检索结果-南通市图书馆

Preparation and development of equine hyperimmune globulin F（ab'）2 against severe acute respiratory syndrome coronavirus

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2005年第12期26卷 1479-1484页

作者： Jia-hai LU~(2,8,9) Zhong-min GUO~(2,9) Wen-yu HAN~(3,9) Guo-ling WANG~(2,9) Ding-mei ZHANG~2 Yi-fei WANG~4 Sheng-yun SUN~4 Qin-he YANG~4 Huan-ying ZHENG~5 Bing L WONG~6 Nan-shan ZHONG~7 2 Sun Yat-sen University,guangzhou 510080,china 3 The Agriculture School of Jilin University,Changchun 130062,china 4 Ji-nan University,guangzhou 510632,china 5 Center for Disease Control and Prevention of Guangdong Province,guangzhou 510300,china 5 Advantek Biologics,Hong Kong,china 7 guangzhou institute of respiratory diseases,guangzhou medical college,guangzhou 510120,china Sun Yat-sen University Guangzhou 510080 China. jiahailu@***

Aim:The resurgence of severe acute respiratory syndrome(SARS)is still a threatbecause the causative agent remaining in animal reservoirs is not fully understood,and sporadic cases continue to be *** high titers of anti-SARShyperimmune globulin to provide an alternative pathway for emergent future pre-vention and treatment of ***:SARS coronavims(CoV)F69(AY313906)and Z2-Y3(AY394989)were isolated and identified from 2 different Cantoneseonset SARS *** was prepared from SARS-CoV F69 *** horses were immunized 4 times and serum was collected periodically tomeasure the profile of specific IgG and neutralizing antibodies using indirect en-zyme-linked immunosorbent assay and a microneutralization *** were col-lected in large amounts at the peak,where IgG was precipitated using ammoniumsulphate and subsequently digested with *** product was then purifiedusing anion-exchange chromatography to obtain F(ab′)2 fragments,Results:Thespecific IgG and neutralizing antibody titers peaked at approximately week 7 afterthe first immunization,with a maximum value of 1:*** sera collected at thepeak were then *** of approximately 15 g F(ab′)2 was obtained from1 litre antiserum and the purity was above 90% with the titer of 1:5120,which couldneutralize the other strain(SARS-CoV Z2-Y3)as ***:This researchprovides a viable strategy for the prevention and treatment of SARS coronavirusinfection with equine hyperimmune globulin,with the purpose of combating anyresurgence of SARS.

关键词： severe acute respiratory syndrome coronavirus neutralizing antibodies hyperimmune globulin cross protection F(ab’)2 fragments

Efficacy of intramuscular BCG polysaccharide nucleotide on mild to moderate bronchial asthma accompanied with allergic rhinitis: a randomized, double blind, placebo-controlled study

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中华医学杂志(英文版) 2005年第19期000卷 13-21页

作者： LI Jing, LUO Ding-fen, LI Sui-ying, SUN Bao-qing and ZHONG Nan-shan guangzhou institute of respiratory Disease, First Affiliated Hospital of guangzhou medical college, guangzhou 510120, china guangzhou institute of respiratory Disease First Affiliated Hospital of Guangzhou Medical College Guangzhou 510120 China

The extensive evidence of Th2 cytokine involvement in the pathogenesis of allergic diseases~ 1,2 suggests a potential target for immunomodulation. Because the Th1 and Th2 cells are reciprocally regulated, several recent studies on Th2-associated diseases including asthma have shown to reverse the Th2 response into a protective Th1 response.~ 3,4

关键词： asthma · allergic rhinitis · Bacillus Calmette-Guérin polysaccharide nucleotide

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

重症新型甲型H1N1流感诊治体会

中国实用内科杂志 2010年第6期30卷 577-580页

作者：黎毅敏广州医学院第一附属医院广州呼吸疾病研究所重症医学科广州510120

2009-03-18墨西哥报道首例甲型H1N1流感病例。至2010-04-11止,世界卫生组织(WHO)登记的确诊病例死亡人数已达17798例。重症病例救治是这一新型甲型流感防控策略的重要内容。本文就诊断和治疗方面的体会,在以下几个方面做一叙述:对重症... 详细信息

2009-03-18墨西哥报道首例甲型H1N1流感病例。至2010-04-11止,世界卫生组织(WHO)登记的确诊病例死亡人数已达17798例。重症病例救治是这一新型甲型流感防控策略的重要内容。本文就诊断和治疗方面的体会,在以下几个方面做一叙述:对重症或危重症病例做到早期识别和早期干预;对于重症H1N1病例,应积极进行氧疗或者机械通气;尽早进行抗病毒治疗;不建议预防性应用抗生素,注意预防医院获得性肺炎(呼吸机相关性肺炎);激素应用要慎重;体外膜肺可作为呼吸支持的一个可选择措施。

关键词：新型甲型H1N1流感机械通气体外肺膜

维普期刊数据库

Weight of CURB-65 for community-acquired pneumonia

在线全文

学校读者我要写书评

暂无评论

Weight of CURB-65 for community-acquired pneumonia

中华医学会呼吸病学年会——2011（第十二次全国呼吸病学学术会议）

作者： Qi Guo) 1 Guangdong medical college 2 guangzhou institute of respiratory diseases(State Key Laboratory of respiratory diseases)

Background The CURB-65 score is a simple well validated tool for the assessment of severity in community-acquired pneumonia(CAP).Whether each of the criteria is of equal weight is not clear. The purpose of this study was to determine the weight of CURB-65. Methods 1230 adult patients admitted to our hospital from 2005 to 2009 for CAP were reviewed retrospectively.

关键词：

The associations of radiological features in mycoplasma pneumoniae pneumonia

在线全文

cnki会议

学校读者我要写书评

暂无评论

The associations of radiological features in mycoplasma pneu...

中华医学会呼吸病学年会——2011（第十二次全国呼吸病学学术会议）

作者： Qi Guo~() 1 Guangdong medical college 2 guangzhou institute of respiratory diseases(State Key Laboratory of respiratory diseases)

Background The associations of radiological features with clinical and laboratory findings in Mycoplasma pneumoniae(***) infection are poorly *** purpose of this study was to assess the associations. Methods A sixty-m...

关键词：

The relationship between antimicrobial consumption and the rates of resistance of Klebsiela pneumoniae in respiratory unit

在线全文

cnki会议

学校读者我要写书评

暂无评论

The relationship between antimicrobial consumption and the r...

两岸三地药理学与临床药理学术会议

作者： YANG Xin-yun~1 ZHUO Chao~2 XIAO Xiang-lin~1 YUAN Jin-Ping~2 YANG Ling~2 (1.First Affiliated Hospital of guangzhou medical college, guangzhou 510120, china 2.guangzhou institute of respiratory Disease, guangzhou 510120, china)

Objective To investigate the relationship between the consumption of antibacterial agents and re- sistance rate of Klebsiela pneumoniae(KP)in the hospital respiratory unit for 3 consecutive years in 2005- *** The total antibacterial consumption expressed as defined DDDs/100BD,as well as resistance rate of total KP and producing ESBLs KP were collected,and their correlation was *** The rate of resistance of KP to cefoperazone/sulbactam,Cefepime,Imipenem,Moxifloxacin was significantly positively associated with the consumption of Cefotaxime,Ceftazidime,Moxifloxacin,Amikacin respectively;A significant positive association was observed between the rate of resistance of KP to Piperacillin/Tazobac- tam,Ceftriaxone and the consumption of Imipenem;The rate of resistance of KP to Piperacillin,Cefo- taxime,Ciprofloxacin was significantly positively associated with the consumption of *** producing bacilli of KP were detected in 44 of 75 isolates (58.7%),The rate of resistance of producing ES- BLs KP to Piperacillin/Tazobactam,Ceftriaxone was significantly positively associated with the consump- tion of Imipenem,Ceftazidime;A significant positive association was observed between the rate of resistance of producing ESBLs KP to Piperacillin,Imipenem and the consumption of *** was no sig- nificant correlation in other *** A relationship existed between antimicrobial consumption and rates of resistance of KP in the hospital respiratory *** must use antibiotics carefully and with rea- son to control and lessen the drug resistance of bacterial.

关键词： klebsiela pneumoniae extended spectrumβlactamases drug resistance consumption of antibacterial agents relationship

The IRTI and CPUS double-blind controlled clinical study on DVT

在线全文

cnki会议

学校读者我要写书评

暂无评论

The IRTI and CPUS double-blind controlled clinical study on ...

中华医学会第五届全国肺栓塞与肺血管病学术会议暨第三届国际肺循环病研讨会

作者： Fangge Deng~ 1 The First Affiliated Hospital of guangzhou medical college,guangzhou institute of respiratory Disease,National Key Laboratory of respiratory Disease,guangzhou,Guangdong,510120 2 The Department of Ultrasound of First Affiliated Hospital of guangzhou medical college,guangzhou,Guangdong, 510120 3 IRS Infrared medical Technology Limited Company,Beijing,100036

Background and purpose Infrared thermal imaging(IRTI) is a kind of new functional imaging detection technology with many advantages such as simple(as the camera to take photo),fast(few minutes),non-invasive,*** pre-empirical study showed that the deep vein thrombosis(DVT) had its own distinct IRTI expression and disposition characteristics(DVT-IRTI).

关键词：

在线全文

cnki会议

学校读者我要写书评

暂无评论

合并鼻炎鼻窦炎和鼻息肉的支气管哮喘

中国实用内科杂志 2009年第4期29卷 306-310页

作者：鲜墨李靖广州医学院第一附属医院广州呼吸疾病研究所变态反应科广州510120

鼻炎、鼻窦炎、鼻息肉和支气管哮喘均为常见的呼吸道疾病,这些疾病在病因学、发病机制和组织病理生理学改变等方面均有相似之处,许多患者常先后或同时罹患上述疾病。它们的相关性已引起国内外学者的广泛关注,而其中合并鼻息肉的鼻-鼻窦... 详细信息

鼻炎、鼻窦炎、鼻息肉和支气管哮喘均为常见的呼吸道疾病,这些疾病在病因学、发病机制和组织病理生理学改变等方面均有相似之处,许多患者常先后或同时罹患上述疾病。它们的相关性已引起国内外学者的广泛关注,而其中合并鼻息肉的鼻-鼻窦炎与支气管哮喘间的关联性更引人注目。但目前这些疾病的相关程度、以及对诊断、治疗理念的认识尚不十分清楚。本文将就上述问题特别是相互间的关联性进行探讨,促进临床医生重视对上述疾病的综合认识,并为其制定合理有效的治疗方案提供参考依据。

关键词：哮喘鼻炎鼻窦炎鼻-鼻窦炎鼻息肉

维普期刊数据库

The relationship between antimicrobial consumption and the rates of resistance of Klebsiela pneumoniae in respiratory unit

在线全文

学校读者我要写书评

暂无评论

沈阳药科大学学报 2008年第S1期25卷 123-123页

作者： YANG Xin-yun1,ZHUO Chao2,XIAO Xiang-lin1,YUAN Jin-Ping2,YANG Ling2(1.First Affiliated Hospital of guangzhou medical college,guangzhou 510120,china 2.guangzhou institute of respiratory Disease,guangzhou 510120,china)

Objective To investigate the relationship between the consumption of antibacterial agents and resistance rate of Klebsiela pneumoniae(KP)in the hospital respiratory unit for 3 consecutive years in *** The total antibacterial consumption expressed as defined DDDs/100BD,as well as resistance rate of total KP and producing ESBLs KP were collected,and their correlation was *** The rate of resistance of KP to cefoperazone/sulbactam,Cefepime,Imipenem,Moxifloxacin was significantly positively associated with the consumption of Cefotaxime,Ceftazidime,Moxifloxacin,Amikacin respectively;A significant positive association was observed between the rate of resistance of KP to Piperacillin/Tazobactam,Ceftriaxone and the consumption of Imipenem;The rate of resistance of KP to Piperacillin,Cefotaxime,Ciprofloxacin was significantly positively associated with the consumption of *** producing bacilli of KP were detected in 44 of 75 isolates(58.7%),The rate of resistance of producing ESBLs KP to Piperacillin/Tazobactam,Ceftriaxone was significantly positively associated with the consumption of Imipenem,Ceftazidime;A significant positive association was observed between the rate of resistance of producing ESBLs KP to Piperacillin,Imipenem and the consumption of *** was no significant correlation in other *** A relationship existed between antimicrobial consumption and rates of resistance of KP in the hospital respiratory *** must use antibiotics carefully and with reason to control and lessen the drug resistance of bacterial.

关键词： klebsiela pneumoniae extended spectrumβlactamases drug resistance consumption of antibacterial agents relationship

维普期刊数据库