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Surface plasmon decorated InGaO deep-UV photodetector array for image sensing and water quality monitoring via highly effective hot electron excitation and interfacial injection

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Science China(Technological Sciences) 2024年第8期67卷 2449-2460页

作者： SHU linCong sha Shulin XI Zhaoying li Lei YAO SuHao ZHANG JiaHan JI XueQiang ZHANG shaoHui bian Ang JIANG MingMing guo YuFeng TANG WeiHua liU zeng Innovation Center of Gallium Oxide Semiconductor(IC-GAO) College of Integrated Circuit Science and EngineeringNanjing University of Posts and TelecommunicationsNanjing 210023China School of Electronic Information Engineering Inner Mongolia UniversityHohhot 010021China College of Science MIIT Key Laboratory of Aerospace Information Materials and PhysicsNanjing University of Aeronautics and AstronauticsNanjing 211106China Collaborative Innovation Center of Advanced Microstructures School of Electronic Science and EngineeringNanjing UniversityNanjing 210093China Institute of Biological and Medical Engineering Guangdong Academy of SciencesGuangzhou 510316China School of Science Jiangsu University of Science and TechnologyZhenjiang 212100China School of Integrated Circuits Beijing University of Posts and TelecommunicationsBeijing 100876China

In addition to the plasmon-mediated resonant coupling mechanism,the excitation of hot electron induced by plasmon presents a promising path for developing high-performance optoelectronic devices tailored for various *** study introduces a sophisticated design for a solar-blind ultraviolet(UV)detector array using linear In-doped Ga_(2)O_(3) (InGaO)modulated by platinum(Pt)nanoparticles(PtNPs).The construction of this array involves depositing a thin film of Ga_(2)O_(3) through the plasmonenhanced chemical vapor deposition(PECVD)***,PtNPs were synthesized via radio-frequency magnetron sputtering and annealing *** performance of these highly uniform arrays is significantly enhanced owing to the generation of high-energy hot *** process is facilitated by non-radiative decay processes induced by ***,the array achieves maximum responsivity(R)of 353 mA/W,external quantum efficiency(EQE)of 173%,detectivity(D*)of approximately 10~(13)Jones,and photoconductive gain of *** addition,the standard deviation for photocurrent stays below17%for more than 80%of the array units within the ***,the application of this array extends to photon detection in the deep-UV(DUV)*** includes critical areas such as imaging sensing and water quality *** leveraging surface plasmon coupling,the array achieves high-performance DUV photon *** approach enables a broad spectrum of practical applications,underscoring the significant potential of this technology for the advancement of DUV detectors.

关键词： InGaO PECVD surface plasmon solar-blind UV photodetector array optoelectronic applications

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A modified PVDF-HFP/PMMA crosslinked co-polymer for high-performance all-solid-state lithium metal batteries

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Particuology 2024年第10期93卷 203-210页

作者： Sijia Wang liang He Mengting Wang xingtong guo Xiangyun qiu Shoudong Xu Petr Senin Ting bian Tao Wei School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang212003China Power&Energy Storage System Research Center College of Mechanical and Electrical EngineeringQingdao UniversityQingdao266071China College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan030024China Institute of Mechanics and Power Engineering Ogarev Mordovia State UniversitySaransk430005Russia

For all-solid-state lithium batteries(ASSLBs),polymer-blended solid composite electrolytes(SCEs)have drawn wide interest owing to their significance in improving the interfacial solid-solid contacts and inhibiting the growth of lithium *** this work,SCEs based on PVDF-HFP/PMMA matrix containing MOFs(NH2-MIL-53(Al))and liTFSI were designed and synthesized employing an easy solution casting *** synthesized samples were examined by XRD,SEM,EDS,and electrochemical *** was found that MPP-2 SCE not only has excellent ionic conductivity at 60℃ of 5.54×10^(−4) S cm^(−1),but also exhibits superior interfacial compatibility in li||li symmetric batteries,which can constantly cycle for about 800 h at 0.1 mA cm^(−2) with no *** assembled li|MPP-2|liFePO4 cell exhibited a first discharge specific capacity of up to 157.1 mAh g^(−1) at 60℃ and 0.2 *** work may help to further advance the progress of ASSLBs in the future.

关键词： NH_(2)-MIL-53(AI) All solid-state lithium batteries(ASSLBs) PMMA PVDF-HFP Solid composite electrolytes(SCEs)

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Male spike strobiles with Gnetum affinity from the Early Cretaceous in western liaoning,Northeast China

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Journal of Systematics and Evolution 2009年第2期47卷 93-102页

作者： 1,2shuang-xing guo 3jin-geng sha 4li-zeng bian 5yin-long qiu 1(Department of Palaeobotany and Palynology,Nanjing Institute of Geology and Paleontology,Chinese Academy of Sciences,Nanjing 210008,China) 2(Laboratory of Biodiversity and Biogeography,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650204,China) 3(State Key Laboratory of Palaeobiology and Stratigraphy,Nanjing Institute of Geology and Palaeontology,Chinese Academy of Sciences,Nanjing 210008,China) 4(College of Earth Sciences,Nanjing University,Nanjing 210093,China) 5(Department of Ecology & Evolutionary Biology,The University Herbarium,University of Michigan,Ann Arbor,MI 48109-1048,USA) Department of Palaeobotany and Palynology Nanjing Institute of Geology and Paleontology Chinese Academy of Sciences Nanjing 210008 China Laboratory of Biodiversity and Biogeography Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204 China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology Chinese Academy of Sciences Nanjing 210008 China College of Earth Sciences Nanjing University Nanjing 210093 China Department of Ecology & Evolutionary Biology The University Herbarium University of Michigan Ann Arbor MI 48109–1048 USA

A fossil with Gnetum affinity was found in the Jianshangou Member(Barremian Age) of the Yixian Formation(Lower Cretaceous Epoch) of the Jehol Group in western liaoning,northeastern *** single fossil specimen is represented by both elongate-cylindrical male spike strobiles which borne within a nodal bract of cauliflorous *** spike strobiles have apparent nodes,invisible internodes,and numerous verticillate involucral *** microsporangiate units within involucral collars are not *** male spike strobiles with verticillate involucral collars occur exclusively in Gnetum;hence,the fossil strobiles are attributed to a new taxon,Khitania columnispicata gen.& ***.,being closely related to *** general isotopic dating suggests an age of Barremian,ca.125-122 million years(Myr) ago for the Jianshangou *** palaeoecological and palaeoclimatic inference based on the compositions of flora and fauna,and lithological characters of the fossil locality suggests that the fossil plants grew in a subtropical mesophytic forest and under a warmer *** remains of male spike strobiles are the first record of gnetalean *** documents the evolution of the distinct gnetoid morphology and indicates a wider range of distribution of Gnetaceae in the Early Cretaceous than present day.

关键词： biogeography Early Cretaceous Gnetum affinity male spike strobiles northeastern China

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Comprehensive reutilization of herbal waste:Coproduction of magnolol,honokiol,and β-amyrin from Magnolia officinalis residue

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Green Energy & Environment 2024年第2期9卷 403-412页

作者： Lukun Xiao Anyi Zhao Jie qiu An liu sha Chen jinzhu Jiang Jun Zhang Cong guo Jipeng Di jintang Cheng Chang Chen Kangxin Hou Aiping Zhang Yan liu Caixia Wang Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing100700China School of Pharmacy Shanxi Medical UniversityTaiyuan030001China

Herbal extraction residues(HERs)cause serious environmental pollution and resource *** this study,a novel green route was designed for the comprehensive reutilization of all components in HERs,taking Magnolia officinalis residues(MOR)as an *** reluctant structure of MOR was first destroyed by alkali pretreatment to release the functional ingredients(magnolol and honokiol)originally remaining in MOR and to make MOR more accessible for hydrolysis.A metal–organic frame material MIL-101(Cr)with a maximum absorption capacity of 255.64 mg g^(-1)was synthesized to absorb the released honokiol and magnolol from the pretreated MOR solutions,and 40 g L^(-1)reducing sugars were obtained with 81.8%enzymatic hydrolysis rate at 10%MOR solid ***,382 mg L-1β-amyrin was produced from MOR hydrolysates by an engineered yeast *** total,1 kg honokiol,8 kg magnolol,and 7.64 kg β-amyrin could produce from 1 ton MOR by this cleaner process with a total economic output of 170,700 RMB.

关键词： Magnolia officinalis residues(MOR) Comprehensive utilization Metal-organic frame material Biosynthesis

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Expert consensus on difficulty assessment of endodontic therapy

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International Journal of Oral Science 2024年第1期16卷 15-25页

作者： Dingming Huang Xiaoyan Wang jingping liang Junqi ling Zhuan bian Qing Yu Benxiang Hou Xinmei Chen Jiyao li ling Ye Lei Cheng Xin Xu Tao Hu Hongkun Wu Bin guo Qin Su Zhi Chen lihong qiu Wenxia Chen Xi Wei Zhengwei Huang jinhua Yu Zhengmei lin Qi Zhang Deqin Yang jin Zhao shuang Pan Jian Yang Jiayuan Wu Yihuai Pan Xiaoli Xie Shuli Deng Xiaojing Huang Lan Zhang lin Yue Xuedong Zhou State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Operative Dentistry and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina Department of Cariology and Endodontology Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina Department of Endodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Clinical Research Center for Oral DiseasesNational Center for StomatologyShanghai Key Laboratory of StomatologyShanghaiChina Department of Operative Dentistry and Endodontics Hospital of StomatologyGuanghuaSchool of StomatologySun Yat-Sen University&Guangdong Provincial Key Laboratory of StomatologyGuangzhouChina The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of StomatologyWuhan UniversityWuhanChina Department of Operative Dentistry&Endodontics School of StomatologyThe Fourth Military Medical UniversityXi’anChina Department of Endodontics Beijing Stomatological HospitalSchool of StomatologyCapital Medical UniversityBeijingChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Preventive Dentistry West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Geriatric dentistry West China Hospital of Stomatology

Endodontic diseases are a kind of chronic infectious oral disease. Common endodontic treatment concepts are based on the removal of inflamed or necrotic pulp tissue and the replacement by gutta-percha. However, it is very essential for endodontic treatment to debride the root canal system and prevent the root canal system from bacterial reinfection after root canal therapy(RCT). Recent research, encompassing bacterial etiology and advanced imaging techniques, contributes to our understanding of the root canal system’s anatomy intricacies and the technique sensitivity of RCT. Success in RCT hinges on factors like patients, infection severity, root canal anatomy, and treatment techniques. Therefore, improving disease management is a key issue to combat endodontic diseases and cure periapical lesions. The clinical difficulty assessment system of RCT is established based on patient conditions, tooth conditions, root canal configuration, and root canal needing retreatment, and emphasizes pre-treatment risk assessment for optimal outcomes. The findings suggest that the presence of risk factors may correlate with the challenge of achieving the high standard required for RCT. These insights contribute not only to improve education but also aid practitioners in treatment planning and referral decision-making within the field of endodontics.

关键词： anatomy difficulty treatment

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颞叶癫痫伴双侧海马硬化与单侧海马硬化的临床特征差异分析

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中华神经医学杂志 2024年第5期23卷 450-457页

作者：陶琪何晨敏邱晶晶杨育育徐莎郭谊李宏丁瑶丁美萍王爽浙江大学医学院附属第二医院神经内科杭州310009 浙江大学医学院附属第二医院放射科杭州310009 湖州市中心医院神经内科湖州313000

目的探讨颞叶癫痫伴双侧海马硬化(TLE-bHS)与颞叶癫痫伴单侧海马硬化(TLE-uHS)临床特征的差异。方法回顾性纳入浙江大学医学院附属第二医院神经内科癫痫中心自2013年1月至2022年1月收治的48例明确诊断为TLE-bHS且临床资料完整的患者(TLE... 详细信息

目的探讨颞叶癫痫伴双侧海马硬化(TLE-bHS)与颞叶癫痫伴单侧海马硬化(TLE-uHS)临床特征的差异。方法回顾性纳入浙江大学医学院附属第二医院神经内科癫痫中心自2013年1月至2022年1月收治的48例明确诊断为TLE-bHS且临床资料完整的患者(TLE-bHS组),以及同期收治的101例明确诊断为TLE-uHS且临床资料完整的患者(TLE-uHS组),分析2组患者的临床资料如发病年龄、病程、既往病史、癫痫发作频率、抗发作药物种类、视频脑电图结果、神经心理测试结果以及治疗结局等方面的差异。结果与TLE-uHS组相比,TLE-bHS组患者男性占比更高,发病年龄更晚,病程更短,癫痫发作频率更高,既往及现用抗发作药物种类更多,癫痫发作时自主神经先兆比例更低、无先兆比例更高,视频脑电图中后头部背景活动偏慢比例更高,记忆商数、言语记忆评分及非言语记忆评分更低,差异均有统计学意义(P5)。另外,2组患者既往病史构成比、发作间期癫痫样异常分布区域构成比的差异亦均有统计学意义(P5),其中TLE-bHS组既往常伴有颅内感染/脑炎史,双侧颞区癫痫样异常比例更高;而TLE-uHS组常伴有热性惊厥史,单侧颞区癫痫样异常比例更高。TLE-bHS组患者中仅10例(20.8%)接受了非药物治疗,包括前颞叶切除手术3例(术后随访2年均为Engel分级Ⅰ级)、神经调控治疗4例、生酮饮食治疗4例;TLE-uHS组患者中55例(54.5%)接受了前颞叶切除手术,术后随访2年时Engel分级Ⅰ级48例(87.3%)、Ⅱ级1例(1.8%)、Ⅲ级4例(7.3%)、Ⅳ级2例(3.6%)。结论TLE-bHS患者与TLE-uHS患者在性别、既往病史、发病年龄、病程、癫痫发作频率、抗发作药物种类、视频脑电图、神经心理测试等方面的差异有助于将两者相鉴别。

关键词：颞叶癫痫双侧海马硬化单侧海马硬化

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Radioimmunotherapy of carcinoma of colon with [131I]-labeled recombinant chimeric monoclonal antibodies to carcinoembryonic antigen

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Acta Pharmacologica Sinica 2005年第10期26卷 1259-1264页

作者： qiu-jun LU~1, Guang-xing bian, Yuan-yuan CHEN, Min ZHANG, shao-ming guo, li-qing WEN Institute of Radiation Medicine, Beijing 100850, China Institute of Radiation Medicine Beijing China

Aim: To study the distribution of [131I]-labeled anti-CEA MoAbs and its therapeutic effect on the human colonic cancer model in nude mice. Methods: A nude mice model of human colonic cancer was established. [~131I]-labeled anti-CEA MoAbs were injected intravenously into mice. The distribution of the MoAbs was then determined and the effect of RIT on human colonic cancer was observed. Results: The [131I]-labeled anti-CEA MoAbs had a specific distribution after injection. Tumor/non-tumor ratios for [131I]-labeled anti-CEA MoAbs were 10-20 times higher than [131I]-labeled IgG 96 h after injection. Thirty days after injection, significant inhibition of the volume and weight of tumor was observed in the treated mice compared with the control. The tumor growth inhibition rate of 3,1 mCi/kg CEA MoAbs group (LS180, LS174T, SW1116) was 47.8%～64.0%. This was 69.6%-78.6% in the 6.25 mCi/kg CEA MoAbs group, and 81.8%-86.2% in the 12.5 mCi/kg [131I]-labeled anti-CEA MoAbs group. The plasma CEA level was alo lower in treated mice. Conclusion: The results indicate that [131I]-labeled anti-CEA MoAbs can be effective in RIT on colonic cancers.

关键词： humanized chimeric recombinant monoclonal antibody radioimmunotherapy colonic cancer nude mice

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Detection and characterization of hepatocellular carcinoma in rats with liver cirrhosis:diagnostic value of combined use of MR positive and negative contrast agents

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Hepatobiliary & Pancreatic Diseases International 2009年第1期8卷 65-70页

作者： guo, Dong-Mei qiu, Tian-shuang bian, Jie liu, Shu-Feng Wang, Chang-Zheng Dalian Univ Technol Dept Elect Engn Dalian 116024 Peoples R China Dalian Med Univ Affiliated Hosp 2 Dept Radiol Dalian 116027 Peoples R China People Hosp Lvshun Dist Dept Radiol Dalian 116041 Peoples R China

BACKGROUND: Gadolinium-enhanced multi-phase dynamic imaging has improved the accuracy of the diagnosis of hypervascular hepatocellular carcinoma (HCC), but using gadolinium-enhanced dynamic imaging alone is problematic in evaluating hypovascular HCC. This work aimed at evaluating the combined use of superparamagnetic iron oxide (SPIO)-enhanced and gadolinium set in distinguishing HCCs from regenerative nodules (RNs) in a rat model induced by diethylnitrosamine (DEN). METHODS: DEN-induced HCC model rats (n=40) and control rats (n=10) were studied. From weeks 16 to 19 after DEN administration, 4 animals were scanned every week. The hepatic changes were tested with a 1.5 Tesla magnet, and MR images of SPIO-enhanced and gadolinium set were obtained. According to the pathologic changes, the tumorigenesis was divided into HCC and RN (diameter of nodules >= 3 mm). Diagnostic accuracy of the combined SPIO-enhanced and gadolinium set and the gadolinium set alone was evaluated using receiver-operating characteristic curves. Sensitivity and specificity of the combined SPIO-enhanced and gadolinium set and the gadolinium set alone were calculated. RESULTS: The listed tests were completed in 29 rats (21 treated and 8 controls). One hundred and six nodules (82 HCCs, 24 RNs) were analyzed. The Az value and sensitivity with the combined SPIO-enhanced and gadolinium set (Az 0.94, sensitivity 0.96) were higher than those with the gadolinium set alone (Az 0.92, sensitivity 0.89). Using the combined SPIO-enhanced and gadolinium set led to detection of 6 nodules which were negative in the gadolinium set alone and 3 nodules were correctly characterized. CONCLUSION: Using the combined SPIO-enhanced and gadolinium set improved the detectability of HCCs and the SPIO-enhanced imaging compensated for the gadolinium set in differentiating HCCs from RNs in a rat model.

关键词： iron oxides gadolinium magnetic resonance imaging hepatocellular carcinoma animal model

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益肾祛痹通络方对肾虚寒湿痹阻型CIA大鼠miR-150-5p/SOCS1轴的调控作用

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时珍国医国药 2024年第4期35卷 773-777页

作者：邱明亮李润洲肖晨晓周鑫珠朱国双莫丽莎刘秋萍朱卫娜江西中医药大学江西南昌330004 江西中医药大学附属医院江西南昌330006

目的探究益肾祛痹通络方对肾虚寒湿痹阻型胶原诱导关节炎大鼠的治疗作用及对miR-150-5p、细胞因子信号抑制因子1(suppressor of cytokine signaling,SOCS 1)的影响。方法20只SPF级SD大鼠,随机选取6只为正常对照组,另外14只构建肾虚寒湿... 详细信息

目的探究益肾祛痹通络方对肾虚寒湿痹阻型胶原诱导关节炎大鼠的治疗作用及对miR-150-5p、细胞因子信号抑制因子1(suppressor of cytokine signaling,SOCS 1)的影响。方法20只SPF级SD大鼠,随机选取6只为正常对照组,另外14只构建肾虚寒湿痹阻型胶原诱导关节炎大鼠模型,成功10只,随机分为模型组、治疗组,各5只。治疗组予益肾祛痹通络方(0.2g/ml)灌胃治疗,每日1次,共2周。模型组及对照组均予生理盐水灌胃处理。HE染色观察踝关节软骨组织病变情况;免疫组化检测踝关节中vimentin的表达水平;qPCR检测踝关节组织中的miR-150-5p、SOCS1 mRNA表达水平;EliSA检测血清中TNF-α、IL-6的表达水平。结果与对照组比较,模型组关节炎指数明显升高(P150-5p水平升高(P1 mRNA的表达水平无明显变化(P>0.05);血清中TNF-α、IL-6的表达水平明显升高(P150-5p水平明显降低(P1mRNA水平明显升高(P150-5p/SOCS1通路,抑制细胞因子表达,改善关节炎症。

关键词：胶原诱导型关节炎大鼠肾虚寒湿痹阻证益肾祛痹通络方 miR-150-5p 细胞因子信号抑制因子1

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A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2

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National Science Review 2021年第8期8卷 147-157页

作者： li Zhang Lei Cao xing-Su Gao Bin-Yang Zheng Yong-Qiang Deng jing-Xin li Rui Feng Qian bian Xi-ling guo Nan Wang Hong-ying qiu Lei Wang Zhen Cui Qing Ye geng Chen Kui-Kui Lu yin Chen Yu-Tao Chen Hong-xing Pan Jiaping Yu Wenrong Yao Bao-li Zhu Jianping Chen Yong liu Cheng-Feng Qin Xiangxi Wang Feng-Cai Zhu National Health Commission of the People’s Republic of China Key Laboratory of Enteric Pathogenic Microbiology (Jiangsu Provincial Center for Disease Control and Prevention) Center for Global Health School of Public HealthNanjing Medical University CAS Key Laboratory of Infection and Immunity National Laboratory of MacromoleculesInstitute of BiophysicsChinese Academy of Sciences Guangzhou Regenerative Medicine and Health Guangdong Laboratory Jiangsu Rec-biotechnology Co.Ltd State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology

Mutations and transient conformational movements of the receptor binding domain(RBD) that make neutralizing epitopes momentarily unavailable present immune escape routes for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). To mitigate viral escape, we developed a cocktail of neutralizing antibodies(NAbs) targeting epitopes located on different domains of spike(S) protein. Screening of a library of monoclonal antibodies generated from peripheral blood mononuclear cells of COVID-19 convalescent patients yielded potent NAbs, targeting the N-terminal domain(NTD) and RBD domain of S, effective at n M concentrations. Remarkably, a combination of RBD-targeting NAbs and NTD-binding NAbs, FC05, enhanced the neutralization potency in cell-based assays and an animal model. Results of competitive surface plasmon resonance assays and cryo-electron microscopy(cryo-EM) structures of antigen-binding fragments bound to S unveil determinants of immunogenicity. Combinations of immunogens, identified in the NTD and RBD of S, when immunized in rabbits and macaques, elicited potent protective immune responses against SARS-CoV-2. More importantly, two immunizations of this combination of NTD and RBD immunogens provided complete protection in macaques against a SARS-CoV-2 challenge, without observable antibody-dependent enhancement of infection. These results provide a proof of concept for neutralization-based immunogen design targeting SARS-CoV-2 NTD and RBD.

关键词： SARS-CoV-2 neutralizing antibodies vaccine development structure-based immunogen design

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