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作者： Yi-Jie Li Brittney O Baumert Nikos Stratakis Jesse A Goodrich Hao-Tian Wu Jing-Xuan He Yin-Qi Zhao Max T Aung Hong-Xu Wang Sandrah P Eckel Douglas I Walker Damaskini Valvi Michele A La Merrill Justin R Ryder Thomas H Inge Todd jenkins Stephanie Sisley Rohit Kohli Stavra A Xanthakos Andrea A Baccarelli rob McConnell David V Conti Lida Chatzi Department of Population and Public Health Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90032United States Barcelona Institute of Global Health Barcelona Institute of Global HealthBarcelona 08036Spain Department of Environmental Health Sciences Mailman School of Public HealthColumbia UniversityNew YorkNY 10032United States Gangarosa Department of Environmental Health Rollins School of Public HealthEmory UniversityAtlantaGA 30329United States Department of Environmental Medicine and Public Health Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Department of Environmental Toxicology University of CaliforniaDavisCA 95616United States Department of Surgery Lurie Children’s Hospital of ChicagoChicagoIL 60611United States Northwestern University Feinberg School of Medicine Northwestern UniversityChicagoIL 60611United States Division of Biostatistics and Epidemiology Cincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States Department of Pediatrics University of Cincinnati College of MedicineCincinnatiOH 45229United States Department of Pediatrics Children’s Nutrition Research Center USDA/ARSBaylor College of MedicineHoustonTX 77030United States Department of Gastroenterology Children’s Hospital Los AngelesLos AngelesCA 90027United States Division of Gastroenterology Hepatology and NutritionCincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases in children and *** ranges in severity from isolated hepatic steatosis to nonalcoholic steatohepatitis(NASH),wherein hepatocellular inflammation and/or fibrosis coexist with *** microRNA(miRNA)levels have been suggested to be altered in NAFLD,but the extent to which miRNA are related to NAFLD features remains *** analysis tested the hypothesis that plasma miRNAs are significantly associated with histological features of NAFLD in *** To investigate the relationship between plasma miRNA expression and NAFLD features among adolescents with *** This study included 81 adolescents diagnosed with NAFLD and 54 adolescents without NAFLD from the Teen-Longitudinal Assessment of Bariatric Surgery ***-operative core liver biopsies were collected from participants and used to characterize histological features of *** samples were collected during surgery for miRNA profiling.A total of 843 plasma miRNAs were profiled using the HTG EdgeSeq *** examined associations of plasma miRNAs and NAFLD features using logistic regression after adjusting for age,sex,race,and other key *** Pathways Analysis was used to identify biological functions of miRNAs that were associated with multiple histological features of *** We identified 16 upregulated plasma miRNAs,including miR-193a-5p and miR-193b-5p,and 22 downregulated plasma miRNAs,including miR-1282 and miR-6734-5p,in adolescents with ***,52,16,15,and 9 plasma miRNAs were associated with NASH,fibrosis,ballooning degeneration,and lobular inflammation,***,16 miRNAs were associated with two or more histological features of *** those miRNAs,miR-411-5p was downregulated in NASH,ballooning,and fibrosis,while miR-122-5p,miR-1343-5p,miR-193a-5p,miR-193b-5p,and miR-7845-5p were consistently and posi

关键词： MicroRNA Nonalcoholic fatty liver disease Non-alcoholic steatohepatitis Liver fibrosis Lobular inflammation Ballooning degeneration

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How completely are randomized controlled trials of non-pharmacological interventions following concussion reported? A systematic review

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Journal of Sport and Health Science 2024年第4期13卷 537-547页

作者： Jacqueline Josee van Ierssel Olivia Galea Kirsten Holte Caroline Luszawski Elizabeth jenkins Jennifer O’Neil Carolyn A Emery Rebekah Mannix Kathryn Schneider Keith Owen Yeates Roger Zemek Children’s Hospital of Eastern Ontario Research Institute OttawaON K1H 8L1Canada The Centre for Health Activity and Rehabilitation ResearchUniversity of OtagoDunedin 9016New Zealand Sport Injury Prevention Research Centre Faculty of KinesiologyUniversity of CalgaryCalgaryAB T2N 1N4Canada Alberta Children’s Hospital Research Institute University of Calgary CalgaryAB T2N 1N4Canada Hotchkiss Brain Institute University of CalgaryCalgaryAB T2N 4N1Canada Department of Psychology University of CalgaryCalgaryAB T2N 1N4Canada g Faculty of MedicineUniversity of OttawaOttawaON K1H 8M5Canada School of Rehabilitation Sciences University of OttawaOttawaON K1H 8M5Canada Bruyere Research Institute OttawaON K1N 5C8Canada Departments of Pediatrics and Emergency Medicine Harvard Medical SchoolBostonMA 02115USA Departments of Pediatrics and Emergency Medicine University of OttawaOttawaON K1H 8M5Canada

Purpose:The study aimed to examine the reporting completeness of randomized controlled trials(RCTs)of non-pharmacological interventions following ***:We searched MEDLINE,Embase,PsycInfo,CINAHL,and Web of Science up to May *** reviewers independently screened studies and assessed reporting completeness using the Template for Intervention Description and Replication(TIDieR),Consensus on Exercise Reporting Template(CERT),and international Consensus on Therapeutic Exercise aNd Training(i-CONTENT)*** information was sought my study authors where reporting was *** of bias(rob)was assessed with the Cochrane rob-2 *** examining non-pharmacological interventions following ***:We included 89 RCTs(n=53 high rob)examining 11 different interventions for concussion:sub-symptom threshold aerobic exercise,cervicovestibular therapy,physical/cognitive rest,vision therapy,education,psychotherapy,hyperbaric oxygen therapy,transcranial magnetic stimulation,blue light therapy,osteopathic manipulation,and head/neck *** scores were:TIDieR 9/12(75%;interquartile range(IQR)=5;range:5-12),CERT 17/19(89%;IQR=2;range:10-19),and i-CONTENT 6/7(86%;IQR=1;range:5-7).Percentage of studies completely reporting all items was TIDieR 35%(31/89),CERT 24%(5/21),and i-CONTENT 10%(2/21).Studies were more completely reported after publication of TIDieR(t_(87)=2.08;p=0.04)and CERT(t_(19)=2.72;p=0.01).Reporting completeness was not strongly associated with journal impact factor(TIDieR:rs=0.27;p=0.01;CERT:r_(s)=-0.44;p=0.06;i-CONTENT:r_(s)=-0.17;p=0.48)or rob(TIDieR:rs=0.11;p=0.31;CERT:rs=0.04;p=0.86;i-CONTENT:rs=0.12;p=0.60).Conclusion:RCTs of non-pharmacological interventions following concussion demonstrate moderate to good reporting completeness,but are often missing key components,particularly modifications,motivational strategies,and qualified *** completeness improved after TIDieR and CERT publication,but p

关键词： Concussion Intervention Randomized controlled trial Systematic review

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Mapping Critical Loads of Acid Deposition for Soils in China

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Tsinghua Science and Technology 2000年第3期5卷 270-278页

作者：段雷郝吉明 Alan jenkins' rob Collins Chris Evans 谢绍东 Department of Environmental Science and Engineering Tsinghua University Beijing 100084 Institute of Hydrology. Wallingford Oxfordshire OXIO 8BB UK Center of Environmental Sciences Peking University Beijing 100871 China

A method described is to produce critical load maps of acid deposition for soils in China. Critical loads were assigned to the most sensitive soil in each 0.1°×0.1° grid square of China based on the Skokloster classification [1] and adjusted for temperature and land use. The map shows that soils with small critical load (<0.5keq·ha -1 ·a -1 ) i.e., highly sensitive to acid deposition, dominate in the south and northeast China. As a result of the adjustment, much of the acid sensitive area in the south estimated by the Skokloster method is lost. This reflects the decreased sensitivity as a result of agricultural activities and increased weathering rate in response to high temperature. Based on the 0.1°×0.1° map, a series of percentile critical load maps at 1°×1° scale were compiled for integrated assessments, as well as a critical load map using the minimum critical load for each grid. Comparison of critical loads with sulphur deposition in 1995 led to the critical load exceedance maps for sulphur deposition, which show that high exceedance areas do not correlate well with the low critical load areas, and almost one fourth of the land area, mainly in the southeast, is subject to the risk of acidification. 

关键词： critical load acid deposition soil sensitivity

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必胜英语大学英语实用听说教程 2 学生用书 4

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丛书名：大学英语立体化网络化系列教材

2004年

作者：（美）rob jenkins Staci Lyn Sabbagh 梁育全蔡维碧范波朱黎勇姜立

《必胜英语》大学英语实用听说教程是北京大学出版社与美国汤姆森学习出版集团（ThomsonLearning）共同推出的新型大学英语听说系列教材。本套教材贯彻教育部有关英语改革的精神。课程设计标准科学，注重学生英语听说能力和英语综合实... 详细信息

ISBN: (纸本)7301066694

《必胜英语》大学英语实用听说教程是北京大学出版社与美国汤姆森学习出版集团（ThomsonLearning）共同推出的新型大学英语听说系列教材。本套教材贯彻教育部有关英语改革的精神。课程设计标准科学，注重学生英语听说能力和英语综合实用能力的培养。围绕听力、对话、阅读与语音练习，把语言学习、生活技巧、现实世界的行为活动融为一体，内容编排丰富多彩、简单上口，决不枯燥。并配有听说技能必需的语法训练，摆脱窠臼，让学生在真实的上下文语境中掌握语法和词汇。《必胜英语》配有CD光盘、录音带和内容生动的教师用书，并向教师赠送可以用于网络教学检查的TestBank，适应个性化教学与网络自主学习训练模式，简单好用，更多...

关键词：听说教学英语教材高等学校

来源：畅想之星图书光盘版（南... 评论

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利用mosquito纳升级液体处理工作站建立微量蛋白质晶体生长体系

利用mosquito纳升级液体处理工作站建立微量蛋白质晶体生长体系

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中国晶体学会第四届全国会员代表大会暨学术会议

作者： Joby jenkins rob Lewis Wayne Bowen Chloё Milburn TTP LabTech Ltd Melbourn Science ParkMelbournHertfordshireSG8 6EEUK

有效的高通量蛋白质晶体筛选系统的一个先决条件是在用悬滴法和坐滴法生长晶体时对微小液滴进行准确的移取和定位。微小液滴移取尚有解决方案,但是由于蛋白质和池液/结晶溶剂的粘性范围广泛,对许多液体处理系统这是一个重大的挑战。TTP ...

有效的高通量蛋白质晶体筛选系统的一个先决条件是在用悬滴法和坐滴法生长晶体时对微小液滴进行准确的移取和定位。微小液滴移取尚有解决方案,但是由于蛋白质和池液/结晶溶剂的粘性范围广泛,对许多液体处理系统这是一个重大的挑战。TTP LabTech的mosquito（?）利用快捷的容积式移液方式可以准确而可靠地吸取和分配50纳升至1.2微升范围的液体,无论液体粘性如何均可在50纳升水平达到小于8%的CV值。Mosquito的微型加样针是一次性的,可保证零交叉污染。

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