane conductance regulator(CFTR),which modulates nuclear factor kB(NF-kB)***,the pathological effects of SARS-CoV-2 E protein on airway epithelial barrier function,Cl^(-)transport and the robust inflammatory response remain to be ***,we have demonstrated that E protein down-regulated the expression of tight junctional proteins,leading to the disruption of the airway epithelial *** addition,E protein triggered the activation of Toll-like receptor(TLR)2/4 and downstream c-Jun N-terminal kinase(JNK)signaling,resulting in an increased intracellular Cl^(-)concentration([Cl^(-)]_(i))via up-regulating phosphodiesterase 4D(PDE4D)expression in airway epithelial *** elevated[Cl^(-)]_(i);contributed to the heightened airway inflammation through promoting the phosphorylation of serum/glucocorticoid regulated kinase 1(SGK1).Moreover,blockade of SGK1 or PDE4 alleviated the robust inflammatory response induced by E ***,these findings provide novel insights into the pathogenic role of SARS-CoV-2 E protein in airway epithelial damage and the ongoing airway inflammation during SARS-CoV-2 infection.

关键词： airway inflammation elevated

Association of accelerometer-measured sleep duration and different intensities of physical activity with incident type 2 diabetes in a population-based cohort study

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Journal of Sport and Health Science 2024年第2期13卷 222-232页

作者： Xinyi Jin Yilin chen Hongliang Feng Mingqing Zhou Joey W.Y.Chang Yaping Liu Alice Pik Shan Kong Xiao Tan yun-Kwok Wing Yannis Yan Liang Jihui Zhang Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Guangdong provincial Key Laboratory of Coronary Heart disease prevention Guangdong Cardiovascular InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China School of Medicine South China University of TechnologyGuangzhou 510641China center for Sleep and Circadian Medicine The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510180China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510282China Guangdong Mental Health center Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510120China Li Chiu Kong Family Sleep Assessment Unit Department of PsychiatryFaculty of MedicineThe Chinese University of Hong KongHong Kong 999077China Department of Psychiatry Faculty of MedicineThe Chinese University of Hong KongHong Kong 999077China Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong KongHong Kong 999077China Department of Medical Sciences Uppsala UniversityUppsala 75185Sweden Department of Big Data in Health Science Zhejiang University School of Public HealthHangzhou 310058China Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China Guangzhou 510260China

Purpose:The aim of the current study was to investigate the association of accelerometer-measured sleep duration and different intensities of physical activity(PA)with the risk of incident type 2 diabetes in a population-based prospective cohort ***:Altogether,88,000 participants(mean age=62.2±7.9 years,mean±SD)were included from the UK *** duration(short:8 h/day)and PA of different intensities were measured using a wrist-won accelerometer over a 7-day period between 2013 and *** was classified according to the median or World Health Organization-recommendation:total volume of PA(high,low),moderate-to-vigorous PA(MVPA)(recommended,not recommended),and light-intensity PA(high,low).Incidence of type 2diabetes was ascertained using hospital records or death ***:During a median follow-up of 7.0 years,1615 incident type 2 diabetes cases were *** with normal sleep duration,short(hazard ratio(HR)=1.21,95%confidence interval(95%CI):1.03-1.41)but not long sleep duration(HR=1.01,95%CI:0.89-1.15)was associated with excessive type 2 diabetes *** increased risk among short sleepers seems to be protected against by *** with normal sleepers with high or recommended PA,short sleepers with low volume of PA(HR=1.81,95%CI:1.46-2.25),not recommended(below the World Health Organization-recommended level of)MVPA(HR=1.92,95%CI:1.55-2.36),or low light-intensity PA(HR=1.49,95%CI:1.13-1.90)had a higher risk of type 2 diabetes,while short sleepers with a high volume of PA(HR=1.14,95%CI:0.88-1.49),recommended MVPA(HR=1.02,95%CI:0.71-1.48),or high light-intensity PA(HR=1.14,95%CI:0.92-1.41)did ***:Accelerometer-measured short but not long sleep duration was associated with a higher risk of incident type 2 diabetes.A higher level of PA,regardless of intensity,potentially ameliorates this excessive risk.

关键词： Light physical activity Sleep duration Triaxial accelerometer Type 2 diabetes UK Biobank

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Recent progress of radionuclides separation by porous materials

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Science China Chemistry 2024年第11期67卷 3515-3577页

作者： Yinghui Xie Long Yu Long chen cheng chen Li Wang Fenglei Liu yun Liao Peng Zhang Tao chen Yihui Yuan Yuexiang Lu Boyang Huang Hui Yang Suhua Wang Shuao Wang Lijian Ma Feng Luo yunhai Liu Baowei Hu Hongqing Wang Duoqiang Pan Wenkun Zhu Ning Wang Zhe Wang Liang Mao Shengqian Ma Xiangke Wang Guangdong provincial Key Laboratory for Green Agricultural Production and Intelligent Equipment School of Environmental Science and Engineering Guangdong University of Petrochemical Technology School of Life Science Shaoxing University College of Environmental Science and Engineering North China Electric Power University State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Soochow University College of Chemistry Sichuan University School of Chemistry and Materials Science East China University of Technology School of Chemistry and Chemical Engineering University of South China Frontiers Science center for Rare Isotopes Lanzhou University State Key Laboratory of Environment-friendly Energy Materials National Co-innovation Center for Nuclear Waste Disposal and Environmental Safety Sichuan Civil-military Integration Institute School of National Defence & Nuclear Science and TechnologySouthwest University of Science and Technology State Key Laboratory of Marine Resource Utilization in South China Sea Collaborative Innovation Center of Marine Science and Technology Hainan University Institute of Nuclear and New Energy Technology Tsinghua University State Key Laboratory of Pollution control and Resource Reuse School of the Environment Nanjing University Department of Chemistry University of North Texas

The separation of radionuclides is critical for the sustainable development of nuclear energy. It is urgent to design and prepare functionalized materials for efficient radionuclides separation. Porous materials are considered excellent candidates for the separation of radionuclides under complex conditions due to their high specific surface areas, tunable pore structures and controllable functionalities. In this review, we summarized the design, preparation and functionalization of porous materials and their application for separation of radionuclides in the past five years, discussed the separation performance and analyzed the structure-activity relationship between various radionuclides and porous materials, and systematically clarified their characterization and mechanism of different type porous materials. We also introduced the detection, irradiation and chemical toxicity of different reflective radionuclides.

关键词： porous materials radionuclides detection separation radiotoxicity interaction mechanism

Contactin-associated protein-like 2(CNTNAP2)mutations impair the essentialα-secretase cleavages,leading to autism-like phenotypes

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1625-1636页

作者： Qing Zhang Mengen Xing Zhengkai Bao Lu Xu Yang Bai Wanqi chen Wenhao Pan Fang Cai Qunxian Wang Shipeng Guo Jing Zhang Zhe Wang Yili Wu yun Zhang Jia-Da Li Weihong Song Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Zhejiang Key Laboratory of Alzheimer's DiseaseZhejiang Provincial Clinical Research Center for Mental DisordersSchool of Mental Health and Wenzhou Kangning HospitalThe Second Affiliated Hospital and Yuying Children's HospitalInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang 325035China Townsend Family Laboratories Department of PsychiatryBrain Research CenterThe University of British Columbia2255 Wesbrook MallVancouverBC V6T 1Z3Canada Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders Ministry of Education Key Laboratory of Child Development and DisordersChildren's Hospital of Chongqing Medical UniversityChongqing 400014China center for Medical Genetics Hunan Key Laboratory of Animal Models for Human DiseasesHunan Key Laboratory of Medical GeneticsHunan International Scientific and Technological Cooperation Base of Animal Models for Human DiseasesSchool of Life SciencesCentral South UniversityChangsha 410078 HunanChina The National Clinical Research center for Geriatric disease Xuanwu HospitalCapital Medical UniversityBeijing 100053Chin

Mutations in the Contactin-associated protein-like 2(CNTNAP2)gene are associated with autism spectrum disorder(ASD),and ectodomain shedding of the CNTNAP2 protein plays a role in its ***,key enzymes involved in the C-terminal cleavage of CNTNAP2 remain largely unknown,and the effect of ASD-associated mutations on this process and its role in ASD pathogenesis remain *** this report we showed that CNTNAP2 undergoes sequential cleavages by furin,ADAM10/17-dependent a-secretase and presenilindependent *** identified that the cleavage sites of ADAM10 and ADAM17 in CNTNAP2 locate at its C-terminal residue I79 and L96,and the main a-cleavage product C79 by ADAM10 is required for the subsequent y-secretase cleavage to generate CNTNAP2 intracellular domain(CICD).ASD-associated CNTNAP2 mutations impair the a-cleavage to generate C79,and the inhibition leads to ASDIlike repetitive and social behavior abnormalties in the Cntnap2l1254T knock-in ***,exogenous expression of 79 improves autism-ike phenotypes in the Cntnap2^(11254T) knock-in and Cntnap2^(-/-)knockout *** data demonstrates that the a-secretase is essential for CNTNAP2 processing and its *** study indicates that inhibition of the cleavage by pathogenic mutations underlies ASD pathogenesis,and upregulation of its C-terminal fragments could have therapeutical potentials for ASD treatment.

关键词： NAP2 cleavage subsequent

Machine-learning-aided Au-based single-atom alloy catalysts discovery for electrochemical NO reduction reaction to NH3

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Rare Metals 2024年第11期 5813-5822页

作者： Hui-Long Jin Qian-Nan Li yun-Yan Tian Shuo-Ao Wang Xing chen Jie-Yu Liu Chang-Hong Wang Hebei provincial Key Laboratory of Information Fusion and Intelligent control College of EngineeringHebei Normal University Institute of Molecular Plus School of ScienceTianjin University

Direct electrochemical conversion of NO to NH3has attracted widespread interest as a green and sustainable strategy for both ammonia synthesis and nitric oxide ***,designing efficient catalysts remains challenging due to the complex reaction mechanism and competing side ***-atom alloy（SAA） catalysts,which increase the atomic efficiency and the chance to tailor the electronic properties of the active center,have become a frontier in this ***,we performed a systematic screening of transition metal-doped Au SAAs（denoted as TM/Au,TM=Sc,Ti,V,Cr,Mn,Fe,Co,Ni,Cu,Zn,Ru,Rh,Pd,Ag and Pt） to find potential catalysts for electrochemical NO reduction reaction（NORR） to *** employing a four-step screening strategy based on density functional theory（DFT） calculations,Zn/Au SAA has been identified as a promising NORR catalyst due to its superior structural stability,reaction activity and *** electron-involved steps on Zn/Au are thermodynamically spontaneous,which results in a positive limiting potential（UL） of 0.15 *** preferred NO affinity compared to H adatom demonstrates that Zn/Au can effectively suppress the hydrogen evolution ***-learning（ML）investigations were adopted to address the uncertainty between the physicochemical properties of SAAs and the NORR *** applied an extreme gradient boosting regression（XGBR） algorithm to predict the limiting potentials in terms of the intrinsic features of the reaction *** coefficient of determination（R2） is 0.97 for the training set and 0.96 for the test *** electronic structure an alysis combined with a compressed-sensing data-an alytics approach further quantitatively verifies the coeffect of d-band center,charge transfer and the radius of doped TM atoms,i.e.,features with the highest level of importance determined by the XGBR *** work provides a theoretical understanding of the complex NORR to NH3mechanisms and sheds light on the rational desi

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