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Survival factors after resection of small hepatocellular carcinoma

Hepatobiliary & Pancreatic Diseases International 2005年第3期4卷 379-384页

作者： departments of Surgical Oncology (Wu FS, Zhao WH, Ma ZM, Teng LS and Wang M) and general Surgery ( Liang TB and Zheng SS) , First Affiliated hospital, Zhejiang University School of medicine, Hangzhou 310003, China department of Surgical Oncology First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China. qiouhang@***

Early resection of hepatocellular carcinoma is a key measure to prolong the survival of patients. This study was designed to summarize our experience in surgical resection of small hepatocellular carcinoma (HCC), and to analyze the factors influencing the postoperative survival of patients. METHODS:The clinicopathologic data of 105 patients with small HCC after resection from 1986 through 2003 were analyzed ; the patients had been followed up for more than half a year (median 33 months). Nine clinicopathologic factors, preoperative α-fetoprotein (AFP) level, liver cirrhosis, Child-Pugh score, tumor size (>2cm vs.≤2 cm) and number (single vs. multiple), capsule formation, portal vein tumor thrombi (PVTT), Edmondson tumor grade and surgical method, were analyzed by the log-rank test and the Cox proportional harzards model analysis. RESULTS:The cumulative 1-,3- and 5-year survival rates after the operation were 86.5%, 70.3% and 55.2%, respectively, and the 1-, 3- and 5-year disease-free survival rates were 78%, 58. 9% and 45. 6%, respectively. One patient died from esophagogastric varices hemorrhage in 2 weeks after reoperation. Thirty-six patients had intrahepatic recurrence or metastasis postoperatively and 34 patients died. The Kaplan-Meier method and the Cox proportional harzards model analysis indicated that poor Child-Pugh score, tumor more than 2 cm in diameter, PVTT and multiple lesions (including satellitic lesions) were adverse factors affecting postoperative survival. The Cox proportional harzards model analysis indicated that tumor size, PVTT and multiple lesions were the factors influencing postoperative disease-free survival. CONCLUSIONS:Limited hepatectomy with a margin more than 1 cm is an appropriate surgical approach. Adverse preoperative Child-Pugh score and postoperative intrahepatic recurrences are the main factors leading to the death of patients with small HCC.

关键词： carcinoma, hepatocellular small hepatocellular carcinoma hepatectomy prognosis

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Mucin-Producing Intrahepatic Biliary Papillomatosis

Mucin-Producing Intrahepatic Biliary Papillomatosis

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2009年浙江省外科学学术年会

作者： department of 1 general Surgery Li Hui-Li hospital Ningbo University School of medicine Ningbo China Shengdong Wu Caide Lu Changjiang Lu Jing Huang department of Pathology Li Hui Li hospital Ningbo University School of medicine Ningbo China Jue Zhou

Purpose Mucin-producing intrahepatic biliary papillomatosis(MPIBP)is an uncommon tumor. The purpose of this study was to evaluate the clinical,radiological,and histopathological characteristics of MPIBP,and its progno...

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Orthotopic transplantation model of human gastrointestinal cancer and detection of micrometastases

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World Journal of Gastroenterology 2001年第3期7卷 381-386页

作者： Jun Hui Cui~1 Uwe Krueger~2 Doris Henne-Bruns~2 Bemd Kremer~2 Holger Kalthoff~2 ~1department of general Surgery,First Affiliated hospital,College of medicine,Zhejiang University,Hangzhou 310003,Zhejiang Province,China ~2department of general Surgery,Christian-Albrechts-University,Kiel,GermanyDr.Jun Hui Cui graduated from Zhejiang Medical University in 1984,earned master degree in 1990,studied in the Surgical department of Kiel University and worked in the Lab of Molecular Oncology of Kiel University from 1994-1997achieved M.D.from Kiel University.Germany,now associate professor of surgery,specialized in colorectal oncology.Adviser of graduated student for master degree,having 20 publications published in key Chinese or English journals. department of general Surgery First Affiliated Hospital College of Medicine Zhejiang University 79 Qingchun Road Hangzhou 310003 Zhejiang ProvinceChina. Cjhui@***

AIM: To establish a relevant animal model of human gastrointestinal cancer, which can be used for repetitive investigations, so as to improve our understanding and management of carcinogenesis and cancer metastasis. METHODS: Intact tissues of human colorectal and pancreatic cancers were transplanted in nude mice. The biological characteristics of the original and the corresponding transplanted tumors were investigated by HE staining, PAS staining and immunostaining. The metastases in the livers and lungs of nude mice were investigated by immunostaining with biotinylated mab KL-1 and by RT-PCR using CK20 specific primers. RESULTS: There were totally 9 of 16 surgical specimens growing in nude mice subcutaneously and/or orthotopically (4 of 6 colorectal and 5 of 10 pancreatic cancer). Tumor cell content of the specimens and freezing of tissue specimens are important factors influencing the growth of transplanted tumor. In the group of fresh tumor tissues with greater than 50% tumor cell content, the success rate of the transplantation was 100% (3 cases of pancreatic cancer and 3 cases of colorectal cancer). The orthotopically trans-planted tumors resemble the original tumor morphologically and biologically, including TAA expression such as CEA by immunohistochemistry, and CEA level in the serum of mice. Ki-67 labeling index and the expression of TAA especially K-ras, 17-1A and RA-96, are associated with the potential of tumor growth in nude mice. Micrometastases in the lungs and livers of tumor bearing mice can be detected by immunostaining with biotinylated mab KL-1 and CK20-specific RT-PCR. CONCLUSION: An orthotopic transplantation model for human colon and pancreatic cancer in nude mice has been set up. We have also established sensitive detection methods with CK-immunohistochemistry and CK20-RT-PCR to study xenotransplanted human cancer and its metastatic cancer cells in the liver and lung of nude mice. This study may be helpful in understanding the mechanism of ca

关键词： Animals Disease Models, Animal Female Gastrointestinal Neoplasms Humans Male Mice Mice, Nude Neoplasm Seeding Neoplasm Transplantation Research Support, Non-U.S. Gov't Transplantation, Heterologous

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激光疏通闭塞性动脉硬化的临床应用

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同济医科大学学报 1991年第6期20卷 387-389页

作者：黄厚珍邓建林赖传善王化敏同济医科大学附属同济医院内科长江航运总医院放射科同济医科大学附属协和医院外科武汉铁路中心医院放射科

经100条死体动物血管和28条活体动物血管的基础实验后,激光疏通血管于1990年4月开始成功应用于7例闭塞性动脉硬化患者。9条血管无1侧出血、穿孔,近期疗效100％。3例1年后复查血管仍保持通畅。

关键词：动脉硬化闭塞性激光疏通临床

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Focal nodular hyperplasia of the liver: pathological analysis of 11 cases

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Hepatobiliary & Pancreatic Diseases International 2004年第2期3卷 199-203页

作者： Yi Pan, Zhao-Ming Wang, Ling-Jun Mou, Xiao-Dong Teng, Zhou-Jun Zheng and Li-Xiong Ying Hangzhou, Chinadepartments of Pathology and general Surgery First Affilia- ted hospital, Zhejiang University School of medicine, Hangzhou 310003, China department of Pathology First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China. tjphy@***

BACKGROUND: Focal nodular hyperplasia (FNH) is a benign tumor-like lesion of the liver, predominantly affect- ing women. Its etiology is obscure and its pathogenesis is poorly understood. FNH should be differentiated from oth- er benign and malignant hepatic lesions. The aim of this study was to explore the pathological characteristics of FNH of the liver. METHODS: Eleven patients with FNH were studied retro- spectively by using hematoxylin and eosin, immunohisto- chemical and histochemical staining. RESULTS: In 8 female and 3 male FNH patients aged 19 to 54 years (mean 32), most of lesions showed central scars macroscopically. Microscopically 8 patients were found of classical type, 2 were of telangiectic type, and 1 was of mixed type. CONCLUSION: FNH is an uncommon benign hyperplastic lesion of the liver. It should be differentiated from hepato- cellular adenoma, alpha-fetoprotein negative hepatocellular carcinoma, and fibrolamellar carcinoma.

关键词： hepatic focal nodular hyperplasia pathology pathological diagnosis

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三叉神经自主神经性头痛的诊治

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中国实用内科杂志 2010年第6期30卷 506-509页

作者：刘若卓解放军总医院神经内科北京100853

文章主要介绍了三叉神经自主神经性头痛的分类及主要类型的临床表现、诊断标准及治疗。其发作具有头痛和显著的头颅副交感神经激活的特点。丛集性头痛急性发作期最有效的治疗是吸氧和皮下使用舒马坦,发作性丛集性头痛预防治疗首选麦角胺... 详细信息

文章主要介绍了三叉神经自主神经性头痛的分类及主要类型的临床表现、诊断标准及治疗。其发作具有头痛和显著的头颅副交感神经激活的特点。丛集性头痛急性发作期最有效的治疗是吸氧和皮下使用舒马坦,发作性丛集性头痛预防治疗首选麦角胺,其次为维拉帕米。慢性丛集性头痛预防治疗,首选维拉帕米联合应用锂盐。阵发性偏侧头痛吲哚美辛有绝对疗效。伴有结膜充血及流泪的单侧短暂持续性神经痛样头痛可选用拉莫三嗪、托吡酯和加巴喷丁治疗。

关键词：丛集性头痛阵发性偏侧头痛伴有结膜充血及流泪的单侧短暂持续性神经痛样头痛

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Studies on self-esteem of penile size in young Koreanmilitary men

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Asian Journal of Andrology 2003年第3期5卷 185-189页

作者： Hwancheol Son Hanjoo Lee Jung-Sik Huh Soo Woong Kim Jae-Seung Paick department of Urology Seoul Municipal Boramae Hospital Seoul Korea department of Neuropsychiatry Seoul National University College of Medicine Seoul Korea department of Urology Cheju National University College of Medicine Jeju Korea department of Urology Seoul National University College of Medicine Seoul 110744 Korea

Aim: To investigate the flaccid and stretched penile sizes of young Korean men and their complexes or pride about their penile size. Methods: After an explanation and agreement to the purpose and methods of this study, 123 Korean men in their early 20's visiting the Jinhae Military general hospital were included in the study. The flaccid penile length, flaccid mid-shaft circumference, stretched length and pre-pubic bone fat pad depth were measured in a warm comfortable environment. The accuracy the subjects assessed their penile size was investigated by asking them to rate their penile size, as 'very small', 'small', 'normal', 'large' or 'very large'. All subjects were asked to complete the Minnesota multiphasic personality inventory (MMPI) test. Results: The mean flaccid length, flaccid circumference, stretched length and fat pad depth of the 123 subjects were (6.9 ± 0.8) cm, (8.5 ±1.1) cm, (9.6 ± 0.8) cm and (1.1 ± 0.4) cm, respectively. The answer distribution on penile size was 1 (0.8 %) 'very small', 29 (23.6 %) 'small', 86 (69.9 %) 'normal', 6 (4.9 %) 'large' and 1 (0.8 %) 'very large'. Subjects who underestimated their penile size showed significantly higher scores on the hypochondriasis (Hs), depression (D) and psychasthenia (Pt) subscales of the MMPI than those in the Unbiased Group (P<0.05). Conclusion: In consultation, with a patient requesting penile augmentation, the urologist should consider the psychologic attitude of the patient to his penile size.

关键词： penile size penile length self esteem MMPI psychology

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Development and validation of a screening instrument for cognitive fluctuation in patientswith neurocognitive disorder with Lewy bodies(NCDLB):the Mayo Fluctuations Scale-Thai version

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general Psychiatry 2018年第4期31卷 10-16页

作者： Papan Thaipisuttikul Pitchayawadee Chittaropas Pattaraporn Wisajun Sudawan Jullagate department of Psychiatry Faculty of MedicineRamathibodi HospitalMahidolUniversityBangkokThailand

Background Prevalence of neurocognitive disorder with Lewy bodies （NCDLB） is low in Asian populations, which may partially refect its diagnostic diffculty. The Mayo Fluctuations Scale, a short questionnaire that evaluates cognitive fuctuation, has been shown to signifcantly differentiate NCDLB from Alzheimer＇s *** This study aimed to develop the Mayo Fluctuations Scale-Thai version and assess its validity to screen NCDLB in an elderly *** The Mayo Fluctuations Scale was translated into Thai. The process involved back-translation, cross-cultural adaptation, feld testing of the prefnal version, as well as fnal adjustments. From all patients attending the Psychiatric and Memory Clinic at Ramathibodi hospital, 135 patients accompanied by their primary caregivers were included. Caregivers were interviewed by research assistants using a four-item scale, and psychiatrists determined patients＇ diagnosis based on the diagnostic and statistical manual of mental disorders （DSM）-5 criteria. Evaluations performed by psychiatrists and research assistants were *** Seventeen participants had been diagnosed with major NCDLB. At a cut-off score of 2 or over, the Mayo Fluctuations Scale exhibited excellent performance to differentiate major NCDLB from other major neurocognitive disorders （NCDs）, with a sensitivity of 94.1% and a specifcity of 71.4%, and acceptable performance to differentiate mild NCDLB from other mild NCDs, with a sensitivity of 60% and a specifcity of 93.1%.Conclusion The Mayo Fluctuations Scale-Thai version is an excellent screening tool for major NCDLB and an acceptable tool that may be used with other additional tests for mild NCDLB. The tool is practical for use in memory and psychiatric clinics. Further validation studies in participants with other specifc clinical conditions are required.

关键词： Development andvalidation of a screening instrument cognitive fuctuation patientswith neurocognitive disorder Lewy bodies (NCDLB) the Mayo Fluctuations Scale-Thai versiond trials

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Effect of primary iris and ciliary body cyst on anterior chamber angle in patients with shallow anterior chamber

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第9期13卷 723-730页

作者： Bing-hong WANG Yu-feng YAO department of Ophthalmology Sir Run Run Shaw Hospital School of MedicineZhejiang UniversityHangzhou 310016China Sir Run Run Shaw Institute of Clinical medicine of Zhejiang University Hangzhou 310016China

Objective:To evaluate the prevalence of primary iris and/or ciliary body cysts in eyes with shallow anterior chamber and their effect on the narrowing of the anterior chamber ***:Among the general physical check-up population,subjects with shallow anterior chambers,as judged by van Herick technique,were recruited for further *** biomicroscope(UBM) was used to detect and measure the cysts located in the iris and/or ciliary body,the anterior chamber depth(ACD),the angle opening distance at 500 μm(AOD500),and the trabecular-iris angle(TIA).A-scan ultrasonography was used to measure the ocular biometry,including lens thickness,axial length,lens/axial length factor(LAF),and relative lens position(RLP).The effect of the cyst on narrowing the corresponding anterior chamber angle and the entire angle was evaluated by the UBM images,ocular biometry,and gonioscopic *** eye with unilateral cyst was compared with the eye without the cyst for further ***:Among the 727 subjects with shallow anterior chamber,primary iris and ciliary body cysts were detected in 250(34.4%) patients;among them 96(38.4%) patients showed unilateral single cyst,21(8.4%) patients had unilateral double cysts,and 42(16.8%) patients manifested unilateral multiple and multi-quadrants *** iris configuration was found in 140 of 361(38.8%) eyes with *** mean size of total cysts was(0.6547±0.2319) *** evaluation of the effect of the cyst size and location on narrowing the corresponding angle to their position,the proportion of the cysts causing corresponding angle narrowing or closure among the cysts larger than 0.8 mm(113/121,93.4%) was found to be significantly higher than that of the cysts smaller than 0.8 mm(373/801,46.6%),and a significant higher proportion was also found in the cysts located at iridociliary sulcus(354/437,81.0%) than in that at the pars plicata(131/484,27.1%).In evaluating the effect of the cyst on the entire anterior ch

关键词： Iris and ciliary body cyst Ultrasound biomicroscope Shallow anterior chamber

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A modified rat model for hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2004年第4期3卷 585-587页

作者： Fu-Chun Yang, Shu-Sen Zheng and Tian-An Jiang Hangzhou, China department of Hepatobiliary Pancreatic Surgery and Liver Transplantation Center, First Affiliated hospital, Zhejiang University School of medicine, Hangzhou 310003, China department of Hepatobiliary Pancreatic Surgery and Liver Transplantation Center First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China.

BACKGROUND: Rat hepatocellular carcinoma ( HCC ) model which has a high analogy to clinical liver cancer is of great value in understanding the pathogenesis and evolution of liver cancer, in searching effective anti-cancer treat- ments ( drug, hepatectomy and liver transplantation ), and designing cancer prevention strategies. In this study we es- tablished a modified rat model of hepatocellular carcinoma to enhance rats' physique and surgical endurance. METHODS: Wistar rats were fed with diethylnitrosamine (DENA) by three methods for evaluation of general condi- tions for 130 days: Doppler ultrasonographic measurement, laparotomy and histopathological examination. RESULTS: No rat died in control group ( group A) and modified DENA-induction-HCC group ( group C), but 6 deaths in classical DENA-induction-HCC group (group B) (survival rate 80%). All survived rats in groups B and C de- veloped diffusive hepatocellular carcinoma and liver cirrho- sis. general appearance of rats in the group C was better than that in the group B. CONCLUSION: With good general conditions for surgery, the modified rat model for hepatocellular carcinoma has a high carcinogenic rate and a high survival rate.

关键词： hepatocellular carcinoma model rat diethylnitrosamine

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