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A Model System of Development Regulated by the Long-distance Transport of mRNA

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j.urnal of Integrative Plant Biology 2010年第1期52卷 40-52页

作者： david j. Hannapel Plant Biology Maj.r 253 Horticulture Hall Iowa State University

BELl-like transcription factors are ubiquitous in plants and interact with KNOTTEDI-types to regulate numerous developmental processes. In potato, the RNA of several BELl-like transcription factors has been identified in phloem cells. One of these, StBEL5, and its Knox protein partner regulate tuber formation by targeting genes that control growth. RNA detection methods and grafting experiments demonstrated that StBEL5 transcripts move across a graft union to localize in stolon tips, the site of tuber induction. This movement of RNA originates in source leaf veins and petioles and is induced by a short-day photoperiod, regulated by the untranslated regions, and correlated with enhanced tuber production. Addition of the StBEL5 untranslated regions to another *** mRNA resulted in its preferential transport to stolon tips leading to increased tuber production. Upon fusion of the untranslated regions of StBEL5 to a β-glucuronidase marker, translation in tobacco protoplasts was repressed by those constructs containing the 3＇ untranslated sequence. The untranslated regions of the StBEL5 mRNA are involved in mediating its long-distance transport and in controlling translation. The 3＇ untranslated sequence contains an abundance of conserved motifs that may serve as binding motifs for RNA-binding proteins. Because of their presence in the phloem sieve tube system, their unique untranslated region sequences and their diverse RNA accumulation patterns, the family of BEL1-like RNAs from potato represents a valuable model for studying the long-distance transport of full-length mRNAs and their role in development.

关键词： BEL A Model System of Development Regulated by the Long-distance Transport of mRNA Long

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LabVIEW GUI

Ribozymes and the mechanisms that underlie RNA catalysis

2002年

作者： david j. Ritter.

来源：畅想之星图书光盘版（南... 评论

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畅想之星图书光盘版（南通市图书馆镜像）

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Frontiers of Chemical Science and Engineering 2016年第2期10卷 178-185页

作者： Timothy j. Wilson Yij.n Liu david M. j. Lilley Cancer Research UK Nucleic Acid Structure Research Group MSI/WTB Complex The University of Dundee Dundee DD1 5EH UK

Ribozymes are widespread, and catalyze some extremely important reactions in the cell. Mechanistically most fall into one of two classes, using either metal ions or general acid-base catalysis. The nucleolytic ribozymes fall into the latter class, mostly using nucleobases. A sub-set of these use a combination of guanine base plus adenine acid to catalyze the cleavage reaction. New ribozymes are still being discovered at regular intervals and we can speculate on the potential existence of ribozymes that catalyze chemistry beyond phosphoryl transfer reactions, perhaps using small-molecule coenzymes.

关键词： RNA catalysis RNA structure catalytic mechanism

Geometrically constrained isogeometric parameterizedlevel-set based topology optimization via trimmed elements

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Frontiers of Mechanical Engineering 2016年第4期11卷 328-343页

作者： Yingj.n WANG david j. BENSON School of Mechanical and Automotive Engineering South China University of Technology Guangzhou 510641 China Department ofMechanical Engineering McGill University Montreal H3AOC3 Canada Department of Structural Engineering University of California SanDiego 92093 USA

In this paper, an approach based on the fast point-in-polygon (PIP) algorithm and trimmed elements is proposed for isogeometric topology optimization (TO) with arbitrary geometric constraints. The isogeometric parameterized level-set-based TO method, which directly uses the non-uniform rational basis splines (NURBS) for both level set function (LSF) parameterization and obj.ctive function calculation, provides higher accuracy and efficiency than previous methods. The integration of trimmed elements is completed by the efficient quadrature rule that can design the quadrature points and weights for arbitrary geometric shape. Numerical examples demonstrate the efficiency and flexibility of the method.

关键词： isogeometric analysis topology optimization level set method arbitrary geometric constraint trimmed element

A laser extinction based sensor for simultaneous droplet size and vapor measurement

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Particuology 2012年第1期10卷 9-16页

作者： Xueqiang Sun david j. Ewing Lin Ma College of Automatic Control and Mechanical Engineering Kunming University Kunming 650214 China Department of Aerospace and Ocean Engineering Virginia Tech Blacksburg VA 24063 USA

Multiphase flows involving liquid droplets in association with gas flow occur in many industrial and sci- entific applications. Recent work has demonstrated the feasibility of using optical techniques based on laser extinction to simultaneously measure vapor concentration and temperature and droplet size and loading. This work introduces the theoretical background for the optimal design of such laser extinction techniques, termed WMLE （wavelength-multiplexed laser extinction）. This paper focuses on the devel- opment of WMLE and presents a systematic methodology to guide the selection of suitable wavelengths and optimize the performance of WMLE for specific applications. WMLE utilizing wavelengths from 0.5 to 10 ixm is illustrated for droplet size and vapor concentration measurements in an example of water spray, and is found to enable unique and sensitive Sauter mean diameter measurement in the range of ~1-15 ~m along with accurate vapor detection. A vapor detection strategy based on differential absorp- tion is developed to extend accurate measurement to a significantly wider range of droplet loading and vapor concentration as compared to strategies based on direct fixed-wavelength absorption. Expected performance of the sensor is modeled for an evaporating spray. This work is expected to lay the ground- work for implementing optical sensors based on WMLE in a variety of research and industrial applications involving multi-phase flows.

关键词： Wavelength-multiplexed laser extinctionDropletMeasurementLaserExtinctionAbsorptionSpectroscopy

Advances in Stability Theory for Complex Systems and Networks

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HSV gene transfer in the treatment of chronic pain

第二十七届中国控制会议

作者： Hill david j. Research School of Information Sciences and Engineering Australian National University

ISBN: (纸本)9787811243901

Throughout natural and engineered systems,questions about stability always *** a power network avoid blackouts?Will the Internet avoid traffic congestion?Will a species population survive?Engineered systems now have features comparable to living systems,namely massive scale,high degrees of nonlinearity,uncertainty and *** systems are summarized as being *** important class of such systems has a well-defined network structure where large numbers of nodes,typically described by nonlinear dynamical systems,are connected by *** theory faces many challenges in providing tools to assess stability and instability for such complex *** this assessment must allow for layers of feedback control which have been implemented to regulate local and global *** paper will describe the advancement of stability theory to deal with complex systems with some emphasis on interconnected systems featuring feedback and network structures.

关键词： Stability Complex systems Networks

来源： cnki会议评论

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cnki会议

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生理学报 2008年第5期60卷 610-616页

作者： david j. Fink Marina Mata University of Michigan and VA Ann Arbor Healthcare System Ann Arbor Michigan 48109 USA

It has proven difficult to use systemic administration of small molecules to selectively modulate *** the past decade,we and others have developed non-replicating herpes simplex virus(HSV)-based vectors to treat chronic *** inoculation of an HSV vector effectively transduces sensory neurons in the dorsal root ganglion;release of transgene-coded inhibitory neurotransmitters or anti-inflammatory peptides reduces pain-related behaviors in rodent models of chronic inflammatory and neuropathic pain.A phase 1 trial of this therapy in patients is set to begin soon.

关键词： HSV 基因慢性疼痛临床分析病症

Targeting chronic and evolving neuroinflammation following traumatic brain inj.ry to improve long-term outcomes: insights from microglial-depletion models

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Neural Regeneration Research 2021年第5期16卷 976-977页

作者： Rebecca j.Henry david j.Loane Department of Anesthesiology and Shock Trauma and Anesthesiology Research(STAR)CenterUniversity of Maryland School of MedicineBaltimoreMDUSA School of Biochemistry and Immunology Trinity Biomedical Sciences InstituteTrinity CollegeDublinIreland

Microglia,the resident innate immune cells of the central nervous system(CNS),play important roles in brain development,maintenance,and *** brain sentinels,microglia adopt a surveillant state in healthy tissue characterized by a ramified scanning morphology that maintains CNS homeostasis and contributes to learningassociated synaptic plasticity.

关键词： inflammation homeostasis traumatic

Oxygation Enhances Growth,Gas Exchange and Salt Tolerance of Vegetable Soybean and Cotton in a Saline Vertisol

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j.urnal of Integrative Plant Biology 2009年第7期51卷 675-688页

作者： Surya P. Bhattarai david j. Midmore Centre for Plant and Water Science Department of Molecular and Life SciencesCentral Queensland University

Impacts of salinity become severe when the soil is deficient in oxygen. OxygaUon （using aerated water for subsurface drip irrigation of crop） could minimize the impact of salinity on plants under oxygen-limiting soil environments. Pot experiments were conducted to evaluate the effects of oxygation （12% air volume/volume of water） on vegetable soybean （moderately salt tolerant） and cotton （salt tolerant） in a salinized vertisol at 2, 8, 14, 20 dS/m ECe. In vegetable soybean, oxygation increased above ground biomass yield and water use efficiency （WUE） by 13% and 22%, respectively, compared with the control. Higher yield with oxygation was accompanied by greater plant height and stem diameter and reduced specific leaf area and leaf Na^＋ and CI^- concentrations. In cotton, oxygation increased lint yield and WUE by 18% and 16%, respectively, compared with the control, and was accompanied by greater canopy light interception, plant height and stem diameter. Oxygation also led to a greater rate of photosynthesis, higher relative water content in the leaf, reduced crop water stress index and lower leaf water potential. It did not, however, affect leaf Na^＋ or CI^- concentration. Oxygation invariably increased, whereas salinity reduced the K^＋： Na^＋ ratio in the leaves of both species. Oxygation improved yield and WUE performance of salt tolerant and moderately tolerant crops under saline soil environments, and this may have a significant impact for irrigated agriculture where saline soils pose constraints to crop production.

关键词： cotton irrigation light interception oxygation saline soil salt exclusion stem diameter vegetable soybean